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D5HCE4

- D5HCE4_SALRM

UniProt

D5HCE4 - D5HCE4_SALRM

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Protein

Thymidine kinase

Gene
tdk, SRM_02778
Organism
Salinibacter ruber (strain M8)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei110 – 1101Proton acceptor By similarityUniRule annotation
Metal bindingi166 – 1661Zinc By similarityUniRule annotation
Metal bindingi169 – 1691Zinc By similarityUniRule annotation
Metal bindingi198 – 1981Zinc By similarityUniRule annotation
Metal bindingi201 – 2011Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi37 – 448ATP By similarityUniRule annotation
Nucleotide bindingi109 – 1124ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding, ZincUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciSRUB761659:GHC6-2816-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:SRM_02778Imported
OrganismiSalinibacter ruber (strain M8)Imported
Taxonomic identifieri761659 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidetes Order II. Incertae sedisRhodothermaceaeSalinibacter
ProteomesiUP000000933: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000076390.
KOiK00857.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D5HCE4-1 [UniParc]FASTAAdd to Basket

« Hide

MQRLRLSPHR AALFMSALEP HIVDRDRTTG WMEVICGSMF SGKTEELIRR    50
LRRARIARQH TRVFKPALDE RYSEDEVVSH NENSVTTTPV EAPPQIQELV 100
QEADVVGIDE AQFFDDDLVP TCQALAEDGH RVIVVGLDTD YRAEPFDPMP 150
QLMAVAEHVT KLHAVCVVCG APANHSQRIV PGEDRVLVGA TEAYEPRCRA 200
CFEPEPVTVT RPRPHTEALR AVATDDADAS TNEADPEAAD AASADGTAA 249
Length:249
Mass (Da):27,401
Last modified:June 15, 2010 - v1
Checksum:iB2B328C1781EB24E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FP565814 Genomic DNA. Translation: CBH25699.1.
RefSeqiWP_013062740.1. NC_014032.1.
YP_003572651.1. NC_014032.1.

Genome annotation databases

EnsemblBacteriaiCBH25699; CBH25699; SRM_02778.
GeneIDi8995327.
KEGGisrm:SRM_02778.
PATRICi35493502. VBISalRub49863_2726.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FP565814 Genomic DNA. Translation: CBH25699.1 .
RefSeqi WP_013062740.1. NC_014032.1.
YP_003572651.1. NC_014032.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBH25699 ; CBH25699 ; SRM_02778 .
GeneIDi 8995327.
KEGGi srm:SRM_02778.
PATRICi 35493502. VBISalRub49863_2726.

Phylogenomic databases

HOGENOMi HOG000076390.
KOi K00857.

Enzyme and pathway databases

BioCyci SRUB761659:GHC6-2816-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Fine-scale evolution: genomic, phenotypic and ecological differentiation in two coexisting Salinibacter ruber strains."
    Pena A., Teeling H., Huerta-Cepas J., Santos F., Yarza P., Brito-Echeverria J., Lucio M., Schmitt-Kopplin P., Meseguer I., Schenowitz C., Dossat C., Barbe V., Dopazo J., Rossello-Mora R., Schuler M., Glockner F.O., Amann R., Gabaldon T., Anton J.
    ISME J. -:0-0(2010)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: M8.
  2. "Genome sequence of Salinibacter ruber M8."
    Genoscope
    Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: M8.

Entry informationi

Entry nameiD5HCE4_SALRM
AccessioniPrimary (citable) accession number: D5HCE4
Entry historyi
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: September 3, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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