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D5U9C9 (D5U9C9_BRAM5) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Bmur_1208 EMBL ADG71302.1
OrganismBrachyspira murdochii (strain ATCC 51284 / DSM 12563 / 56-150) (Serpulina murdochii) [Complete proteome] [HAMAP] EMBL ADG71302.1
Taxonomic identifier526224 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesBrachyspiraceaeBrachyspira

Protein attributes

Sequence length322 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain121 – 319199ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding148 – 20255ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2741Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2861Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2861Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2881Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
D5U9C9 [UniParc].

Last modified July 13, 2010. Version 1.
Checksum: C1C4E97F577FEC68

FASTA32235,959
        10         20         30         40         50         60 
MMINETLRKD ILNRFKNKKI AVLHGGQNEE REVSLRSGKN VYKALTSFEE LKDNCILIDV 

        70         80         90        100        110        120 
QDAYDLVKTL KENNIEYCYN ILHGTSGEDG TIQGLLESLN IKYTGENILV SAVCMNKVYT 

       130        140        150        160        170        180 
KRIWKSSNVS TSDFVLLKDV KDVNNTSAGG LNFPIIIKPI SSGSSVGVSL IKNKEEFDNT 

       190        200        210        220        230        240 
IKKIEDINNY FLEPYIKGKE ITVGLVKEED DIYVFPILGI NSKNEIYDYD AKYTPGKTEL 

       250        260        270        280        290        300 
EVPAKISKDI EKKVIETCKR AYTVLGCGGL SRIDAIIAND EVYLMEVNTQ SGMTDTSDVP 

       310        320 
AMAKNCGIEF ADLALYILGL LK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001959 Genomic DNA. Translation: ADG71302.1.
RefSeqYP_003633501.1. NC_014150.1.

3D structure databases

ProteinModelPortalD5U9C9.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADG71302; ADG71302; Bmur_1208.
GeneID9142193.
KEGGbrm:Bmur_1208.
PATRIC38144582. VBIBraMur21074_1222.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000011592.
KOK01921.

Enzyme and pathway databases

BioCycBMUR526224:GHIV-1226-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD5U9C9_BRAM5
AccessionPrimary (citable) accession number: D5U9C9
Entry history
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: June 11, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)