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Protein

1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase

Gene

mshB

Organism
Tsukamurella paurometabola (strain ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040) (Corynebacterium paurometabolum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway.UniRule annotation

Catalytic activityi

1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + H2O = 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + acetate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi11 – 111ZincUniRule annotation
Metal bindingi14 – 141ZincUniRule annotation
Metal bindingi154 – 1541ZincUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciTPAU521096:GI2W-1154-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylaseUniRule annotation (EC:3.5.1.103UniRule annotation)
Short name:
GlcNAc-Ins deacetylaseUniRule annotation
Alternative name(s):
N-acetyl-1-D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase
Gene namesi
Name:mshBUniRule annotation
Ordered Locus Names:Tpau_1146
OrganismiTsukamurella paurometabola (strain ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040) (Corynebacterium paurometabolum)
Taxonomic identifieri521096 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesTsukamurellaceaeTsukamurella
Proteomesi
  • UP000001213 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2972971D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylasePRO_0000400233Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi521096.Tpau_1146.

Structurei

3D structure databases

ProteinModelPortaliD5UVX0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MshB deacetylase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108KZ5. Bacteria.
COG2120. LUCA.
HOGENOMiHOG000241173.
KOiK15525.
OMAiMMGLATN.
OrthoDBiPOG091H08W5.

Family and domain databases

Gene3Di3.40.50.10320. 1 hit.
HAMAPiMF_01696. MshB. 1 hit.
InterProiIPR003737. GlcNAc_PI_deacetylase-related.
IPR024078. LmbE-like_dom.
IPR017810. Mycothiol_biosynthesis_MshB.
[Graphical view]
PANTHERiPTHR12993. PTHR12993. 1 hit.
PfamiPF02585. PIG-L. 1 hit.
[Graphical view]
SUPFAMiSSF102588. SSF102588. 1 hit.
TIGRFAMsiTIGR03445. mycothiol_MshB. 1 hit.

Sequencei

Sequence statusi: Complete.

D5UVX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRRLLLVHA HPDDETITTG GTIARYLSEG AEVTVVTCTL GEEGEVMDPP
60 70 80 90 100
YAQLVADQAD QLGGYRIAEL TRALAALSEP AGPVLRPRFL GGAGRWRDSG
110 120 130 140 150
MAGTPAADHP RAFASADRIA ADGPVALLAG IIRELRPQVV VTYDQVGGYG
160 170 180 190 200
HPDHIAAHTV TTAAVDAAAA SGLPGEQWAV AKLYWTVAGR GQIDRGVAAF
210 220 230 240 250
AETELPGDWS VPESASLPAH DDAALTALID TRDVAGRKVA ALRAHATQLA
260 270 280 290
VAPCGTAFAL TNLIAQPVLT EEAYILVRGT AAPGPDGLER DLFAGLE
Length:297
Mass (Da):30,890
Last modified:July 13, 2010 - v1
Checksum:i57036B0CF46A59F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001966 Genomic DNA. Translation: ADG77777.1.
RefSeqiWP_013125815.1. NC_014158.1.

Genome annotation databases

EnsemblBacteriaiADG77777; ADG77777; Tpau_1146.
KEGGitpr:Tpau_1146.
PATRICi38305519. VBITsuPau718_1127.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001966 Genomic DNA. Translation: ADG77777.1.
RefSeqiWP_013125815.1. NC_014158.1.

3D structure databases

ProteinModelPortaliD5UVX0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi521096.Tpau_1146.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADG77777; ADG77777; Tpau_1146.
KEGGitpr:Tpau_1146.
PATRICi38305519. VBITsuPau718_1127.

Phylogenomic databases

eggNOGiENOG4108KZ5. Bacteria.
COG2120. LUCA.
HOGENOMiHOG000241173.
KOiK15525.
OMAiMMGLATN.
OrthoDBiPOG091H08W5.

Enzyme and pathway databases

BioCyciTPAU521096:GI2W-1154-MONOMER.

Family and domain databases

Gene3Di3.40.50.10320. 1 hit.
HAMAPiMF_01696. MshB. 1 hit.
InterProiIPR003737. GlcNAc_PI_deacetylase-related.
IPR024078. LmbE-like_dom.
IPR017810. Mycothiol_biosynthesis_MshB.
[Graphical view]
PANTHERiPTHR12993. PTHR12993. 1 hit.
PfamiPF02585. PIG-L. 1 hit.
[Graphical view]
SUPFAMiSSF102588. SSF102588. 1 hit.
TIGRFAMsiTIGR03445. mycothiol_MshB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMSHB_TSUPD
AccessioniPrimary (citable) accession number: D5UVX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: July 13, 2010
Last modified: September 7, 2016
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.