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D5UQA0

- D5UQA0_TSUPD

UniProt

D5UQA0 - D5UQA0_TSUPD

Protein
Submitted name:

Isocitrate dehydrogenase, NADP-dependent

Gene

Tpau_2261

Organism
Tsukamurella paurometabola (strain ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040) (Corynebacterium paurometabolum)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi
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    • History
      Entry version 30 (01 Oct 2014)
      Sequence version 1 (13 Jul 2010)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei147 – 1471SubstrateUniRule annotation
    Sitei257 – 2571Critical for catalysisUniRule annotation
    Metal bindingi352 – 3521Magnesium or manganese
    Sitei422 – 4221Critical for catalysisUniRule annotation
    Binding sitei550 – 5501SubstrateUniRule annotation
    Metal bindingi551 – 5511Magnesium or manganese
    Metal bindingi555 – 5551Magnesium or manganese

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseImported

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciTPAU521096:GI2W-2282-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Isocitrate dehydrogenase, NADP-dependentImported (EC:1.1.1.42Imported)
    Gene namesi
    Ordered Locus Names:Tpau_2261Imported
    OrganismiTsukamurella paurometabola (strain ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040) (Corynebacterium paurometabolum)Imported
    Taxonomic identifieri521096 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeTsukamurellaceaeTsukamurella
    ProteomesiUP000001213: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliD5UQA0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni134 – 1418Substrate bindingUniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000240860.
    KOiK00031.

    Family and domain databases

    Gene3Di3.40.718.10. 3 hits.
    InterProiIPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PfamiPF03971. IDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    D5UQA0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAQQQTIIY TLTDEAPLLA TAAFLPIIRT FAGPAGIDVQ TSDISVAARI    50
    LAAFPERLTE EQRVTDNLAA LGELTQDPSA NIIKLPNISA SVPQLLAAIT 100
    ELQEKGYDIP DLPSEPKTDE ERDIATRYST ILGSAVNPVL RQGNSDRRAP 150
    KAVKEYARKH PHSMGEWSMA SRSHVAHMKH GDFYHGEKSM TIDKDRDVRM 200
    ELVTADGNTN VLKPSVTLGP GDVMDSMFMS KKALLDFYEE QMQDAYETGV 250
    MFSLHVKATM MKVSHPIVFG HAVRVFYKEA FAKHHDLFEE LGVNVNNGLG 300
    DLYDKIATLP ASKHEEIVKD LHACHEHRPE LAMVDSARGI SNFHSPSDVI 350
    VDASMPAMIR AGGKMYGADG RTKDTKAVMP ESTFARIYQE IINFCKTNGA 400
    FDPRTMGTVP NVGLMAQKAE EYGSHDKTFE VPAAGTANIV DNATGEVLLS 450
    QEVEEGDIWR MCTVKDAPIR DWIKLAVNRA RNSGTPVLFW LDPYRPHENE 500
    LIAKVKAELE NYDTEGLDIQ IMSQVRAMRY TLERAMRGLD TIAATGNILR 550
    DYLTDLFPIL ELGTSAKMLS IVPLMAGGGM YETGAGGSAP KHVKQLVEEN 600
    HLRWDSLGEF LALAVSLEET GLKNDNKHAV TLAKTLDAAT GKLLENNKAP 650
    SRSTGELDNR GSQFYLALYW AQELAAQTDD PELAEKFAPL AAALAEHEET 700
    IVAELAAVQG EPADIGGYYY PDPEKMATVM RPSATFNADL DSVQS 745
    Length:745
    Mass (Da):81,811
    Last modified:July 13, 2010 - v1
    Checksum:i01480C8C902172A9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001966 Genomic DNA. Translation: ADG78870.1.
    RefSeqiWP_013126892.1. NC_014158.1.
    YP_003647209.1. NC_014158.1.

    Genome annotation databases

    EnsemblBacteriaiADG78870; ADG78870; Tpau_2261.
    GeneIDi9156417.
    KEGGitpr:Tpau_2261.
    PATRICi38307825. VBITsuPau718_2263.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001966 Genomic DNA. Translation: ADG78870.1 .
    RefSeqi WP_013126892.1. NC_014158.1.
    YP_003647209.1. NC_014158.1.

    3D structure databases

    ProteinModelPortali D5UQA0.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADG78870 ; ADG78870 ; Tpau_2261 .
    GeneIDi 9156417.
    KEGGi tpr:Tpau_2261.
    PATRICi 38307825. VBITsuPau718_2263.

    Phylogenomic databases

    HOGENOMi HOG000240860.
    KOi K00031.

    Enzyme and pathway databases

    BioCyci TPAU521096:GI2W-2282-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 3 hits.
    InterProi IPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    Pfami PF03971. IDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040Imported.

    Entry informationi

    Entry nameiD5UQA0_TSUPD
    AccessioniPrimary (citable) accession number: D5UQA0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 13, 2010
    Last sequence update: July 13, 2010
    Last modified: October 1, 2014
    This is version 30 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3