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D5VJ79

- D5VJ79_CAUST

UniProt

D5VJ79 - D5VJ79_CAUST

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Protein
Homoserine dehydrogenase
Gene
Cseg_1683
Organism
Caulobacter segnis (strain ATCC 21756 / DSM 7131 / JCM 7823 / NBRC 15250 / LMG 17158 / TK0059) (Mycoplana segnis)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

L-homoserine + NAD(P)+ = L-aspartate 4-semialdehyde + NAD(P)H.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei106 – 1061NADP By similarity
Binding sitei191 – 1911Substrate By similarity
Active sitei206 – 2061Proton donor By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 188NADP By similarity

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. amino acid binding Source: InterPro
  3. homoserine dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. isoleucine biosynthetic process Source: UniProtKB-KW
  2. methionine biosynthetic process Source: UniProtKB-KW
  3. threonine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesis, Isoleucine biosynthesisUniRule annotation, Methionine biosynthesisUniRule annotation, Threonine biosynthesisUniRule annotation

Keywords - Ligandi

NADPUniRule annotation

Enzyme and pathway databases

BioCyciCSEG509190:GHVG-1709-MONOMER.
UniPathwayiUPA00050; UER00063.
UPA00051; UER00465.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine dehydrogenaseUniRule annotation (EC:1.1.1.3UniRule annotation)
Gene namesi
Ordered Locus Names:Cseg_1683Imported
OrganismiCaulobacter segnis (strain ATCC 21756 / DSM 7131 / JCM 7823 / NBRC 15250 / LMG 17158 / TK0059) (Mycoplana segnis)Imported
Taxonomic identifieri509190 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
ProteomesiUP000002629: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the homoserine dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076615.
KOiK00003.
OMAiAHVEGIT.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002912. ACT_dom.
IPR005106. Asp/hSer_DH_NAD-bd.
IPR016204. HDH.
IPR001342. HDH_cat.
IPR019811. HDH_CS.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01842. ACT. 1 hit.
PF00742. Homoserine_dh. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000098. Homoser_dehydrog. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
PS01042. HOMOSER_DHGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D5VJ79-1 [UniParc]FASTAAdd to Basket

« Hide

MTNKTWRVGV AGLGTVGGGL LQFLAERPGF APAGDKAVVT AVSARSKSRP    50
RTVDISNLAW FDDPVALAGS PDVDLFVELI GGSDGPAKAA VETALKSGKP 100
VVTANKALIA VHGAELAALA ESQGVPLLFE AAVMGGTPAV KMLREAMVGD 150
DVVSVAGILN GTCNFILSEM EKTGRSFADV LREAQGLGYA EADPTMDVGG 200
FDAGHKISIL AALAFGCAPN FEAAEIEGIS DVDLLDIKLA KDLGYRIKLI 250
AGAAKAEDGV AVKVHPSLVP LDHPLAQAGG ALNALFIEGT RIGRIFIQGP 300
GAGAGPTAAA VAADIADVMT RAVRPVFQAP AGDLKPFIAI DPARAVGKAY 350
LRIMVQDQPG VIAAISETLA ECGVSIDSFL QKPIEGAGGV PIVLVTHATP 400
ESKLLDAISR IEKLQTVLER PRLLRVARI 429
Length:429
Mass (Da):44,149
Last modified:July 13, 2010 - v1
Checksum:iA0420ABCEBF1325D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002008 Genomic DNA. Translation: ADG10167.1.
RefSeqiYP_003592785.1. NC_014100.1.

Genome annotation databases

EnsemblBacteriaiADG10167; ADG10167; Cseg_1683.
GeneIDi9103182.
KEGGicse:Cseg_1683.
PATRICi37203433. VBICauSeg118057_1726.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002008 Genomic DNA. Translation: ADG10167.1 .
RefSeqi YP_003592785.1. NC_014100.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADG10167 ; ADG10167 ; Cseg_1683 .
GeneIDi 9103182.
KEGGi cse:Cseg_1683.
PATRICi 37203433. VBICauSeg118057_1726.

Phylogenomic databases

HOGENOMi HOG000076615.
KOi K00003.
OMAi AHVEGIT.

Enzyme and pathway databases

UniPathwayi UPA00050 ; UER00063 .
UPA00051 ; UER00465 .
BioCyci CSEG509190:GHVG-1709-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR002912. ACT_dom.
IPR005106. Asp/hSer_DH_NAD-bd.
IPR016204. HDH.
IPR001342. HDH_cat.
IPR019811. HDH_CS.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF01842. ACT. 1 hit.
PF00742. Homoserine_dh. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000098. Homoser_dehydrog. 1 hit.
PROSITEi PS51671. ACT. 1 hit.
PS01042. HOMOSER_DHGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 21756 / DSM 7131 / JCM 7823 / NBRC 15250 / LMG 17158 / TK0059.

Entry informationi

Entry nameiD5VJ79_CAUST
AccessioniPrimary (citable) accession number: D5VJ79
Entry historyi
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: July 9, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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