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D5VSH2

- D5VSH2_METIM

UniProt

D5VSH2 - D5VSH2_METIM

Protein

Probable thymidylate kinase

Gene

tmk

Organism
Methanocaldococcus infernus (strain DSM 11812 / JCM 15783 / ME)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 22 (01 Oct 2014)
      Sequence version 1 (13 Jul 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + dTMP = ADP + dTDP.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi7 – 148ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidylate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dTDP biosynthetic process Source: InterPro
    2. dTTP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    KinaseUniRule annotationImported, Transferase

    Keywords - Biological processi

    Nucleotide biosynthesisUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMINF573063:GHL3-877-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable thymidylate kinaseUniRule annotation (EC:2.7.4.9UniRule annotation)
    Alternative name(s):
    dTMP kinaseUniRule annotation
    Gene namesi
    Name:tmkUniRule annotation
    Ordered Locus Names:Metin_0861Imported
    OrganismiMethanocaldococcus infernus (strain DSM 11812 / JCM 15783 / ME)Imported
    Taxonomic identifieri573063 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
    ProteomesiUP000002061: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidylate kinase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000229077.
    KOiK00943.
    OMAiYVYSSIV.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00165. Thymidylate_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR018095. Thymidylate_kin_CS.
    IPR018094. Thymidylate_kinase.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
    PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D5VSH2-1 [UniParc]FASTAAdd to Basket

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    MFIVFEGIDG SGKTTLSKML AKELSGYWTC EPTDGEIGRL IRSYLSSGNI    50
    DNISLSLLFA ADRVEHCKEI EKVLNSGRDV ICDRYLYSSI AYQSSLGVEE 100
    NFLWEINKYA IKPDLVFLLV VDVDEAMKRV KGKDIFENKN FLEKVQEKYL 150
    ELAKRFNFIV IDTTNISIEE AYNKVRVKVY ECKC 184
    Length:184
    Mass (Da):21,139
    Last modified:July 13, 2010 - v1
    Checksum:i50F61AE87095A13D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002009 Genomic DNA. Translation: ADG13525.1.
    RefSeqiYP_003616489.1. NC_014122.1.

    Genome annotation databases

    EnsemblBacteriaiADG13525; ADG13525; Metin_0861.
    GeneIDi9131875.
    KEGGimif:Metin_0861.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002009 Genomic DNA. Translation: ADG13525.1 .
    RefSeqi YP_003616489.1. NC_014122.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADG13525 ; ADG13525 ; Metin_0861 .
    GeneIDi 9131875.
    KEGGi mif:Metin_0861.

    Phylogenomic databases

    HOGENOMi HOG000229077.
    KOi K00943.
    OMAi YVYSSIV.

    Enzyme and pathway databases

    BioCyci MINF573063:GHL3-877-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00165. Thymidylate_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR018095. Thymidylate_kin_CS.
    IPR018094. Thymidylate_kinase.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00041. DTMP_kinase. 1 hit.
    PROSITEi PS01331. THYMIDYLATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Methanocaldococcus infernus ME."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Munk A.C., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Mikhailova N., Sieprawska-Lupa M., Whitman W.B., Woyke T.
      Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 11812 / JCM 15783 / MEImported.

    Entry informationi

    Entry nameiD5VSH2_METIM
    AccessioniPrimary (citable) accession number: D5VSH2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 13, 2010
    Last sequence update: July 13, 2010
    Last modified: October 1, 2014
    This is version 22 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3