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D5UVY2 (D5UVY2_TSUPD) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 16. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase HAMAP-Rule MF_02122
EC=2.3.1.117 HAMAP-Rule MF_02122
Alternative name(s):
Tetrahydrodipicolinate N-succinyltransferase HAMAP-Rule MF_02122
Tetrahydropicolinate succinylase HAMAP-Rule MF_02122
Gene names
Name:dapD HAMAP-Rule MF_02122
Ordered Locus Names:Tpau_1158 EMBL ADG77789.1
OrganismTsukamurella paurometabola (strain ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040) (Corynebacterium paurometabolum) [Complete proteome] [HAMAP] EMBL ADG77789.1
Taxonomic identifier521096 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Tsukamurellaceae › Tsukamurella ›

Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA By similarity. HAMAP-Rule MF_02122

Catalytic activity

Succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate. HAMAP-Rule MF_02122

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 1/3. HAMAP-Rule MF_02122

Subunit structure

Homotrimer By similarity. HAMAP-Rule MF_02122

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_02122.

Sequence similarities

Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family. HAMAP-Rule MF_02122

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region256 – 2572Succinyl-CoA binding By similarity HAMAP-Rule MF_02122
Region289 – 2924Succinyl-CoA binding By similarity HAMAP-Rule MF_02122

Sites

Active site1981Acyl-anhydride intermediate By similarity HAMAP-Rule MF_02122
Metal binding1651Magnesium 1; shared with trimeric partners By similarity HAMAP-Rule MF_02122
Metal binding1821Magnesium 2; shared with trimeric partners By similarity HAMAP-Rule MF_02122
Binding site2001Succinyl-CoA By similarity HAMAP-Rule MF_02122
Binding site2151Succinyl-CoA; via amide nitrogen By similarity HAMAP-Rule MF_02122
Binding site2181Succinyl-CoA By similarity HAMAP-Rule MF_02122
Binding site2411Succinyl-CoA; via amide nitrogen By similarity HAMAP-Rule MF_02122
Binding site2641Succinyl-CoA; via carbonyl oxygen By similarity HAMAP-Rule MF_02122
Binding site2761Succinyl-CoA By similarity HAMAP-Rule MF_02122

Sequences

Sequence LengthMass (Da)Tools
D5UVY2 [UniParc].

Last modified July 13, 2010. Version 1.
Checksum: 1C7E39A139C89411

FASTA31632,882
        10         20         30         40         50         60 
MTNRGAVAYG LATITDDGTV LDTWFPAPEL TDGAGTTGSD HDPAGAPEEL TALAGTDADR 

        70         80         90        100        110        120 
KVRLVVVKTT IADLAAAPID AHDVYLRLHL LSHRLVQPHG LSLEGQFGLL ANVVWTNFGP 

       130        140        150        160        170        180 
CAPAGFELVR AALRKRGQVT VYSLDKFPRM VDYVLPTGVR IGDADRVRLG AHLAEGTTVM 

       190        200        210        220        230        240 
HEGFVNFNAG TLGTAMVEGR ISAGVVIGDH SDVGGGASTM GTLSGGGKEI IKLGERCLLG 

       250        260        270        280        290        300 
ANSGLGIPLG DDCVLEAGLY LTAGTKVTGP DGTQVKAREL AGQSNLLFRR NSVTGAVEVV 

       310 
PWKSEGVELN AALHKN

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001966 Genomic DNA. Translation: ADG77789.1.
RefSeqYP_003646128.1. NC_014158.1.

3D structure databases

ProteinModelPortalD5UVY2.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADG77789; ADG77789; Tpau_1158.
GeneID9155298.
KEGGtpr:Tpau_1158.
PATRIC38305541. VBITsuPau718_1138.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000248194.
KOK00674.

Enzyme and pathway databases

UniPathwayUPA00034; UER00019.

Family and domain databases

HAMAPMF_02122. DapD_type2.
InterProIPR019875. DapD_actinobacteria.
IPR011004. Trimer_LpxA-like.
IPR026586. Type2_DapD.
[Graphical view]
SUPFAMSSF51161. Trimer_LpxA_like. 1 hit.
TIGRFAMsTIGR03535. DapD_actino. 1 hit.
ProtoNetSearch...

Entry information

Entry nameD5UVY2_TSUPD
AccessionPrimary (citable) accession number: D5UVY2
Entry history
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: May 1, 2013
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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