Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

D5U0N4 (D5U0N4_THEAM) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2 HAMAP-Rule MF_00713

EC=1.4.4.2 HAMAP-Rule MF_00713
Alternative name(s):
Glycine cleavage system P-protein subunit 2 HAMAP-Rule MF_00713
Glycine decarboxylase subunit 2 HAMAP-Rule MF_00713
Glycine dehydrogenase (aminomethyl-transferring) subunit 2 HAMAP-Rule MF_00713
Gene names
Name:gcvPB HAMAP-Rule MF_00713
Ordered Locus Names:Tagg_0409 EMBL ADG90684.1
OrganismThermosphaera aggregans (strain DSM 11486 / M11TL) [Complete proteome] [HAMAP] EMBL ADG90684.1
Taxonomic identifier633148 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeThermosphaera

Protein attributes

Sequence length519 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00713

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00713

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00713

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity. HAMAP-Rule MF_00713

Sequence similarities

Belongs to the GcvP family. C-terminal subunit subfamily. HAMAP-Rule MF_00713

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Amino acid modifications

Modified residue2791N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_00713

Sequences

Sequence LengthMass (Da)Tools
D5U0N4 [UniParc].

Last modified July 13, 2010. Version 1.
Checksum: 5C55EE753C527B5C

FASTA51957,652
        10         20         30         40         50         60 
MFRQAKWSEP LIFELSVKGR RGFLVPEPEK EVKEKVGSIK LSEDMARTTD PDLPELSEVD 

        70         80         90        100        110        120 
VMRHFTRLTE MAYGVDNGPV PLGSCTMKYN PRIAWEVASD HRILGLHPLQ DEDTVQGLLE 

       130        140        150        160        170        180 
MIYEMQKWLA NITGMDYCSL HPAAGAHGEL AGILLIRKYH ELKGQIDKKT EIIVPDSAHG 

       190        200        210        220        230        240 
TNPASAAMGG FKVVEIPSNS DGNVDLEALK SVVGESTAGL MITNPSTLGL FEENILEIAR 

       250        260        270        280        290        300 
IIHSVDGLLY YDGANLNGIM GYARPGDMGF DIAHLNVHKT FGAPHGGGGP GAGPVCIKDR 

       310        320        330        340        350        360 
VVDAEKNIRL SDLLPGYYVI YDEKTGKYRL KGPGENSIGF LKAFFGNITP LIWGYTYILM 

       370        380        390        400        410        420 
MGNEGLRKVT ELAVLNTNYF IKLMENVKGY EIPYGKGRFR KHEVVLSAQP MTEELGVTAE 

       430        440        450        460        470        480 
DVAKGLLDAG FYAPTIYFPL IVKEALMTEF TETETIENIE KYAERLKEIS RIAYQDPKEP 

       490        500        510 
KKWPVNTSVG RIDLIKANHP STVTPTWRLH LKRVKGEIK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001939 Genomic DNA. Translation: ADG90684.1.
RefSeqYP_003649636.1. NC_014160.1.

3D structure databases

ProteinModelPortalD5U0N4.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADG90684; ADG90684; Tagg_0409.
GeneID9165423.
KEGGtag:Tagg_0409.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000239368.
KOK00283.
OMAMHINLHK.

Enzyme and pathway databases

BioCycTAGG633148:GHBI-419-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00713. GcvPB.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameD5U0N4_THEAM
AccessionPrimary (citable) accession number: D5U0N4
Entry history
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: February 19, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)