ID   P5F1B_HUMAN             Reviewed;         359 AA.
AC   Q06416; D5K9S4; D5K9S9; D5K9T0; D5K9T1; D5K9T3; D5K9U3; D5K9U6; D5K9V4;
AC   D5K9V6; D5K9W0; D5K9W2; D5K9W7; D5K9X2; D5K9X3; D5K9X5; D5K9X8; D5K9X9;
AC   E9LRB1; E9LRB2; E9LRH5; E9LRH6; E9LRH7; E9LRK4; E9LRK5; E9LRK7; E9LRK8;
AC   E9LRM7; E9LRM9; E9LRN2; E9LRN4; E9LRN5; E9LRP8; E9LRQ0; E9LRQ2; E9LRQ3;
AC   E9LRQ4; E9LRQ5; E9LRS3; Q2VIK6; Q9BZV7; Q9BZV9;
DT   01-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT   16-NOV-2011, sequence version 2.
DT   24-JAN-2024, entry version 180.
DE   RecName: Full=Putative POU domain, class 5, transcription factor 1B;
DE   AltName: Full=Oct4-pg1;
DE   AltName: Full=Octamer-binding protein 3-like;
DE   AltName: Full=Octamer-binding transcription factor 3-like;
GN   Name=POU5F1B;
GN   Synonyms=OCT4PG1, OTF3C, OTF3P1, POU5F1P1, POU5FLC20, POU5FLC8;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Liver;
RX   PubMed=1408763; DOI=10.1093/nar/20.17.4613;
RA   Takeda J., Seino S., Bell G.I.;
RT   "Human Oct3 gene family: cDNA sequences, alternative splicing, gene
RT   organization, chromosomal location, and expression at low levels in adult
RT   tissues.";
RL   Nucleic Acids Res. 20:4613-4620(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16201836; DOI=10.1371/journal.pbio.0030357;
RA   Marques A.C., Dupanloup I., Vinckenbosch N., Reymond A., Kaessmann H.;
RT   "Emergence of young human genes after a burst of retroposition in
RT   primates.";
RL   PLoS Biol. 3:E357-E357(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS THR-182 AND ASP-214.
RC   TISSUE=Kidney;
RA   van Roozendaal K.E.P., Gillis A.J.M., van Asseldonk M., Oosterhuis J.W.,
RA   Looijenga L.H.J., van Zoelen E.J.J.;
RT   "Identification and expression analysis of novel intron-less human
RT   POU5F1/OCT3 related POU domain genes.";
RL   Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Mammary cancer;
RA   Zhao F.-Q., Buss K.;
RT   "Differential expression of Oct-4 gene and pseudogene in normal and breast
RT   cancer cells.";
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ARG-33; GLU-176; THR-182; ASP-214 AND
RP   GLN-238, AND TISSUE SPECIFICITY.
RC   TISSUE=Glial tumor, and Mammary cancer;
RX   PubMed=21341266; DOI=10.1002/path.2827;
RA   Zhao S., Yuan Q., Hao H., Guo Y., Liu S., Zhang Y., Wang J., Liu H.,
RA   Wang F., Liu K., Ling E.A., Hao A.;
RT   "Expression of OCT4 pseudogenes in human tumours: lessons from glioma and
RT   breast carcinoma.";
RL   J. Pathol. 223:672-682(2011).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA   Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA   Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA   Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA   Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA   Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA   Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA   O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA   Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA   Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA   Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA   Platzer M., Shimizu N., Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [7]
RP   TISSUE SPECIFICITY.
RX   PubMed=16229821; DOI=10.1016/j.bbrc.2005.09.157;
RA   Suo G., Han J., Wang X., Zhang J., Zhao Y., Zhao Y., Dai J.;
RT   "Oct4 pseudogenes are transcribed in cancers.";
RL   Biochem. Biophys. Res. Commun. 337:1047-1051(2005).
RN   [8]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=18949397;
RA   Panagopoulos I., Moeller E., Collin A., Mertens F.;
RT   "The POU5F1P1 pseudogene encodes a putative protein similar to POU5F1
RT   isoform 1.";
RL   Oncol. Rep. 20:1029-1033(2008).
