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D5VTF3 (D5VTF3_METIM) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Homoserine kinase HAMAP-Rule MF_00384
Short name=HK HAMAP-Rule MF_00384
Short name=HSK HAMAP-Rule MF_00384
EC=2.7.1.39 HAMAP-Rule MF_00384
Gene names
Name:thrB HAMAP-Rule MF_00384
Ordered Locus Names:Metin_1203
OrganismMethanocaldococcus infernus (strain DSM 11812 / JCM 15783 / ME) [Complete proteome] [HAMAP]
Taxonomic identifier573063 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus ›

Protein attributes

Sequence length290 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate By similarity. HAMAP-Rule MF_00384

Catalytic activity

ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP-Rule MF_00384

Pathway

Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP-Rule MF_00384

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00384.

Sequence similarities

Belongs to the GHMP kinase family. Homoserine kinase subfamily. HAMAP-Rule MF_00384

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding81 – 9111ATP By similarity HAMAP-Rule MF_00384

Sequences

Sequence LengthMass (Da)Tools
D5VTF3 [UniParc].

Last modified July 13, 2010. Version 1.
Checksum: 6CBC63B3ABC7C485

FASTA29031,739
        10         20         30         40         50         60 
MKVKAPCSSA NLGVGFDVFG LCLEEPYDII EVKKIDEGIE IEGKDIPLNP KENVAGVVAE 

        70         80         90        100        110        120 
KMLKDFNIES GVKIKIKKGI KGGSGLGSSA ASAAGTAFAI NELFNLKLSK LKLVDYASYG 

       130        140        150        160        170        180 
ELIASGAKHA DNVAPAIYGG FTIVNYNPLN VLHIDVDFNV IVAIPNVKIE TKKAREIIPK 

       190        200        210        220        230        240 
EVSLKDMVHN LGRATGMIYA LFNNDLELFG KYMMEDKIVE PYRGKLIPHY FEVKEKLKNL 

       250        260        270        280        290 
AYGVCISGSG PSILVIPKEE FQDEIIDILS SYYDKIIKTR VGKGCELYKA

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References

[1]"Complete sequence of Methanocaldococcus infernus ME."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Munk A.C., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Mikhailova N., Sieprawska-Lupa M., Whitman W.B., Woyke T.
Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 11812 / JCM 15783 / ME.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002009 Genomic DNA. Translation: ADG13856.1.
RefSeqYP_003616820.1. NC_014122.1.

3D structure databases

ProteinModelPortalD5VTF3.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADG13856; ADG13856; Metin_1203.
GeneID9132222.
KEGGmif:Metin_1203.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000247197.
KOK00872.
OMALHEPYRW.

Enzyme and pathway databases

BioCycMINF573063:GHL3-1224-MONOMER.
UniPathwayUPA00050; UER00064.

Family and domain databases

Gene3D3.30.230.10. 1 hit.
HAMAPMF_00384. Homoser_kinase.
InterProIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PfamPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFPIRSF000676. Homoser_kin. 1 hit.
PRINTSPR00958. HOMSERKINASE.
SUPFAMSSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMsTIGR00191. thrB. 1 hit.
PROSITEPS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD5VTF3_METIM
AccessionPrimary (citable) accession number: D5VTF3
Entry history
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: May 1, 2013
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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