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D5H6C9

- D5H6C9_SALRM

UniProt

D5H6C9 - D5H6C9_SALRM

Protein

Alanine racemase

Gene

alr

Organism
Salinibacter ruber (strain M8)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 1 (15 Jun 2010)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei99 – 991Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei196 – 1961SubstrateUniRule annotation
    Active sitei326 – 3261Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei374 – 3741Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciSRUB761659:GHC6-671-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:alrImported
    Ordered Locus Names:SRM_00663Imported
    OrganismiSalinibacter ruber (strain M8)Imported
    Taxonomic identifieri761659 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidetes Order II. Incertae sedisRhodothermaceaeSalinibacter
    ProteomesiUP000000933: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei99 – 991N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD5H6C9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000031444.
    KOiK01775.
    PhylomeDBiD5H6C9.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D5H6C9-1 [UniParc]FASTAAdd to Basket

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    MPVDSTGRGP VGCEAGGRGE HVRRAIGAGS FGNHRPGRRL SCACSLIFAR    50
    SPVPFAIDRS PHTVGAAPVT ATVDLAAIQH NAGVLQERAG GADVMAIIKA 100
    DAYGHGVRPV ARAAYEAGIR HYGVARLPEG VHLREAGHGG RILVLGAPAP 150
    TQLPRYAEYD LDLTVPSADI AAAVVRHASP EAPLRVHVTV DTGMGRLGLA 200
    PDDVPAVMTR LADAPGVRLA GLWTHFATAD APGSSFAQTQ LDRFRAVVDA 250
    VDVDVEHVHA ANTGGLLTIG APTHEFDASL VRSGIALYGL AATPELSARL 300
    DLRPAMRLAA RVTHLKTVPA GTPISYGAQW EAPRRTRIAT LGIGYGDGYP 350
    RRCSGRASVR IGGASCPIVG TICMDMCMVD LGPPNEAPAT RVDRGDEAVL 400
    FGPAGPTAYD VAQWSDTIPY EILCGVSPRV PRRHVNCTDE NGTDENGTDD 450
    MRAPSRLTRP TASGG 465
    Length:465
    Mass (Da):48,585
    Last modified:June 15, 2010 - v1
    Checksum:i3A63DD4326E1328B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FP565814 Genomic DNA. Translation: CBH23584.1.
    RefSeqiWP_013061103.1. NC_014032.1.
    YP_003570537.1. NC_014032.1.

    Genome annotation databases

    EnsemblBacteriaiCBH23584; CBH23584; SRM_00663.
    GeneIDi8994114.
    KEGGisrm:SRM_00663.
    PATRICi35489224. VBISalRub49863_0619.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FP565814 Genomic DNA. Translation: CBH23584.1 .
    RefSeqi WP_013061103.1. NC_014032.1.
    YP_003570537.1. NC_014032.1.

    3D structure databases

    ProteinModelPortali D5H6C9.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CBH23584 ; CBH23584 ; SRM_00663 .
    GeneIDi 8994114.
    KEGGi srm:SRM_00663.
    PATRICi 35489224. VBISalRub49863_0619.

    Phylogenomic databases

    HOGENOMi HOG000031444.
    KOi K01775.
    PhylomeDBi D5H6C9.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci SRUB761659:GHC6-671-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Fine-scale evolution: genomic, phenotypic and ecological differentiation in two coexisting Salinibacter ruber strains."
      Pena A., Teeling H., Huerta-Cepas J., Santos F., Yarza P., Brito-Echeverria J., Lucio M., Schmitt-Kopplin P., Meseguer I., Schenowitz C., Dossat C., Barbe V., Dopazo J., Rossello-Mora R., Schuler M., Glockner F.O., Amann R., Gabaldon T., Anton J.
      ISME J. -:0-0(2010)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: M8.
    2. "Genome sequence of Salinibacter ruber M8."
      Genoscope
      Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: M8Imported.

    Entry informationi

    Entry nameiD5H6C9_SALRM
    AccessioniPrimary (citable) accession number: D5H6C9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 15, 2010
    Last sequence update: June 15, 2010
    Last modified: October 1, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3