Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Alanine racemase

Gene

alr

Organism
Salinibacter ruber (strain M8)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathway:iD-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei99 – 991Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei196 – 1961SubstrateUniRule annotation
Active sitei326 – 3261Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei374 – 3741Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciSRUB761659:GHC6-671-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:SRM_00663Imported
OrganismiSalinibacter ruber (strain M8)Imported
Taxonomic identifieri761659 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidetes Order II. Incertae sedisRhodothermaceaeSalinibacter
ProteomesiUP000000933 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei99 – 991N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD5H6C9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
PhylomeDBiD5H6C9.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D5H6C9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVDSTGRGP VGCEAGGRGE HVRRAIGAGS FGNHRPGRRL SCACSLIFAR
60 70 80 90 100
SPVPFAIDRS PHTVGAAPVT ATVDLAAIQH NAGVLQERAG GADVMAIIKA
110 120 130 140 150
DAYGHGVRPV ARAAYEAGIR HYGVARLPEG VHLREAGHGG RILVLGAPAP
160 170 180 190 200
TQLPRYAEYD LDLTVPSADI AAAVVRHASP EAPLRVHVTV DTGMGRLGLA
210 220 230 240 250
PDDVPAVMTR LADAPGVRLA GLWTHFATAD APGSSFAQTQ LDRFRAVVDA
260 270 280 290 300
VDVDVEHVHA ANTGGLLTIG APTHEFDASL VRSGIALYGL AATPELSARL
310 320 330 340 350
DLRPAMRLAA RVTHLKTVPA GTPISYGAQW EAPRRTRIAT LGIGYGDGYP
360 370 380 390 400
RRCSGRASVR IGGASCPIVG TICMDMCMVD LGPPNEAPAT RVDRGDEAVL
410 420 430 440 450
FGPAGPTAYD VAQWSDTIPY EILCGVSPRV PRRHVNCTDE NGTDENGTDD
460
MRAPSRLTRP TASGG
Length:465
Mass (Da):48,585
Last modified:June 15, 2010 - v1
Checksum:i3A63DD4326E1328B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP565814 Genomic DNA. Translation: CBH23584.1.

Genome annotation databases

EnsemblBacteriaiCBH23584; CBH23584; SRM_00663.
KEGGisrm:SRM_00663.
PATRICi35489224. VBISalRub49863_0619.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP565814 Genomic DNA. Translation: CBH23584.1.

3D structure databases

ProteinModelPortaliD5H6C9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCBH23584; CBH23584; SRM_00663.
KEGGisrm:SRM_00663.
PATRICi35489224. VBISalRub49863_0619.

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
PhylomeDBiD5H6C9.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciSRUB761659:GHC6-671-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Fine-scale evolution: genomic, phenotypic and ecological differentiation in two coexisting Salinibacter ruber strains."
    Pena A., Teeling H., Huerta-Cepas J., Santos F., Yarza P., Brito-Echeverria J., Lucio M., Schmitt-Kopplin P., Meseguer I., Schenowitz C., Dossat C., Barbe V., Dopazo J., Rossello-Mora R., Schuler M., Glockner F.O., Amann R., Gabaldon T., Anton J.
    ISME J. -:0-0(2010)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: M8.
  2. "Genome sequence of Salinibacter ruber M8."
    Genoscope
    Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: M8Imported.

Entry informationi

Entry nameiD5H6C9_SALRM
AccessioniPrimary (citable) accession number: D5H6C9
Entry historyi
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: July 22, 2015
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.