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Protein

Alanine racemase

Gene

alr

Organism
Moraxella catarrhalis (strain RH4)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei35 – 351Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei137 – 1371SubstrateUniRule annotation
Active sitei264 – 2641Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei316 – 3161Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciMCAT749219:GHBK-1060-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:MCR_1036Imported
OrganismiMoraxella catarrhalis (strain RH4)Imported
Taxonomic identifieri749219 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeMoraxella
ProteomesiUP000000930: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei35 – 351N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD5VC98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031446.
KOiK01775.
OMAiMFIVKAN.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

D5VC98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSTSITIHP NALTHNLQII KSQLDRTTKV LAMVKADAYG HGIDATIPAL
60 70 80 90 100
IHADGFGVAC LSEAMAVKQV LDGMNVKKPI VLIEGAFSLD EWKVAIDHDF
110 120 130 140 150
GCLIHHENQL TWALSHRPKQ DQFCHTIWLK YNTGMSRLGF NDDHIITAAK
160 170 180 190 200
SLADAGYRLI LTSHFACADD KSHPLNAQQI SKFDQALACI RSFAPDTLAS
210 220 230 240 250
LCNSAGIFNF KHQHHDWVRA GIALYGSKPI TDQSAKALNL MPAMTLSAQV
260 270 280 290 300
MAIHTLAAGD SIGYSALWAA QKPHQIAVVS IGYGDGYPRV VMGAKVSVTD
310 320 330 340 350
TSGNRHLCDI IGRVAMDMFM IDIDGLDIAI NTPVVLWGDS PTIDEVAMCA
360 370 380
GTIGYELMCR LTTRPKRCIM DTYLPKKEFK
Length:380
Mass (Da):41,586
Last modified:July 13, 2010 - v1
Checksum:i02A8FE3C9173AEF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002005 Genomic DNA. Translation: ADG61301.1.
RefSeqiYP_003627194.1. NC_014147.1.

Genome annotation databases

EnsemblBacteriaiADG61301; ADG61301; MCR_1036.
GeneIDi9135746.
KEGGimct:MCR_1036.
PATRICi38207923. VBIMorCat148474_1032.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002005 Genomic DNA. Translation: ADG61301.1.
RefSeqiYP_003627194.1. NC_014147.1.

3D structure databases

ProteinModelPortaliD5VC98.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADG61301; ADG61301; MCR_1036.
GeneIDi9135746.
KEGGimct:MCR_1036.
PATRICi38207923. VBIMorCat148474_1032.

Phylogenomic databases

HOGENOMiHOG000031446.
KOiK01775.
OMAiMFIVKAN.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciMCAT749219:GHBK-1060-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome analysis of Moraxella catarrhalis strain RH4, a human respiratory tract pathogen."
    de Vries S.P., van Hijum S.A., Schueler W., Riesbeck K., Hays J.P., Hermans P.W., Bootsma H.J.
    J. Bacteriol. 192:3574-3583(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RH4Imported.

Entry informationi

Entry nameiD5VC98_MORCR
AccessioniPrimary (citable) accession number: D5VC98
Entry historyi
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: March 4, 2015
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.