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Protein

Homoserine dehydrogenase

Gene

Cseg_1683

Organism
Caulobacter segnis (strain ATCC 21756 / DSM 7131 / JCM 7823 / NBRC 15250 / LMG 17158 / TK0059) (Mycoplana segnis)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-homoserine + NAD(P)+ = L-aspartate 4-semialdehyde + NAD(P)H.UniRule annotation

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 3 of the subpathway that synthesizes L-homoserine from L-aspartate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Aspartokinase (Cseg_0894)
  2. Aspartate-semialdehyde dehydrogenase (asd), Aspartate-semialdehyde dehydrogenase (asd)
  3. Homoserine dehydrogenase (Cseg_1683)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homoserine from L-aspartate, the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Pathwayi: L-threonine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-threonine from L-aspartate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Aspartokinase (Cseg_0894)
  2. Aspartate-semialdehyde dehydrogenase (asd), Aspartate-semialdehyde dehydrogenase (asd)
  3. Homoserine dehydrogenase (Cseg_1683)
  4. Homoserine kinase (thrB)
  5. no protein annotated in this organism
This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei106NADPUniRule annotation1
Binding sitei191SubstrateUniRule annotation1
Active sitei206Proton donorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 18NADPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
Biological processAmino-acid biosynthesis, Branched-chain amino acid biosynthesis, Isoleucine biosynthesisUniRule annotation, Methionine biosynthesisUniRule annotation, Threonine biosynthesisUniRule annotation
LigandNADPUniRule annotation

Enzyme and pathway databases

BioCyciCSEG509190:G1GKR-1722-MONOMER
UniPathwayiUPA00050; UER00063
UPA00051; UER00465

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine dehydrogenaseUniRule annotation (EC:1.1.1.3UniRule annotation)
Gene namesi
Ordered Locus Names:Cseg_1683Imported
OrganismiCaulobacter segnis (strain ATCC 21756 / DSM 7131 / JCM 7823 / NBRC 15250 / LMG 17158 / TK0059) (Mycoplana segnis)Imported
Taxonomic identifieri509190 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000002629 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi509190.Cseg_1683

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini350 – 425ACTInterPro annotationAdd BLAST76

Sequence similaritiesi

Belongs to the homoserine dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D6E Bacteria
COG0460 LUCA
HOGENOMiHOG000076615
KOiK00003
OMAiFEASVCG
OrthoDBiPOG091H01V3

Family and domain databases

InterProiView protein in InterPro
IPR002912 ACT_dom
IPR005106 Asp/hSer_DH_NAD-bd
IPR016204 HDH
IPR001342 HDH_cat
IPR019811 HDH_CS
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF01842 ACT, 1 hit
PF00742 Homoserine_dh, 1 hit
PF03447 NAD_binding_3, 1 hit
PIRSFiPIRSF000098 Homoser_dehydrog, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS51671 ACT, 1 hit
PS01042 HOMOSER_DHGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

D5VJ79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNKTWRVGV AGLGTVGGGL LQFLAERPGF APAGDKAVVT AVSARSKSRP
60 70 80 90 100
RTVDISNLAW FDDPVALAGS PDVDLFVELI GGSDGPAKAA VETALKSGKP
110 120 130 140 150
VVTANKALIA VHGAELAALA ESQGVPLLFE AAVMGGTPAV KMLREAMVGD
160 170 180 190 200
DVVSVAGILN GTCNFILSEM EKTGRSFADV LREAQGLGYA EADPTMDVGG
210 220 230 240 250
FDAGHKISIL AALAFGCAPN FEAAEIEGIS DVDLLDIKLA KDLGYRIKLI
260 270 280 290 300
AGAAKAEDGV AVKVHPSLVP LDHPLAQAGG ALNALFIEGT RIGRIFIQGP
310 320 330 340 350
GAGAGPTAAA VAADIADVMT RAVRPVFQAP AGDLKPFIAI DPARAVGKAY
360 370 380 390 400
LRIMVQDQPG VIAAISETLA ECGVSIDSFL QKPIEGAGGV PIVLVTHATP
410 420
ESKLLDAISR IEKLQTVLER PRLLRVARI
Length:429
Mass (Da):44,149
Last modified:July 13, 2010 - v1
Checksum:iA0420ABCEBF1325D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002008 Genomic DNA Translation: ADG10167.1
RefSeqiWP_013078824.1, NC_014100.1

Genome annotation databases

EnsemblBacteriaiADG10167; ADG10167; Cseg_1683
GeneIDi35837349
KEGGicse:Cseg_1683

Similar proteinsi

Entry informationi

Entry nameiD5VJ79_CAUST
AccessioniPrimary (citable) accession number: D5VJ79
Entry historyiIntegrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: April 25, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health