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D5VAD8 (CPDA_MORCR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Short name=3',5'-cyclic AMP phosphodiesterase
Short name=cAMP phosphodiesterase
EC=3.1.4.17
Gene names
Name:cpdA
Ordered Locus Names:MCR_0369
OrganismMoraxella catarrhalis (strain RH4) [Complete proteome] [HAMAP]
Taxonomic identifier749219 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeMoraxella

Protein attributes

Sequence length277 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes By similarity. HAMAP-Rule MF_00905

Catalytic activity

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate. HAMAP-Rule MF_00905

Cofactor

Binds 2 metal cations per subunit By similarity. HAMAP-Rule MF_00905

Sequence similarities

Belongs to the cAMP phosphodiesterase class-III family.

Ontologies

Keywords
   LigandcAMP
Metal-binding
Nucleotide-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_function3',5'-cyclic-AMP phosphodiesterase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

nucleotide binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2772773',5'-cyclic adenosine monophosphate phosphodiesterase CpdA HAMAP-Rule MF_00905
PRO_0000413369

Regions

Nucleotide binding83 – 842cAMP By similarity

Sites

Metal binding171Metal cation 1 By similarity
Metal binding191Metal cation 1 By similarity
Metal binding531Metal cation 1 By similarity
Metal binding531Metal cation 2 By similarity
Metal binding831Metal cation 2 By similarity
Metal binding1651Metal cation 2 By similarity
Metal binding2041Metal cation 2 By similarity
Metal binding2061Metal cation 1 By similarity
Binding site191cAMP By similarity
Binding site531cAMP By similarity
Binding site2061cAMP By similarity

Sequences

Sequence LengthMass (Da)Tools
D5VAD8 [UniParc].

Last modified July 13, 2010. Version 1.
Checksum: D671DDEBAA0D9647

FASTA27731,630
        10         20         30         40         50         60 
MPNITNNHTF NIVQLSDLHL TGDIGQAPSY QRFLAVFQTA KHLNPDLWLL TGDLVNDGNS 

        70         80         90        100        110        120 
DAYDWLFNQL QATKIPYLAV AGNHDVTHEI GIHLAHQERI HVPILPDRRL KNCFRYTFQA 

       130        140        150        160        170        180 
GHDWQILLLN SSVSGEIFGL LTHETLLWLD QTLTTHFEQT IIALHHHPTK VSSDWIDAHL 

       190        200        210        220        230        240 
LKNHQDFWHV IKKHAHVHTI LCGHVHQVHT LHPLPAHQVQ LLSCPSTDRQ FMPFVDNFQI 

       250        260        270 
ADTPAGCRMI QIDNKGIVSS YIQIVQNTHS FCLNNAN 

« Hide

References

[1]"Genome analysis of Moraxella catarrhalis strain RH4, a human respiratory tract pathogen."
de Vries S.P., van Hijum S.A., Schueler W., Riesbeck K., Hays J.P., Hermans P.W., Bootsma H.J.
J. Bacteriol. 192:3574-3583(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RH4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002005 Genomic DNA. Translation: ADG60641.1.
RefSeqYP_003626534.1. NC_014147.1.

3D structure databases

ProteinModelPortalD5VAD8.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADG60641; ADG60641; MCR_0369.
GeneID9135070.
KEGGmct:MCR_0369.
PATRIC38206581. VBIMorCat148474_0371.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000289889.
KOK03651.
OMAWIDAHIT.

Enzyme and pathway databases

BioCycMCAT749219:GHBK-384-MONOMER.

Family and domain databases

HAMAPMF_00905. cAMP_phophodiest_CpdA.
InterProIPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCPDA_MORCR
AccessionPrimary (citable) accession number: D5VAD8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: July 13, 2010
Last modified: April 16, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families