CC   -!- FUNCTION: Shows weak transcriptional activator activity.
CC       {ECO:0000269|PubMed:18949397}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC       ECO:0000255|PROSITE-ProRule:PRU00530, ECO:0000269|PubMed:18949397}.
CC   -!- TISSUE SPECIFICITY: Detected at the mRNA level in several cancer
CC       tissues (breast, uterine cervix, lung, thyroid gland, esophagus, colon,
CC       urinary bladder, and glioma), but absent in normal tissues.
CC       {ECO:0000269|PubMed:16229821, ECO:0000269|PubMed:21341266}.
CC   -!- SIMILARITY: Belongs to the POU transcription factor family. Class-5
CC       subfamily. {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. Several pseudogenes of
CC       POU5F1 have been described on chromosomes 1, 3, 8, 10 and 12. Two of
CC       them, localized on chromosomes 8 and 10 have been shown to be
CC       preferentially transcribed in cancer tissues and may be involved in the
CC       regulation of POU5F1 gene activity in carcinogenesis. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Z11901; CAA77953.1; -; Genomic_DNA.
DR   EMBL; DQ120688; ABB92462.1; -; Genomic_DNA.
DR   EMBL; AF268615; AAG53083.1; -; mRNA.
DR   EMBL; AF268618; AAG53085.1; -; mRNA.
DR   EMBL; DQ486513; ABF29403.1; -; mRNA.
DR   EMBL; GU480835; ADE48561.1; -; mRNA.
DR   EMBL; GU480840; ADE48566.1; -; mRNA.
DR   EMBL; GU480841; ADE48567.1; -; mRNA.
DR   EMBL; GU480842; ADE48568.1; -; mRNA.
DR   EMBL; GU480845; ADE48570.1; -; mRNA.
DR   EMBL; GU480864; ADE48580.1; -; mRNA.
DR   EMBL; GU480868; ADE48583.1; -; mRNA.
DR   EMBL; GU480878; ADE48591.1; -; mRNA.
DR   EMBL; GU480880; ADE48593.1; -; mRNA.
DR   EMBL; GU480883; ADE48596.1; -; mRNA.
DR   EMBL; GU480886; ADE48597.1; -; mRNA.
DR   EMBL; GU480889; ADE48599.1; -; mRNA.
DR   EMBL; GU480896; ADE48604.1; -; mRNA.
DR   EMBL; GU480902; ADE48606.1; -; mRNA.
DR   EMBL; GU480905; ADE48609.1; -; mRNA.
DR   EMBL; GU480906; ADE48610.1; -; mRNA.
DR   EMBL; GU480908; ADE48612.1; -; mRNA.
DR   EMBL; GU480911; ADE48614.1; -; mRNA.
DR   EMBL; GU480912; ADE48615.1; -; mRNA.
DR   EMBL; GU480913; ADE48616.1; -; mRNA.
DR   EMBL; HQ122710; ADW77351.1; -; mRNA.
DR   EMBL; HQ122711; ADW77352.1; -; mRNA.
DR   EMBL; HQ122712; ADW77353.1; -; mRNA.
DR   EMBL; HQ122713; ADW77354.1; -; mRNA.
DR   EMBL; HQ122714; ADW77355.1; -; mRNA.
DR   EMBL; HQ122716; ADW77356.1; -; mRNA.
DR   EMBL; HQ122717; ADW77357.1; -; mRNA.
DR   EMBL; HQ122718; ADW77358.1; -; mRNA.
DR   EMBL; HQ122719; ADW77359.1; -; mRNA.
DR   EMBL; HQ122721; ADW77360.1; -; mRNA.
DR   EMBL; HQ122749; ADW77385.1; -; mRNA.
DR   EMBL; HQ122750; ADW77386.1; -; mRNA.
DR   EMBL; HQ122751; ADW77387.1; -; mRNA.
DR   EMBL; HQ122752; ADW77388.1; -; mRNA.
