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UniProtKB - D5T4Q4 (D5T4Q4_LEUKI)

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Protein

Acetate kinase

Gene

ackA

Organism
Leuconostoc kimchii (strain IMSNU 11154 / KCTC 2386 / IH25)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Mg2+. Can also accept Mn2+.UniRule annotation

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA), Acetate kinase (ackA)
  2. no protein annotated in this organism
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi8MagnesiumUniRule annotation1
Binding sitei15ATPUniRule annotation1
Binding sitei111SubstrateUniRule annotation1
Active sitei168Proton donor/acceptorUniRule annotation1
Sitei200Transition state stabilizerUniRule annotation1
Sitei261Transition state stabilizerUniRule annotation1
Metal bindingi403MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi228 – 232ATPUniRule annotation5
Nucleotide bindingi303 – 305ATPUniRule annotation3
Nucleotide bindingi350 – 354ATPUniRule annotation5

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionKinaseUniRule annotationSAAS annotationImported, Transferase
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00340; UER00458.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
Name:ackAUniRule annotation
Ordered Locus Names:LKI_09930Imported
OrganismiLeuconostoc kimchii (strain IMSNU 11154 / KCTC 2386 / IH25)Imported
Taxonomic identifieri762051 [NCBI]
Taxonomic lineageiBacteria › Firmicutes › Bacilli › Lactobacillales › Leuconostocaceae › Leuconostoc ›
Proteomesi
  • UP000002362 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi762051.LKI_09930.

Structurei

3D structure databases

ProteinModelPortaliD5T4Q4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105C6H. Bacteria.
COG0282. LUCA.
HOGENOMiHOG000288398.
KOiK00925.
OrthoDBiPOG091H02K4.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase. 1 hit.
InterProiView protein in InterPro
IPR004372. Ac/propionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiView protein in Pfam
PF00871. Acetate_kinase. 2 hits.
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiView protein in PROSITE
PS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

D5T4Q4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKIMAVNAG SSSLKFQLLE MPEEMVLMQG IIERIGQDNA EISIKYGKDI 
        60         70         80         90        100
EPKRLIGAEE GHITLTKNGG QKFEHEMAIK DHDQAIDVLL QKLTDLGIVK 
       110        120        130        140        150
DFNEITGVGH RVVAGGEWFN HSVVVNDDVL TKIDRLADYA PLHNPANAMG 
       160        170        180        190        200
IRAFQKLLPD ALSVAVFDTS FHQTMPEKNY LYSIPYEYYA RYGARKYGAH 
       210        220        230        240        250
GTSHRYVTER AAKKLDIPLD EFNAISFHLG AGASITAIKN GKSYDTSMGF 
       260        270        280        290        300
TPLAGLTMAT RSGDVDPSLV YYIQEREGLS NEEMLSVLNK KSGLLGISTI 
       310        320        330        340        350
SSDMRDLEEV QETNTHAKLA LDMFYDRVIR YAGQYFAELG RVDAVIFTAG 
       360        370        380        390        400
IGENDAVTRA KVLESLAFAG VKLDAEANNV RGKEAILTTD DSSVTGLLIP 
       410 
TNEELMIARD VEALR
Length:415
Mass (Da):45,734
Last modified:July 13, 2010 - v1
Checksum:i2145BD86E9B13334
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001758 Genomic DNA. Translation: ADG41525.1.
RefSeqiWP_013104111.1. NC_014136.1.

Genome annotation databases

EnsemblBacteriaiADG41525; ADG41525; LKI_09930.
KEGGilki:LKI_09930.
PATRICifig|762051.18.peg.1996.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001758 Genomic DNA. Translation: ADG41525.1.
RefSeqiWP_013104111.1. NC_014136.1.

3D structure databases

ProteinModelPortaliD5T4Q4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi762051.LKI_09930.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADG41525; ADG41525; LKI_09930.
KEGGilki:LKI_09930.
PATRICifig|762051.18.peg.1996.

Phylogenomic databases

eggNOGiENOG4105C6H. Bacteria.
COG0282. LUCA.
HOGENOMiHOG000288398.
KOiK00925.
OrthoDBiPOG091H02K4.

Enzyme and pathway databases

UniPathwayiUPA00340; UER00458.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase. 1 hit.
InterProiView protein in InterPro
IPR004372. Ac/propionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiView protein in Pfam
PF00871. Acetate_kinase. 2 hits.
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiView protein in PROSITE
PS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiD5T4Q4_LEUKI
AccessioniPrimary (citable) accession number: D5T4Q4
Entry historyiIntegrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: June 7, 2017
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.