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D5UIS2

- D5UIS2_CELFN

UniProt

D5UIS2 - D5UIS2_CELFN

Protein

Alanine racemase

Gene

Cfla_2600

Organism
Cellulomonas flavigena (strain ATCC 482 / DSM 20109 / NCIB 8073 / NRS 134)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 30 (01 Oct 2014)
      Sequence version 1 (13 Jul 2010)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei49 – 491Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei148 – 1481SubstrateUniRule annotation
    Active sitei282 – 2821Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei335 – 3351Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciCFLA446466:GHDJ-2642-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:Cfla_2600Imported
    OrganismiCellulomonas flavigena (strain ATCC 482 / DSM 20109 / NCIB 8073 / NRS 134)Imported
    Taxonomic identifieri446466 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeCellulomonadaceaeCellulomonas
    ProteomesiUP000000849: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei49 – 491N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD5UIS2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000031444.
    KOiK01775.
    OMAiPSECAGV.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D5UIS2-1 [UniParc]FASTAAdd to Basket

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    MPTHDPRGER LAGVNDFPAR AVVDLGAVRG NVRALAAHAP TAQVMAVVKA    50
    DAYGHGLVPS ALAALEGGAT WLGTAQVPEA LHLRRAGVTG ARILTWLYAP 100
    GAPLREAVEA DVDLSVASRW ALDDVVAAAR EAGRTARVHL KVDTGLGRNG 150
    LVPAQLPEVL TAALAAEAEG VVRVVGVWSH LAFADAPDHA VVAQQAGVFA 200
    EAVAAVEAAG ARLEVRHLAN SAATLTSPAL HWDLVRPGIA VYGLSPVPQL 250
    GGPERFGLVP AMTFEAQLAT VKPVPAGSGV SYGHEYVVPH DTVLGVVPVG 300
    YADGVPRHAS GSAERWGGPV QVGGRRLGVA GRVCMDQVVL DLGPGATESA 350
    GDRVVLWGDG RDGGPTAQDW ADVAGTISYE LVTRLGARVP RTYVDSARVA 400
    APAPSEGGGA 410
    Length:410
    Mass (Da):41,951
    Last modified:July 13, 2010 - v1
    Checksum:iACD23BCB97DA0DDA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001964 Genomic DNA. Translation: ADG75488.1.
    RefSeqiYP_003637687.1. NC_014151.1.

    Genome annotation databases

    EnsemblBacteriaiADG75488; ADG75488; Cfla_2600.
    GeneIDi9146504.
    KEGGicfl:Cfla_2600.
    PATRICi38153247. VBICelFla99035_2624.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001964 Genomic DNA. Translation: ADG75488.1 .
    RefSeqi YP_003637687.1. NC_014151.1.

    3D structure databases

    ProteinModelPortali D5UIS2.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADG75488 ; ADG75488 ; Cfla_2600 .
    GeneIDi 9146504.
    KEGGi cfl:Cfla_2600.
    PATRICi 38153247. VBICelFla99035_2624.

    Phylogenomic databases

    HOGENOMi HOG000031444.
    KOi K01775.
    OMAi PSECAGV.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci CFLA446466:GHDJ-2642-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 482 / DSM 20109 / NCIB 8073 / NRS 134Imported.

    Entry informationi

    Entry nameiD5UIS2_CELFN
    AccessioniPrimary (citable) accession number: D5UIS2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 13, 2010
    Last sequence update: July 13, 2010
    Last modified: October 1, 2014
    This is version 30 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3