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Protein
Submitted name:

Large-conductance calcium-activated potassium channel alpha subunit

Gene

KCNMA1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channelSAAS annotation

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Names & Taxonomyi

Protein namesi
Submitted name:
Large-conductance calcium-activated potassium channel alpha subunitImported
Gene namesi
Name:KCNMA1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Transmembranei127 – 144HelicalSequence analysisAdd BLAST18
Transmembranei165 – 181HelicalSequence analysisAdd BLAST17
Transmembranei246 – 267HelicalSequence analysisAdd BLAST22
Transmembranei282 – 301HelicalSequence analysisAdd BLAST20
Transmembranei313 – 331HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PeptideAtlasiD5MRH1.
PRIDEiD5MRH1.

Structurei

3D structure databases

ProteinModelPortaliD5MRH1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini129 – 337Ion_transInterPro annotationAdd BLAST209

Sequence similaritiesi

Belongs to the potassium channel family.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

HOGENOMiHOG000019856.

Family and domain databases

Gene3Di3.40.50.720. 3 hits.
InterProiIPR005821. Ion_trans_dom.
IPR003929. K_chnl_Ca-activ_BK_asu.
IPR016040. NAD(P)-bd_dom.
IPR028325. VG_K_chnl.
[Graphical view]
PfamiPF03493. BK_channel_a. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR01449. BKCHANNELA.
PR00169. KCHANNEL.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

D5MRH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANGGGGGGG SSGGGGGGGG SSLRMSSNIH ANHLSLDASS SSSSSSSSSS
60 70 80 90 100
SSSSSSSSSS VHEPKMDALI IPVTMEVPCD SRGQRMWWAF LASSMVTFFG
110 120 130 140 150
GLFIILLWRT LKYLWTVCCH CGGKTKVVLV FALSIGALVI YFIDSSNPIE
160 170 180 190 200
SCQNFYKDFT LQIDMAFNVF FLLYFGLRFI AANDKLWFWL EVNSVVDFFT
210 220 230 240 250
VPPVFVSVYL NRSWLGLRFL RALRLIQFSE ILQFLNILKT SNSIKLVNLL
260 270 280 290 300
SIFISTWLTA AGFIHLVENS GDPWENFQNN QALTYWECVY LLMVTMSTVG
310 320 330 340 350
YGDVYAKTTL GRLFMVFFIL GGLAMFASYV PEIIELIGNR KKYGGSYSAV
360 370 380 390 400
SGRKHIVVCG HITLESVSNF LKDFLHKDRD DVNVEIVFLH NISPNLELEA
410 420 430 440 450
LFKRHFTQVE FYQGSVLNPH DLARVKIESA DACLILANKY CADPDAEDAS
460 470 480 490 500
NIMRVISIKN YHPKIRIITQ MLQYHNKAHL LNIPSWNWKE GDDAICLAEL
510 520 530 540 550
KLGFIAQSCL AQGLSTMLAN LFSMRSFIKI EEDTWQKYYL EGVSNEMYTE
560 570 580 590 600
YLSSAFVGLS FPTVCELCFV KLKLLMIAIE YKSANRESRS RKRILINPGN
610 620 630 640 650
HLKIQEGTLG FFIASDAKEV KRAFFYCKAC HDDITDPKRI KKCGCKRLED
660 670 680 690 700
EQPSTLSPKK KQRNGGMRNS PNTSPKLMRH DPLLIPGNDQ IDNMDSNVKK
710 720 730 740 750
YDSTGMFHWC APKEIEKVIL TRSEAAMTVL SGHVVVCIFG DVSSALIGLR
760 770 780 790 800
NLVMPLRASN FHYHELKHIV FVGSIEYLKR EWETLHNFPK VSILPGTPLS
810 820 830 840 850
RADLRAVNIN LCDMCVILSA NQNNIDDTSL QDKECILASL NIKSMQFDDS
860 870 880 890 900
IGVLQANSQG FTPPGMDRSS PDNSPVHGML RQPSITTGVN IPIITELVND
910 920 930 940 950
TNVQFLDQDD DDDPDTELYL TQPFACGTAF AVSVLDSLMS ATYFNDNILT
960 970 980 990 1000
LIRTLVTGGA TPELEALIAE ENALRGGYST PQTLANRDRC RVAQLALLDG
1010 1020 1030 1040 1050
PFADLGDGGC YGDLFCKALK TYNMLCFGIY RLRDAHLSTP SQCTKRYVIT
1060 1070 1080 1090 1100
NPPYEFELVP TDLIFCLMQF DHNAGQSRAS LSHSSHSSQS SSKKSSSVHS
1110 1120
IPSTANRQNR PKSRESRDKQ NRKEMVYR
Length:1,128
Mass (Da):125,857
Last modified:July 13, 2010 - v1
Checksum:i5E1A8BBCD3C4E294
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB524033 mRNA. Translation: BAJ07308.1.
RefSeqiNP_001258447.1. NM_001271518.1.
UniGeneiHs.144795.
Hs.658064.

Genome annotation databases

GeneIDi3778.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB524033 mRNA. Translation: BAJ07308.1.
RefSeqiNP_001258447.1. NM_001271518.1.
UniGeneiHs.144795.
Hs.658064.

3D structure databases

ProteinModelPortaliD5MRH1.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiD5MRH1.
PRIDEiD5MRH1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3778.

Organism-specific databases

CTDi3778.

Phylogenomic databases

HOGENOMiHOG000019856.

Miscellaneous databases

ChiTaRSiKCNMA1. human.
GenomeRNAii3778.

Family and domain databases

Gene3Di3.40.50.720. 3 hits.
InterProiIPR005821. Ion_trans_dom.
IPR003929. K_chnl_Ca-activ_BK_asu.
IPR016040. NAD(P)-bd_dom.
IPR028325. VG_K_chnl.
[Graphical view]
PfamiPF03493. BK_channel_a. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR01449. BKCHANNELA.
PR00169. KCHANNEL.
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiD5MRH1_HUMAN
AccessioniPrimary (citable) accession number: D5MRH1
Entry historyi
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: November 30, 2016
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.