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D5H6C9

- D5H6C9_SALRM

UniProt

D5H6C9 - D5H6C9_SALRM

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Protein

Alanine racemase

Gene

alr

Organism
Salinibacter ruber (strain M8)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Note: Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei99 – 991Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei196 – 1961SubstrateUniRule annotation
Active sitei326 – 3261Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei374 – 3741Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciSRUB761659:GHC6-671-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:SRM_00663Imported
OrganismiSalinibacter ruber (strain M8)Imported
Taxonomic identifieri761659 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidetes Order II. Incertae sedisRhodothermaceaeSalinibacter
ProteomesiUP000000933: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei99 – 991N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD5H6C9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
PhylomeDBiD5H6C9.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D5H6C9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPVDSTGRGP VGCEAGGRGE HVRRAIGAGS FGNHRPGRRL SCACSLIFAR
60 70 80 90 100
SPVPFAIDRS PHTVGAAPVT ATVDLAAIQH NAGVLQERAG GADVMAIIKA
110 120 130 140 150
DAYGHGVRPV ARAAYEAGIR HYGVARLPEG VHLREAGHGG RILVLGAPAP
160 170 180 190 200
TQLPRYAEYD LDLTVPSADI AAAVVRHASP EAPLRVHVTV DTGMGRLGLA
210 220 230 240 250
PDDVPAVMTR LADAPGVRLA GLWTHFATAD APGSSFAQTQ LDRFRAVVDA
260 270 280 290 300
VDVDVEHVHA ANTGGLLTIG APTHEFDASL VRSGIALYGL AATPELSARL
310 320 330 340 350
DLRPAMRLAA RVTHLKTVPA GTPISYGAQW EAPRRTRIAT LGIGYGDGYP
360 370 380 390 400
RRCSGRASVR IGGASCPIVG TICMDMCMVD LGPPNEAPAT RVDRGDEAVL
410 420 430 440 450
FGPAGPTAYD VAQWSDTIPY EILCGVSPRV PRRHVNCTDE NGTDENGTDD
460
MRAPSRLTRP TASGG
Length:465
Mass (Da):48,585
Last modified:June 15, 2010 - v1
Checksum:i3A63DD4326E1328B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP565814 Genomic DNA. Translation: CBH23584.1.
RefSeqiWP_013061103.1. NC_014032.1.
YP_003570537.1. NC_014032.1.

Genome annotation databases

EnsemblBacteriaiCBH23584; CBH23584; SRM_00663.
GeneIDi8994114.
KEGGisrm:SRM_00663.
PATRICi35489224. VBISalRub49863_0619.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP565814 Genomic DNA. Translation: CBH23584.1 .
RefSeqi WP_013061103.1. NC_014032.1.
YP_003570537.1. NC_014032.1.

3D structure databases

ProteinModelPortali D5H6C9.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBH23584 ; CBH23584 ; SRM_00663 .
GeneIDi 8994114.
KEGGi srm:SRM_00663.
PATRICi 35489224. VBISalRub49863_0619.

Phylogenomic databases

HOGENOMi HOG000031444.
KOi K01775.
PhylomeDBi D5H6C9.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci SRUB761659:GHC6-671-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Fine-scale evolution: genomic, phenotypic and ecological differentiation in two coexisting Salinibacter ruber strains."
    Pena A., Teeling H., Huerta-Cepas J., Santos F., Yarza P., Brito-Echeverria J., Lucio M., Schmitt-Kopplin P., Meseguer I., Schenowitz C., Dossat C., Barbe V., Dopazo J., Rossello-Mora R., Schuler M., Glockner F.O., Amann R., Gabaldon T., Anton J.
    ISME J. -:0-0(2010)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: M8.
  2. "Genome sequence of Salinibacter ruber M8."
    Genoscope
    Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: M8Imported.

Entry informationi

Entry nameiD5H6C9_SALRM
AccessioniPrimary (citable) accession number: D5H6C9
Entry historyi
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: November 26, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3