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Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Moraxella catarrhalis (strain BBH18)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

a metal cationUniRule annotationNote: Binds 2 metal cations per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi17Metal cation 1UniRule annotation1
Metal bindingi19Metal cation 1UniRule annotation1
Binding sitei19cAMPUniRule annotation1
Metal bindingi53Metal cation 1UniRule annotation1
Metal bindingi53Metal cation 2UniRule annotation1
Binding sitei53cAMPUniRule annotation1
Metal bindingi83Metal cation 2UniRule annotation1
Metal bindingi165Metal cation 2UniRule annotation1
Metal bindingi204Metal cation 2UniRule annotation1
Metal bindingi206Metal cation 1UniRule annotation1
Binding sitei206cAMPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi83 – 84cAMPUniRule annotation2

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.53UniRule annotation)
Short name:
3',5'-cyclic AMP phosphodiesteraseUniRule annotation
Short name:
cAMP phosphodiesteraseUniRule annotation
Gene namesi
Name:cpdAUniRule annotation
Ordered Locus Names:MCR_0369
OrganismiMoraxella catarrhalis (strain BBH18)
Taxonomic identifieri1236608 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeMoraxella
Proteomesi
  • UP000000930 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004133691 – 2773',5'-cyclic adenosine monophosphate phosphodiesterase CpdAAdd BLAST277

Structurei

3D structure databases

ProteinModelPortaliD5VAD8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000289889.
KOiK03651.
OrthoDBiPOG091H05L5.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PANTHERiPTHR12905:SF7. PTHR12905:SF7. 1 hit.
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

D5VAD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNITNNHTF NIVQLSDLHL TGDIGQAPSY QRFLAVFQTA KHLNPDLWLL
60 70 80 90 100
TGDLVNDGNS DAYDWLFNQL QATKIPYLAV AGNHDVTHEI GIHLAHQERI
110 120 130 140 150
HVPILPDRRL KNCFRYTFQA GHDWQILLLN SSVSGEIFGL LTHETLLWLD
160 170 180 190 200
QTLTTHFEQT IIALHHHPTK VSSDWIDAHL LKNHQDFWHV IKKHAHVHTI
210 220 230 240 250
LCGHVHQVHT LHPLPAHQVQ LLSCPSTDRQ FMPFVDNFQI ADTPAGCRMI
260 270
QIDNKGIVSS YIQIVQNTHS FCLNNAN
Length:277
Mass (Da):31,630
Last modified:July 13, 2010 - v1
Checksum:iD671DDEBAA0D9647
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002005 Genomic DNA. Translation: ADG60641.1.
RefSeqiWP_003660880.1. NC_014147.1.

Genome annotation databases

EnsemblBacteriaiADG60641; ADG60641; MCR_0369.
GeneIDi9135070.
KEGGimct:MCR_0369.
PATRICi38206581. VBIMorCat148474_0371.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002005 Genomic DNA. Translation: ADG60641.1.
RefSeqiWP_003660880.1. NC_014147.1.

3D structure databases

ProteinModelPortaliD5VAD8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADG60641; ADG60641; MCR_0369.
GeneIDi9135070.
KEGGimct:MCR_0369.
PATRICi38206581. VBIMorCat148474_0371.

Phylogenomic databases

HOGENOMiHOG000289889.
KOiK03651.
OrthoDBiPOG091H05L5.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PANTHERiPTHR12905:SF7. PTHR12905:SF7. 1 hit.
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCPDA_MORCB
AccessioniPrimary (citable) accession number: D5VAD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: July 13, 2010
Last modified: November 30, 2016
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.