DR   EMBL; HQ122781; ADW77415.1; -; mRNA.
DR   EMBL; HQ122782; ADW77416.1; -; mRNA.
DR   EMBL; HQ122783; ADW77417.1; -; mRNA.
DR   EMBL; HQ122784; ADW77418.1; -; mRNA.
DR   EMBL; HQ122785; ADW77419.1; -; mRNA.
DR   EMBL; HQ122786; ADW77420.1; -; mRNA.
DR   EMBL; HQ122787; ADW77421.1; -; mRNA.
DR   EMBL; HQ122788; ADW77422.1; -; mRNA.
DR   EMBL; HQ122789; ADW77423.1; -; mRNA.
DR   EMBL; HQ122790; ADW77424.1; -; mRNA.
DR   EMBL; HQ122816; ADW77444.1; -; mRNA.
DR   EMBL; HQ122817; ADW77445.1; -; mRNA.
DR   EMBL; HQ122818; ADW77446.1; -; mRNA.
DR   EMBL; HQ122819; ADW77447.1; -; mRNA.
DR   EMBL; HQ122820; ADW77448.1; -; mRNA.
DR   EMBL; HQ122821; ADW77449.1; -; mRNA.
DR   EMBL; HQ122822; ADW77450.1; -; mRNA.
DR   EMBL; HQ122823; ADW77451.1; -; mRNA.
DR   EMBL; HQ122824; ADW77452.1; -; mRNA.
DR   EMBL; HQ122825; ADW77453.1; -; mRNA.
DR   EMBL; HQ122826; ADW77454.1; -; mRNA.
DR   EMBL; HQ122827; ADW77455.1; -; mRNA.
DR   EMBL; HQ122841; ADW77467.1; -; mRNA.
DR   EMBL; HQ122842; ADW77468.1; -; mRNA.
DR   EMBL; HQ122843; ADW77469.1; -; mRNA.
DR   EMBL; HQ122844; ADW77470.1; -; mRNA.
DR   EMBL; HQ122845; ADW77471.1; -; mRNA.
DR   EMBL; HQ122846; ADW77472.1; -; mRNA.
DR   EMBL; HQ122848; ADW77473.1; -; mRNA.
DR   EMBL; HQ122849; ADW77474.1; -; mRNA.
DR   EMBL; HQ122851; ADW77475.1; -; mRNA.
DR   EMBL; HQ122852; ADW77476.1; -; mRNA.
DR   EMBL; HQ122853; ADW77477.1; -; mRNA.
DR   EMBL; HQ122854; ADW77478.1; -; mRNA.
DR   EMBL; HQ122855; ADW77479.1; -; mRNA.
DR   EMBL; HQ122856; ADW77480.1; -; mRNA.
DR   EMBL; HQ122857; ADW77481.1; -; mRNA.
DR   EMBL; HQ122864; ADW77487.1; -; mRNA.
DR   EMBL; HQ122865; ADW77488.1; -; mRNA.
DR   EMBL; HQ122866; ADW77489.1; -; mRNA.
DR   EMBL; HQ122867; ADW77490.1; -; mRNA.
DR   EMBL; HQ122868; ADW77491.1; -; mRNA.
DR   EMBL; HQ122869; ADW77492.1; -; mRNA.
DR   EMBL; HQ122870; ADW77493.1; -; mRNA.
DR   EMBL; HQ122871; ADW77494.1; -; mRNA.
DR   EMBL; HQ122874; ADW77495.1; -; mRNA.
DR   EMBL; HQ122876; ADW77496.1; -; mRNA.
DR   EMBL; HQ122877; ADW77497.1; -; mRNA.
DR   EMBL; HQ122878; ADW77498.1; -; mRNA.
DR   EMBL; HQ122879; ADW77499.1; -; mRNA.
DR   EMBL; HQ122880; ADW77500.1; -; mRNA.
DR   EMBL; HQ122881; ADW77501.1; -; mRNA.
DR   EMBL; HQ122882; ADW77502.1; -; mRNA.
