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D5VTS8 (D5VTS8_METIM) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylamine--glycine ligase HAMAP-Rule MF_00138
EC=6.3.4.13 HAMAP-Rule MF_00138
Alternative name(s):
GARS HAMAP-Rule MF_00138
Glycinamide ribonucleotide synthetase HAMAP-Rule MF_00138
Phosphoribosylglycinamide synthetase HAMAP-Rule MF_00138
Gene names
Name:purD HAMAP-Rule MF_00138
Ordered Locus Names:Metin_1331
OrganismMethanocaldococcus infernus (strain DSM 11812 / JCM 15783 / ME) [Complete proteome] [HAMAP]
Taxonomic identifier573063 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus ›

Protein attributes

Sequence length447 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide. HAMAP-Rule MF_00138

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00138

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. HAMAP-Rule MF_00138

Sequence similarities

Belongs to the GARS family. HAMAP-Rule MF_00138

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00138

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain109 – 324216ATP-grasp By similarity HAMAP-Rule MF_00138
Nucleotide binding140 – 20263ATP By similarity HAMAP-Rule MF_00138

Sites

Metal binding2821Magnesium or manganese 1 By similarity HAMAP-Rule MF_00138
Metal binding2941Magnesium or manganese 1 By similarity HAMAP-Rule MF_00138
Metal binding2941Magnesium or manganese 2 By similarity HAMAP-Rule MF_00138
Metal binding2961Magnesium or manganese 2 By similarity HAMAP-Rule MF_00138

Sequences

Sequence LengthMass (Da)Tools
D5VTS8 [UniParc].

Last modified July 13, 2010. Version 1.
Checksum: F5E8432C1E02C99F

FASTA44749,758
        10         20         30         40         50         60 
MVKVLLIGGG ARESAIAHAL KKSDIKLYTL MKNKNPGIAR LSEEIRLAKE TELNEIEDFA 

        70         80         90        100        110        120 
KKINPDLAII GPEAPLEKGA VDLLESLGVP TVGPSKEAAK IETSKEFMRN LFKKYNIKGS 

       130        140        150        160        170        180 
LLWKSFDEYG EELESFIDEL TEKGIKAVVK PVGLTGGKGV KVVGEQLKDN EEAKKYAKEI 

       190        200        210        220        230        240 
FESGLGGGKV LIEEKLEGVE FTLHGFVDKD NIKFTPFVQD HPHALEGDKG SITGGMGSYS 

       250        260        270        280        290        300 
CPNHKLPFLT EEDAKEAKEI MEETVKALKK EVDGYKGILY GQFMLTKDGP KIIEYNARFG 

       310        320        330        340        350        360 
DPEAMNILAI LKSNFLDICE AIVNRRLDKV DVEFENKATV CKYVVPMGYP DKPVRGEEIY 

       370        380        390        400        410        420 
VDEEKIKKVG AILHYASVDE RDGKLYMTGS RAVAVVGVSD TIEEAERIAE EATKFINGRV 

       430        440 
YHRSDIGKKE LIRKRIEKMR KLRGLVI

« Hide

References

[1]"Complete sequence of Methanocaldococcus infernus ME."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Munk A.C., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Mikhailova N., Sieprawska-Lupa M., Whitman W.B., Woyke T.
Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 11812 / JCM 15783 / ME.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002009 Genomic DNA. Translation: ADG13981.1.
RefSeqYP_003616945.1. NC_014122.1.

3D structure databases

ProteinModelPortalD5VTS8.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADG13981; ADG13981; Metin_1331.
GeneID9132362.
KEGGmif:Metin_1331.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000033464.
KOK01945.
OMAMGAYTPL.

Enzyme and pathway databases

BioCycMINF573063:GHL3-1364-MONOMER.
UniPathwayUPA00074; UER00125.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.600.10. 1 hit.
HAMAPMF_00138. GARS.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR020559. PRibGlycinamide_synth_CS.
IPR020562. PRibGlycinamide_synth_N.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamPF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. PreATP-grasp-like. 1 hit.
SSF51246. Rudmnt_hyb_motif. 1 hit.
TIGRFAMsTIGR00877. purD. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00184. GARS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD5VTS8_METIM
AccessionPrimary (citable) accession number: D5VTS8
Entry history
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: May 1, 2013
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info