UniProtKB - D5T4Q4 (D5T4Q4_LEUKI)
(max 400 entries)x
Your basket is currently empty. i
Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)
Protein
Acetate kinase
Gene
ackA
Organism
Leuconostoc kimchii (strain IMSNU 11154 / KCTC 2386 / IH25)
Status
Functioni
Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation
Catalytic activityi
ATP + acetate = ADP + acetyl phosphate.UniRule annotation
Cofactori
: acetyl-CoA biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotationProteins known to be involved in the 2 steps of the subpathway in this organism are:
- Acetate kinase (ackA), Acetate kinase (ackA)
- no protein annotated in this organism
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 8 | MagnesiumUniRule annotation | 1 | |
Binding sitei | 15 | ATPUniRule annotation | 1 | |
Binding sitei | 111 | SubstrateUniRule annotation | 1 | |
Active sitei | 168 | Proton donor/acceptorUniRule annotation | 1 | |
Sitei | 200 | Transition state stabilizerUniRule annotation | 1 | |
Sitei | 261 | Transition state stabilizerUniRule annotation | 1 | |
Metal bindingi | 403 | MagnesiumUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 228 – 232 | ATPUniRule annotation | 5 | |
Nucleotide bindingi | 303 – 305 | ATPUniRule annotation | 3 | |
Nucleotide bindingi | 350 – 354 | ATPUniRule annotation | 5 |
GO - Molecular functioni
- acetate kinase activity Source: UniProtKB-UniRule
- ATP binding Source: UniProtKB-KW
- magnesium ion binding Source: UniProtKB-UniRule
GO - Biological processi
- acetyl-CoA biosynthetic process Source: UniProtKB-UniPathway
- organic acid metabolic process Source: InterPro
Keywordsi
Molecular function | KinaseUniRule annotationSAAS annotationImported, Transferase |
Ligand | ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding |
Enzyme and pathway databases
UniPathwayi | UPA00340; UER00458. |
Names & Taxonomyi
Protein namesi | Recommended name: Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)Alternative name(s): AcetokinaseUniRule annotation |
Gene namesi | Name:ackAUniRule annotation Ordered Locus Names:LKI_09930Imported |
Organismi | Leuconostoc kimchii (strain IMSNU 11154 / KCTC 2386 / IH25)Imported |
Taxonomic identifieri | 762051 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Lactobacillales › Leuconostocaceae › Leuconostoc › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotationSAAS annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmUniRule annotationSAAS annotationInteractioni
Subunit structurei
Homodimer.UniRule annotation
Protein-protein interaction databases
STRINGi | 762051.LKI_09930. |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG4105C6H. Bacteria. COG0282. LUCA. |
HOGENOMi | HOG000288398. |
KOi | K00925. |
OrthoDBi | POG091H02K4. |
Family and domain databases
HAMAPi | MF_00020. Acetate_kinase. 1 hit. |
InterProi | View protein in InterPro IPR004372. Ac/propionate_kinase. IPR000890. Aliphatic_acid_kin_short-chain. IPR023865. Aliphatic_acid_kinase_CS. |
PANTHERi | PTHR21060. PTHR21060. 1 hit. |
Pfami | View protein in Pfam PF00871. Acetate_kinase. 2 hits. |
PIRSFi | PIRSF000722. Acetate_prop_kin. 1 hit. |
PRINTSi | PR00471. ACETATEKNASE. |
TIGRFAMsi | TIGR00016. ackA. 1 hit. |
PROSITEi | View protein in PROSITE PS01075. ACETATE_KINASE_1. 1 hit. PS01076. ACETATE_KINASE_2. 1 hit. |
i Sequence
Sequence statusi: Complete.
D5T4Q4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKIMAVNAG SSSLKFQLLE MPEEMVLMQG IIERIGQDNA EISIKYGKDI
60 70 80 90 100
EPKRLIGAEE GHITLTKNGG QKFEHEMAIK DHDQAIDVLL QKLTDLGIVK
110 120 130 140 150
DFNEITGVGH RVVAGGEWFN HSVVVNDDVL TKIDRLADYA PLHNPANAMG
160 170 180 190 200
IRAFQKLLPD ALSVAVFDTS FHQTMPEKNY LYSIPYEYYA RYGARKYGAH
210 220 230 240 250
GTSHRYVTER AAKKLDIPLD EFNAISFHLG AGASITAIKN GKSYDTSMGF
260 270 280 290 300
TPLAGLTMAT RSGDVDPSLV YYIQEREGLS NEEMLSVLNK KSGLLGISTI
310 320 330 340 350
SSDMRDLEEV QETNTHAKLA LDMFYDRVIR YAGQYFAELG RVDAVIFTAG
360 370 380 390 400
IGENDAVTRA KVLESLAFAG VKLDAEANNV RGKEAILTTD DSSVTGLLIP
410
TNEELMIARD VEALR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP001758 Genomic DNA. Translation: ADG41525.1. |
RefSeqi | WP_013104111.1. NC_014136.1. |
Genome annotation databases
EnsemblBacteriai | ADG41525; ADG41525; LKI_09930. |
KEGGi | lki:LKI_09930. |
PATRICi | fig|762051.18.peg.1996. |
Similar proteinsi
Entry informationi
Entry namei | D5T4Q4_LEUKI | |
Accessioni | D5T4Q4Primary (citable) accession number: D5T4Q4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 13, 2010 |
Last sequence update: | July 13, 2010 | |
Last modified: | March 28, 2018 | |
This is version 60 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |