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D5VFB6 (D5VFB6_CAUST) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047
EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Cseg_1146
OrganismCaulobacter segnis (strain ATCC 21756 / DSM 7131 / JCM 7823 / NBRC 15250 / LMG 17158 / TK0059) (Mycoplana segnis) [Complete proteome] [HAMAP]
Taxonomic identifier509190 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter ›

Protein attributes

Sequence length319 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS000291

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS000291

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS000291

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS000291

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS000291.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047 SAAS SAAS000291

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain107 – 307201ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding134 – 18855ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2601Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2741Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2741Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2761Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
D5VFB6 [UniParc].

Last modified July 13, 2010. Version 1.
Checksum: 8FE06A3AD4A3C0FC

FASTA31933,655
        10         20         30         40         50         60 
MTQQPLSGRH IAVLLGGPSS ERKVSLVSGA ECADALERLG AKVTRIDAGP DIAQVLTAAK 

        70         80         90        100        110        120 
PDLVFNALHG EWGEDGCVQG VLETLKLPYT HSGVLASALA MDKAKAKAVL AAAGVVVPGG 

       130        140        150        160        170        180 
GLFNRHDVAR DHVLPPPYVV KPNAEGSSVG VFIVKEGANR PPEEVGAPSW TFGEEVMVEP 

       190        200        210        220        230        240 
YIRGLELAVA VMGEANGPRA LAVTDIRAST GFYDYEAKYS EGGSIHVLPA PIPDGVRDRA 

       250        260        270        280        290        300 
MRMAELAHTA LGCRSVTRSD LRYDDINDIL VLLEVNTQPG MTPTSLAPEQ AAHVGIPFDQ 

       310 
LVLWIVEDAY ARRNAGGTA

« Hide

References

[1]"Genome sequences of eight morphologically diverse alphaproteobacteria."
US DOE Joint Genome Institute
Brown P.J., Kysela D.T., Buechlein A., Hemmerich C., Brun Y.V.
J. Bacteriol. 193:4567-4568(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 21756 / DSM 7131 / JCM 7823 / NBRC 15250 / LMG 17158 / TK0059.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002008 Genomic DNA. Translation: ADG09648.1.
RefSeqYP_003592266.1. NC_014100.1.

3D structure databases

ProteinModelPortalD5VFB6.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADG09648; ADG09648; Cseg_1146.
GeneID9102640.
KEGGcse:Cseg_1146.
PATRIC37202315. VBICauSeg118057_1174.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000011592.
KOK01921.
OMAVEDASCD.

Enzyme and pathway databases

BioCycCSEG509190:GHVG-1167-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. PreATP-grasp-like. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD5VFB6_CAUST
AccessionPrimary (citable) accession number: D5VFB6
Entry history
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: May 29, 2013
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info