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D5TZI6

- D5TZI6_THEAM

UniProt

D5TZI6 - D5TZI6_THEAM

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Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene

pckG

Organism
Thermosphaera aggregans (strain DSM 11486 / M11TL)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.UniRule annotation

Catalytic activityi

GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Binds 1 manganese ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei94 – 941SubstrateUniRule annotation
Binding sitei229 – 2291Substrate; via amide nitrogenUniRule annotation
Metal bindingi236 – 2361ManganeseUniRule annotation
Binding sitei236 – 2361SubstrateUniRule annotation
Metal bindingi255 – 2551Manganese; via tele nitrogenUniRule annotation
Active sitei279 – 2791UniRule annotation
Metal bindingi295 – 2951ManganeseUniRule annotation
Binding sitei393 – 3931GTPUniRule annotation
Binding sitei424 – 4241GTPUniRule annotation

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-HAMAP
  2. kinase activity Source: UniProtKB-KW
  3. manganese ion binding Source: UniProtKB-HAMAP
  4. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, KinaseImported, Lyase, Transferase

Keywords - Biological processi

GluconeogenesisUniRule annotation

Keywords - Ligandi

GTP-bindingUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, PyruvateImported

Enzyme and pathway databases

BioCyciTAGG633148:GHBI-3-MONOMER.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation (EC:4.1.1.32UniRule annotation)
Short name:
PEP carboxykinaseUniRule annotation
Short name:
PEPCKUniRule annotation
Gene namesi
Name:pckGUniRule annotation
Ordered Locus Names:Tagg_0003Imported
OrganismiThermosphaera aggregans (strain DSM 11486 / M11TL)Imported
Taxonomic identifieri633148 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeThermosphaera
ProteomesiUP000002376: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni391 – 3933Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000191700.
KOiK01596.
OMAiSEFLLYR.

Family and domain databases

Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00452. PEPCK_GTP.
InterProiIPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view]
PANTHERiPTHR11561. PTHR11561. 1 hit.
PfamiPF00821. PEPCK. 1 hit.
[Graphical view]
PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.

Sequencei

Sequence statusi: Complete.

D5TZI6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
METQGFCTES LNALKPYMSS RELGKLARIR DCSLVEWIRQ VVEHLKPSSI
60 70 80 90 100
FINTGSEEDL DYIRRRAVEN KEEYVSSYNQ LHTVHFDGVR DLARDRGNTK
110 120 130 140 150
IMTGKGVKIP LVNSGEREEL KKEVWEIYRD IMRGKEMFIG FYCFGPRGSP
160 170 180 190 200
FTLYGVQVTD SAYVVHSENI LYRVCYDEFT RNDRIEYMRF LHSSGERDEN
210 220 230 240 250
GWSKNISKRR IYIDPEEMIT YSVNTQYAGN TVGLKKLSLR LCVYKGFREG
260 270 280 290 300
WLCEHMFIIG MKGSGDRVAY FTGAFPAGCG KTSTALIADL VVGDDLAIIR
310 320 330 340 350
NVDGVARAVN PEVGMFGIID GVNPVDDAEI YKILTSRTSE VIFANVLYTE
360 370 380 390 400
DGDVWWNGKE GAPKPGVNYA GEWWPGKRDE NGNPIPPSHP NARFTTSIFY
410 420 430 440 450
LSRVDPRIND PMGVPVSGMI FGGRDSDTWV PVEEAFDWFH GIVTKGASLE
460 470 480 490 500
SERTTAVLGQ AGVREFNPFA ILDFLSISPG AFIDLHFRFA RELSQSPKVY
510 520 530 540 550
GVNYFLRGED GRFLTEKVDK RVWLRWMEKR VHGELDAVET PTGYIPIYSD
560 570 580 590 600
LVDLFNKELG KEFPESLYEK LFTVRVKQHL DKIERIWRIY AEIPDTPALF
610 620 630
FSILKEEKQR LVNARNRFGD FISPFRLDRA
Length:630
Mass (Da):72,093
Last modified:July 13, 2010 - v1
Checksum:i04EF80C467CDB31E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001939 Genomic DNA. Translation: ADG90286.1.
RefSeqiYP_003649238.1. NC_014160.1.

Genome annotation databases

EnsemblBacteriaiADG90286; ADG90286; Tagg_0003.
GeneIDi9165007.
KEGGitag:Tagg_0003.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001939 Genomic DNA. Translation: ADG90286.1 .
RefSeqi YP_003649238.1. NC_014160.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADG90286 ; ADG90286 ; Tagg_0003 .
GeneIDi 9165007.
KEGGi tag:Tagg_0003.

Phylogenomic databases

HOGENOMi HOG000191700.
KOi K01596.
OMAi SEFLLYR.

Enzyme and pathway databases

UniPathwayi UPA00138 .
BioCyci TAGG633148:GHBI-3-MONOMER.

Family and domain databases

Gene3Di 3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPi MF_00452. PEPCK_GTP.
InterProi IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view ]
PANTHERi PTHR11561. PTHR11561. 1 hit.
Pfami PF00821. PEPCK. 1 hit.
[Graphical view ]
PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMi SSF68923. SSF68923. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 11486 / M11TLImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DSM 11486.

Entry informationi

Entry nameiD5TZI6_THEAM
AccessioniPrimary (citable) accession number: D5TZI6
Entry historyi
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: October 29, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3