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D5VC98

- D5VC98_MORCR

UniProt

D5VC98 - D5VC98_MORCR

Protein

Alanine racemase

Gene

alr

Organism
Moraxella catarrhalis (strain RH4)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (13 Jul 2010)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei35 – 351Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei137 – 1371SubstrateUniRule annotation
    Active sitei264 – 2641Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei316 – 3161Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciMCAT749219:GHBK-1060-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:alrImported
    Ordered Locus Names:MCR_1036Imported
    OrganismiMoraxella catarrhalis (strain RH4)Imported
    Taxonomic identifieri749219 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeMoraxella
    ProteomesiUP000000930: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei35 – 351N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD5VC98.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000031446.
    KOiK01775.
    OMAiLKYNTGM.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    D5VC98-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRSTSITIHP NALTHNLQII KSQLDRTTKV LAMVKADAYG HGIDATIPAL    50
    IHADGFGVAC LSEAMAVKQV LDGMNVKKPI VLIEGAFSLD EWKVAIDHDF 100
    GCLIHHENQL TWALSHRPKQ DQFCHTIWLK YNTGMSRLGF NDDHIITAAK 150
    SLADAGYRLI LTSHFACADD KSHPLNAQQI SKFDQALACI RSFAPDTLAS 200
    LCNSAGIFNF KHQHHDWVRA GIALYGSKPI TDQSAKALNL MPAMTLSAQV 250
    MAIHTLAAGD SIGYSALWAA QKPHQIAVVS IGYGDGYPRV VMGAKVSVTD 300
    TSGNRHLCDI IGRVAMDMFM IDIDGLDIAI NTPVVLWGDS PTIDEVAMCA 350
    GTIGYELMCR LTTRPKRCIM DTYLPKKEFK 380
    Length:380
    Mass (Da):41,586
    Last modified:July 13, 2010 - v1
    Checksum:i02A8FE3C9173AEF3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002005 Genomic DNA. Translation: ADG61301.1.
    RefSeqiYP_003627194.1. NC_014147.1.

    Genome annotation databases

    EnsemblBacteriaiADG61301; ADG61301; MCR_1036.
    GeneIDi9135746.
    KEGGimct:MCR_1036.
    PATRICi38207923. VBIMorCat148474_1032.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002005 Genomic DNA. Translation: ADG61301.1 .
    RefSeqi YP_003627194.1. NC_014147.1.

    3D structure databases

    ProteinModelPortali D5VC98.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADG61301 ; ADG61301 ; MCR_1036 .
    GeneIDi 9135746.
    KEGGi mct:MCR_1036.
    PATRICi 38207923. VBIMorCat148474_1032.

    Phylogenomic databases

    HOGENOMi HOG000031446.
    KOi K01775.
    OMAi LKYNTGM.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci MCAT749219:GHBK-1060-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome analysis of Moraxella catarrhalis strain RH4, a human respiratory tract pathogen."
      de Vries S.P., van Hijum S.A., Schueler W., Riesbeck K., Hays J.P., Hermans P.W., Bootsma H.J.
      J. Bacteriol. 192:3574-3583(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RH4Imported.

    Entry informationi

    Entry nameiD5VC98_MORCR
    AccessioniPrimary (citable) accession number: D5VC98
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 13, 2010
    Last sequence update: July 13, 2010
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3