DR   EMBL; HQ122883; ADW77503.1; -; mRNA.
DR   EMBL; HQ122884; ADW77504.1; -; mRNA.
DR   EMBL; HQ122885; ADW77505.1; -; mRNA.
DR   EMBL; HQ122886; ADW77506.1; -; mRNA.
DR   EMBL; HQ122887; ADW77507.1; -; mRNA.
DR   EMBL; HQ122891; ADW77511.1; -; mRNA.
DR   EMBL; HQ122892; ADW77512.1; -; mRNA.
DR   EMBL; HQ122893; ADW77513.1; -; mRNA.
DR   EMBL; HQ122895; ADW77514.1; -; mRNA.
DR   EMBL; HQ122898; ADW77515.1; -; mRNA.
DR   EMBL; HQ122900; ADW77516.1; -; mRNA.
DR   EMBL; HQ122902; ADW77517.1; -; mRNA.
DR   EMBL; HQ122903; ADW77518.1; -; mRNA.
DR   EMBL; AC016883; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS55274.1; -.
DR   RefSeq; NP_001153014.1; NM_001159542.1.
DR   AlphaFoldDB; Q06416; -.
DR   SMR; Q06416; -.
DR   STRING; 9606.ENSP00000419298; -.
DR   GlyGen; Q06416; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q06416; -.
DR   PhosphoSitePlus; Q06416; -.
DR   BioMuta; POU5F1B; -.
DR   DMDM; 357528826; -.
DR   jPOST; Q06416; -.
DR   MassIVE; Q06416; -.
DR   MaxQB; Q06416; -.
DR   PaxDb; 9606-ENSP00000419298; -.
DR   PeptideAtlas; Q06416; -.
DR   Antibodypedia; 54266; 117 antibodies from 21 providers.
DR   DNASU; 5462; -.
DR   Ensembl; ENST00000465342.4; ENSP00000419298.2; ENSG00000212993.6.
DR   Ensembl; ENST00000645438.1; ENSP00000495779.1; ENSG00000212993.6.
DR   Ensembl; ENST00000696633.1; ENSP00000512769.1; ENSG00000212993.6.
DR   GeneID; 5462; -.
DR   KEGG; hsa:5462; -.
DR   MANE-Select; ENST00000696633.1; ENSP00000512769.1; NM_001159542.3; NP_001153014.1.
DR   UCSC; uc003ysf.4; human.
DR   AGR; HGNC:9223; -.
DR   CTD; 5462; -.
DR   DisGeNET; 5462; -.
DR   GeneCards; POU5F1B; -.
DR   HGNC; HGNC:9223; POU5F1B.
DR   HPA; ENSG00000212993; Tissue enhanced (choroid).
DR   MIM; 615739; gene.
DR   neXtProt; NX_Q06416; -.
DR   OpenTargets; ENSG00000212993; -.
DR   PharmGKB; PA33547; -.
DR   VEuPathDB; HostDB:ENSG00000212993; -.
DR   eggNOG; KOG3802; Eukaryota.
DR   GeneTree; ENSGT00940000155046; -.
DR   HOGENOM; CLU_066243_0_0_1; -.
DR   InParanoid; Q06416; -.
DR   OMA; YTQADMG; -.
DR   OrthoDB; 4250502at2759; -.
DR   PhylomeDB; Q06416; -.
DR   TreeFam; TF316413; -.
DR   PathwayCommons; Q06416; -.
DR   BioGRID-ORCS; 5462; 315 hits in 1072 CRISPR screens.
DR   GenomeRNAi; 5462; -.
DR   Pharos; Q06416; Tbio.
DR   Proteomes; UP000005640; Chromosome 8.
DR   RNAct; Q06416; Protein.
DR   Bgee; ENSG00000212993; Expressed in primordial germ cell in gonad and 77 other cell types or tissues.
DR   GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR   GO; GO:0005829; C:cytosol; IDA:HPA.
DR   GO; GO:0005739; C:mitochondrion; IDA:HPA.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; TAS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; NAS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR013847; POU.
