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D5VTF3

- D5VTF3_METIM

UniProt

D5VTF3 - D5VTF3_METIM

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Protein

Homoserine kinase

Gene

thrB

Organism
Methanocaldococcus infernus (strain DSM 11812 / JCM 15783 / ME)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.UniRule annotation

Catalytic activityi

ATP + L-homoserine = ADP + O-phospho-L-homoserine.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi81 – 9111ATPUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. homoserine kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. threonine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Threonine biosynthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMINF573063:GHL3-1224-MONOMER.
UniPathwayiUPA00050; UER00064.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine kinaseUniRule annotation (EC:2.7.1.39UniRule annotation)
Short name:
HKUniRule annotation
Short name:
HSKUniRule annotation
Gene namesi
Name:thrBUniRule annotation
Ordered Locus Names:Metin_1203Imported
OrganismiMethanocaldococcus infernus (strain DSM 11812 / JCM 15783 / ME)Imported
Taxonomic identifieri573063 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000002061: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD5VTF3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GHMP kinase family. Homoserine kinase subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000247197.
KOiK00872.
OMAiMQDRLHQ.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPiMF_00384. Homoser_kinase.
InterProiIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PfamiPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000676. Homoser_kin. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsiTIGR00191. thrB. 1 hit.
PROSITEiPS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D5VTF3 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKVKAPCSSA NLGVGFDVFG LCLEEPYDII EVKKIDEGIE IEGKDIPLNP
60 70 80 90 100
KENVAGVVAE KMLKDFNIES GVKIKIKKGI KGGSGLGSSA ASAAGTAFAI
110 120 130 140 150
NELFNLKLSK LKLVDYASYG ELIASGAKHA DNVAPAIYGG FTIVNYNPLN
160 170 180 190 200
VLHIDVDFNV IVAIPNVKIE TKKAREIIPK EVSLKDMVHN LGRATGMIYA
210 220 230 240 250
LFNNDLELFG KYMMEDKIVE PYRGKLIPHY FEVKEKLKNL AYGVCISGSG
260 270 280 290
PSILVIPKEE FQDEIIDILS SYYDKIIKTR VGKGCELYKA
Length:290
Mass (Da):31,739
Last modified:July 13, 2010 - v1
Checksum:i6CBC63B3ABC7C485
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002009 Genomic DNA. Translation: ADG13856.1.
RefSeqiWP_013100601.1. NC_014122.1.
YP_003616820.1. NC_014122.1.

Genome annotation databases

EnsemblBacteriaiADG13856; ADG13856; Metin_1203.
GeneIDi9132222.
KEGGimif:Metin_1203.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002009 Genomic DNA. Translation: ADG13856.1 .
RefSeqi WP_013100601.1. NC_014122.1.
YP_003616820.1. NC_014122.1.

3D structure databases

ProteinModelPortali D5VTF3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADG13856 ; ADG13856 ; Metin_1203 .
GeneIDi 9132222.
KEGGi mif:Metin_1203.

Phylogenomic databases

HOGENOMi HOG000247197.
KOi K00872.
OMAi MQDRLHQ.

Enzyme and pathway databases

UniPathwayi UPA00050 ; UER00064 .
BioCyci MINF573063:GHL3-1224-MONOMER.

Family and domain databases

Gene3Di 3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPi MF_00384. Homoser_kinase.
InterProi IPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view ]
Pfami PF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000676. Homoser_kin. 1 hit.
SUPFAMi SSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsi TIGR00191. thrB. 1 hit.
PROSITEi PS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Methanocaldococcus infernus ME."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Munk A.C., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Mikhailova N., Sieprawska-Lupa M., Whitman W.B., Woyke T.
    Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 11812 / JCM 15783 / MEImported.

Entry informationi

Entry nameiD5VTF3_METIM
AccessioniPrimary (citable) accession number: D5VTF3
Entry historyi
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: October 29, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3