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Protein

Mycothiol acetyltransferase

Gene

mshD

Organism
Cellulomonas flavigena (strain ATCC 482 / DSM 20109 / NCIB 8073 / NRS 134)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.UniRule annotation

Catalytic activityi

Desacetylmycothiol + acetyl-CoA = CoA + mycothiol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei44Desacetylmycothiol; via amide nitrogenUniRule annotation1
Binding sitei196DesacetylmycothiolUniRule annotation1
Binding sitei235DesacetylmycothiolUniRule annotation1
Binding sitei253DesacetylmycothiolUniRule annotation1
Binding sitei291Desacetylmycothiol; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Mycothiol acetyltransferaseUniRule annotation (EC:2.3.1.189UniRule annotation)
Short name:
MSH acetyltransferaseUniRule annotation
Alternative name(s):
Mycothiol synthaseUniRule annotation
Gene namesi
Name:mshDUniRule annotation
Ordered Locus Names:Cfla_2814
OrganismiCellulomonas flavigena (strain ATCC 482 / DSM 20109 / NCIB 8073 / NRS 134)
Taxonomic identifieri446466 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesCellulomonadaceaeCellulomonas
Proteomesi
  • UP000000849 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004002441 – 348Mycothiol acetyltransferaseAdd BLAST348

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi446466.Cfla_2814.

Structurei

3D structure databases

ProteinModelPortaliD5UJR1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 156N-acetyltransferase 1UniRule annotationAdd BLAST145
Domaini169 – 330N-acetyltransferase 2UniRule annotationAdd BLAST162

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni91 – 93Acetyl-CoA binding 1UniRule annotation3
Regioni257 – 259Acetyl-CoA binding 2UniRule annotation3
Regioni264 – 270Acetyl-CoA binding 2UniRule annotation7
Regioni296 – 301Acetyl-CoA binding 2UniRule annotation6

Sequence similaritiesi

Belongs to the acetyltransferase family. MshD subfamily.UniRule annotation
Contains 2 N-acetyltransferase domains.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4108RTV. Bacteria.
COG0456. LUCA.
HOGENOMiHOG000248937.
KOiK15520.
OMAiMLYVDES.
OrthoDBiPOG091H09IL.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
HAMAPiMF_01698. MshD. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR017813. Mycothiol_AcTrfase.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 2 hits.
[Graphical view]
PIRSFiPIRSF021524. MSH_acetyltransferase. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR03448. mycothiol_MshD. 1 hit.
PROSITEiPS51186. GNAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D5UJR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSDIEAPTS LTSMRGALPP AVADDVRALH LTTVRHDGVP PLSEQPLLWL
60 70 80 90 100
SDQEAPVVHV LAWHAVTGGA QELVGYAQVD VGSSTTARAE LVVAPGHRRR
110 120 130 140 150
GTGRSLLAHA AQEAASIPGR RLHVWAHGDL PAARATAAAT GLVVVRELWR
160 170 180 190 200
MAVDVTQHPP GAPQLPPGVA VRAFVPGQDE DAWRRVNARA FAHHPEQGRM
210 220 230 240 250
TSADLRARES EPWFDPAGFL LAERDGQLLG SVWTKVHPGS EAPDGAPGEE
260 270 280 290 300
VGEIYVVGVD PDAQGLGMGR ALTALGLAHL RDRGLRTVIL YTGAENTVAV
310 320 330 340
HTYRRAGFAR TAVDVMYGPP PAGSPAHGTP LVRVTDTPSS PGDATMGS
Length:348
Mass (Da):36,655
Last modified:July 13, 2010 - v1
Checksum:i5769D294F034DC0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001964 Genomic DNA. Translation: ADG75699.1.
RefSeqiWP_013118030.1. NC_014151.1.

Genome annotation databases

EnsemblBacteriaiADG75699; ADG75699; Cfla_2814.
KEGGicfl:Cfla_2814.
PATRICi38153693. VBICelFla99035_2843.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001964 Genomic DNA. Translation: ADG75699.1.
RefSeqiWP_013118030.1. NC_014151.1.

3D structure databases

ProteinModelPortaliD5UJR1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi446466.Cfla_2814.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADG75699; ADG75699; Cfla_2814.
KEGGicfl:Cfla_2814.
PATRICi38153693. VBICelFla99035_2843.

Phylogenomic databases

eggNOGiENOG4108RTV. Bacteria.
COG0456. LUCA.
HOGENOMiHOG000248937.
KOiK15520.
OMAiMLYVDES.
OrthoDBiPOG091H09IL.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
HAMAPiMF_01698. MshD. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR017813. Mycothiol_AcTrfase.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 2 hits.
[Graphical view]
PIRSFiPIRSF021524. MSH_acetyltransferase. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR03448. mycothiol_MshD. 1 hit.
PROSITEiPS51186. GNAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMSHD_CELFN
AccessioniPrimary (citable) accession number: D5UJR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: July 13, 2010
Last modified: November 2, 2016
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.