D5VP75 (D5VP75_CAUST) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Methionyl-tRNA formyltransferase HAMAP-Rule MF_00182
EC=2.1.2.9 HAMAP-Rule MF_00182

Gene names

Name:	fmt HAMAP-Rule MF_00182
Ordered Locus Names:	Cseg_3878

Organism

Caulobacter segnis (strain ATCC 21756 / DSM 7131 / JCM 7823 / NBRC 15250 / LMG 17158 / TK0059) (Mycoplana segnis) [Complete proteome] [HAMAP]

Taxonomic identifier

509190 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter › Caulobacter segnis

Protein attributes

Sequence length	308 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP By similarity. HAMAP-Rule MF_00182 SAAS SAAS005794
Catalytic activity	10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet). HAMAP-Rule MF_00182 SAAS SAAS005794
Sequence similarities	Belongs to the fmt family. HAMAP-Rule MF_00182

Ontologies

Keywords
Biological process	Protein biosynthesis HAMAP-Rule MF_00182 SAAS SAAS005794
Molecular function	Methyltransferase HAMAP-Rule MF_00182 SAAS SAAS005794 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	translational initiation Inferred from electronic annotation. Source: GOC
Molecular_function	methionyl-tRNA formyltransferase activity Inferred from electronic annotation. Source: HAMAP methyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	109 – 112	4	Tetrahydrofolate (THF) binding By similarity HAMAP-Rule MF_00182

Sequences

	Sequence		Length	Mass (Da)
	D5VP75 [UniParc]. Last modified July 13, 2010. Version 1. Checksum: 4803CA0FC99DF3F0	FASTA	308	32,638
	10 20 30 40 50 60 MRIAFLGTPD FAVTCLAELV ASGHEIVAVY SQPPAPRGRG QELKPSPVHA FAEGLGLPVR 70 80 90 100 110 120 TPVSMKTPEE IEAFKALDLD AAVVVAFGQI LVKDVLEAPR HGCFNLHASL LPRWRGAAPI 130 140 150 160 170 180 QRAIMAGDPV TGVQVMRMSE GLDEGPILMS EQVAIAADDT AATLHDKLAT VGARLLPVAL 190 200 210 220 230 240 AAIEREVVRE TPQSEDGVTY AKKIKSAEAR IDWTRPAAEV DRHIRGLSPF PGAWFEAPSE 250 260 270 280 290 300 KGPVRVKALL SRVEAASGVA GTALDDALLI ACGEASIRLL KAQREGKGVQ DAETFTRGFP IPAGTVLA

References

[1]

"Genome sequences of eight morphologically diverse alphaproteobacteria." US DOE Joint Genome Institute Brown P.J., Kysela D.T., Buechlein A., Hemmerich C., Brun Y.V. J. Bacteriol. 193:4567-4568(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 21756 / DSM 7131 / JCM 7823 / NBRC 15250 / LMG 17158 / TK0059.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP002008 Genomic DNA. Translation: ADG12298.1.
RefSeq	YP_003594916.1. NC_014100.1.
3D structure databases
ProteinModelPortal	D5VP75.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ADG12298; ADG12298; Cseg_3878.
GeneID	9105404.
KEGG	cse:Cseg_3878.
PATRIC	37207954. VBICauSeg118057_3957.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000261177.
KO	K00604.
OMA	GITLMQM.
Enzyme and pathway databases
BioCyc	CSEG509190:GHVG-3931-MONOMER.
Family and domain databases
Gene3D	3.10.25.10. 1 hit. 3.40.50.170. 1 hit.
HAMAP	MF_00182. Formyl_trans.
InterPro	IPR005794. Fmt. IPR005793. Formyl_trans_C. IPR002376. Formyl_transf_N. IPR011034. Formyl_transferase_C-like. IPR015518. Met_tRNA_Form_TA-like. [Graphical view]
PANTHER	PTHR11138. PTHR11138. 1 hit.
Pfam	PF02911. Formyl_trans_C. 1 hit. PF00551. Formyl_trans_N. 1 hit. [Graphical view]
SUPFAM	SSF50486. FMT_C_like. 1 hit. SSF53328. formyl_transf. 1 hit.
TIGRFAMs	TIGR00460. fmt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

D5VP75_CAUST

Accession

Primary (citable) accession number: D5VP75

Entry history

Integrated into UniProtKB/TrEMBL:	July 13, 2010
Last sequence update:	July 13, 2010
Last modified:	May 1, 2013
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)