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Protein

Dihydrofolate reductase

Gene

dfrK

Organism
Staphylococcus aureus
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.UniRule annotation

Catalytic activityi

5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH.UniRule annotation

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Dihydrofolate reductase (dhfrXII), Dihydrofolate reductase (dfrK), Dihydrofolate reductase (dfrA), Dihydrofolate reductase type 1 from Tn4003 (dfrA), Dihydrofolate reductase (dfrA), Dihydrofolate reductase (dfrK), Dihydrofolate reductase (dfrA), Dihydrofolate reductase (folA), Dihydrofolate reductase (BSZ10_04505), Dihydrofolate reductase (B9Y41_06955), Dihydrofolate reductase (dfrK), Dihydrofolate reductase (dfrA_1), Dihydrofolate reductase (dfrK), Dihydrofolate reductase (dfrA), Dihydrofolate reductase (C7J96_04650), Dihydrofolate reductase (dfrG)
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processOne-carbon metabolismUniRule annotation
LigandNADPUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00077; UER00158

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrofolate reductaseUniRule annotation (EC:1.5.1.3UniRule annotation)
Gene namesi
Name:dfrKImported
OrganismiStaphylococcus aureusImported
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 160DHFRInterPro annotationAdd BLAST159

Sequence similaritiesi

Belongs to the dihydrofolate reductase family.UniRule annotation

Family and domain databases

CDDicd00209 DHFR, 1 hit
Gene3Di3.40.430.10, 1 hit
InterProiView protein in InterPro
IPR012259 DHFR
IPR024072 DHFR-like_dom_sf
IPR017925 DHFR_CS
IPR001796 DHFR_dom
PANTHERiPTHR22778:SF16 PTHR22778:SF16, 1 hit
PfamiView protein in Pfam
PF00186 DHFR_1, 1 hit
PIRSFiPIRSF000194 DHFR, 1 hit
SUPFAMiSSF53597 SSF53597, 1 hit
PROSITEiView protein in PROSITE
PS00075 DHFR_1, 1 hit
PS51330 DHFR_2, 1 hit

Sequencei

Sequence statusi: Complete.

D5H463-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVSLIAAMD KNRVLGKEND IPWRIPKDWE YVKNTTKGYP IILGRKNLES
60 70 80 90 100
IGRALPGRRN IILTRDKGFS FNGCEIVHSI EDVFEICNNE EEIFIFGGEQ
110 120 130 140 150
IYNLFLPYVE KMYITKIHYE FEGDTFFPEV NYEEWSEVSV TQGITDEKNP
160
YTYYFHIYER KAS
Length:163
Mass (Da):19,257
Last modified:June 15, 2010 - v1
Checksum:iAC88BA646D552E2E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN812951 Genomic DNA Translation: CBL80435.1
RefSeqiWP_063844483.1, NG_047760.1

Similar proteinsi

Entry informationi

Entry nameiD5H463_STAAU
AccessioniPrimary (citable) accession number: D5H463
Entry historyiIntegrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: March 28, 2018
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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