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D5VT38

- HPRT_METIM

UniProt

D5VT38 - HPRT_METIM

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Protein

Hypoxanthine/guanine phosphoribosyltransferase

Gene

hpt

Organism
Methanocaldococcus infernus (strain DSM 11812 / JCM 15783 / ME)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.UniRule annotation

Catalytic activityi

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. guanine phosphoribosyltransferase activity Source: UniProtKB-EC
  2. hypoxanthine phosphoribosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. IMP salvage Source: UniProtKB-UniPathway
  2. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

BioCyciMINF573063:GHL3-1103-MONOMER.
UniPathwayiUPA00591; UER00648.

Names & Taxonomyi

Protein namesi
Recommended name:
Hypoxanthine/guanine phosphoribosyltransferaseUniRule annotation (EC:2.4.2.8UniRule annotation)
Short name:
HGPRTaseUniRule annotation
Gene namesi
Name:hptUniRule annotation
Ordered Locus Names:Metin_1083
OrganismiMethanocaldococcus infernus (strain DSM 11812 / JCM 15783 / ME)
Taxonomic identifieri573063 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000002061: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 183183Hypoxanthine/guanine phosphoribosyltransferasePRO_0000415467Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD5VT38.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000228520.
KOiK00759.
OMAiMIAIINA.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01467. Hypx_phosphoribosyltr.
InterProiIPR026597. HGPRTase-like.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D5VT38-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLEESLKKC PVIKRGEYNY FVHPITDGIP LVEPSLLREV ACRILKIVDF
60 70 80 90 100
SEVDKIVTAE AMGIHLATTL SLYTDIPFVI IRKRSYGLEG EIPVFQKTGY
110 120 130 140 150
SKGQLYVNGI KEGDKVVIVD DVISTGGTMI AIIEALKRAG AEIKDIVCVI
160 170 180
ERGKGREIVE KKTGYKIKTL VKIDVVDGKV VIK
Length:183
Mass (Da):20,292
Last modified:July 13, 2010 - v1
Checksum:i2AA2CCD386688307
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002009 Genomic DNA. Translation: ADG13741.1.
RefSeqiWP_013100486.1. NC_014122.1.
YP_003616705.1. NC_014122.1.

Genome annotation databases

EnsemblBacteriaiADG13741; ADG13741; Metin_1083.
GeneIDi9132101.
KEGGimif:Metin_1083.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002009 Genomic DNA. Translation: ADG13741.1 .
RefSeqi WP_013100486.1. NC_014122.1.
YP_003616705.1. NC_014122.1.

3D structure databases

ProteinModelPortali D5VT38.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADG13741 ; ADG13741 ; Metin_1083 .
GeneIDi 9132101.
KEGGi mif:Metin_1083.

Phylogenomic databases

HOGENOMi HOG000228520.
KOi K00759.
OMAi MIAIINA.

Enzyme and pathway databases

UniPathwayi UPA00591 ; UER00648 .
BioCyci MINF573063:GHL3-1103-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
HAMAPi MF_01467. Hypx_phosphoribosyltr.
InterProi IPR026597. HGPRTase-like.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view ]
Pfami PF00156. Pribosyltran. 1 hit.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 1 hit.
PROSITEi PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Methanocaldococcus infernus ME."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Munk A.C., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Mikhailova N., Sieprawska-Lupa M., Whitman W.B., Woyke T.
    Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 11812 / JCM 15783 / ME.

Entry informationi

Entry nameiHPRT_METIM
AccessioniPrimary (citable) accession number: D5VT38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: July 13, 2010
Last modified: October 29, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3