Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

D5HCE4

- D5HCE4_SALRM

UniProt

D5HCE4 - D5HCE4_SALRM

Protein

Thymidine kinase

Gene

tdk

Organism
Salinibacter ruber (strain M8)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (15 Jun 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei110 – 1101Proton acceptorUniRule annotation
    Metal bindingi166 – 1661ZincUniRule annotation
    Metal bindingi169 – 1691ZincUniRule annotation
    Metal bindingi198 – 1981ZincUniRule annotation
    Metal bindingi201 – 2011ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi37 – 448ATPUniRule annotation
    Nucleotide bindingi109 – 1124ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationImported, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciSRUB761659:GHC6-2816-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotationImported
    Ordered Locus Names:SRM_02778Imported
    OrganismiSalinibacter ruber (strain M8)Imported
    Taxonomic identifieri761659 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidetes Order II. Incertae sedisRhodothermaceaeSalinibacter
    ProteomesiUP000000933: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotationSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000076390.
    KOiK00857.

    Family and domain databases

    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D5HCE4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQRLRLSPHR AALFMSALEP HIVDRDRTTG WMEVICGSMF SGKTEELIRR    50
    LRRARIARQH TRVFKPALDE RYSEDEVVSH NENSVTTTPV EAPPQIQELV 100
    QEADVVGIDE AQFFDDDLVP TCQALAEDGH RVIVVGLDTD YRAEPFDPMP 150
    QLMAVAEHVT KLHAVCVVCG APANHSQRIV PGEDRVLVGA TEAYEPRCRA 200
    CFEPEPVTVT RPRPHTEALR AVATDDADAS TNEADPEAAD AASADGTAA 249
    Length:249
    Mass (Da):27,401
    Last modified:June 15, 2010 - v1
    Checksum:iB2B328C1781EB24E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FP565814 Genomic DNA. Translation: CBH25699.1.
    RefSeqiWP_013062740.1. NC_014032.1.
    YP_003572651.1. NC_014032.1.

    Genome annotation databases

    EnsemblBacteriaiCBH25699; CBH25699; SRM_02778.
    GeneIDi8995327.
    KEGGisrm:SRM_02778.
    PATRICi35493502. VBISalRub49863_2726.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FP565814 Genomic DNA. Translation: CBH25699.1 .
    RefSeqi WP_013062740.1. NC_014032.1.
    YP_003572651.1. NC_014032.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CBH25699 ; CBH25699 ; SRM_02778 .
    GeneIDi 8995327.
    KEGGi srm:SRM_02778.
    PATRICi 35493502. VBISalRub49863_2726.

    Phylogenomic databases

    HOGENOMi HOG000076390.
    KOi K00857.

    Enzyme and pathway databases

    BioCyci SRUB761659:GHC6-2816-MONOMER.

    Family and domain databases

    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Fine-scale evolution: genomic, phenotypic and ecological differentiation in two coexisting Salinibacter ruber strains."
      Pena A., Teeling H., Huerta-Cepas J., Santos F., Yarza P., Brito-Echeverria J., Lucio M., Schmitt-Kopplin P., Meseguer I., Schenowitz C., Dossat C., Barbe V., Dopazo J., Rossello-Mora R., Schuler M., Glockner F.O., Amann R., Gabaldon T., Anton J.
      ISME J. -:0-0(2010)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: M8.
    2. "Genome sequence of Salinibacter ruber M8."
      Genoscope
      Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: M8Imported.

    Entry informationi

    Entry nameiD5HCE4_SALRM
    AccessioniPrimary (citable) accession number: D5HCE4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 15, 2010
    Last sequence update: June 15, 2010
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3