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D5H3J5

- D5H3J5_HUMAN

UniProt

D5H3J5 - D5H3J5_HUMAN

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Protein
Submitted name: MHC class I antigen
Gene
HLA-B
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Involved in the presentation of foreign antigens to the immune system By similarity.SAAS annotations

GO - Molecular functioni

  1. peptide antigen binding Source: InterPro

GO - Biological processi

  1. antigen processing and presentation of peptide antigen via MHC class I Source: UniProtKB-KW
  2. immune response Source: InterPro
  3. positive regulation of T cell mediated cytotoxicity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Submitted name:
MHC class I antigenImported
Gene namesi
Name:HLA-BImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. MHC class I protein complex Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC ISAAS annotations

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotations

Family & Domainsi

Sequence similaritiesi

Belongs to the MHC class I family.UniRule annotation
Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotations

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Phylogenomic databases

OMAiCEGEANP.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D5H3J5-1 [UniParc]FASTAAdd to Basket

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MRVTAPRTLL LLLWGAVALT ETWAGSHSMR YFYTAMSRPG RGEPRFITVG    50
YVDDTLFVRF DSDATSPRKE PRAPWIEQEG PEYWDRETQI SKTNTQTYRE 100
NLRTALRYYN QSEAGSHIIQ RMYGCDVGPD GRLLRGYDQD AYDGKDYIAL 150
NEDLSSWTAA DTAAQITQRK WEAARVAEQD RAYLEGLCVE SLRRYLENGK 200
ETLQRADPPK THVTHHPISD HEVTLRCWAL GFYPAEITLT WQRDGEDQTQ 250
DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP 300
SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS 350
DSAQGSDVSL TA 362
Length:362
Mass (Da):40,481
Last modified:June 15, 2010 - v1
Checksum:iE45C71FDEFC628AD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HM595428 Genomic DNA. Translation: ADQ48112.1.
HQ693697 Genomic DNA. Translation: AEF97826.1.
JX196202 Genomic DNA. Translation: AFM91112.1.
JX564251 Genomic DNA. Translation: AGI65158.1.
AB774993 Genomic DNA. Translation: BAN59839.1.
FN796495 Genomic DNA. Translation: CBL53180.1.
HG794398 Genomic DNA. Translation: CDK41207.1.
HG970094 Genomic DNA. Translation: CDO58211.1.
UniGeneiHs.654404.
Hs.77961.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HM595428 Genomic DNA. Translation: ADQ48112.1 .
HQ693697 Genomic DNA. Translation: AEF97826.1 .
JX196202 Genomic DNA. Translation: AFM91112.1 .
JX564251 Genomic DNA. Translation: AGI65158.1 .
AB774993 Genomic DNA. Translation: BAN59839.1 .
FN796495 Genomic DNA. Translation: CBL53180.1 .
HG794398 Genomic DNA. Translation: CDK41207.1 .
HG970094 Genomic DNA. Translation: CDO58211.1 .
UniGenei Hs.654404.
Hs.77961.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

OMAi CEGEANP.

Miscellaneous databases

ChiTaRSi HLA-B. human.
NextBioi 35491803.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view ]
PRINTSi PR01638. MHCCLASSI.
SMARTi SM00407. IGc1. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A NEW SYNONYMOUS B*4402 ALLELE DEMONSTRATES THE RELEVANCE OF EFI STANDARD NR L1.4100: ANNEALING POSITION OF PRIMERS MUST BE DEFINED."
    Jongsma T.W., Lems S.P.M., Hepkema B.G.
    Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Hepkema B.
    Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Characterization and polymorphism analyses of HLA-B genomic full length in Chinese Han population."
    Xu Y., Deng Z., Yang B.
    Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  4. "New B*44:02 Allele Variant."
    Serov Y.A., Hommel-Berrey G.A., House K.D., Arnoff T.S., Lobashevsky A.L.
    Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  5. "New HLA class I alleles containing non-coding haplotype-specific SNPs."
    Sayer D.C., Alizadeh M., Hogan H.M., Senitzer D., Gendzekhadze K., Humphreys I.
    Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  6. "Phase-defined complete sequencing of the HLA genes by next-generation sequencing."
    Hosomichi K., Jinam T.A., Mitsunaga S., Nakaoka H., Inoue I.
    BMC Genomics 14:355-355(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  7. "The novel HLA-B*44:02:27 allele, identified by sequencing-based typing of a candidate stem-cell donor."
    van Soest M., Rosel M., de Graaff A., Zwan B., Spierings E.
    Tissue Antigens 81:230-231(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  8. "Confirmatory sequencing of HLA-B*44:02:01:01."
    McWhinnie A.J., Robinson J.
    Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Saliva collectionImported.
  9. "Confirmatory sequencing of HLA-B*44:02:01:03."
    McWhinnie A.J., Robinson J.
    Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Peripheral bloodImported.

Entry informationi

Entry nameiD5H3J5_HUMAN
AccessioniPrimary (citable) accession number: D5H3J5
Entry historyi
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: September 3, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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