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D5UQA0

- D5UQA0_TSUPD

UniProt

D5UQA0 - D5UQA0_TSUPD

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Protein
Submitted name:

Isocitrate dehydrogenase, NADP-dependent

Gene
Tpau_2261
Organism
Tsukamurella paurometabola (strain ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040) (Corynebacterium paurometabolum)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei147 – 1471Substrate By similarity
Sitei257 – 2571Critical for catalysis By similarityUniRule annotation
Metal bindingi352 – 3521Magnesium or manganese By similarityUniRule annotation
Sitei422 – 4221Critical for catalysis By similarityUniRule annotation
Binding sitei550 – 5501Substrate By similarityUniRule annotation
Metal bindingi551 – 5511Magnesium or manganese By similarityUniRule annotation
Metal bindingi555 – 5551Magnesium or manganese By similarityUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciTPAU521096:GI2W-2282-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase, NADP-dependentImported (EC:1.1.1.42Imported)
Gene namesi
Ordered Locus Names:Tpau_2261Imported
OrganismiTsukamurella paurometabola (strain ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040) (Corynebacterium paurometabolum)Imported
Taxonomic identifieri521096 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeTsukamurellaceaeTsukamurella
ProteomesiUP000001213: Chromosome

Structurei

3D structure databases

ProteinModelPortaliD5UQA0.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1418Substrate binding By similarity

Phylogenomic databases

HOGENOMiHOG000240860.
KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

D5UQA0-1 [UniParc]FASTAAdd to Basket

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MSAQQQTIIY TLTDEAPLLA TAAFLPIIRT FAGPAGIDVQ TSDISVAARI    50
LAAFPERLTE EQRVTDNLAA LGELTQDPSA NIIKLPNISA SVPQLLAAIT 100
ELQEKGYDIP DLPSEPKTDE ERDIATRYST ILGSAVNPVL RQGNSDRRAP 150
KAVKEYARKH PHSMGEWSMA SRSHVAHMKH GDFYHGEKSM TIDKDRDVRM 200
ELVTADGNTN VLKPSVTLGP GDVMDSMFMS KKALLDFYEE QMQDAYETGV 250
MFSLHVKATM MKVSHPIVFG HAVRVFYKEA FAKHHDLFEE LGVNVNNGLG 300
DLYDKIATLP ASKHEEIVKD LHACHEHRPE LAMVDSARGI SNFHSPSDVI 350
VDASMPAMIR AGGKMYGADG RTKDTKAVMP ESTFARIYQE IINFCKTNGA 400
FDPRTMGTVP NVGLMAQKAE EYGSHDKTFE VPAAGTANIV DNATGEVLLS 450
QEVEEGDIWR MCTVKDAPIR DWIKLAVNRA RNSGTPVLFW LDPYRPHENE 500
LIAKVKAELE NYDTEGLDIQ IMSQVRAMRY TLERAMRGLD TIAATGNILR 550
DYLTDLFPIL ELGTSAKMLS IVPLMAGGGM YETGAGGSAP KHVKQLVEEN 600
HLRWDSLGEF LALAVSLEET GLKNDNKHAV TLAKTLDAAT GKLLENNKAP 650
SRSTGELDNR GSQFYLALYW AQELAAQTDD PELAEKFAPL AAALAEHEET 700
IVAELAAVQG EPADIGGYYY PDPEKMATVM RPSATFNADL DSVQS 745
Length:745
Mass (Da):81,811
Last modified:July 13, 2010 - v1
Checksum:i01480C8C902172A9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001966 Genomic DNA. Translation: ADG78870.1.
RefSeqiWP_013126892.1. NC_014158.1.
YP_003647209.1. NC_014158.1.

Genome annotation databases

EnsemblBacteriaiADG78870; ADG78870; Tpau_2261.
GeneIDi9156417.
KEGGitpr:Tpau_2261.
PATRICi38307825. VBITsuPau718_2263.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001966 Genomic DNA. Translation: ADG78870.1 .
RefSeqi WP_013126892.1. NC_014158.1.
YP_003647209.1. NC_014158.1.

3D structure databases

ProteinModelPortali D5UQA0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADG78870 ; ADG78870 ; Tpau_2261 .
GeneIDi 9156417.
KEGGi tpr:Tpau_2261.
PATRICi 38307825. VBITsuPau718_2263.

Phylogenomic databases

HOGENOMi HOG000240860.
KOi K00031.

Enzyme and pathway databases

BioCyci TPAU521096:GI2W-2282-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040.

Entry informationi

Entry nameiD5UQA0_TSUPD
AccessioniPrimary (citable) accession number: D5UQA0
Entry historyi
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: September 3, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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