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D5H0P0 (D5H0P0_LACCS) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047 EMBL CBL49575.1
Ordered Locus Names:LCRIS_00128 EMBL CBL49575.1
OrganismLactobacillus crispatus (strain ST1) [Complete proteome] [HAMAP] EMBL CBL49575.1
Taxonomic identifier748671 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length360 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain134 – 343210ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding169 – 22456ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2971Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3101Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3101Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3121Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
D5H0P0 [UniParc].

Last modified June 15, 2010. Version 1.
Checksum: E092F4890AD3CB51

FASTA36040,093
        10         20         30         40         50         60 
MTKKLQVGLI FGGNSSEYEV SIVSGHNIYK AIDKDKFDVH PIWITNEGYF ANEEESFKVL 

        70         80         90        100        110        120 
DDPSYQVKNP HKVNNISNLI ELENLPEIDV FFPIVHGNLG EDGVLQGLFR LMDKPFVGDD 

       130        140        150        160        170        180 
VLGAAVTMDK EFTKILAQRV GVPVADWISI KRFEYDDKKN AKLNYEKVAE KLGRDMFVKP 

       190        200        210        220        230        240 
SNQGSSVGVS HVTNADEYTA ALKEAFKYDD KVLVEKTVPG TEVETAVLGN DKPIVAGVGQ 

       250        260        270        280        290        300 
ITNAKGSFYT YENKYDDNST SKLQIPADLP QEIIDTVREN ARKVYAATEC SGMARIDSML 

       310        320        330        340        350        360 
TPGGKVVLTE VNALPGFTNI SMYPKLFEEA GVPYSELITR LIEAGMDRFD HKKTLLHKHD 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of Lactobacillus crispatus ST1."
Ojala T., Kuparinen V., Koskinen J.P., Alatalo E., Holm L., Auvinen P., Edelman S., Westerlund-Wikstrom B., Korhonen T.K., Paulin L., Kankainen M.
J. Bacteriol. 192:3547-3548(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ST1.
[2]"Genome Sequence of Lactobacillus crispatus ST1."
Ojala T., Kuparinen V., Koskinen J.P., Alatalo E., Holm L., Auvinen P., Edelman S., Westerlund-Wikstroem B., Korhonen T.K., Paulin L., Kankainen M.
Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: ST1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FN692037 Genomic DNA. Translation: CBL49575.1.
RefSeqYP_003600600.1. NC_014106.1.

3D structure databases

ProteinModelPortalD5H0P0.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCBL49575; CBL49575; LCRIS_00128.
GeneID9105891.
KEGGlcr:LCRIS_00128.
PATRIC37238995. VBILacCri149433_0120.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000011593.
KOK01921.
OMAKLAFQYD.

Enzyme and pathway databases

BioCycLCRI748671:GIX1-136-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD5H0P0_LACCS
AccessionPrimary (citable) accession number: D5H0P0
Entry history
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: June 11, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)