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D5VA53 (D5VA53_MORCR) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047
EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddlB EMBL ADG60556.1
Synonyms:ddl HAMAP-Rule MF_00047
Ordered Locus Names:MCR_0284 EMBL ADG60556.1
OrganismMoraxella catarrhalis (strain RH4) [Complete proteome] [HAMAP]
Taxonomic identifier749219 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Moraxella ›

Protein attributes

Sequence length307 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047 SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain109 – 304196ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding135 – 19056ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2581Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2711Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2711Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2731Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
D5VA53 [UniParc].

Last modified July 13, 2010. Version 1.
Checksum: 2593AD82EE3F0322

FASTA30733,662
        10         20         30         40         50         60 
MSKLNTKDGQ NFGKVAVICG GKSTEREVSL NSGMAVLNAL LSKGVDAHHF DPADTDISHL 

        70         80         90        100        110        120 
RAYDRVFNVL HGTFGEDGSL QGVLDGFNLP YTGCGVLASA IAMDKFRCRL LWQSLGLPNV 

       130        140        150        160        170        180 
PYVVLHDDSD FSAVEREFGL PLFVKPAAEG SSVGVFMVEQ AGDLAKIYPK LKQYHGEILA 

       190        200        210        220        230        240 
EKAMMGGEYA IPLLGEQVLP SIRIIPKGKF YDYEAKYLRD DTIYQCPSDL TPEQERQMGE 

       250        260        270        280        290        300 
LALKAFRAIG GRGWSRVDFL KGHDGKLYVL EINTVPGMTD HSLVPMAAKE AGIGFDELCL 


QILRQTL

« Hide

References

[1]"Genome analysis of Moraxella catarrhalis strain RH4, a human respiratory tract pathogen."
de Vries S.P., van Hijum S.A., Schueler W., Riesbeck K., Hays J.P., Hermans P.W., Bootsma H.J.
J. Bacteriol. 192:3574-3583(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RH4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002005 Genomic DNA. Translation: ADG60556.1.
RefSeqYP_003626449.1. NC_014147.1.

3D structure databases

ProteinModelPortalD5VA53.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADG60556; ADG60556; MCR_0284.
GeneID9134980.
KEGGmct:MCR_0284.
PATRIC38206405. VBIMorCat148474_0288.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000011592.
KOK01921.

Enzyme and pathway databases

BioCycMCAT749219:GHBK-292-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. PreATP-grasp-like. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD5VA53_MORCR
AccessionPrimary (citable) accession number: D5VA53
Entry history
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: May 1, 2013
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info