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Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Brachyspira murdochii (strain ATCC 51284 / DSM 12563 / 56-150) (Serpulina murdochii)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotationSAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 2 magnesium or manganese ions per subunit.UniRule annotation
  • Mn2+SAAS annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi274Magnesium or manganese 1UniRule annotation1
Metal bindingi286Magnesium or manganese 1UniRule annotation1
Metal bindingi286Magnesium or manganese 2UniRule annotation1
Metal bindingi288Magnesium or manganese 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processCell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotationSAAS annotation (EC:6.3.2.4UniRule annotationSAAS annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlUniRule annotation
Ordered Locus Names:Bmur_1208Imported
OrganismiBrachyspira murdochii (strain ATCC 51284 / DSM 12563 / 56-150) (Serpulina murdochii)Imported
Taxonomic identifieri526224 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesBrachyspiralesBrachyspiraceaeBrachyspira
Proteomesi
  • UP000001915 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi526224.Bmur_1208.

Structurei

3D structure databases

ProteinModelPortaliD5U9C9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini121 – 319ATP-graspInterPro annotationAdd BLAST199

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CPF. Bacteria.
COG1181. LUCA.
HOGENOMiHOG000011592.
KOiK01921.
OMAiYETKYTE.
OrthoDBiPOG091H00GT.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig. 1 hit.
InterProiView protein in InterPro
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
PfamiView protein in Pfam
PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
PIRSFiPIRSF039102. Ddl/VanB. 2 hits.
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEiView protein in PROSITE
PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.

Sequencei

Sequence statusi: Complete.

D5U9C9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMINETLRKD ILNRFKNKKI AVLHGGQNEE REVSLRSGKN VYKALTSFEE
60 70 80 90 100
LKDNCILIDV QDAYDLVKTL KENNIEYCYN ILHGTSGEDG TIQGLLESLN
110 120 130 140 150
IKYTGENILV SAVCMNKVYT KRIWKSSNVS TSDFVLLKDV KDVNNTSAGG
160 170 180 190 200
LNFPIIIKPI SSGSSVGVSL IKNKEEFDNT IKKIEDINNY FLEPYIKGKE
210 220 230 240 250
ITVGLVKEED DIYVFPILGI NSKNEIYDYD AKYTPGKTEL EVPAKISKDI
260 270 280 290 300
EKKVIETCKR AYTVLGCGGL SRIDAIIAND EVYLMEVNTQ SGMTDTSDVP
310 320
AMAKNCGIEF ADLALYILGL LK
Length:322
Mass (Da):35,959
Last modified:July 13, 2010 - v1
Checksum:iC1C4E97F577FEC68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001959 Genomic DNA. Translation: ADG71302.1.
RefSeqiWP_013113725.1. NC_014150.1.

Genome annotation databases

EnsemblBacteriaiADG71302; ADG71302; Bmur_1208.
KEGGibrm:Bmur_1208.

Similar proteinsi

Entry informationi

Entry nameiD5U9C9_BRAM5
AccessioniPrimary (citable) accession number: D5U9C9
Entry historyiIntegrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: September 27, 2017
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported