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D5TZI6

- D5TZI6_THEAM

UniProt

D5TZI6 - D5TZI6_THEAM

Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene

pckG

Organism
Thermosphaera aggregans (strain DSM 11486 / M11TL)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 30 (01 Oct 2014)
      Sequence version 1 (13 Jul 2010)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.UniRule annotation

    Catalytic activityi

    GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

    Cofactori

    Binds 1 manganese ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei94 – 941SubstrateUniRule annotation
    Binding sitei229 – 2291Substrate; via amide nitrogenUniRule annotation
    Metal bindingi236 – 2361ManganeseUniRule annotation
    Binding sitei236 – 2361SubstrateUniRule annotation
    Metal bindingi255 – 2551Manganese; via tele nitrogenUniRule annotation
    Active sitei279 – 2791UniRule annotation
    Metal bindingi295 – 2951ManganeseUniRule annotation
    Binding sitei393 – 3931GTPUniRule annotation
    Binding sitei424 – 4241GTPUniRule annotation

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-HAMAP
    2. kinase activity Source: UniProtKB-KW
    3. manganese ion binding Source: UniProtKB-HAMAP
    4. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    DecarboxylaseUniRule annotation, KinaseImported, Lyase, Transferase

    Keywords - Biological processi

    GluconeogenesisUniRule annotation

    Keywords - Ligandi

    GTP-bindingUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, PyruvateImported

    Enzyme and pathway databases

    BioCyciTAGG633148:GHBI-3-MONOMER.
    UniPathwayiUPA00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation (EC:4.1.1.32UniRule annotation)
    Short name:
    PEP carboxykinaseUniRule annotation
    Short name:
    PEPCKUniRule annotation
    Gene namesi
    Name:pckGUniRule annotation
    Ordered Locus Names:Tagg_0003Imported
    OrganismiThermosphaera aggregans (strain DSM 11486 / M11TL)Imported
    Taxonomic identifieri633148 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeThermosphaera
    ProteomesiUP000002376: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni391 – 3933Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000191700.
    KOiK01596.
    OMAiSEFLLYR.

    Family and domain databases

    Gene3Di3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPiMF_00452. PEPCK_GTP.
    InterProiIPR013035. PEP_carboxykinase_C.
    IPR008209. PEP_carboxykinase_GTP.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view]
    PANTHERiPTHR11561. PTHR11561. 1 hit.
    PfamiPF00821. PEPCK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
    SUPFAMiSSF68923. SSF68923. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    D5TZI6-1 [UniParc]FASTAAdd to Basket

    « Hide

    METQGFCTES LNALKPYMSS RELGKLARIR DCSLVEWIRQ VVEHLKPSSI    50
    FINTGSEEDL DYIRRRAVEN KEEYVSSYNQ LHTVHFDGVR DLARDRGNTK 100
    IMTGKGVKIP LVNSGEREEL KKEVWEIYRD IMRGKEMFIG FYCFGPRGSP 150
    FTLYGVQVTD SAYVVHSENI LYRVCYDEFT RNDRIEYMRF LHSSGERDEN 200
    GWSKNISKRR IYIDPEEMIT YSVNTQYAGN TVGLKKLSLR LCVYKGFREG 250
    WLCEHMFIIG MKGSGDRVAY FTGAFPAGCG KTSTALIADL VVGDDLAIIR 300
    NVDGVARAVN PEVGMFGIID GVNPVDDAEI YKILTSRTSE VIFANVLYTE 350
    DGDVWWNGKE GAPKPGVNYA GEWWPGKRDE NGNPIPPSHP NARFTTSIFY 400
    LSRVDPRIND PMGVPVSGMI FGGRDSDTWV PVEEAFDWFH GIVTKGASLE 450
    SERTTAVLGQ AGVREFNPFA ILDFLSISPG AFIDLHFRFA RELSQSPKVY 500
    GVNYFLRGED GRFLTEKVDK RVWLRWMEKR VHGELDAVET PTGYIPIYSD 550
    LVDLFNKELG KEFPESLYEK LFTVRVKQHL DKIERIWRIY AEIPDTPALF 600
    FSILKEEKQR LVNARNRFGD FISPFRLDRA 630
    Length:630
    Mass (Da):72,093
    Last modified:July 13, 2010 - v1
    Checksum:i04EF80C467CDB31E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001939 Genomic DNA. Translation: ADG90286.1.
    RefSeqiWP_013128879.1. NC_014160.1.
    YP_003649238.1. NC_014160.1.

    Genome annotation databases

    EnsemblBacteriaiADG90286; ADG90286; Tagg_0003.
    GeneIDi9165007.
    KEGGitag:Tagg_0003.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001939 Genomic DNA. Translation: ADG90286.1 .
    RefSeqi WP_013128879.1. NC_014160.1.
    YP_003649238.1. NC_014160.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADG90286 ; ADG90286 ; Tagg_0003 .
    GeneIDi 9165007.
    KEGGi tag:Tagg_0003.

    Phylogenomic databases

    HOGENOMi HOG000191700.
    KOi K01596.
    OMAi SEFLLYR.

    Enzyme and pathway databases

    UniPathwayi UPA00138 .
    BioCyci TAGG633148:GHBI-3-MONOMER.

    Family and domain databases

    Gene3Di 3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPi MF_00452. PEPCK_GTP.
    InterProi IPR013035. PEP_carboxykinase_C.
    IPR008209. PEP_carboxykinase_GTP.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view ]
    PANTHERi PTHR11561. PTHR11561. 1 hit.
    Pfami PF00821. PEPCK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
    SUPFAMi SSF68923. SSF68923. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 11486 / M11TLImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: DSM 11486.

    Entry informationi

    Entry nameiD5TZI6_THEAM
    AccessioniPrimary (citable) accession number: D5TZI6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 13, 2010
    Last sequence update: July 13, 2010
    Last modified: October 1, 2014
    This is version 30 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3