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D5V0N9

- CPDA_ARCNC

UniProt

D5V0N9 - CPDA_ARCNC

Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Arcobacter nitrofigilis (strain ATCC 33309 / DSM 7299 / LMG 7604 / NCTC 12251 / CI) (Campylobacter nitrofigilis)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (13 Jul 2010)
      Previous versions | rss
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    Functioni

    Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

    Catalytic activityi

    Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

    Cofactori

    Binds 2 metal cations per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi8 – 81Metal cation 1UniRule annotation
    Metal bindingi10 – 101Metal cation 1UniRule annotation
    Binding sitei10 – 101cAMPUniRule annotation
    Metal bindingi50 – 501Metal cation 1UniRule annotation
    Metal bindingi50 – 501Metal cation 2UniRule annotation
    Binding sitei50 – 501cAMPUniRule annotation
    Metal bindingi80 – 801Metal cation 2UniRule annotation
    Metal bindingi154 – 1541Metal cation 2UniRule annotation
    Metal bindingi194 – 1941Metal cation 2UniRule annotation
    Metal bindingi196 – 1961Metal cation 1UniRule annotation
    Binding sitei196 – 1961cAMPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi80 – 812cAMPUniRule annotation

    GO - Molecular functioni

    1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-HAMAP
    3. nucleotide binding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cAMP, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciANIT572480:GJ62-2231-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.17UniRule annotation)
    Short name:
    3',5'-cyclic AMP phosphodiesteraseUniRule annotation
    Short name:
    cAMP phosphodiesteraseUniRule annotation
    Gene namesi
    Name:cpdAUniRule annotation
    Ordered Locus Names:Arnit_2199
    OrganismiArcobacter nitrofigilis (strain ATCC 33309 / DSM 7299 / LMG 7604 / NCTC 12251 / CI) (Campylobacter nitrofigilis)
    Taxonomic identifieri572480 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeArcobacter
    ProteomesiUP000000939: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2732733',5'-cyclic adenosine monophosphate phosphodiesterase CpdAPRO_0000413364Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliD5V0N9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000238352.
    OMAiFDGPHPF.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    HAMAPiMF_00905. cAMP_phophodiest_CpdA.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    D5V0N9-1 [UniParc]FASTAAdd to Basket

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    MIVVQVSDTH IKSKGKLAYN KVDIHKALYN CILHINNLKP KPDLVIFTGD    50
    ITDNGTNEEY KLFKETVKLL DVPFYVIPGN HDNAENLKRE FEEYDWFEEN 100
    NHLSLVIEDF PIRIIGLDSS IKGKSYGGLS EERLLWLEKQ LNKFPDKKVL 150
    LFIHHPPVKI GIEHMDVQNL QIGRERLADL LGKYEQVLAL ACGHVHRVST 200
    TLWNKIIVLT AASPSHQVAL DLRKDAKAEF VMEPPSVQLH YWTEEQGLTT 250
    HTSYIGKFEG PYPFYNEKGE LID 273
    Length:273
    Mass (Da):31,373
    Last modified:July 13, 2010 - v1
    Checksum:i2F230D65CA257CB6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001999 Genomic DNA. Translation: ADG93851.1.
    RefSeqiWP_013135996.1. NC_014166.1.
    YP_003656358.1. NC_014166.1.

    Genome annotation databases

    EnsemblBacteriaiADG93851; ADG93851; Arnit_2199.
    GeneIDi9172362.
    KEGGiant:Arnit_2199.
    PATRICi38117018. VBIArcNit33843_2182.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001999 Genomic DNA. Translation: ADG93851.1 .
    RefSeqi WP_013135996.1. NC_014166.1.
    YP_003656358.1. NC_014166.1.

    3D structure databases

    ProteinModelPortali D5V0N9.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADG93851 ; ADG93851 ; Arnit_2199 .
    GeneIDi 9172362.
    KEGGi ant:Arnit_2199.
    PATRICi 38117018. VBIArcNit33843_2182.

    Phylogenomic databases

    HOGENOMi HOG000238352.
    OMAi FDGPHPF.

    Enzyme and pathway databases

    BioCyci ANIT572480:GJ62-2231-MONOMER.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    HAMAPi MF_00905. cAMP_phophodiest_CpdA.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33309 / DSM 7299 / LMG 7604 / NCTC 12251 / CI.

    Entry informationi

    Entry nameiCPDA_ARCNC
    AccessioniPrimary (citable) accession number: D5V0N9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2011
    Last sequence update: July 13, 2010
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3