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D5HCE4

- D5HCE4_SALRM

UniProt

D5HCE4 - D5HCE4_SALRM

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Protein

Thymidine kinase

Gene

tdk

Organism
Salinibacter ruber (strain M8)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei110 – 1101Proton acceptorUniRule annotation
Metal bindingi166 – 1661ZincUniRule annotation
Metal bindingi169 – 1691ZincUniRule annotation
Metal bindingi198 – 1981ZincUniRule annotation
Metal bindingi201 – 2011ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi37 – 448ATPUniRule annotation
Nucleotide bindingi109 – 1124ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciSRUB761659:GHC6-2816-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:SRM_02778Imported
OrganismiSalinibacter ruber (strain M8)Imported
Taxonomic identifieri761659 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidetes Order II. Incertae sedisRhodothermaceaeSalinibacter
ProteomesiUP000000933: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076390.
KOiK00857.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D5HCE4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQRLRLSPHR AALFMSALEP HIVDRDRTTG WMEVICGSMF SGKTEELIRR
60 70 80 90 100
LRRARIARQH TRVFKPALDE RYSEDEVVSH NENSVTTTPV EAPPQIQELV
110 120 130 140 150
QEADVVGIDE AQFFDDDLVP TCQALAEDGH RVIVVGLDTD YRAEPFDPMP
160 170 180 190 200
QLMAVAEHVT KLHAVCVVCG APANHSQRIV PGEDRVLVGA TEAYEPRCRA
210 220 230 240
CFEPEPVTVT RPRPHTEALR AVATDDADAS TNEADPEAAD AASADGTAA
Length:249
Mass (Da):27,401
Last modified:June 15, 2010 - v1
Checksum:iB2B328C1781EB24E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP565814 Genomic DNA. Translation: CBH25699.1.
RefSeqiWP_013062740.1. NC_014032.1.
YP_003572651.1. NC_014032.1.

Genome annotation databases

EnsemblBacteriaiCBH25699; CBH25699; SRM_02778.
GeneIDi8995327.
KEGGisrm:SRM_02778.
PATRICi35493502. VBISalRub49863_2726.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP565814 Genomic DNA. Translation: CBH25699.1 .
RefSeqi WP_013062740.1. NC_014032.1.
YP_003572651.1. NC_014032.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBH25699 ; CBH25699 ; SRM_02778 .
GeneIDi 8995327.
KEGGi srm:SRM_02778.
PATRICi 35493502. VBISalRub49863_2726.

Phylogenomic databases

HOGENOMi HOG000076390.
KOi K00857.

Enzyme and pathway databases

BioCyci SRUB761659:GHC6-2816-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Fine-scale evolution: genomic, phenotypic and ecological differentiation in two coexisting Salinibacter ruber strains."
    Pena A., Teeling H., Huerta-Cepas J., Santos F., Yarza P., Brito-Echeverria J., Lucio M., Schmitt-Kopplin P., Meseguer I., Schenowitz C., Dossat C., Barbe V., Dopazo J., Rossello-Mora R., Schuler M., Glockner F.O., Amann R., Gabaldon T., Anton J.
    ISME J. -:0-0(2010)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: M8.
  2. "Genome sequence of Salinibacter ruber M8."
    Genoscope
    Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: M8Imported.

Entry informationi

Entry nameiD5HCE4_SALRM
AccessioniPrimary (citable) accession number: D5HCE4
Entry historyi
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: November 26, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3