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Protein

Alanine racemase

Gene

Cseg_2315

Organism
Caulobacter segnis (strain ATCC 21756 / DSM 7131 / JCM 7823 / NBRC 15250 / LMG 17158 / TK0059) (Mycoplana segnis)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathway: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (Cseg_2315)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei135 – 1351SubstrateUniRule annotation
Active sitei257 – 2571Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei305 – 3051Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciCSEG509190:GHVG-2351-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Cseg_2315Imported
OrganismiCaulobacter segnis (strain ATCC 21756 / DSM 7131 / JCM 7823 / NBRC 15250 / LMG 17158 / TK0059) (Mycoplana segnis)Imported
Taxonomic identifieri509190 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
ProteomesiUP000002629 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei37 – 371N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi509190.Cseg_2315.

Structurei

3D structure databases

ProteinModelPortaliD5VH57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031445.
KOiK01775.
OMAiWKGGAAI.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D5VH57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDLHDARLT IDLDALAANH AALQARAGDA EVAPAVKANA YGLGAARVAD
60 70 80 90 100
RLWAEGVRSF YVARLAEGVA LRAALGDREA AIYVLDGATP GAGDALEGAR
110 120 130 140 150
LTPVLNSLPQ IEAWNAQARA GRLKAALHLD TGMNRLGLRP EELKVLLGAT
160 170 180 190 200
DRLKRLDLEL VISHLACADV PDHPMNTRQL ERFSEAVAQL PNARKSFANS
210 220 230 240 250
AGLFLGEAYR FDQARPGISL YGGGPEGRPH PEIRAVATVE APILQVRVVP
260 270 280 290 300
RGETVGYGAT WTAPDTTRIA IVGAGYADGV PRASHPKGQV WFDGARRQML
310 320 330 340 350
GRVSMDLMAV DVTDCDAARP GAMVELLGSN MPIDDAATAA GTTAYELLTN
360
IAPRARRIYR
Length:360
Mass (Da):38,289
Last modified:July 13, 2010 - v1
Checksum:iDB62F87E4BA5DDA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002008 Genomic DNA. Translation: ADG10775.1.
RefSeqiWP_013079428.1. NC_014100.1.
YP_003593393.1. NC_014100.1.

Genome annotation databases

EnsemblBacteriaiADG10775; ADG10775; Cseg_2315.
KEGGicse:Cseg_2315.
PATRICi37204725. VBICauSeg118057_2364.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002008 Genomic DNA. Translation: ADG10775.1.
RefSeqiWP_013079428.1. NC_014100.1.
YP_003593393.1. NC_014100.1.

3D structure databases

ProteinModelPortaliD5VH57.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi509190.Cseg_2315.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADG10775; ADG10775; Cseg_2315.
KEGGicse:Cseg_2315.
PATRICi37204725. VBICauSeg118057_2364.

Phylogenomic databases

HOGENOMiHOG000031445.
KOiK01775.
OMAiWKGGAAI.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciCSEG509190:GHVG-2351-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 21756 / DSM 7131 / JCM 7823 / NBRC 15250 / LMG 17158 / TK0059Imported.

Entry informationi

Entry nameiD5VH57_CAUST
AccessioniPrimary (citable) accession number: D5VH57
Entry historyi
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: June 24, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.