ackA

Functionⁱ

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityⁱ

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactorⁱ

Mg²⁺UniRule annotation, Mn²⁺UniRule annotationNote: Mg²⁺. Can also accept Mn²⁺.UniRule annotation

Pathwayⁱ: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:

Acetate kinase (ackA), Acetate kinase (ackA)
no protein annotated in this organism

This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	8	MagnesiumUniRule annotation	1
Binding siteⁱ	15	ATPUniRule annotation	1
Binding siteⁱ	111	SubstrateUniRule annotation	1
Active siteⁱ	168	Proton donor/acceptorUniRule annotation	1
Siteⁱ	200	Transition state stabilizerUniRule annotation	1
Siteⁱ	261	Transition state stabilizerUniRule annotation	1
Metal bindingⁱ	403	MagnesiumUniRule annotation	1

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	228 – 232	ATPUniRule annotation	5
Nucleotide bindingⁱ	303 – 305	ATPUniRule annotation	3
Nucleotide bindingⁱ	350 – 354	ATPUniRule annotation	5

GO - Molecular functionⁱ

acetate kinase activity Source: UniProtKB-HAMAP
ATP binding Source: UniProtKB-KW
magnesium ion binding Source: UniProtKB-HAMAP

Complete GO annotation...

GO - Biological processⁱ

acetyl-CoA biosynthetic process Source: UniProtKB-UniPathway
organic acid metabolic process Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	KinaseUniRule annotationSAAS annotationImported, Transferase
Ligand	ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayⁱ	UPA00340; UER00458.

UniPathwayⁱ

UPA00340; UER00458.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation) Alternative name(s): AcetokinaseUniRule annotation
Gene namesⁱ	Name:ackAUniRule annotation Ordered Locus Names:LKI_09930Imported
Organismⁱ	Leuconostoc kimchii (strain IMSNU 11154 / KCTC 2386 / IH25)Imported
Taxonomic identifierⁱ	762051 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Firmicutes › Bacilli › Lactobacillales › Leuconostocaceae › Leuconostoc › Leuconostoc kimchii
Proteomesⁱ	UP000002362 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Automatic assertion according to rulesⁱ
- HAMAP-Rule:MF_00020
SAAS annotation
Automatic assertion according to rulesⁱ
- SAAS:SAAS00011667

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

CytoplasmUniRule annotationSAAS annotation

Interactionⁱ

Subunit structureⁱ

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGⁱ	762051.LKI_09930.

STRINGⁱ

762051.LKI_09930.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	D5T4Q4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the acetokinase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGⁱ	ENOG4105C6H. Bacteria. COG0282. LUCA.
HOGENOMⁱ	HOG000288398.
KEGG Orthology (KO) More...KOⁱ	K00925.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H02K4.

Family and domain databases

HAMAPⁱ	MF_00020. Acetate_kinase. 1 hit.
InterProⁱ	View protein in InterPro IPR004372. Ac/propionate_kinase. IPR000890. Aliphatic_acid_kin_short-chain. IPR023865. Aliphatic_acid_kinase_CS.
PANTHERⁱ	PTHR21060. PTHR21060. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00871. Acetate_kinase. 2 hits.
PIRSFⁱ	PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSⁱ	PR00471. ACETATEKNASE.
TIGRFAMsⁱ	TIGR00016. ackA. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01075. ACETATE_KINASE_1. 1 hit. PS01076. ACETATE_KINASE_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

D5T4Q4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSKIMAVNAG SSSLKFQLLE MPEEMVLMQG IIERIGQDNA EISIKYGKDI 
        60         70         80         90        100
EPKRLIGAEE GHITLTKNGG QKFEHEMAIK DHDQAIDVLL QKLTDLGIVK 
       110        120        130        140        150
DFNEITGVGH RVVAGGEWFN HSVVVNDDVL TKIDRLADYA PLHNPANAMG 
       160        170        180        190        200
IRAFQKLLPD ALSVAVFDTS FHQTMPEKNY LYSIPYEYYA RYGARKYGAH 
       210        220        230        240        250
GTSHRYVTER AAKKLDIPLD EFNAISFHLG AGASITAIKN GKSYDTSMGF 
       260        270        280        290        300
TPLAGLTMAT RSGDVDPSLV YYIQEREGLS NEEMLSVLNK KSGLLGISTI 
       310        320        330        340        350
SSDMRDLEEV QETNTHAKLA LDMFYDRVIR YAGQYFAELG RVDAVIFTAG 
       360        370        380        390        400
IGENDAVTRA KVLESLAFAG VKLDAEANNV RGKEAILTTD DSSVTGLLIP 
       410 
TNEELMIARD VEALR

Length:415

Mass (Da):45,734

Last modified:July 13, 2010 - v1

Checksum:ⁱ2145BD86E9B13334

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP001758 Genomic DNA. Translation: ADG41525.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_013104111.1. NC_014136.1.

Genome annotation databases

EnsemblBacteriaⁱ	ADG41525; ADG41525; LKI_09930.
KEGGⁱ	lki:LKI_09930.
PATRICⁱ	fig\|762051.18.peg.1996.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP001758 Genomic DNA. Translation: ADG41525.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_013104111.1. NC_014136.1.

3D structure databases

ProteinModelPortalⁱ	D5T4Q4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	762051.LKI_09930.

STRINGⁱ

762051.LKI_09930.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ADG41525; ADG41525; LKI_09930.
KEGGⁱ	lki:LKI_09930.
PATRICⁱ	fig\|762051.18.peg.1996.

Phylogenomic databases

eggNOGⁱ	ENOG4105C6H. Bacteria. COG0282. LUCA.
HOGENOMⁱ	HOG000288398.
KEGG Orthology (KO) More...KOⁱ	K00925.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H02K4.

Enzyme and pathway databases

UniPathwayⁱ	UPA00340; UER00458.

UniPathwayⁱ

UPA00340; UER00458.

Family and domain databases

HAMAPⁱ	MF_00020. Acetate_kinase. 1 hit.
InterProⁱ	View protein in InterPro IPR004372. Ac/propionate_kinase. IPR000890. Aliphatic_acid_kin_short-chain. IPR023865. Aliphatic_acid_kinase_CS.
PANTHERⁱ	PTHR21060. PTHR21060. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00871. Acetate_kinase. 2 hits.
PIRSFⁱ	PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSⁱ	PR00471. ACETATEKNASE.
TIGRFAMsⁱ	TIGR00016. ackA. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01075. ACETATE_KINASE_1. 1 hit. PS01076. ACETATE_KINASE_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	D5T4Q4_LEUKI
Accessionⁱ	D5T4Q4Primary (citable) accession number: D5T4Q4
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	July 13, 2010
	Last sequence update:	July 13, 2010
	Last modified:	July 5, 2017
	This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - D5T4Q4 (D5T4Q4_LEUKI)

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Acetate kinase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: acetyl-CoA biosynthesis

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

Pathwayⁱ: acetyl-CoA biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