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D5V0N9

- CPDA_ARCNC

UniProt

D5V0N9 - CPDA_ARCNC

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Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene
cpdA, Arnit_2199
Organism
Arcobacter nitrofigilis (strain ATCC 33309 / DSM 7299 / LMG 7604 / NCTC 12251 / CI) (Campylobacter nitrofigilis)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes By similarity.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

Binds 2 metal cations per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi8 – 81Metal cation 1 By similarity
Metal bindingi10 – 101Metal cation 1 By similarity
Binding sitei10 – 101cAMP By similarity
Metal bindingi50 – 501Metal cation 1 By similarity
Metal bindingi50 – 501Metal cation 2 By similarity
Binding sitei50 – 501cAMP By similarity
Metal bindingi80 – 801Metal cation 2 By similarity
Metal bindingi154 – 1541Metal cation 2 By similarity
Metal bindingi194 – 1941Metal cation 2 By similarity
Metal bindingi196 – 1961Metal cation 1 By similarity
Binding sitei196 – 1961cAMP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi80 – 812cAMP By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-HAMAP
  3. nucleotide binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciANIT572480:GJ62-2231-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA (EC:3.1.4.17)
Short name:
3',5'-cyclic AMP phosphodiesterase
Short name:
cAMP phosphodiesterase
Gene namesi
Name:cpdA
Ordered Locus Names:Arnit_2199
OrganismiArcobacter nitrofigilis (strain ATCC 33309 / DSM 7299 / LMG 7604 / NCTC 12251 / CI) (Campylobacter nitrofigilis)
Taxonomic identifieri572480 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeArcobacter
ProteomesiUP000000939: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2732733',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotationPRO_0000413364Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliD5V0N9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000238352.
OMAiFDGPHPF.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

D5V0N9-1 [UniParc]FASTAAdd to Basket

« Hide

MIVVQVSDTH IKSKGKLAYN KVDIHKALYN CILHINNLKP KPDLVIFTGD    50
ITDNGTNEEY KLFKETVKLL DVPFYVIPGN HDNAENLKRE FEEYDWFEEN 100
NHLSLVIEDF PIRIIGLDSS IKGKSYGGLS EERLLWLEKQ LNKFPDKKVL 150
LFIHHPPVKI GIEHMDVQNL QIGRERLADL LGKYEQVLAL ACGHVHRVST 200
TLWNKIIVLT AASPSHQVAL DLRKDAKAEF VMEPPSVQLH YWTEEQGLTT 250
HTSYIGKFEG PYPFYNEKGE LID 273
Length:273
Mass (Da):31,373
Last modified:July 13, 2010 - v1
Checksum:i2F230D65CA257CB6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001999 Genomic DNA. Translation: ADG93851.1.
RefSeqiWP_013135996.1. NC_014166.1.
YP_003656358.1. NC_014166.1.

Genome annotation databases

EnsemblBacteriaiADG93851; ADG93851; Arnit_2199.
GeneIDi9172362.
KEGGiant:Arnit_2199.
PATRICi38117018. VBIArcNit33843_2182.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001999 Genomic DNA. Translation: ADG93851.1 .
RefSeqi WP_013135996.1. NC_014166.1.
YP_003656358.1. NC_014166.1.

3D structure databases

ProteinModelPortali D5V0N9.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADG93851 ; ADG93851 ; Arnit_2199 .
GeneIDi 9172362.
KEGGi ant:Arnit_2199.
PATRICi 38117018. VBIArcNit33843_2182.

Phylogenomic databases

HOGENOMi HOG000238352.
OMAi FDGPHPF.

Enzyme and pathway databases

BioCyci ANIT572480:GJ62-2231-MONOMER.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
HAMAPi MF_00905. cAMP_phophodiest_CpdA.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33309 / DSM 7299 / LMG 7604 / NCTC 12251 / CI.

Entry informationi

Entry nameiCPDA_ARCNC
AccessioniPrimary (citable) accession number: D5V0N9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: July 13, 2010
Last modified: September 3, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3