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D5U0N4

- D5U0N4_THEAM

UniProt

D5U0N4 - D5U0N4_THEAM

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Thermosphaera aggregans (strain DSM 11486 / M11TL)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (13 Jul 2010)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    BioCyciTAGG633148:GHBI-419-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 2UniRule annotation
    Glycine decarboxylase subunit 2UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
    Gene namesi
    Name:gcvPBUniRule annotation
    Ordered Locus Names:Tagg_0409Imported
    OrganismiThermosphaera aggregans (strain DSM 11486 / M11TL)Imported
    Taxonomic identifieri633148 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeThermosphaera
    ProteomesiUP000002376: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei279 – 2791N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD5U0N4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000239368.
    KOiK00283.
    OMAiLGETPWD.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_00713. GcvPB.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR023012. GDC_P_su2.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    D5U0N4-1 [UniParc]FASTAAdd to Basket

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    MFRQAKWSEP LIFELSVKGR RGFLVPEPEK EVKEKVGSIK LSEDMARTTD    50
    PDLPELSEVD VMRHFTRLTE MAYGVDNGPV PLGSCTMKYN PRIAWEVASD 100
    HRILGLHPLQ DEDTVQGLLE MIYEMQKWLA NITGMDYCSL HPAAGAHGEL 150
    AGILLIRKYH ELKGQIDKKT EIIVPDSAHG TNPASAAMGG FKVVEIPSNS 200
    DGNVDLEALK SVVGESTAGL MITNPSTLGL FEENILEIAR IIHSVDGLLY 250
    YDGANLNGIM GYARPGDMGF DIAHLNVHKT FGAPHGGGGP GAGPVCIKDR 300
    VVDAEKNIRL SDLLPGYYVI YDEKTGKYRL KGPGENSIGF LKAFFGNITP 350
    LIWGYTYILM MGNEGLRKVT ELAVLNTNYF IKLMENVKGY EIPYGKGRFR 400
    KHEVVLSAQP MTEELGVTAE DVAKGLLDAG FYAPTIYFPL IVKEALMTEF 450
    TETETIENIE KYAERLKEIS RIAYQDPKEP KKWPVNTSVG RIDLIKANHP 500
    STVTPTWRLH LKRVKGEIK 519
    Length:519
    Mass (Da):57,652
    Last modified:July 13, 2010 - v1
    Checksum:i5C55EE753C527B5C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001939 Genomic DNA. Translation: ADG90684.1.
    RefSeqiWP_013129277.1. NC_014160.1.
    YP_003649636.1. NC_014160.1.

    Genome annotation databases

    EnsemblBacteriaiADG90684; ADG90684; Tagg_0409.
    GeneIDi9165423.
    KEGGitag:Tagg_0409.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001939 Genomic DNA. Translation: ADG90684.1 .
    RefSeqi WP_013129277.1. NC_014160.1.
    YP_003649636.1. NC_014160.1.

    3D structure databases

    ProteinModelPortali D5U0N4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADG90684 ; ADG90684 ; Tagg_0409 .
    GeneIDi 9165423.
    KEGGi tag:Tagg_0409.

    Phylogenomic databases

    HOGENOMi HOG000239368.
    KOi K00283.
    OMAi LGETPWD.

    Enzyme and pathway databases

    BioCyci TAGG633148:GHBI-419-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_00713. GcvPB.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR023012. GDC_P_su2.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 11486 / M11TLImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: DSM 11486.

    Entry informationi

    Entry nameiD5U0N4_THEAM
    AccessioniPrimary (citable) accession number: D5U0N4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 13, 2010
    Last sequence update: July 13, 2010
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3