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D5U0N4

- D5U0N4_THEAM

UniProt

D5U0N4 - D5U0N4_THEAM

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene
gcvPB, Tagg_0409
Organism
Thermosphaera aggregans (strain DSM 11486 / M11TL)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciTAGG633148:GHBI-419-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Gene namesi
Name:gcvPBUniRule annotation
Ordered Locus Names:Tagg_0409Imported
OrganismiThermosphaera aggregans (strain DSM 11486 / M11TL)Imported
Taxonomic identifieri633148 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeThermosphaera
ProteomesiUP000002376: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei279 – 2791N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD5U0N4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000239368.
KOiK00283.
OMAiLGETPWD.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

D5U0N4-1 [UniParc]FASTAAdd to Basket

« Hide

MFRQAKWSEP LIFELSVKGR RGFLVPEPEK EVKEKVGSIK LSEDMARTTD    50
PDLPELSEVD VMRHFTRLTE MAYGVDNGPV PLGSCTMKYN PRIAWEVASD 100
HRILGLHPLQ DEDTVQGLLE MIYEMQKWLA NITGMDYCSL HPAAGAHGEL 150
AGILLIRKYH ELKGQIDKKT EIIVPDSAHG TNPASAAMGG FKVVEIPSNS 200
DGNVDLEALK SVVGESTAGL MITNPSTLGL FEENILEIAR IIHSVDGLLY 250
YDGANLNGIM GYARPGDMGF DIAHLNVHKT FGAPHGGGGP GAGPVCIKDR 300
VVDAEKNIRL SDLLPGYYVI YDEKTGKYRL KGPGENSIGF LKAFFGNITP 350
LIWGYTYILM MGNEGLRKVT ELAVLNTNYF IKLMENVKGY EIPYGKGRFR 400
KHEVVLSAQP MTEELGVTAE DVAKGLLDAG FYAPTIYFPL IVKEALMTEF 450
TETETIENIE KYAERLKEIS RIAYQDPKEP KKWPVNTSVG RIDLIKANHP 500
STVTPTWRLH LKRVKGEIK 519
Length:519
Mass (Da):57,652
Last modified:July 13, 2010 - v1
Checksum:i5C55EE753C527B5C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001939 Genomic DNA. Translation: ADG90684.1.
RefSeqiWP_013129277.1. NC_014160.1.
YP_003649636.1. NC_014160.1.

Genome annotation databases

EnsemblBacteriaiADG90684; ADG90684; Tagg_0409.
GeneIDi9165423.
KEGGitag:Tagg_0409.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001939 Genomic DNA. Translation: ADG90684.1 .
RefSeqi WP_013129277.1. NC_014160.1.
YP_003649636.1. NC_014160.1.

3D structure databases

ProteinModelPortali D5U0N4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADG90684 ; ADG90684 ; Tagg_0409 .
GeneIDi 9165423.
KEGGi tag:Tagg_0409.

Phylogenomic databases

HOGENOMi HOG000239368.
KOi K00283.
OMAi LGETPWD.

Enzyme and pathway databases

BioCyci TAGG633148:GHBI-419-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 11486 / M11TL.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DSM 11486.

Entry informationi

Entry nameiD5U0N4_THEAM
AccessioniPrimary (citable) accession number: D5U0N4
Entry historyi
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: September 3, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi