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D5H3J5

- D5H3J5_HUMAN

UniProt

D5H3J5 - D5H3J5_HUMAN

Protein
Submitted name:

MHC class I antigen

Gene

HLA-B

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (15 Jun 2010)
      Previous versions | rss
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    Functioni

    Involved in the presentation of foreign antigens to the immune system.SAAS annotation

    GO - Molecular functioni

    1. peptide antigen binding Source: InterPro

    GO - Biological processi

    1. antigen processing and presentation of peptide antigen via MHC class I Source: UniProtKB-KW
    2. immune response Source: InterPro
    3. positive regulation of T cell mediated cytotoxicity Source: InterPro

    Keywords - Biological processi

    Immunity

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    MHC class I antigenImported
    Gene namesi
    Name:HLA-BImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. MHC class I protein complex Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, MHC ISAAS annotation

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Structurei

    3D structure databases

    SMRiD5H3J5. Positions 25-300.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MHC class I family.UniRule annotation
    Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    OMAiCEGEANP.
    PhylomeDBiD5H3J5.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    IPR010579. MHC_I_a_C.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    PF06623. MHC_I_C. 1 hit.
    [Graphical view]
    PRINTSiPR01638. MHCCLASSI.
    SMARTiSM00407. IGc1. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D5H3J5-1 [UniParc]FASTAAdd to Basket

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    MRVTAPRTLL LLLWGAVALT ETWAGSHSMR YFYTAMSRPG RGEPRFITVG    50
    YVDDTLFVRF DSDATSPRKE PRAPWIEQEG PEYWDRETQI SKTNTQTYRE 100
    NLRTALRYYN QSEAGSHIIQ RMYGCDVGPD GRLLRGYDQD AYDGKDYIAL 150
    NEDLSSWTAA DTAAQITQRK WEAARVAEQD RAYLEGLCVE SLRRYLENGK 200
    ETLQRADPPK THVTHHPISD HEVTLRCWAL GFYPAEITLT WQRDGEDQTQ 250
    DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP 300
    SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS 350
    DSAQGSDVSL TA 362
    Length:362
    Mass (Da):40,481
    Last modified:June 15, 2010 - v1
    Checksum:iE45C71FDEFC628AD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HM595428 Genomic DNA. Translation: ADQ48112.1.
    HQ693697 Genomic DNA. Translation: AEF97826.1.
    JX196202 Genomic DNA. Translation: AFM91112.1.
    JX564251 Genomic DNA. Translation: AGI65158.1.
    AB774993 Genomic DNA. Translation: BAN59839.1.
    FN796495 Genomic DNA. Translation: CBL53180.1.
    HG794398 Genomic DNA. Translation: CDK41207.1.
    HG970094 Genomic DNA. Translation: CDO58211.1.
    UniGeneiHs.654404.
    Hs.77961.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HM595428 Genomic DNA. Translation: ADQ48112.1 .
    HQ693697 Genomic DNA. Translation: AEF97826.1 .
    JX196202 Genomic DNA. Translation: AFM91112.1 .
    JX564251 Genomic DNA. Translation: AGI65158.1 .
    AB774993 Genomic DNA. Translation: BAN59839.1 .
    FN796495 Genomic DNA. Translation: CBL53180.1 .
    HG794398 Genomic DNA. Translation: CDK41207.1 .
    HG970094 Genomic DNA. Translation: CDO58211.1 .
    UniGenei Hs.654404.
    Hs.77961.

    3D structure databases

    SMRi D5H3J5. Positions 25-300.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    OMAi CEGEANP.
    PhylomeDBi D5H3J5.

    Miscellaneous databases

    ChiTaRSi HLA-B. human.
    NextBioi 35491803.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    IPR010579. MHC_I_a_C.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    PF06623. MHC_I_C. 1 hit.
    [Graphical view ]
    PRINTSi PR01638. MHCCLASSI.
    SMARTi SM00407. IGc1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A NEW SYNONYMOUS B*4402 ALLELE DEMONSTRATES THE RELEVANCE OF EFI STANDARD NR L1.4100: ANNEALING POSITION OF PRIMERS MUST BE DEFINED."
      Jongsma T.W., Lems S.P.M., Hepkema B.G.
      Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    2. Hepkema B.
      Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    3. "Characterization and polymorphism analyses of HLA-B genomic full length in Chinese Han population."
      Xu Y., Deng Z., Yang B.
      Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    4. "New B*44:02 Allele Variant."
      Serov Y.A., Hommel-Berrey G.A., House K.D., Arnoff T.S., Lobashevsky A.L.
      Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    5. "New HLA class I alleles containing non-coding haplotype-specific SNPs."
      Sayer D.C., Alizadeh M., Hogan H.M., Senitzer D., Gendzekhadze K., Humphreys I.
      Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    6. "Phase-defined complete sequencing of the HLA genes by next-generation sequencing."
      Hosomichi K., Jinam T.A., Mitsunaga S., Nakaoka H., Inoue I.
      BMC Genomics 14:355-355(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    7. "The novel HLA-B*44:02:27 allele, identified by sequencing-based typing of a candidate stem-cell donor."
      van Soest M., Rosel M., de Graaff A., Zwan B., Spierings E.
      Tissue Antigens 81:230-231(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    8. "Confirmatory sequencing of HLA-B*44:02:01:01."
      McWhinnie A.J., Robinson J.
      Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Saliva collectionImported.
    9. "Confirmatory sequencing of HLA-B*44:02:01:03."
      McWhinnie A.J., Robinson J.
      Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Peripheral bloodImported.

    Entry informationi

    Entry nameiD5H3J5_HUMAN
    AccessioniPrimary (citable) accession number: D5H3J5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 15, 2010
    Last sequence update: June 15, 2010
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.