D5VJ79 (D5VJ79_CAUST) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Homoserine dehydrogenase RuleBase RU000579
EC=1.1.1.3 RuleBase RU000579

Gene names

Ordered Locus Names:

Cseg_1683

Organism

Caulobacter segnis (strain ATCC 21756 / DSM 7131 / JCM 7823 / NBRC 15250 / LMG 17158 / TK0059) (Mycoplana segnis) [Complete proteome] [HAMAP]

Taxonomic identifier

509190 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter › Caulobacter segnis

Protein attributes

Sequence length	429 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-homoserine + NAD(P)+ = L-aspartate 4-semialdehyde + NAD(P)H. RuleBase RU000579
Pathway	Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3. RuleBase RU000579 Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5. RuleBase RU000579
Sequence similarities	Belongs to the homoserine dehydrogenase family. RuleBase RU004171

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Branched-chain amino acid biosynthesis Isoleucine biosynthesis RuleBase RU000579 Methionine biosynthesis RuleBase RU000579 Threonine biosynthesis RuleBase RU000579
Ligand	NADP RuleBase RU000579 PIRSR PIRSR000098-2
Molecular function	Oxidoreductase RuleBase RU000579 EMBL ADG10167.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	isoleucine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW methionine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	NADP binding Inferred from electronic annotation. Source: InterPro amino acid binding Inferred from electronic annotation. Source: InterPro homoserine dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	11 – 18	8	NADP By similarity PIRSR PIRSR000098-2
Sites
	Active site	206	1	Proton donor By similarity
	Binding site	106	1	NADP By similarity PIRSR PIRSR000098-2
	Binding site	191	1	Substrate By similarity PIRSR PIRSR000098-2

Sequences

	Sequence		Length	Mass (Da)
	D5VJ79 [UniParc]. Last modified July 13, 2010. Version 1. Checksum: A0420ABCEBF1325D	FASTA	429	44,149
	10 20 30 40 50 60 MTNKTWRVGV AGLGTVGGGL LQFLAERPGF APAGDKAVVT AVSARSKSRP RTVDISNLAW 70 80 90 100 110 120 FDDPVALAGS PDVDLFVELI GGSDGPAKAA VETALKSGKP VVTANKALIA VHGAELAALA 130 140 150 160 170 180 ESQGVPLLFE AAVMGGTPAV KMLREAMVGD DVVSVAGILN GTCNFILSEM EKTGRSFADV 190 200 210 220 230 240 LREAQGLGYA EADPTMDVGG FDAGHKISIL AALAFGCAPN FEAAEIEGIS DVDLLDIKLA 250 260 270 280 290 300 KDLGYRIKLI AGAAKAEDGV AVKVHPSLVP LDHPLAQAGG ALNALFIEGT RIGRIFIQGP 310 320 330 340 350 360 GAGAGPTAAA VAADIADVMT RAVRPVFQAP AGDLKPFIAI DPARAVGKAY LRIMVQDQPG 370 380 390 400 410 420 VIAAISETLA ECGVSIDSFL QKPIEGAGGV PIVLVTHATP ESKLLDAISR IEKLQTVLER PRLLRVARI

References

[1]

"Genome sequences of eight morphologically diverse alphaproteobacteria." US DOE Joint Genome Institute Brown P.J., Kysela D.T., Buechlein A., Hemmerich C., Brun Y.V. J. Bacteriol. 193:4567-4568(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 21756 / DSM 7131 / JCM 7823 / NBRC 15250 / LMG 17158 / TK0059.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP002008 Genomic DNA. Translation: ADG10167.1.
RefSeq	YP_003592785.1. NC_014100.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ADG10167; ADG10167; Cseg_1683.
GeneID	9103182.
KEGG	cse:Cseg_1683.
PATRIC	37203433. VBICauSeg118057_1726.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000076615.
KO	K00003.
OMA	EWIAGII.
Enzyme and pathway databases
BioCyc	CSEG509190:GHVG-1709-MONOMER.
UniPathway	UPA00050; UER00063. UPA00051; UER00465.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
InterPro	IPR002912. ACT_dom. IPR005106. Asp/hSer_DH_NAD-bd. IPR016204. HDH. IPR001342. HDH_cat. IPR019811. HDH_CS. IPR016040. NAD(P)-bd_dom. [Graphical view]
Pfam	PF01842. ACT. 1 hit. PF00742. Homoserine_dh. 1 hit. PF03447. NAD_binding_3. 1 hit. [Graphical view]
PIRSF	PIRSF000098. Homoser_dehydrog. 1 hit.
PROSITE	PS01042. HOMOSER_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

D5VJ79_CAUST

Accession

Primary (citable) accession number: D5VJ79

Entry history

Integrated into UniProtKB/TrEMBL:	July 13, 2010
Last sequence update:	July 13, 2010
Last modified:	May 1, 2013
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)