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D5VAD8

- CPDA_MORCR

UniProt

D5VAD8 - CPDA_MORCR

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Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene
cpdA, MCR_0369
Organism
Moraxella catarrhalis (strain RH4)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes By similarity.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

Binds 2 metal cations per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi17 – 171Metal cation 1 By similarity
Metal bindingi19 – 191Metal cation 1 By similarity
Binding sitei19 – 191cAMP By similarity
Metal bindingi53 – 531Metal cation 1 By similarity
Metal bindingi53 – 531Metal cation 2 By similarity
Binding sitei53 – 531cAMP By similarity
Metal bindingi83 – 831Metal cation 2 By similarity
Metal bindingi165 – 1651Metal cation 2 By similarity
Metal bindingi204 – 2041Metal cation 2 By similarity
Metal bindingi206 – 2061Metal cation 1 By similarity
Binding sitei206 – 2061cAMP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi83 – 842cAMP By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-HAMAP
  3. nucleotide binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMCAT749219:GHBK-384-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA (EC:3.1.4.17)
Short name:
3',5'-cyclic AMP phosphodiesterase
Short name:
cAMP phosphodiesterase
Gene namesi
Name:cpdA
Ordered Locus Names:MCR_0369
OrganismiMoraxella catarrhalis (strain RH4)
Taxonomic identifieri749219 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeMoraxella
ProteomesiUP000000930: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2772773',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotationPRO_0000413369Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliD5VAD8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000289889.
KOiK03651.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

D5VAD8-1 [UniParc]FASTAAdd to Basket

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MPNITNNHTF NIVQLSDLHL TGDIGQAPSY QRFLAVFQTA KHLNPDLWLL    50
TGDLVNDGNS DAYDWLFNQL QATKIPYLAV AGNHDVTHEI GIHLAHQERI 100
HVPILPDRRL KNCFRYTFQA GHDWQILLLN SSVSGEIFGL LTHETLLWLD 150
QTLTTHFEQT IIALHHHPTK VSSDWIDAHL LKNHQDFWHV IKKHAHVHTI 200
LCGHVHQVHT LHPLPAHQVQ LLSCPSTDRQ FMPFVDNFQI ADTPAGCRMI 250
QIDNKGIVSS YIQIVQNTHS FCLNNAN 277
Length:277
Mass (Da):31,630
Last modified:July 13, 2010 - v1
Checksum:iD671DDEBAA0D9647
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002005 Genomic DNA. Translation: ADG60641.1.
RefSeqiYP_003626534.1. NC_014147.1.

Genome annotation databases

EnsemblBacteriaiADG60641; ADG60641; MCR_0369.
GeneIDi9135070.
KEGGimct:MCR_0369.
PATRICi38206581. VBIMorCat148474_0371.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002005 Genomic DNA. Translation: ADG60641.1 .
RefSeqi YP_003626534.1. NC_014147.1.

3D structure databases

ProteinModelPortali D5VAD8.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADG60641 ; ADG60641 ; MCR_0369 .
GeneIDi 9135070.
KEGGi mct:MCR_0369.
PATRICi 38206581. VBIMorCat148474_0371.

Phylogenomic databases

HOGENOMi HOG000289889.
KOi K03651.

Enzyme and pathway databases

BioCyci MCAT749219:GHBK-384-MONOMER.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
HAMAPi MF_00905. cAMP_phophodiest_CpdA.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome analysis of Moraxella catarrhalis strain RH4, a human respiratory tract pathogen."
    de Vries S.P., van Hijum S.A., Schueler W., Riesbeck K., Hays J.P., Hermans P.W., Bootsma H.J.
    J. Bacteriol. 192:3574-3583(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RH4.

Entry informationi

Entry nameiCPDA_MORCR
AccessioniPrimary (citable) accession number: D5VAD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: July 13, 2010
Last modified: June 11, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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