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D5VZG6

- D5VZG6_CLOB2

UniProt

D5VZG6 - D5VZG6_CLOB2

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Protein
Alanine racemase
Gene
alr-1, CBF_1716
Organism
Clostridium botulinum (strain 230613 / Type F)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei38 – 381Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei136 – 1361Substrate By similarityUniRule annotation
Active sitei267 – 2671Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei315 – 3151Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationsImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciCBOT758678:GLBH-1716-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alr-1Imported
Ordered Locus Names:CBF_1716Imported
OrganismiClostridium botulinum (strain 230613 / Type F)Imported
Taxonomic identifieri758678 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000002367: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei38 – 381N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD5VZG6.

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiFIMSHLA.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D5VZG6-1 [UniParc]FASTAAdd to Basket

« Hide

MFRNHRPVWE EVNLDNLSYN MRNIKKKVNC KEIFAVVKAN GYGHGALDIA    50
STLLENGATR LSVACLSEAT ELREGGITCP INILGITPPT LFEDIIDYNI 100
EPVVFSYDYA NQLSKAASLK NRIVKTHIAV DTGMGRLGFD PTVESLEEIK 150
RIQDLSNIKI EGLCSHFSSS DENDKSYSEY QFKIFQNFRK KLIGINMKIP 200
IYHMSNSAAI IDLPSTYLDA VRAGIILYGY YPSMEVNKEN LHIKQVMTLK 250
ANIVHIKTID SGKYVGYNRK FKTKRKSKIA ILPLGYGDGY TRFLSNRGKV 300
IINGQYAPIV GNICMDQCMI DVTDIKEVKV GDEVIIIGKD NINNLRYDAE 350
DIASKVGMTS GEIMSIISKR VPRVYIKNGN IVKVRNYIA 389
Length:389
Mass (Da):43,729
Last modified:July 13, 2010 - v1
Checksum:i4C23B6613A3E74DE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002011 Genomic DNA. Translation: ADF99430.1.
RefSeqiWP_012099742.1. NC_017297.1.
YP_005674631.1. NC_017297.1.

Genome annotation databases

EnsemblBacteriaiADF99430; ADF99430; CBF_1716.
GeneIDi12229580.
KEGGicbm:CBF_1716.
PATRICi36788089. VBICloBot152196_1752.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002011 Genomic DNA. Translation: ADF99430.1 .
RefSeqi WP_012099742.1. NC_017297.1.
YP_005674631.1. NC_017297.1.

3D structure databases

ProteinModelPortali D5VZG6.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADF99430 ; ADF99430 ; CBF_1716 .
GeneIDi 12229580.
KEGGi cbm:CBF_1716.
PATRICi 36788089. VBICloBot152196_1752.

Phylogenomic databases

HOGENOMi HOG000031444.
KOi K01775.
OMAi FIMSHLA.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci CBOT758678:GLBH-1716-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of a type F Clostridium botulinum strain."
    Tian R., Li T.
    Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 230613 / Type F.

Entry informationi

Entry nameiD5VZG6_CLOB2
AccessioniPrimary (citable) accession number: D5VZG6
Entry historyi
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: September 3, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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