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Protein

Probable thymidylate kinase

Gene

tmk

Organism
Methanocaldococcus infernus (strain DSM 11812 / JCM 15783 / ME)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + dTMP = ADP + dTDP.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 148ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Biological processi

Nucleotide biosynthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMINF573063:GHL3-877-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable thymidylate kinaseUniRule annotation (EC:2.7.4.9UniRule annotation)
Alternative name(s):
dTMP kinaseUniRule annotation
Gene namesi
Name:tmkUniRule annotation
Ordered Locus Names:Metin_0861Imported
OrganismiMethanocaldococcus infernus (strain DSM 11812 / JCM 15783 / ME)Imported
Taxonomic identifieri573063 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000002061 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi573063.Metin_0861.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000229077.
KOiK00943.
OMAiYVYSSIV.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D5VSH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFIVFEGIDG SGKTTLSKML AKELSGYWTC EPTDGEIGRL IRSYLSSGNI
60 70 80 90 100
DNISLSLLFA ADRVEHCKEI EKVLNSGRDV ICDRYLYSSI AYQSSLGVEE
110 120 130 140 150
NFLWEINKYA IKPDLVFLLV VDVDEAMKRV KGKDIFENKN FLEKVQEKYL
160 170 180
ELAKRFNFIV IDTTNISIEE AYNKVRVKVY ECKC
Length:184
Mass (Da):21,139
Last modified:July 13, 2010 - v1
Checksum:i50F61AE87095A13D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002009 Genomic DNA. Translation: ADG13525.1.
RefSeqiWP_013100271.1. NC_014122.1.
YP_003616489.1. NC_014122.1.

Genome annotation databases

EnsemblBacteriaiADG13525; ADG13525; Metin_0861.
GeneIDi9131875.
KEGGimif:Metin_0861.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002009 Genomic DNA. Translation: ADG13525.1.
RefSeqiWP_013100271.1. NC_014122.1.
YP_003616489.1. NC_014122.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi573063.Metin_0861.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADG13525; ADG13525; Metin_0861.
GeneIDi9131875.
KEGGimif:Metin_0861.

Phylogenomic databases

HOGENOMiHOG000229077.
KOiK00943.
OMAiYVYSSIV.

Enzyme and pathway databases

BioCyciMINF573063:GHL3-877-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of Methanocaldococcus infernus ME."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Munk A.C., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Mikhailova N., Sieprawska-Lupa M., Whitman W.B., Woyke T.
    Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 11812 / JCM 15783 / MEImported.

Entry informationi

Entry nameiD5VSH2_METIM
AccessioniPrimary (citable) accession number: D5VSH2
Entry historyi
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: June 24, 2015
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.