Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

D5SME2 (D5SME2_PLAL2) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Plim_0009 EMBL ADG65862.1
OrganismPlanctomyces limnophilus (strain ATCC 43296 / DSM 3776 / IFAM 1008 / 290) [Complete proteome] [HAMAP] EMBL ADG65862.1
Taxonomic identifier521674 [NCBI]
Taxonomic lineageBacteriaPlanctomycetesPlanctomycetiaPlanctomycetalesPlanctomycetaceaePlanctomyces

Protein attributes

Sequence length338 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain114 – 312199ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding143 – 19856ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2661Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2791Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2791Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2811Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
D5SME2 [UniParc].

Last modified July 13, 2010. Version 1.
Checksum: 89F692F5E89B1E8B

FASTA33837,544
        10         20         30         40         50         60 
MSRGNIQSAA TNPPRWNIAL LAGGDSDERS ISLRSGQAVC QALQERGHFI LPIDPAIVSL 

        70         80         90        100        110        120 
KGMDWNGFDA VFIALHGRFG EDGGVQTLLE ESGIPYTGSS SQASRLAFDK RIAKQNFDRM 

       130        140        150        160        170        180 
QVPTPAWCEL SPHESFDSLL MKAKELGWPV VIKPASQGSS LGVSIVRQPE QLQSAYERAR 

       190        200        210        220        230        240 
HYDEALIMEA AIVGSEWTVG LHDDEILPPI CIETDREFFD WVAKYEDDHT RYIFDKPLPA 

       250        260        270        280        290        300 
TCRQKLETAC RGAVHALGVT GISRVDLMLD SEGNPWVLEI NTIPGLTDHS LVPKAAQQAG 

       310        320        330 
WSLGELCEES IHRAIQRRPR RPHLLRRASF STQARQRP 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001744 Genomic DNA. Translation: ADG65862.1.
RefSeqYP_003628061.1. NC_014148.1.

3D structure databases

ProteinModelPortalD5SME2.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADG65862; ADG65862; Plim_0009.
GeneID9136662.
KEGGplm:Plim_0009.
PATRIC38235438. VBIPlaLim6916_0010.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000011592.
KOK01921.
OMALCRWIVE.

Enzyme and pathway databases

BioCycPLIM521674:GKE7-9-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD5SME2_PLAL2
AccessionPrimary (citable) accession number: D5SME2
Entry history
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: June 11, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)