DR   InterPro; IPR000327; POU_dom.
DR   PANTHER; PTHR11636; POU DOMAIN; 1.
DR   PANTHER; PTHR11636:SF86; POU DOMAIN, CLASS 5, TRANSCRIPTION FACTOR 1-RELATED; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF00157; Pou; 1.
DR   PRINTS; PR00028; POUDOMAIN.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM00352; POU; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS00035; POU_1; 1.
DR   PROSITE; PS00465; POU_2; 1.
DR   PROSITE; PS51179; POU_3; 1.
DR   Genevisible; Q06416; HS.
PE   5: Uncertain;
KW   Activator; DNA-binding; Homeobox; Nucleus; Phosphoprotein;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..359
FT                   /note="Putative POU domain, class 5, transcription factor
FT                   1B"
FT                   /id="PRO_0000100753"
FT   DOMAIN          138..212
FT                   /note="POU-specific"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00530"
FT   DNA_BIND        229..288
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          87..116
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          287..322
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        90..113
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         111
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q01860"
FT   MOD_RES         235
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q01860"
FT   MOD_RES         236
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q01860"
FT   MOD_RES         288
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q01860"
FT   MOD_RES         289
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q01860"
FT   MOD_RES         354
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q01860"
FT   VARIANT         33
FT                   /note="L -> R (in dbSNP:rs1061394)"
FT                   /evidence="ECO:0000269|PubMed:21341266"
FT                   /id="VAR_067432"
FT   VARIANT         69
FT                   /note="L -> F (in dbSNP:rs1061395)"
FT                   /id="VAR_067433"
FT   VARIANT         176
FT                   /note="G -> E (in dbSNP:rs6998061)"
FT                   /evidence="ECO:0000269|PubMed:21341266"
FT                   /id="VAR_067434"
FT   VARIANT         182
FT                   /note="K -> T (in dbSNP:rs13273814)"
FT                   /evidence="ECO:0000269|PubMed:21341266, ECO:0000269|Ref.3"
FT                   /id="VAR_067435"
FT   VARIANT         214
FT                   /note="N -> D (in dbSNP:rs13274084)"
FT                   /evidence="ECO:0000269|PubMed:21341266, ECO:0000269|Ref.3"
FT                   /id="VAR_067436"
FT   VARIANT         238
FT                   /note="E -> Q (in dbSNP:rs7002225)"
FT                   /evidence="ECO:0000269|PubMed:21341266"
FT                   /id="VAR_067437"
FT   VARIANT         313
FT                   /note="P -> L (in dbSNP:rs556361752)"
FT                   /id="VAR_067438"
FT   CONFLICT        10
FT                   /note="A -> T (in Ref. 5; ADE48599)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        13
FT                   /note="P -> L (in Ref. 5; ADE48609/ADW77452)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        14
FT                   /note="P -> T (in Ref. 5; ADW77351)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        23..25
FT                   /note="WGA -> GGP (in Ref. 5; ADE48566/ADE48597)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        31
FT                   /note="D -> G (in Ref. 5; ADE48567)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        31
FT                   /note="D -> V (in Ref. 5; ADE48570)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        35
FT                   /note="W -> R (in Ref. 5;
FT                   ADW77415/ADW77416/ADW77417/ADW77420/ADW77421)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        39
FT                   /note="Q -> R (in Ref. 5; ADE48583)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        76
FT                   /note="C -> R (in Ref. 5; ADW77445)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        79
FT                   /note="Q -> H (in Ref. 5; ADW77469)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        91
FT                   /note="E -> V (in Ref. 5; ADE48610/ADW77455)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        106
FT                   /note="N -> S (in Ref. 5; ADE48612)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        107
FT                   /note="S -> Y (in Ref. 5; ADW77513/ADW77518)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        129
FT                   /note="L -> Q (in Ref. 5; ADE48580)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        130
FT                   /note="E -> G (in Ref. 5; ADW77492)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        132
