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D5V0N9 (CPDA_ARCNC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Short name=3',5'-cyclic AMP phosphodiesterase
Short name=cAMP phosphodiesterase
EC=3.1.4.17
Gene names
Name:cpdA
Ordered Locus Names:Arnit_2199
OrganismArcobacter nitrofigilis (strain ATCC 33309 / DSM 7299 / LMG 7604 / NCTC 12251 / CI) (Campylobacter nitrofigilis) [Complete proteome] [HAMAP]
Taxonomic identifier572480 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeArcobacter

Protein attributes

Sequence length273 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes By similarity. HAMAP-Rule MF_00905

Catalytic activity

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate. HAMAP-Rule MF_00905

Cofactor

Binds 2 metal cations per subunit By similarity. HAMAP-Rule MF_00905

Sequence similarities

Belongs to the cAMP phosphodiesterase class-III family.

Ontologies

Keywords
   LigandcAMP
Metal-binding
Nucleotide-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_function3',5'-cyclic-AMP phosphodiesterase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

nucleotide binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2732733',5'-cyclic adenosine monophosphate phosphodiesterase CpdA HAMAP-Rule MF_00905
PRO_0000413364

Regions

Nucleotide binding80 – 812cAMP By similarity

Sites

Metal binding81Metal cation 1 By similarity
Metal binding101Metal cation 1 By similarity
Metal binding501Metal cation 1 By similarity
Metal binding501Metal cation 2 By similarity
Metal binding801Metal cation 2 By similarity
Metal binding1541Metal cation 2 By similarity
Metal binding1941Metal cation 2 By similarity
Metal binding1961Metal cation 1 By similarity
Binding site101cAMP By similarity
Binding site501cAMP By similarity
Binding site1961cAMP By similarity

Sequences

Sequence LengthMass (Da)Tools
D5V0N9 [UniParc].

Last modified July 13, 2010. Version 1.
Checksum: 2F230D65CA257CB6

FASTA27331,373
        10         20         30         40         50         60 
MIVVQVSDTH IKSKGKLAYN KVDIHKALYN CILHINNLKP KPDLVIFTGD ITDNGTNEEY 

        70         80         90        100        110        120 
KLFKETVKLL DVPFYVIPGN HDNAENLKRE FEEYDWFEEN NHLSLVIEDF PIRIIGLDSS 

       130        140        150        160        170        180 
IKGKSYGGLS EERLLWLEKQ LNKFPDKKVL LFIHHPPVKI GIEHMDVQNL QIGRERLADL 

       190        200        210        220        230        240 
LGKYEQVLAL ACGHVHRVST TLWNKIIVLT AASPSHQVAL DLRKDAKAEF VMEPPSVQLH 

       250        260        270 
YWTEEQGLTT HTSYIGKFEG PYPFYNEKGE LID 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001999 Genomic DNA. Translation: ADG93851.1.
RefSeqYP_003656358.1. NC_014166.1.

3D structure databases

ProteinModelPortalD5V0N9.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADG93851; ADG93851; Arnit_2199.
GeneID9172362.
KEGGant:Arnit_2199.
PATRIC38117018. VBIArcNit33843_2182.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000238352.

Enzyme and pathway databases

BioCycANIT572480:GJ62-2231-MONOMER.

Family and domain databases

HAMAPMF_00905. cAMP_phophodiest_CpdA.
InterProIPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCPDA_ARCNC
AccessionPrimary (citable) accession number: D5V0N9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: July 13, 2010
Last modified: April 16, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families