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D5VJ79

- D5VJ79_CAUST

UniProt

D5VJ79 - D5VJ79_CAUST

Protein

Homoserine dehydrogenase

Gene

Cseg_1683

Organism
Caulobacter segnis (strain ATCC 21756 / DSM 7131 / JCM 7823 / NBRC 15250 / LMG 17158 / TK0059) (Mycoplana segnis)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 1 (13 Jul 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-homoserine + NAD(P)+ = L-aspartate 4-semialdehyde + NAD(P)H.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei106 – 1061NADP
    Binding sitei191 – 1911Substrate
    Active sitei206 – 2061Proton donorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 188NADP

    GO - Molecular functioni

    1. amino acid binding Source: InterPro
    2. homoserine dehydrogenase activity Source: UniProtKB-EC
    3. NADP binding Source: InterPro

    GO - Biological processi

    1. isoleucine biosynthetic process Source: UniProtKB-KW
    2. methionine biosynthetic process Source: UniProtKB-KW
    3. threonine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Amino-acid biosynthesis, Branched-chain amino acid biosynthesis, Isoleucine biosynthesisUniRule annotation, Methionine biosynthesisUniRule annotation, Threonine biosynthesisUniRule annotation

    Keywords - Ligandi

    NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciCSEG509190:GHVG-1709-MONOMER.
    UniPathwayiUPA00050; UER00063.
    UPA00051; UER00465.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homoserine dehydrogenaseUniRule annotation (EC:1.1.1.3UniRule annotation)
    Gene namesi
    Ordered Locus Names:Cseg_1683Imported
    OrganismiCaulobacter segnis (strain ATCC 21756 / DSM 7131 / JCM 7823 / NBRC 15250 / LMG 17158 / TK0059) (Mycoplana segnis)Imported
    Taxonomic identifieri509190 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
    ProteomesiUP000002629: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the homoserine dehydrogenase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000076615.
    KOiK00003.
    OMAiAHVEGIT.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR002912. ACT_dom.
    IPR005106. Asp/hSer_DH_NAD-bd.
    IPR016204. HDH.
    IPR001342. HDH_cat.
    IPR019811. HDH_CS.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF01842. ACT. 1 hit.
    PF00742. Homoserine_dh. 1 hit.
    PF03447. NAD_binding_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000098. Homoser_dehydrog. 1 hit.
    PROSITEiPS51671. ACT. 1 hit.
    PS01042. HOMOSER_DHGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D5VJ79-1 [UniParc]FASTAAdd to Basket

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    MTNKTWRVGV AGLGTVGGGL LQFLAERPGF APAGDKAVVT AVSARSKSRP    50
    RTVDISNLAW FDDPVALAGS PDVDLFVELI GGSDGPAKAA VETALKSGKP 100
    VVTANKALIA VHGAELAALA ESQGVPLLFE AAVMGGTPAV KMLREAMVGD 150
    DVVSVAGILN GTCNFILSEM EKTGRSFADV LREAQGLGYA EADPTMDVGG 200
    FDAGHKISIL AALAFGCAPN FEAAEIEGIS DVDLLDIKLA KDLGYRIKLI 250
    AGAAKAEDGV AVKVHPSLVP LDHPLAQAGG ALNALFIEGT RIGRIFIQGP 300
    GAGAGPTAAA VAADIADVMT RAVRPVFQAP AGDLKPFIAI DPARAVGKAY 350
    LRIMVQDQPG VIAAISETLA ECGVSIDSFL QKPIEGAGGV PIVLVTHATP 400
    ESKLLDAISR IEKLQTVLER PRLLRVARI 429
    Length:429
    Mass (Da):44,149
    Last modified:July 13, 2010 - v1
    Checksum:iA0420ABCEBF1325D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002008 Genomic DNA. Translation: ADG10167.1.
    RefSeqiYP_003592785.1. NC_014100.1.

    Genome annotation databases

    EnsemblBacteriaiADG10167; ADG10167; Cseg_1683.
    GeneIDi9103182.
    KEGGicse:Cseg_1683.
    PATRICi37203433. VBICauSeg118057_1726.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002008 Genomic DNA. Translation: ADG10167.1 .
    RefSeqi YP_003592785.1. NC_014100.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADG10167 ; ADG10167 ; Cseg_1683 .
    GeneIDi 9103182.
    KEGGi cse:Cseg_1683.
    PATRICi 37203433. VBICauSeg118057_1726.

    Phylogenomic databases

    HOGENOMi HOG000076615.
    KOi K00003.
    OMAi AHVEGIT.

    Enzyme and pathway databases

    UniPathwayi UPA00050 ; UER00063 .
    UPA00051 ; UER00465 .
    BioCyci CSEG509190:GHVG-1709-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR002912. ACT_dom.
    IPR005106. Asp/hSer_DH_NAD-bd.
    IPR016204. HDH.
    IPR001342. HDH_cat.
    IPR019811. HDH_CS.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF01842. ACT. 1 hit.
    PF00742. Homoserine_dh. 1 hit.
    PF03447. NAD_binding_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000098. Homoser_dehydrog. 1 hit.
    PROSITEi PS51671. ACT. 1 hit.
    PS01042. HOMOSER_DHGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 21756 / DSM 7131 / JCM 7823 / NBRC 15250 / LMG 17158 / TK0059Imported.

    Entry informationi

    Entry nameiD5VJ79_CAUST
    AccessioniPrimary (citable) accession number: D5VJ79
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 13, 2010
    Last sequence update: July 13, 2010
    Last modified: October 1, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3