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D5VAD8

- CPDA_MORCR

UniProt

D5VAD8 - CPDA_MORCR

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Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Moraxella catarrhalis (strain RH4)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

a metal cationUniRule annotationNote: Binds 2 metal cations per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi17 – 171Metal cation 1UniRule annotation
Metal bindingi19 – 191Metal cation 1UniRule annotation
Binding sitei19 – 191cAMPUniRule annotation
Metal bindingi53 – 531Metal cation 1UniRule annotation
Metal bindingi53 – 531Metal cation 2UniRule annotation
Binding sitei53 – 531cAMPUniRule annotation
Metal bindingi83 – 831Metal cation 2UniRule annotation
Metal bindingi165 – 1651Metal cation 2UniRule annotation
Metal bindingi204 – 2041Metal cation 2UniRule annotation
Metal bindingi206 – 2061Metal cation 1UniRule annotation
Binding sitei206 – 2061cAMPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi83 – 842cAMPUniRule annotation

GO - Molecular functioni

  1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-HAMAP
  3. nucleotide binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMCAT749219:GHBK-384-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.17UniRule annotation)
Short name:
3',5'-cyclic AMP phosphodiesteraseUniRule annotation
Short name:
cAMP phosphodiesteraseUniRule annotation
Gene namesi
Name:cpdAUniRule annotation
Ordered Locus Names:MCR_0369
OrganismiMoraxella catarrhalis (strain RH4)
Taxonomic identifieri749219 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeMoraxella
ProteomesiUP000000930: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2772773',5'-cyclic adenosine monophosphate phosphodiesterase CpdAPRO_0000413369Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliD5VAD8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000289889.
KOiK03651.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

D5VAD8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPNITNNHTF NIVQLSDLHL TGDIGQAPSY QRFLAVFQTA KHLNPDLWLL
60 70 80 90 100
TGDLVNDGNS DAYDWLFNQL QATKIPYLAV AGNHDVTHEI GIHLAHQERI
110 120 130 140 150
HVPILPDRRL KNCFRYTFQA GHDWQILLLN SSVSGEIFGL LTHETLLWLD
160 170 180 190 200
QTLTTHFEQT IIALHHHPTK VSSDWIDAHL LKNHQDFWHV IKKHAHVHTI
210 220 230 240 250
LCGHVHQVHT LHPLPAHQVQ LLSCPSTDRQ FMPFVDNFQI ADTPAGCRMI
260 270
QIDNKGIVSS YIQIVQNTHS FCLNNAN
Length:277
Mass (Da):31,630
Last modified:July 13, 2010 - v1
Checksum:iD671DDEBAA0D9647
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002005 Genomic DNA. Translation: ADG60641.1.
RefSeqiYP_003626534.1. NC_014147.1.

Genome annotation databases

EnsemblBacteriaiADG60641; ADG60641; MCR_0369.
GeneIDi9135070.
KEGGimct:MCR_0369.
PATRICi38206581. VBIMorCat148474_0371.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002005 Genomic DNA. Translation: ADG60641.1 .
RefSeqi YP_003626534.1. NC_014147.1.

3D structure databases

ProteinModelPortali D5VAD8.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADG60641 ; ADG60641 ; MCR_0369 .
GeneIDi 9135070.
KEGGi mct:MCR_0369.
PATRICi 38206581. VBIMorCat148474_0371.

Phylogenomic databases

HOGENOMi HOG000289889.
KOi K03651.

Enzyme and pathway databases

BioCyci MCAT749219:GHBK-384-MONOMER.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
HAMAPi MF_00905. cAMP_phophodiest_CpdA.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome analysis of Moraxella catarrhalis strain RH4, a human respiratory tract pathogen."
    de Vries S.P., van Hijum S.A., Schueler W., Riesbeck K., Hays J.P., Hermans P.W., Bootsma H.J.
    J. Bacteriol. 192:3574-3583(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RH4.

Entry informationi

Entry nameiCPDA_MORCR
AccessioniPrimary (citable) accession number: D5VAD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: July 13, 2010
Last modified: November 26, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3