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D5VTF3

- D5VTF3_METIM

UniProt

D5VTF3 - D5VTF3_METIM

Protein

Homoserine kinase

Gene

thrB

Organism
Methanocaldococcus infernus (strain DSM 11812 / JCM 15783 / ME)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (13 Jul 2010)
      Previous versions | rss
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    Functioni

    Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.UniRule annotation

    Catalytic activityi

    ATP + L-homoserine = ADP + O-phospho-L-homoserine.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi81 – 9111ATPUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. homoserine kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. threonine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    KinaseUniRule annotationImported, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Threonine biosynthesisUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMINF573063:GHL3-1224-MONOMER.
    UniPathwayiUPA00050; UER00064.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homoserine kinaseUniRule annotation (EC:2.7.1.39UniRule annotation)
    Short name:
    HKUniRule annotation
    Short name:
    HSKUniRule annotation
    Gene namesi
    Name:thrBUniRule annotation
    Ordered Locus Names:Metin_1203Imported
    OrganismiMethanocaldococcus infernus (strain DSM 11812 / JCM 15783 / ME)Imported
    Taxonomic identifieri573063 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
    ProteomesiUP000002061: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD5VTF3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GHMP kinase family. Homoserine kinase subfamily.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000247197.
    KOiK00872.
    OMAiMQDRLHQ.

    Family and domain databases

    Gene3Di3.30.230.10. 1 hit.
    3.30.70.890. 1 hit.
    HAMAPiMF_00384. Homoser_kinase.
    InterProiIPR013750. GHMP_kinase_C_dom.
    IPR006204. GHMP_kinase_N_dom.
    IPR006203. GHMP_knse_ATP-bd_CS.
    IPR000870. Homoserine_kinase.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    [Graphical view]
    PfamiPF08544. GHMP_kinases_C. 1 hit.
    PF00288. GHMP_kinases_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000676. Homoser_kin. 1 hit.
    SUPFAMiSSF54211. SSF54211. 1 hit.
    SSF55060. SSF55060. 1 hit.
    TIGRFAMsiTIGR00191. thrB. 1 hit.
    PROSITEiPS00627. GHMP_KINASES_ATP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D5VTF3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVKAPCSSA NLGVGFDVFG LCLEEPYDII EVKKIDEGIE IEGKDIPLNP    50
    KENVAGVVAE KMLKDFNIES GVKIKIKKGI KGGSGLGSSA ASAAGTAFAI 100
    NELFNLKLSK LKLVDYASYG ELIASGAKHA DNVAPAIYGG FTIVNYNPLN 150
    VLHIDVDFNV IVAIPNVKIE TKKAREIIPK EVSLKDMVHN LGRATGMIYA 200
    LFNNDLELFG KYMMEDKIVE PYRGKLIPHY FEVKEKLKNL AYGVCISGSG 250
    PSILVIPKEE FQDEIIDILS SYYDKIIKTR VGKGCELYKA 290
    Length:290
    Mass (Da):31,739
    Last modified:July 13, 2010 - v1
    Checksum:i6CBC63B3ABC7C485
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002009 Genomic DNA. Translation: ADG13856.1.
    RefSeqiYP_003616820.1. NC_014122.1.

    Genome annotation databases

    EnsemblBacteriaiADG13856; ADG13856; Metin_1203.
    GeneIDi9132222.
    KEGGimif:Metin_1203.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002009 Genomic DNA. Translation: ADG13856.1 .
    RefSeqi YP_003616820.1. NC_014122.1.

    3D structure databases

    ProteinModelPortali D5VTF3.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADG13856 ; ADG13856 ; Metin_1203 .
    GeneIDi 9132222.
    KEGGi mif:Metin_1203.

    Phylogenomic databases

    HOGENOMi HOG000247197.
    KOi K00872.
    OMAi MQDRLHQ.

    Enzyme and pathway databases

    UniPathwayi UPA00050 ; UER00064 .
    BioCyci MINF573063:GHL3-1224-MONOMER.

    Family and domain databases

    Gene3Di 3.30.230.10. 1 hit.
    3.30.70.890. 1 hit.
    HAMAPi MF_00384. Homoser_kinase.
    InterProi IPR013750. GHMP_kinase_C_dom.
    IPR006204. GHMP_kinase_N_dom.
    IPR006203. GHMP_knse_ATP-bd_CS.
    IPR000870. Homoserine_kinase.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    [Graphical view ]
    Pfami PF08544. GHMP_kinases_C. 1 hit.
    PF00288. GHMP_kinases_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000676. Homoser_kin. 1 hit.
    SUPFAMi SSF54211. SSF54211. 1 hit.
    SSF55060. SSF55060. 1 hit.
    TIGRFAMsi TIGR00191. thrB. 1 hit.
    PROSITEi PS00627. GHMP_KINASES_ATP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Methanocaldococcus infernus ME."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Munk A.C., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Mikhailova N., Sieprawska-Lupa M., Whitman W.B., Woyke T.
      Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 11812 / JCM 15783 / MEImported.

    Entry informationi

    Entry nameiD5VTF3_METIM
    AccessioniPrimary (citable) accession number: D5VTF3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 13, 2010
    Last sequence update: July 13, 2010
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3