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D5U228

- D5U228_THEAM

UniProt

D5U228 - D5U228_THEAM

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Protein

Ribulose bisphosphate carboxylase

Gene

rbcL

Organism
Thermosphaera aggregans (strain DSM 11486 / M11TL)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the addition of molecular CO2 and H2O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.UniRule annotation

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

Cofactori

Note: Binds 1 magnesium ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei164 – 1641Proton acceptorUniRule annotation
Binding sitei166 – 1661SubstrateUniRule annotation
Metal bindingi190 – 1901Magnesium; via carbamate groupUniRule annotation
Metal bindingi192 – 1921MagnesiumUniRule annotation
Metal bindingi193 – 1931MagnesiumUniRule annotation
Active sitei282 – 2821Proton acceptorUniRule annotation
Binding sitei283 – 2831SubstrateUniRule annotation
Binding sitei315 – 3151SubstrateUniRule annotation
Sitei323 – 3231Transition state stabilizerUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. oxidoreductase activity Source: UniProtKB-KW
  3. ribulose-bisphosphate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. AMP catabolic process Source: UniProtKB-HAMAP
  2. carbon fixation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported, OxidoreductaseUniRule annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciTAGG633148:GHBI-919-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylaseUniRule annotation (EC:4.1.1.39UniRule annotation)
Short name:
RuBisCOUniRule annotation
Gene namesi
Name:rbcLUniRule annotation
Ordered Locus Names:Tagg_0906Imported
OrganismiThermosphaera aggregans (strain DSM 11486 / M11TL)Imported
Taxonomic identifieri633148 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeThermosphaera
ProteomesiUP000002376: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei190 – 1901N6-carboxylysineUniRule annotation

Interactioni

Subunit structurei

Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD5U228.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni368 – 3703Substrate bindingUniRule annotation
Regioni390 – 3934Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the RuBisCO large chain family. Type III subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000230831.
KOiK01601.
OMAiVIVTFRV.

Family and domain databases

Gene3Di3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPiMF_01133. RuBisCO_L_type3.
InterProiIPR017712. RuBisCO_III.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view]
PfamiPF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view]
SUPFAMiSSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsiTIGR03326. rubisco_III. 1 hit.

Sequencei

Sequence statusi: Complete.

D5U228-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPEKFDFETY HEYIDRTFKP DPDNHVIAVF RIKPAQGFTI DDAAGGVAAE
60 70 80 90 100
SSTGTWTTVY NWYDRERVRR LSGRAYEFLD LKDGSWIVKI AYPVELFEEG
110 120 130 140 150
NIPGLLASIA GNVFGMRRVE GLRLEDIYLP GGFLKDFKGP SKGVEGVREI
160 170 180 190 200
FKVKDRPIVG TVPKPKVGYS PEEVEKLATE LLMGGLDYIK DDENLTSPKY
210 220 230 240 250
CSFEARAKAI MKVIDKVEKE TGERKAWFAN ITADVREMEK RLRLVADYGN
260 270 280 290 300
PYVMVDVVVS GWGVLNYIRD LAEEYGLAVH AHRAMHASFT RNPYHGISMF
310 320 330 340 350
VLAKLYRVIG VDQLHVGTAG AGKLEGGRLD VIRCAKILRE QSFTPDPEDP
360 370 380 390 400
FHLPQDMRHI KPAMPVSSGG LHPGNLPPVI DALGPDIVLQ VGGGVVGHPD
410 420 430 440
GPRAGAMAVR QALDAIVKGI PLDKYAESHR ELARALEKWG FVKPI
Length:445
Mass (Da):49,428
Last modified:July 13, 2010 - v1
Checksum:i358B529EF1A31E75
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001939 Genomic DNA. Translation: ADG91178.1.
RefSeqiWP_013129771.1. NC_014160.1.
YP_003650130.1. NC_014160.1.

Genome annotation databases

EnsemblBacteriaiADG91178; ADG91178; Tagg_0906.
GeneIDi9165923.
KEGGitag:Tagg_0906.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001939 Genomic DNA. Translation: ADG91178.1 .
RefSeqi WP_013129771.1. NC_014160.1.
YP_003650130.1. NC_014160.1.

3D structure databases

ProteinModelPortali D5U228.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADG91178 ; ADG91178 ; Tagg_0906 .
GeneIDi 9165923.
KEGGi tag:Tagg_0906.

Phylogenomic databases

HOGENOMi HOG000230831.
KOi K01601.
OMAi VIVTFRV.

Enzyme and pathway databases

BioCyci TAGG633148:GHBI-919-MONOMER.

Family and domain databases

Gene3Di 3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPi MF_01133. RuBisCO_L_type3.
InterProi IPR017712. RuBisCO_III.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view ]
Pfami PF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view ]
SUPFAMi SSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsi TIGR03326. rubisco_III. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 11486 / M11TLImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DSM 11486.

Entry informationi

Entry nameiD5U228_THEAM
AccessioniPrimary (citable) accession number: D5U228
Entry historyi
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: November 26, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O2 to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3