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Protein
Submitted name:

Isocitrate dehydrogenase, NADP-dependent

Gene

BC1002_0850

Organism
Burkholderia sp. (strain CCGE1002)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei147 – 1471SubstrateUniRule annotation
Sitei257 – 2571Critical for catalysisUniRule annotation
Metal bindingi352 – 3521Magnesium or manganeseUniRule annotation
Sitei422 – 4221Critical for catalysisUniRule annotation
Binding sitei550 – 5501SubstrateUniRule annotation
Metal bindingi551 – 5511Magnesium or manganeseUniRule annotation
Metal bindingi555 – 5551Magnesium or manganeseUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciBSP640511:GJ7J-859-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase, NADP-dependentImported (EC:1.1.1.42Imported)
Gene namesi
Ordered Locus Names:BC1002_0850Imported
OrganismiBurkholderia sp. (strain CCGE1002)Imported
Taxonomic identifieri640511 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
ProteomesiUP000002190 Componenti: Chromosome 1

Interactioni

Protein-protein interaction databases

STRINGi640511.BC1002_0850.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1418Substrate bindingUniRule annotation

Phylogenomic databases

HOGENOMiHOG000240860.
KOiK00031.
OMAiNSGQMWG.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

D5W5A4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTQQPTIIY TLTDEAPLLA TAAFLPIIRT FTRPAGIEVE TSDISVAGRI
60 70 80 90 100
LGEFPEFLTE AQRVPDNLAE LGRLTSLPDT NIIKLPNISA SVPQLTSAIK
110 120 130 140 150
ELQAKGYKVP DYPEDPKTDA EKAIRQRYSK CLGSAVNPVL REGNSDRRAP
160 170 180 190 200
AAVKNYARKH PHSMTEWSMA SRTHVATMRH GDFYHGEKSM TLDRARDVKM
210 220 230 240 250
ELVTKNGKTI VLKPKVALED GEIIDSMFMS KKALLAFYED QMEDARKTGM
260 270 280 290 300
MLSLHVKATM MKISHPIVFG HAVKVFYKDA FAKHGKLFEE LGVNVNNGLV
310 320 330 340 350
NLYEKIEALP ESQREEVIRD LHACHEHRPE LAMVDSAKGI SNLHAPNDVI
360 370 380 390 400
VDASMPAMIR AGGKMWGADG RPKDTKAVIP ESTFARIYQE IINFCKTNGA
410 420 430 440 450
FDPVTMGTVP NVGLMAQKAE EYGSHDKTFE VPEDGEARIV DLASGEVLLT
460 470 480 490 500
QNVEQGDIWR MCEVKDAAIR DWVKLAVTRV RNSRTPAVFW LDPYRPHEAE
510 520 530 540 550
LIKKVEAYLK DYDTTGLDIQ IMSQVRAMRY TLERVVRGLD TISVTGNILR
560 570 580 590 600
DYLTDLFPIM ELGTSAKMLS IVPLMAGGGM YETGAGGSAP KHVKQLVEEN
610 620 630 640 650
HLRWDSLGEF LALAVSLEEL GIKTGNNRAK ILAKTLDTAT GKLLDNNRSP
660 670 680 690 700
SPKTGELDNR GSQFYLAMYW AQELAAQTDD AALAAQFAPL ATQLTANEQV
710 720 730 740
IVAELASVQG APADIGGYYK PDFNKLEEVM RPSRTFNEAL KAVRVE
Length:746
Mass (Da):82,635
Last modified:July 13, 2010 - v1
Checksum:i05503DBB412A69BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002013 Genomic DNA. Translation: ADG14946.1.
RefSeqiWP_013088834.1. NC_014117.1.

Genome annotation databases

EnsemblBacteriaiADG14946; ADG14946; BC1002_0850.
KEGGibge:BC1002_0850.
PATRICi37210454. VBIBurSp41388_0840.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002013 Genomic DNA. Translation: ADG14946.1.
RefSeqiWP_013088834.1. NC_014117.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi640511.BC1002_0850.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADG14946; ADG14946; BC1002_0850.
KEGGibge:BC1002_0850.
PATRICi37210454. VBIBurSp41388_0840.

Phylogenomic databases

HOGENOMiHOG000240860.
KOiK00031.
OMAiNSGQMWG.

Enzyme and pathway databases

BioCyciBSP640511:GJ7J-859-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome 1 of Burkholderia sp. CCGE1002."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Martinez-Romero E., Hernandez M.A.R., Tiedje J.M., Woyke T.
    Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CCGE1002Imported.

Entry informationi

Entry nameiD5W5A4_BURSC
AccessioniPrimary (citable) accession number: D5W5A4
Entry historyi
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: July 22, 2015
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.