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D5W5A4

- D5W5A4_BURSC

UniProt

D5W5A4 - D5W5A4_BURSC

Protein
Submitted name:

Isocitrate dehydrogenase, NADP-dependent

Gene

BC1002_0850

Organism
Burkholderia sp. (strain CCGE1002)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (13 Jul 2010)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei147 – 1471SubstrateUniRule annotation
    Sitei257 – 2571Critical for catalysisUniRule annotation
    Metal bindingi352 – 3521Magnesium or manganeseUniRule annotation
    Sitei422 – 4221Critical for catalysisUniRule annotation
    Binding sitei550 – 5501SubstrateUniRule annotation
    Metal bindingi551 – 5511Magnesium or manganeseUniRule annotation
    Metal bindingi555 – 5551Magnesium or manganeseUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseImported

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciBSP640511:GJ7J-859-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Isocitrate dehydrogenase, NADP-dependentImported (EC:1.1.1.42Imported)
    Gene namesi
    Ordered Locus Names:BC1002_0850Imported
    OrganismiBurkholderia sp. (strain CCGE1002)Imported
    Taxonomic identifieri640511 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
    ProteomesiUP000002190: Chromosome 1

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni134 – 1418Substrate bindingUniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000240860.
    KOiK00031.

    Family and domain databases

    Gene3Di3.40.718.10. 3 hits.
    InterProiIPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PfamiPF03971. IDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    D5W5A4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTQQPTIIY TLTDEAPLLA TAAFLPIIRT FTRPAGIEVE TSDISVAGRI    50
    LGEFPEFLTE AQRVPDNLAE LGRLTSLPDT NIIKLPNISA SVPQLTSAIK 100
    ELQAKGYKVP DYPEDPKTDA EKAIRQRYSK CLGSAVNPVL REGNSDRRAP 150
    AAVKNYARKH PHSMTEWSMA SRTHVATMRH GDFYHGEKSM TLDRARDVKM 200
    ELVTKNGKTI VLKPKVALED GEIIDSMFMS KKALLAFYED QMEDARKTGM 250
    MLSLHVKATM MKISHPIVFG HAVKVFYKDA FAKHGKLFEE LGVNVNNGLV 300
    NLYEKIEALP ESQREEVIRD LHACHEHRPE LAMVDSAKGI SNLHAPNDVI 350
    VDASMPAMIR AGGKMWGADG RPKDTKAVIP ESTFARIYQE IINFCKTNGA 400
    FDPVTMGTVP NVGLMAQKAE EYGSHDKTFE VPEDGEARIV DLASGEVLLT 450
    QNVEQGDIWR MCEVKDAAIR DWVKLAVTRV RNSRTPAVFW LDPYRPHEAE 500
    LIKKVEAYLK DYDTTGLDIQ IMSQVRAMRY TLERVVRGLD TISVTGNILR 550
    DYLTDLFPIM ELGTSAKMLS IVPLMAGGGM YETGAGGSAP KHVKQLVEEN 600
    HLRWDSLGEF LALAVSLEEL GIKTGNNRAK ILAKTLDTAT GKLLDNNRSP 650
    SPKTGELDNR GSQFYLAMYW AQELAAQTDD AALAAQFAPL ATQLTANEQV 700
    IVAELASVQG APADIGGYYK PDFNKLEEVM RPSRTFNEAL KAVRVE 746
    Length:746
    Mass (Da):82,635
    Last modified:July 13, 2010 - v1
    Checksum:i05503DBB412A69BA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002013 Genomic DNA. Translation: ADG14946.1.
    RefSeqiWP_013088834.1. NC_014117.1.
    YP_003604457.1. NC_014117.1.

    Genome annotation databases

    EnsemblBacteriaiADG14946; ADG14946; BC1002_0850.
    GeneIDi9088520.
    KEGGibge:BC1002_0850.
    PATRICi37210454. VBIBurSp41388_0840.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002013 Genomic DNA. Translation: ADG14946.1 .
    RefSeqi WP_013088834.1. NC_014117.1.
    YP_003604457.1. NC_014117.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADG14946 ; ADG14946 ; BC1002_0850 .
    GeneIDi 9088520.
    KEGGi bge:BC1002_0850.
    PATRICi 37210454. VBIBurSp41388_0840.

    Phylogenomic databases

    HOGENOMi HOG000240860.
    KOi K00031.

    Enzyme and pathway databases

    BioCyci BSP640511:GJ7J-859-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 3 hits.
    InterProi IPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    Pfami PF03971. IDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Burkholderia sp. CCGE1002."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Martinez-Romero E., Hernandez M.A.R., Tiedje J.M., Woyke T.
      Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CCGE1002Imported.

    Entry informationi

    Entry nameiD5W5A4_BURSC
    AccessioniPrimary (citable) accession number: D5W5A4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 13, 2010
    Last sequence update: July 13, 2010
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3