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Protein

Homoserine dehydrogenase

Gene

Cseg_1683

Organism
Caulobacter segnis (strain ATCC 21756 / DSM 7131 / JCM 7823 / NBRC 15250 / LMG 17158 / TK0059) (Mycoplana segnis)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-homoserine + NAD(P)+ = L-aspartate 4-semialdehyde + NAD(P)H.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei206 – 2061Proton donorUniRule annotation

GO - Molecular functioni

  1. amino acid binding Source: InterPro
  2. homoserine dehydrogenase activity Source: UniProtKB-EC
  3. NADP binding Source: InterPro

GO - Biological processi

  1. isoleucine biosynthetic process Source: UniProtKB-KW
  2. methionine biosynthetic process Source: UniProtKB-KW
  3. threonine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesis, Isoleucine biosynthesisUniRule annotation, Methionine biosynthesisUniRule annotation, Threonine biosynthesisUniRule annotation

Keywords - Ligandi

NADPUniRule annotation

Enzyme and pathway databases

BioCyciCSEG509190:GHVG-1709-MONOMER.
UniPathwayiUPA00050; UER00063.
UPA00051; UER00465.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine dehydrogenaseUniRule annotation (EC:1.1.1.3UniRule annotation)
Gene namesi
Ordered Locus Names:Cseg_1683Imported
OrganismiCaulobacter segnis (strain ATCC 21756 / DSM 7131 / JCM 7823 / NBRC 15250 / LMG 17158 / TK0059) (Mycoplana segnis)Imported
Taxonomic identifieri509190 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
ProteomesiUP000002629: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the homoserine dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076615.
KOiK00003.
OMAiIGGYEPA.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002912. ACT_dom.
IPR005106. Asp/hSer_DH_NAD-bd.
IPR016204. HDH.
IPR001342. HDH_cat.
IPR019811. HDH_CS.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01842. ACT. 1 hit.
PF00742. Homoserine_dh. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000098. Homoser_dehydrog. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
PS01042. HOMOSER_DHGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D5VJ79-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTNKTWRVGV AGLGTVGGGL LQFLAERPGF APAGDKAVVT AVSARSKSRP
60 70 80 90 100
RTVDISNLAW FDDPVALAGS PDVDLFVELI GGSDGPAKAA VETALKSGKP
110 120 130 140 150
VVTANKALIA VHGAELAALA ESQGVPLLFE AAVMGGTPAV KMLREAMVGD
160 170 180 190 200
DVVSVAGILN GTCNFILSEM EKTGRSFADV LREAQGLGYA EADPTMDVGG
210 220 230 240 250
FDAGHKISIL AALAFGCAPN FEAAEIEGIS DVDLLDIKLA KDLGYRIKLI
260 270 280 290 300
AGAAKAEDGV AVKVHPSLVP LDHPLAQAGG ALNALFIEGT RIGRIFIQGP
310 320 330 340 350
GAGAGPTAAA VAADIADVMT RAVRPVFQAP AGDLKPFIAI DPARAVGKAY
360 370 380 390 400
LRIMVQDQPG VIAAISETLA ECGVSIDSFL QKPIEGAGGV PIVLVTHATP
410 420
ESKLLDAISR IEKLQTVLER PRLLRVARI
Length:429
Mass (Da):44,149
Last modified:July 13, 2010 - v1
Checksum:iA0420ABCEBF1325D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002008 Genomic DNA. Translation: ADG10167.1.
RefSeqiWP_013078824.1. NC_014100.1.
YP_003592785.1. NC_014100.1.

Genome annotation databases

EnsemblBacteriaiADG10167; ADG10167; Cseg_1683.
GeneIDi9103182.
KEGGicse:Cseg_1683.
PATRICi37203433. VBICauSeg118057_1726.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002008 Genomic DNA. Translation: ADG10167.1.
RefSeqiWP_013078824.1. NC_014100.1.
YP_003592785.1. NC_014100.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADG10167; ADG10167; Cseg_1683.
GeneIDi9103182.
KEGGicse:Cseg_1683.
PATRICi37203433. VBICauSeg118057_1726.

Phylogenomic databases

HOGENOMiHOG000076615.
KOiK00003.
OMAiIGGYEPA.

Enzyme and pathway databases

UniPathwayiUPA00050; UER00063.
UPA00051; UER00465.
BioCyciCSEG509190:GHVG-1709-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002912. ACT_dom.
IPR005106. Asp/hSer_DH_NAD-bd.
IPR016204. HDH.
IPR001342. HDH_cat.
IPR019811. HDH_CS.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01842. ACT. 1 hit.
PF00742. Homoserine_dh. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000098. Homoser_dehydrog. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
PS01042. HOMOSER_DHGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 21756 / DSM 7131 / JCM 7823 / NBRC 15250 / LMG 17158 / TK0059Imported.

Entry informationi

Entry nameiD5VJ79_CAUST
AccessioniPrimary (citable) accession number: D5VJ79
Entry historyi
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: February 4, 2015
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.