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D5U0C7

- D5U0C7_THEAM

UniProt

D5U0C7 - D5U0C7_THEAM

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Protein

Glyceraldehyde-3-phosphate dehydrogenase

Gene

gap

Organism
Thermosphaera aggregans (strain DSM 11486 / M11TL)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

D-glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl phosphate + NAD(P)H.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei109 – 1091NAD; via amide nitrogenUniRule annotation
Active sitei139 – 1391NucleophileUniRule annotation
Binding sitei167 – 1671NADUniRule annotation
Binding sitei301 – 3011NAD; via carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 122NADUniRule annotation

GO - Molecular functioni

  1. glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity Source: UniProtKB-EC
  2. glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity Source: UniProtKB-HAMAP
  3. NAD binding Source: InterPro
  4. NADP binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotation

Keywords - Biological processi

GlycolysisUniRule annotation

Keywords - Ligandi

NADUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciTAGG633148:GHBI-310-MONOMER.
UniPathwayiUPA00109; UER00184.

Names & Taxonomyi

Protein namesi
Recommended name:
Glyceraldehyde-3-phosphate dehydrogenaseUniRule annotation (EC:1.2.1.59UniRule annotation)
Short name:
GAPDHUniRule annotation
Alternative name(s):
NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenaseUniRule annotation
Gene namesi
Name:gapUniRule annotation
Ordered Locus Names:Tagg_0301Imported
OrganismiThermosphaera aggregans (strain DSM 11486 / M11TL)Imported
Taxonomic identifieri633148 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeThermosphaera
ProteomesiUP000002376: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni138 – 1403Glyceraldehyde 3-phosphate bindingUniRule annotation
Regioni193 – 1942Glyceraldehyde 3-phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000223361.
KOiK00150.
OMAiVTVPSHH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00559. G3P_dehdrog_arch.
InterProiIPR020831. GlycerAld/Erythrose_P_DH.
IPR020830. GlycerAld_3-P_DH_AS.
IPR020829. GlycerAld_3-P_DH_cat.
IPR020828. GlycerAld_3-P_DH_NAD(P)-bd.
IPR006436. Glyceraldehyde-3-P_DH_2_arc.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02800. Gp_dh_C. 1 hit.
PF00044. Gp_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000149. GAP_DH. 1 hit.
SMARTiSM00846. Gp_dh_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01546. GAPDH-II_archae. 1 hit.
PROSITEiPS00071. GAPDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D5U0C7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVKVGVNGYG TIGKRVADAI LKNPRFQLVG IVKYNPDYSS KIAFKKGINI
60 70 80 90 100
YVPQDKWRDF ESTGITPKGT IQEFLEESSI IIDASPNGKG AANLSLYKGA
110 120 130 140 150
GKPAIFQGGE KPEVAELSYS TYCNYDEAFG RKYLRVVSCN TTGILRVLCA
160 170 180 190 200
LHREFNVKRA RVLVIRRGAD PKEDARGPIN SIKLESFEDV SHHGKDAMLV
210 220 230 240 250
LPSVKIISQA VVVPTTLMHV QYLDIDVASP VTRSQVIEAL SKHARILLVN
260 270 280 290 300
PKKTGIDSTS KLIEAARDFL RSRNDIYENI VFENTIIVSD NNISLIQAIH
310 320 330 340
QESIVVPENM DALYAIANIR LPFEKVVEET DRLLGVGGLK DVF
Length:343
Mass (Da):37,975
Last modified:July 13, 2010 - v1
Checksum:i356D92B0171D6F33
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001939 Genomic DNA. Translation: ADG90577.1.
RefSeqiYP_003649529.1. NC_014160.1.

Genome annotation databases

EnsemblBacteriaiADG90577; ADG90577; Tagg_0301.
GeneIDi9165314.
KEGGitag:Tagg_0301.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001939 Genomic DNA. Translation: ADG90577.1 .
RefSeqi YP_003649529.1. NC_014160.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADG90577 ; ADG90577 ; Tagg_0301 .
GeneIDi 9165314.
KEGGi tag:Tagg_0301.

Phylogenomic databases

HOGENOMi HOG000223361.
KOi K00150.
OMAi VTVPSHH.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00184 .
BioCyci TAGG633148:GHBI-310-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00559. G3P_dehdrog_arch.
InterProi IPR020831. GlycerAld/Erythrose_P_DH.
IPR020830. GlycerAld_3-P_DH_AS.
IPR020829. GlycerAld_3-P_DH_cat.
IPR020828. GlycerAld_3-P_DH_NAD(P)-bd.
IPR006436. Glyceraldehyde-3-P_DH_2_arc.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF02800. Gp_dh_C. 1 hit.
PF00044. Gp_dh_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000149. GAP_DH. 1 hit.
SMARTi SM00846. Gp_dh_N. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01546. GAPDH-II_archae. 1 hit.
PROSITEi PS00071. GAPDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 11486 / M11TLImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DSM 11486.

Entry informationi

Entry nameiD5U0C7_THEAM
AccessioniPrimary (citable) accession number: D5U0C7
Entry historyi
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: November 26, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3