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D5V0N9

- CPDA_ARCNC

UniProt

D5V0N9 - CPDA_ARCNC

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Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Arcobacter nitrofigilis (strain ATCC 33309 / DSM 7299 / LMG 7604 / NCTC 12251 / CI) (Campylobacter nitrofigilis)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

a metal cationUniRule annotationNote: Binds 2 metal cations per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi8 – 81Metal cation 1UniRule annotation
Metal bindingi10 – 101Metal cation 1UniRule annotation
Binding sitei10 – 101cAMPUniRule annotation
Metal bindingi50 – 501Metal cation 1UniRule annotation
Metal bindingi50 – 501Metal cation 2UniRule annotation
Binding sitei50 – 501cAMPUniRule annotation
Metal bindingi80 – 801Metal cation 2UniRule annotation
Metal bindingi154 – 1541Metal cation 2UniRule annotation
Metal bindingi194 – 1941Metal cation 2UniRule annotation
Metal bindingi196 – 1961Metal cation 1UniRule annotation
Binding sitei196 – 1961cAMPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi80 – 812cAMPUniRule annotation

GO - Molecular functioni

  1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-HAMAP
  3. nucleotide binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciANIT572480:GJ62-2231-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.17UniRule annotation)
Short name:
3',5'-cyclic AMP phosphodiesteraseUniRule annotation
Short name:
cAMP phosphodiesteraseUniRule annotation
Gene namesi
Name:cpdAUniRule annotation
Ordered Locus Names:Arnit_2199
OrganismiArcobacter nitrofigilis (strain ATCC 33309 / DSM 7299 / LMG 7604 / NCTC 12251 / CI) (Campylobacter nitrofigilis)
Taxonomic identifieri572480 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeArcobacter
ProteomesiUP000000939: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2732733',5'-cyclic adenosine monophosphate phosphodiesterase CpdAPRO_0000413364Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliD5V0N9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000238352.
OMAiFDGPHPF.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

D5V0N9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIVVQVSDTH IKSKGKLAYN KVDIHKALYN CILHINNLKP KPDLVIFTGD
60 70 80 90 100
ITDNGTNEEY KLFKETVKLL DVPFYVIPGN HDNAENLKRE FEEYDWFEEN
110 120 130 140 150
NHLSLVIEDF PIRIIGLDSS IKGKSYGGLS EERLLWLEKQ LNKFPDKKVL
160 170 180 190 200
LFIHHPPVKI GIEHMDVQNL QIGRERLADL LGKYEQVLAL ACGHVHRVST
210 220 230 240 250
TLWNKIIVLT AASPSHQVAL DLRKDAKAEF VMEPPSVQLH YWTEEQGLTT
260 270
HTSYIGKFEG PYPFYNEKGE LID
Length:273
Mass (Da):31,373
Last modified:July 13, 2010 - v1
Checksum:i2F230D65CA257CB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001999 Genomic DNA. Translation: ADG93851.1.
RefSeqiYP_003656358.1. NC_014166.1.

Genome annotation databases

EnsemblBacteriaiADG93851; ADG93851; Arnit_2199.
GeneIDi9172362.
KEGGiant:Arnit_2199.
PATRICi38117018. VBIArcNit33843_2182.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001999 Genomic DNA. Translation: ADG93851.1 .
RefSeqi YP_003656358.1. NC_014166.1.

3D structure databases

ProteinModelPortali D5V0N9.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADG93851 ; ADG93851 ; Arnit_2199 .
GeneIDi 9172362.
KEGGi ant:Arnit_2199.
PATRICi 38117018. VBIArcNit33843_2182.

Phylogenomic databases

HOGENOMi HOG000238352.
OMAi FDGPHPF.

Enzyme and pathway databases

BioCyci ANIT572480:GJ62-2231-MONOMER.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
HAMAPi MF_00905. cAMP_phophodiest_CpdA.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33309 / DSM 7299 / LMG 7604 / NCTC 12251 / CI.

Entry informationi

Entry nameiCPDA_ARCNC
AccessioniPrimary (citable) accession number: D5V0N9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: July 13, 2010
Last modified: November 26, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3