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Protein
Submitted name:

MHC class I antigen

Gene

HLA-B

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the presentation of foreign antigens to the immune system.SAAS annotation

GO - Biological processi

Keywordsi

Biological processImmunity

Names & Taxonomyi

Protein namesi
Submitted name:
MHC class I antigenImported
Gene namesi
Name:HLA-BImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei308 – 330HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane, MHC ISAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_501456991025 – 362Sequence analysisAdd BLAST338

Keywords - PTMi

Disulfide bondSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 295Ig-likeInterPro annotationAdd BLAST87

Sequence similaritiesi

Belongs to the MHC class I family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

OrthoDBiEOG091G09OH

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
IPR010579 MHC_I_a_C
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PF06623 MHC_I_C, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequencei

Sequence statusi: Complete.

D5H3J5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVTAPRTLL LLLWGAVALT ETWAGSHSMR YFYTAMSRPG RGEPRFITVG
60 70 80 90 100
YVDDTLFVRF DSDATSPRKE PRAPWIEQEG PEYWDRETQI SKTNTQTYRE
110 120 130 140 150
NLRTALRYYN QSEAGSHIIQ RMYGCDVGPD GRLLRGYDQD AYDGKDYIAL
160 170 180 190 200
NEDLSSWTAA DTAAQITQRK WEAARVAEQD RAYLEGLCVE SLRRYLENGK
210 220 230 240 250
ETLQRADPPK THVTHHPISD HEVTLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP
310 320 330 340 350
SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS
360
DSAQGSDVSL TA
Length:362
Mass (Da):40,481
Last modified:June 15, 2010 - v1
Checksum:iE45C71FDEFC628AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM595428 Genomic DNA Translation: ADQ48112.1
HQ693697 Genomic DNA Translation: AEF97826.1
JX196202 Genomic DNA Translation: AFM91112.1
JX564251 Genomic DNA Translation: AGI65158.1
KU319293 Genomic DNA Translation: ANG08708.1
KU319294 Genomic DNA Translation: ANG08709.1
KX707639 Genomic DNA Translation: ARB15852.1
KX707643 Genomic DNA Translation: ARB15856.1
KY486793 Genomic DNA Translation: ASE99671.1
KY419488 Genomic DNA Translation: ASU50379.1
MG450956 Genomic DNA Translation: AUQ33292.1
MG553983 Genomic DNA Translation: AUQ35640.1
MG680154 Genomic DNA Translation: AUT12115.1
MG873454 Genomic DNA Translation: AVK88306.1
AB774993 Genomic DNA Translation: BAN59839.1
FN796495 Genomic DNA Translation: CBL53180.1
HG794398 Genomic DNA Translation: CDK41207.1
HG970094 Genomic DNA Translation: CDO58211.1
LN810112 Genomic DNA Translation: CEO86989.1
LN810137 Genomic DNA Translation: CEO87014.1
LT599208 Genomic DNA Translation: SBW38429.1
LT599215 Genomic DNA Translation: SBW38436.1
LT599224 Genomic DNA Translation: SBW38445.1
LT599272 Genomic DNA Translation: SBW38493.1
LT599283 Genomic DNA Translation: SBW38504.1
LT599296 Genomic DNA Translation: SBW38517.1
LT838210 Genomic DNA Translation: SMB18745.1
LT968806 Genomic DNA Translation: SOU95338.1
LT968833 Genomic DNA Translation: SOU95365.1
UniGeneiHs.654404
Hs.726974
Hs.77961

Similar proteinsi

Entry informationi

Entry nameiD5H3J5_HUMAN
AccessioniPrimary (citable) accession number: D5H3J5
Entry historyiIntegrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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