ID   CNPD3_MORCB             Reviewed;         277 AA.
AC   D5VAD8;
DT   19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT   13-JUL-2010, sequence version 1.
DT   27-MAR-2024, entry version 65.
DE   RecName: Full=Probable cyclic nucleotide phosphodiesterase MCR_0369 {ECO:0000250|UniProtKB:P9WP65};
DE            EC=3.1.4.- {ECO:0000250|UniProtKB:P9WP65};
GN   OrderedLocusNames=MCR_0369;
OS   Moraxella catarrhalis (strain BBH18).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC   Moraxella.
OX   NCBI_TaxID=1236608;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BBH18;
RX   PubMed=20453089; DOI=10.1128/jb.00121-10;
RA   de Vries S.P., van Hijum S.A., Schueler W., Riesbeck K., Hays J.P.,
RA   Hermans P.W., Bootsma H.J.;
RT   "Genome analysis of Moraxella catarrhalis strain RH4, a human respiratory
RT   tract pathogen.";
RL   J. Bacteriol. 192:3574-3583(2010).
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000250|UniProtKB:Q6XBH1};
CC       Note=Binds 2 Fe(2+) ions per subunit. {ECO:0000250|UniProtKB:Q6XBH1};
CC   -!- SIMILARITY: Belongs to the cyclic nucleotide phosphodiesterase class-
CC       III family. {ECO:0000305}.
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DR   EMBL; CP002005; ADG60641.1; -; Genomic_DNA.
DR   RefSeq; WP_003660880.1; NC_014147.1.
DR   AlphaFoldDB; D5VAD8; -.
DR   SMR; D5VAD8; -.
DR   STRING; 1236608.MCR_0369; -.
DR   GeneID; 66586170; -.
DR   KEGG; mct:MCR_0369; -.
DR   PATRIC; fig|1236608.7.peg.385; -.
DR   HOGENOM; CLU_070320_0_0_6; -.
DR   Proteomes; UP000000930; Chromosome.
DR   GO; GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.60.21.10; -; 1.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   PANTHER; PTHR42988:SF2; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE CBUA0032-RELATED; 1.
DR   PANTHER; PTHR42988; PHOSPHOHYDROLASE; 1.
DR   Pfam; PF00149; Metallophos; 1.
DR   SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Iron; Metal-binding; Nucleotide-binding.
FT   CHAIN           1..277
FT                   /note="Probable cyclic nucleotide phosphodiesterase
FT                   MCR_0369"
FT                   /id="PRO_0000413369"
FT   BINDING         17
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:Q6XBH1"
FT   BINDING         19
FT                   /ligand="AMP"
FT                   /ligand_id="ChEBI:CHEBI:456215"
FT                   /evidence="ECO:0000250|UniProtKB:P9WP65"
FT   BINDING         19
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:Q6XBH1"
FT   BINDING         53
FT                   /ligand="AMP"
FT                   /ligand_id="ChEBI:CHEBI:456215"
FT                   /evidence="ECO:0000250|UniProtKB:P9WP65"
FT   BINDING         53
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:Q6XBH1"
FT   BINDING         53
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:Q6XBH1"
FT   BINDING         83..84
FT                   /ligand="AMP"
FT                   /ligand_id="ChEBI:CHEBI:456215"
FT                   /evidence="ECO:0000250|UniProtKB:P9WP65"
FT   BINDING         83
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:Q6XBH1"
FT   BINDING         165
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:Q6XBH1"
FT   BINDING         204
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:Q6XBH1"
FT   BINDING         206
FT                   /ligand="AMP"
FT                   /ligand_id="ChEBI:CHEBI:456215"
FT                   /evidence="ECO:0000250|UniProtKB:P9WP65"
FT   BINDING         206
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:Q6XBH1"
SQ   SEQUENCE   277 AA;  31630 MW;  D671DDEBAA0D9647 CRC64;
     MPNITNNHTF NIVQLSDLHL TGDIGQAPSY QRFLAVFQTA KHLNPDLWLL TGDLVNDGNS
     DAYDWLFNQL QATKIPYLAV AGNHDVTHEI GIHLAHQERI HVPILPDRRL KNCFRYTFQA
     GHDWQILLLN SSVSGEIFGL LTHETLLWLD QTLTTHFEQT IIALHHHPTK VSSDWIDAHL
     LKNHQDFWHV IKKHAHVHTI LCGHVHQVHT LHPLPAHQVQ LLSCPSTDRQ FMPFVDNFQI
     ADTPAGCRMI QIDNKGIVSS YIQIVQNTHS FCLNNAN
//