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Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Arcobacter nitrofigilis (strain ATCC 33309 / DSM 7299 / LMG 7604 / NCTC 12251 / CI) (Campylobacter nitrofigilis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

a metal cationUniRule annotationNote: Binds 2 metal cations per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi8Metal cation 1UniRule annotation1
Metal bindingi10Metal cation 1UniRule annotation1
Binding sitei10cAMPUniRule annotation1
Metal bindingi50Metal cation 1UniRule annotation1
Metal bindingi50Metal cation 2UniRule annotation1
Binding sitei50cAMPUniRule annotation1
Metal bindingi80Metal cation 2UniRule annotation1
Metal bindingi154Metal cation 2UniRule annotation1
Metal bindingi194Metal cation 2UniRule annotation1
Metal bindingi196Metal cation 1UniRule annotation1
Binding sitei196cAMPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi80 – 81cAMPUniRule annotation2

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandcAMP, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciANIT572480:G1GKP-2185-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.53UniRule annotation)
Short name:
3',5'-cyclic AMP phosphodiesteraseUniRule annotation
Short name:
cAMP phosphodiesteraseUniRule annotation
Gene namesi
Name:cpdAUniRule annotation
Ordered Locus Names:Arnit_2199
OrganismiArcobacter nitrofigilis (strain ATCC 33309 / DSM 7299 / LMG 7604 / NCTC 12251 / CI) (Campylobacter nitrofigilis)
Taxonomic identifieri572480 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeArcobacter
Proteomesi
  • UP000000939 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004133641 – 2733',5'-cyclic adenosine monophosphate phosphodiesterase CpdAAdd BLAST273

Proteomic databases

PRIDEiD5V0N9

Interactioni

Protein-protein interaction databases

STRINGi572480.Arnit_2199

Structurei

3D structure databases

ProteinModelPortaliD5V0N9
SMRiD5V0N9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41070EG Bacteria
COG1409 LUCA
HOGENOMiHOG000238352
KOiK03651
OMAiTGIGHMD
OrthoDBiPOG091H05L5

Family and domain databases

CDDicd07402 MPP_GpdQ, 1 hit
HAMAPiMF_00905 cAMP_phophodiest_CpdA, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR026575 cAMP_Pdiest_CpdA
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit

Sequencei

Sequence statusi: Complete.

D5V0N9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVVQVSDTH IKSKGKLAYN KVDIHKALYN CILHINNLKP KPDLVIFTGD
60 70 80 90 100
ITDNGTNEEY KLFKETVKLL DVPFYVIPGN HDNAENLKRE FEEYDWFEEN
110 120 130 140 150
NHLSLVIEDF PIRIIGLDSS IKGKSYGGLS EERLLWLEKQ LNKFPDKKVL
160 170 180 190 200
LFIHHPPVKI GIEHMDVQNL QIGRERLADL LGKYEQVLAL ACGHVHRVST
210 220 230 240 250
TLWNKIIVLT AASPSHQVAL DLRKDAKAEF VMEPPSVQLH YWTEEQGLTT
260 270
HTSYIGKFEG PYPFYNEKGE LID
Length:273
Mass (Da):31,373
Last modified:July 13, 2010 - v1
Checksum:i2F230D65CA257CB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001999 Genomic DNA Translation: ADG93851.1
RefSeqiWP_013135996.1, NC_014166.1

Genome annotation databases

EnsemblBacteriaiADG93851; ADG93851; Arnit_2199
KEGGiant:Arnit_2199

Similar proteinsi

Entry informationi

Entry nameiCPDA_ARCNC
AccessioniPrimary (citable) accession number: D5V0N9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: July 13, 2010
Last modified: May 23, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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