Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

D5UQA0

- D5UQA0_TSUPD

UniProt

D5UQA0 - D5UQA0_TSUPD

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name:

Isocitrate dehydrogenase, NADP-dependent

Gene

Tpau_2261

Organism
Tsukamurella paurometabola (strain ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040) (Corynebacterium paurometabolum)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi

Functioni

Cofactori

Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei147 – 1471SubstrateUniRule annotation
Sitei257 – 2571Critical for catalysisUniRule annotation
Metal bindingi352 – 3521Magnesium or manganese
Sitei422 – 4221Critical for catalysisUniRule annotation
Binding sitei550 – 5501SubstrateUniRule annotation
Metal bindingi551 – 5511Magnesium or manganese
Metal bindingi555 – 5551Magnesium or manganese

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciTPAU521096:GI2W-2282-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase, NADP-dependentImported (EC:1.1.1.42Imported)
Gene namesi
Ordered Locus Names:Tpau_2261Imported
OrganismiTsukamurella paurometabola (strain ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040) (Corynebacterium paurometabolum)Imported
Taxonomic identifieri521096 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeTsukamurellaceaeTsukamurella
ProteomesiUP000001213: Chromosome

Structurei

3D structure databases

ProteinModelPortaliD5UQA0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1418Substrate bindingUniRule annotation

Phylogenomic databases

HOGENOMiHOG000240860.
KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

D5UQA0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAQQQTIIY TLTDEAPLLA TAAFLPIIRT FAGPAGIDVQ TSDISVAARI
60 70 80 90 100
LAAFPERLTE EQRVTDNLAA LGELTQDPSA NIIKLPNISA SVPQLLAAIT
110 120 130 140 150
ELQEKGYDIP DLPSEPKTDE ERDIATRYST ILGSAVNPVL RQGNSDRRAP
160 170 180 190 200
KAVKEYARKH PHSMGEWSMA SRSHVAHMKH GDFYHGEKSM TIDKDRDVRM
210 220 230 240 250
ELVTADGNTN VLKPSVTLGP GDVMDSMFMS KKALLDFYEE QMQDAYETGV
260 270 280 290 300
MFSLHVKATM MKVSHPIVFG HAVRVFYKEA FAKHHDLFEE LGVNVNNGLG
310 320 330 340 350
DLYDKIATLP ASKHEEIVKD LHACHEHRPE LAMVDSARGI SNFHSPSDVI
360 370 380 390 400
VDASMPAMIR AGGKMYGADG RTKDTKAVMP ESTFARIYQE IINFCKTNGA
410 420 430 440 450
FDPRTMGTVP NVGLMAQKAE EYGSHDKTFE VPAAGTANIV DNATGEVLLS
460 470 480 490 500
QEVEEGDIWR MCTVKDAPIR DWIKLAVNRA RNSGTPVLFW LDPYRPHENE
510 520 530 540 550
LIAKVKAELE NYDTEGLDIQ IMSQVRAMRY TLERAMRGLD TIAATGNILR
560 570 580 590 600
DYLTDLFPIL ELGTSAKMLS IVPLMAGGGM YETGAGGSAP KHVKQLVEEN
610 620 630 640 650
HLRWDSLGEF LALAVSLEET GLKNDNKHAV TLAKTLDAAT GKLLENNKAP
660 670 680 690 700
SRSTGELDNR GSQFYLALYW AQELAAQTDD PELAEKFAPL AAALAEHEET
710 720 730 740
IVAELAAVQG EPADIGGYYY PDPEKMATVM RPSATFNADL DSVQS
Length:745
Mass (Da):81,811
Last modified:July 13, 2010 - v1
Checksum:i01480C8C902172A9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001966 Genomic DNA. Translation: ADG78870.1.
RefSeqiYP_003647209.1. NC_014158.1.

Genome annotation databases

EnsemblBacteriaiADG78870; ADG78870; Tpau_2261.
GeneIDi9156417.
KEGGitpr:Tpau_2261.
PATRICi38307825. VBITsuPau718_2263.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001966 Genomic DNA. Translation: ADG78870.1 .
RefSeqi YP_003647209.1. NC_014158.1.

3D structure databases

ProteinModelPortali D5UQA0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADG78870 ; ADG78870 ; Tpau_2261 .
GeneIDi 9156417.
KEGGi tpr:Tpau_2261.
PATRICi 38307825. VBITsuPau718_2263.

Phylogenomic databases

HOGENOMi HOG000240860.
KOi K00031.

Enzyme and pathway databases

BioCyci TPAU521096:GI2W-2282-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040Imported.

Entry informationi

Entry nameiD5UQA0_TSUPD
AccessioniPrimary (citable) accession number: D5UQA0
Entry historyi
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: October 29, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3