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D5TZI6 (D5TZI6_THEAM) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoenolpyruvate carboxykinase [GTP] HAMAP-Rule MF_00452

Short name=PEP carboxykinase HAMAP-Rule MF_00452
Short name=PEPCK HAMAP-Rule MF_00452
EC=4.1.1.32 HAMAP-Rule MF_00452
Alternative name(s):
Phosphoenolpyruvate carboxylase HAMAP-Rule MF_00452
Gene names
Name:pckG HAMAP-Rule MF_00452
Ordered Locus Names:Tagg_0003 EMBL ADG90286.1
OrganismThermosphaera aggregans (strain DSM 11486 / M11TL) [Complete proteome] [HAMAP] EMBL ADG90286.1
Taxonomic identifier633148 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeThermosphaera

Protein attributes

Sequence length630 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle By similarity. HAMAP-Rule MF_00452

Catalytic activity

GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2. HAMAP-Rule MF_00452

Cofactor

Binds 1 manganese ion per subunit By similarity. HAMAP-Rule MF_00452

Pathway

Carbohydrate biosynthesis; gluconeogenesis. HAMAP-Rule MF_00452

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00452.

Sequence similarities

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. HAMAP-Rule MF_00452

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region391 – 3933Substrate binding By similarity HAMAP-Rule MF_00452

Sites

Active site2791 By similarity HAMAP-Rule MF_00452
Metal binding2361Manganese By similarity HAMAP-Rule MF_00452
Metal binding2551Manganese; via tele nitrogen By similarity HAMAP-Rule MF_00452
Metal binding2951Manganese By similarity HAMAP-Rule MF_00452
Binding site941Substrate By similarity HAMAP-Rule MF_00452
Binding site2291Substrate; via amide nitrogen By similarity HAMAP-Rule MF_00452
Binding site2361Substrate By similarity HAMAP-Rule MF_00452
Binding site3931GTP By similarity HAMAP-Rule MF_00452
Binding site4241GTP By similarity HAMAP-Rule MF_00452

Sequences

Sequence LengthMass (Da)Tools
D5TZI6 [UniParc].

Last modified July 13, 2010. Version 1.
Checksum: 04EF80C467CDB31E

FASTA63072,093
        10         20         30         40         50         60 
METQGFCTES LNALKPYMSS RELGKLARIR DCSLVEWIRQ VVEHLKPSSI FINTGSEEDL 

        70         80         90        100        110        120 
DYIRRRAVEN KEEYVSSYNQ LHTVHFDGVR DLARDRGNTK IMTGKGVKIP LVNSGEREEL 

       130        140        150        160        170        180 
KKEVWEIYRD IMRGKEMFIG FYCFGPRGSP FTLYGVQVTD SAYVVHSENI LYRVCYDEFT 

       190        200        210        220        230        240 
RNDRIEYMRF LHSSGERDEN GWSKNISKRR IYIDPEEMIT YSVNTQYAGN TVGLKKLSLR 

       250        260        270        280        290        300 
LCVYKGFREG WLCEHMFIIG MKGSGDRVAY FTGAFPAGCG KTSTALIADL VVGDDLAIIR 

       310        320        330        340        350        360 
NVDGVARAVN PEVGMFGIID GVNPVDDAEI YKILTSRTSE VIFANVLYTE DGDVWWNGKE 

       370        380        390        400        410        420 
GAPKPGVNYA GEWWPGKRDE NGNPIPPSHP NARFTTSIFY LSRVDPRIND PMGVPVSGMI 

       430        440        450        460        470        480 
FGGRDSDTWV PVEEAFDWFH GIVTKGASLE SERTTAVLGQ AGVREFNPFA ILDFLSISPG 

       490        500        510        520        530        540 
AFIDLHFRFA RELSQSPKVY GVNYFLRGED GRFLTEKVDK RVWLRWMEKR VHGELDAVET 

       550        560        570        580        590        600 
PTGYIPIYSD LVDLFNKELG KEFPESLYEK LFTVRVKQHL DKIERIWRIY AEIPDTPALF 

       610        620        630 
FSILKEEKQR LVNARNRFGD FISPFRLDRA 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001939 Genomic DNA. Translation: ADG90286.1.
RefSeqYP_003649238.1. NC_014160.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADG90286; ADG90286; Tagg_0003.
GeneID9165007.
KEGGtag:Tagg_0003.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000191700.
KOK01596.
OMAWMRFGED.

Enzyme and pathway databases

BioCycTAGG633148:GHBI-3-MONOMER.
UniPathwayUPA00138.

Family and domain databases

Gene3D3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPMF_00452. PEPCK_GTP.
InterProIPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view]
PANTHERPTHR11561. PTHR11561. 1 hit.
PfamPF00821. PEPCK. 1 hit.
[Graphical view]
PIRSFPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMSSF68923. SSF68923. 1 hit.
ProtoNetSearch...

Entry information

Entry nameD5TZI6_THEAM
AccessionPrimary (citable) accession number: D5TZI6
Entry history
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: February 19, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)