FT                   /note="N -> D (in Ref. 5; ADW77447)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        138
FT                   /note="D -> G (in Ref. 5; ADE48599)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        150
FT                   /note="A -> T (in Ref. 5; ADE48616)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        152
FT                   /note="L -> F (in Ref. 5; ADW77351)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        155
FT                   /note="Q -> R (in Ref. 5;
FT                   ADW77490/ADW77499/ADW77502/ADW77503)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        160
FT                   /note="L -> P (in Ref. 5; ADW77417)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        163
FT                   /note="T -> A (in Ref. 5; ADE48580)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        169
FT                   /note="L -> F (in Ref. 5; ADW77415/ADW77420/ADW77421)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        169
FT                   /note="L -> P (in Ref. 5; ADE48561)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        169
FT                   /note="L -> R (in Ref. 5; ADE48583)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        196
FT                   /note="N -> D (in Ref. 5; ADW77492)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        197
FT                   /note="M -> I (in Ref. 1; CAA77953)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        201
FT                   /note="R -> W (in Ref. 5; ADE48615)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        208
FT                   /note="V -> E (in Ref. 5; ADW77493/ADW77501/ADW77506)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        211
FT                   /note="A -> T (in Ref. 5;
FT                   ADE48593/ADW77355/ADW77358/ADW77387/ADW77418/ADW77423)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        235
FT                   /note="T -> A (in Ref. 5; ADW77518/ADW77513)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        241
FT                   /note="V -> M (in Ref. 5;
FT                   ADW77488/ADW77496/ADW77504/ADW77507)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        246
FT                   /note="E -> G (in Ref. 5; ADW77492)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        249
FT                   /note="F -> L (in Ref. 5; ADW77474/ADW77481)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        250
FT                   /note="L -> P (in Ref. 5; ADE48580)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        250
FT                   /note="L -> Q (in Ref. 5; ADW77475)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        259
FT                   /note="I -> T (in Ref. 5;
FT                   ADW77488/ADW77496/ADW77504/ADW77507)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        264
FT                   /note="Q -> H (in Ref. 5; ADE48609/ADW77452)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        264
FT                   /note="Q -> L (in Ref. 5; ADW77477/ADW77476/ADW77467)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        272
FT                   /note="V -> M (in Ref. 5; ADW77472/ADW77479)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        276..278
FT                   /note="WFC -> CFG (in Ref. 5; ADW77495)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        282
FT                   /note="Q -> R (in Ref. 5; ADW77494)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        284
FT                   /note="G -> S (in Ref. 5; ADW77469)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        295
FT                   /note="E -> V (in Ref. 5; ADE48583)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        318
FT                   /note="H -> Q (in Ref. 5; ADW77444/ADW77445)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        321
FT                   /note="T -> I (in Ref. 5; ADW77476/ADW77467/ADW77477)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        326
FT                   /note="S -> G (in Ref. 5; ADW77444/ADW77445)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        331
FT                   /note="A -> T (in Ref. 5; ADW77447/ADW77448/ADW77451)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        340
FT                   /note="E -> V (in Ref. 5; ADE48570)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   359 AA;  38588 MW;  9AF853B116FCB75A CRC64;
     MAGHLASDFA FSPPPGGGGD GPWGAEPGWV DPLTWLSFQG PPGGPGIGPG VGPGSEVWGI
     PPCPPPYELC GGMAYCGPQV GVGLVPQGGL ETSQPESEAG VGVESNSNGA SPEPCTVPPG
     AVKLEKEKLE QNPEKSQDIK ALQKELEQFA KLLKQKRITL GYTQADVGLI LGVLFGKVFS
     QKTICRFEAL QLSFKNMCKL RPLLQKWVEE ADNNENLQEI CKAETLMQAR KRKRTSIENR
     VRGNLENLFL QCPKPTLQIS HIAQQLGLEK DVVRVWFCNR RQKGKRSSSD YAQREDFEAA
     GSPFSGGPVS FPPAPGPHFG TPGYGSPHFT ALYSSVPFPE GEVFPPVSVI TLGSPMHSN
//