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Protein
Submitted name:

MHC class I antigen

Gene

HLA-B

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in the presentation of foreign antigens to the immune system.SAAS annotation

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Submitted name:
MHC class I antigenImported
Gene namesi
Name:HLA-BImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei308 – 330HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC ISAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_500841339225 – 362Sequence analysisAdd BLAST338

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSG00000228964.

Structurei

3D structure databases

SMRiD5H3J5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 295Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST87

Sequence similaritiesi

Belongs to the MHC class I family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

OMAiLENICVQ.
OrthoDBiEOG091G09OH.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D5H3J5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVTAPRTLL LLLWGAVALT ETWAGSHSMR YFYTAMSRPG RGEPRFITVG
60 70 80 90 100
YVDDTLFVRF DSDATSPRKE PRAPWIEQEG PEYWDRETQI SKTNTQTYRE
110 120 130 140 150
NLRTALRYYN QSEAGSHIIQ RMYGCDVGPD GRLLRGYDQD AYDGKDYIAL
160 170 180 190 200
NEDLSSWTAA DTAAQITQRK WEAARVAEQD RAYLEGLCVE SLRRYLENGK
210 220 230 240 250
ETLQRADPPK THVTHHPISD HEVTLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP
310 320 330 340 350
SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS
360
DSAQGSDVSL TA
Length:362
Mass (Da):40,481
Last modified:June 15, 2010 - v1
Checksum:iE45C71FDEFC628AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM595428 Genomic DNA. Translation: ADQ48112.1.
HQ693697 Genomic DNA. Translation: AEF97826.1.
JX196202 Genomic DNA. Translation: AFM91112.1.
JX564251 Genomic DNA. Translation: AGI65158.1.
KU319293 Genomic DNA. Translation: ANG08708.1.
KU319294 Genomic DNA. Translation: ANG08709.1.
AB774993 Genomic DNA. Translation: BAN59839.1.
FN796495 Genomic DNA. Translation: CBL53180.1.
HG794398 Genomic DNA. Translation: CDK41207.1.
HG970094 Genomic DNA. Translation: CDO58211.1.
LN810112 Genomic DNA. Translation: CEO86989.1.
LN810137 Genomic DNA. Translation: CEO87014.1.
LT599208 Genomic DNA. Translation: SBW38429.1.
LT599215 Genomic DNA. Translation: SBW38436.1.
LT599224 Genomic DNA. Translation: SBW38445.1.
LT599272 Genomic DNA. Translation: SBW38493.1.
LT599283 Genomic DNA. Translation: SBW38504.1.
LT599296 Genomic DNA. Translation: SBW38517.1.
UniGeneiHs.654404.
Hs.726974.
Hs.77961.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM595428 Genomic DNA. Translation: ADQ48112.1.
HQ693697 Genomic DNA. Translation: AEF97826.1.
JX196202 Genomic DNA. Translation: AFM91112.1.
JX564251 Genomic DNA. Translation: AGI65158.1.
KU319293 Genomic DNA. Translation: ANG08708.1.
KU319294 Genomic DNA. Translation: ANG08709.1.
AB774993 Genomic DNA. Translation: BAN59839.1.
FN796495 Genomic DNA. Translation: CBL53180.1.
HG794398 Genomic DNA. Translation: CDK41207.1.
HG970094 Genomic DNA. Translation: CDO58211.1.
LN810112 Genomic DNA. Translation: CEO86989.1.
LN810137 Genomic DNA. Translation: CEO87014.1.
LT599208 Genomic DNA. Translation: SBW38429.1.
LT599215 Genomic DNA. Translation: SBW38436.1.
LT599224 Genomic DNA. Translation: SBW38445.1.
LT599272 Genomic DNA. Translation: SBW38493.1.
LT599283 Genomic DNA. Translation: SBW38504.1.
LT599296 Genomic DNA. Translation: SBW38517.1.
UniGeneiHs.654404.
Hs.726974.
Hs.77961.

3D structure databases

SMRiD5H3J5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

OMAiLENICVQ.
OrthoDBiEOG091G09OH.

Miscellaneous databases

ChiTaRSiHLA-B. human.

Gene expression databases

BgeeiENSG00000228964.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiD5H3J5_HUMAN
AccessioniPrimary (citable) accession number: D5H3J5
Entry historyi
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: November 30, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.