Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

D5VAD8

- CPDA_MORCR

UniProt

D5VAD8 - CPDA_MORCR

Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Moraxella catarrhalis (strain RH4)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (13 Jul 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

    Catalytic activityi

    Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

    Cofactori

    Binds 2 metal cations per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi17 – 171Metal cation 1UniRule annotation
    Metal bindingi19 – 191Metal cation 1UniRule annotation
    Binding sitei19 – 191cAMPUniRule annotation
    Metal bindingi53 – 531Metal cation 1UniRule annotation
    Metal bindingi53 – 531Metal cation 2UniRule annotation
    Binding sitei53 – 531cAMPUniRule annotation
    Metal bindingi83 – 831Metal cation 2UniRule annotation
    Metal bindingi165 – 1651Metal cation 2UniRule annotation
    Metal bindingi204 – 2041Metal cation 2UniRule annotation
    Metal bindingi206 – 2061Metal cation 1UniRule annotation
    Binding sitei206 – 2061cAMPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi83 – 842cAMPUniRule annotation

    GO - Molecular functioni

    1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-HAMAP
    3. nucleotide binding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cAMP, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMCAT749219:GHBK-384-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.17UniRule annotation)
    Short name:
    3',5'-cyclic AMP phosphodiesteraseUniRule annotation
    Short name:
    cAMP phosphodiesteraseUniRule annotation
    Gene namesi
    Name:cpdAUniRule annotation
    Ordered Locus Names:MCR_0369
    OrganismiMoraxella catarrhalis (strain RH4)
    Taxonomic identifieri749219 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeMoraxella
    ProteomesiUP000000930: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2772773',5'-cyclic adenosine monophosphate phosphodiesterase CpdAPRO_0000413369Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliD5VAD8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000289889.
    KOiK03651.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    HAMAPiMF_00905. cAMP_phophodiest_CpdA.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    D5VAD8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPNITNNHTF NIVQLSDLHL TGDIGQAPSY QRFLAVFQTA KHLNPDLWLL    50
    TGDLVNDGNS DAYDWLFNQL QATKIPYLAV AGNHDVTHEI GIHLAHQERI 100
    HVPILPDRRL KNCFRYTFQA GHDWQILLLN SSVSGEIFGL LTHETLLWLD 150
    QTLTTHFEQT IIALHHHPTK VSSDWIDAHL LKNHQDFWHV IKKHAHVHTI 200
    LCGHVHQVHT LHPLPAHQVQ LLSCPSTDRQ FMPFVDNFQI ADTPAGCRMI 250
    QIDNKGIVSS YIQIVQNTHS FCLNNAN 277
    Length:277
    Mass (Da):31,630
    Last modified:July 13, 2010 - v1
    Checksum:iD671DDEBAA0D9647
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002005 Genomic DNA. Translation: ADG60641.1.
    RefSeqiYP_003626534.1. NC_014147.1.

    Genome annotation databases

    EnsemblBacteriaiADG60641; ADG60641; MCR_0369.
    GeneIDi9135070.
    KEGGimct:MCR_0369.
    PATRICi38206581. VBIMorCat148474_0371.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002005 Genomic DNA. Translation: ADG60641.1 .
    RefSeqi YP_003626534.1. NC_014147.1.

    3D structure databases

    ProteinModelPortali D5VAD8.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADG60641 ; ADG60641 ; MCR_0369 .
    GeneIDi 9135070.
    KEGGi mct:MCR_0369.
    PATRICi 38206581. VBIMorCat148474_0371.

    Phylogenomic databases

    HOGENOMi HOG000289889.
    KOi K03651.

    Enzyme and pathway databases

    BioCyci MCAT749219:GHBK-384-MONOMER.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    HAMAPi MF_00905. cAMP_phophodiest_CpdA.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome analysis of Moraxella catarrhalis strain RH4, a human respiratory tract pathogen."
      de Vries S.P., van Hijum S.A., Schueler W., Riesbeck K., Hays J.P., Hermans P.W., Bootsma H.J.
      J. Bacteriol. 192:3574-3583(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RH4.

    Entry informationi

    Entry nameiCPDA_MORCR
    AccessioniPrimary (citable) accession number: D5VAD8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2011
    Last sequence update: July 13, 2010
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3