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Protein

Homoserine kinase

Gene

thrB

Organism
Methanocaldococcus infernus (strain DSM 11812 / JCM 15783 / ME)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.UniRule annotation

Catalytic activityi

ATP + L-homoserine = ADP + O-phospho-L-homoserine.UniRule annotation

Pathwayi: L-threonine biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes L-threonine from L-aspartate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Aspartokinase (Metin_0677)
  2. Aspartate-semialdehyde dehydrogenase (asd)
  3. no protein annotated in this organism
  4. Homoserine kinase (thrB)
  5. Threonine synthase (Metin_1025)
This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi81 – 91ATPUniRule annotationAdd BLAST11

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processAmino-acid biosynthesis, Threonine biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00050; UER00064.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine kinaseUniRule annotation (EC:2.7.1.39UniRule annotation)
Short name:
HKUniRule annotation
Short name:
HSKUniRule annotation
Gene namesi
Name:thrBUniRule annotation
Ordered Locus Names:Metin_1203Imported
OrganismiMethanocaldococcus infernus (strain DSM 11812 / JCM 15783 / ME)Imported
Taxonomic identifieri573063 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000002061 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi573063.Metin_1203.

Structurei

3D structure databases

ProteinModelPortaliD5VTF3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 140GHMP_kinases_NInterPro annotationAdd BLAST68
Domaini197 – 274GHMP_kinases_CInterPro annotationAdd BLAST78

Sequence similaritiesi

Belongs to the GHMP kinase family. Homoserine kinase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01027. Archaea.
COG0083. LUCA.
HOGENOMiHOG000247197.
KOiK00872.
OMAiPDNVAPC.
OrthoDBiPOG093Z0AGJ.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPiMF_00384. Homoser_kinase. 1 hit.
InterProiView protein in InterPro
IPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
PfamiView protein in Pfam
PF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
PIRSFiPIRSF000676. Homoser_kin. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsiTIGR00191. thrB. 1 hit.
PROSITEiView protein in PROSITE
PS00627. GHMP_KINASES_ATP. 1 hit.

Sequencei

Sequence statusi: Complete.

D5VTF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVKAPCSSA NLGVGFDVFG LCLEEPYDII EVKKIDEGIE IEGKDIPLNP
60 70 80 90 100
KENVAGVVAE KMLKDFNIES GVKIKIKKGI KGGSGLGSSA ASAAGTAFAI
110 120 130 140 150
NELFNLKLSK LKLVDYASYG ELIASGAKHA DNVAPAIYGG FTIVNYNPLN
160 170 180 190 200
VLHIDVDFNV IVAIPNVKIE TKKAREIIPK EVSLKDMVHN LGRATGMIYA
210 220 230 240 250
LFNNDLELFG KYMMEDKIVE PYRGKLIPHY FEVKEKLKNL AYGVCISGSG
260 270 280 290
PSILVIPKEE FQDEIIDILS SYYDKIIKTR VGKGCELYKA
Length:290
Mass (Da):31,739
Last modified:July 13, 2010 - v1
Checksum:i6CBC63B3ABC7C485
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002009 Genomic DNA. Translation: ADG13856.1.
RefSeqiWP_013100601.1. NC_014122.1.

Genome annotation databases

EnsemblBacteriaiADG13856; ADG13856; Metin_1203.
GeneIDi9132222.
KEGGimif:Metin_1203.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiD5VTF3_METIM
AccessioniPrimary (citable) accession number: D5VTF3
Entry historyiIntegrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: June 7, 2017
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported