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D5GM60

- DAPB_TUBMM

UniProt

D5GM60 - DAPB_TUBMM

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Protein
Probable dipeptidyl-aminopeptidase B
Gene
DAPB, GSTUM_00010539001
Organism
Tuber melanosporum (strain Mel28) (Perigord black truffle)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei746 – 7461Charge relay system By similarity
Active sitei823 – 8231Charge relay system By similarity
Active sitei856 – 8561Charge relay system By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:DAPB
ORF Names:GSTUM_00010539001
OrganismiTuber melanosporum (strain Mel28) (Perigord black truffle)
Taxonomic identifieri656061 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaPezizomycetesPezizalesTuberaceaeTuber
ProteomesiUP000006911: Unassembled WGS sequence

Subcellular locationi

Vacuole membrane; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8888Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei89 – 10921Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini110 – 907798Vacuolar Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 907907Probable dipeptidyl-aminopeptidase B
PRO_0000412166Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi185 – 1851N-linked (GlcNAc...) Reviewed prediction
Glycosylationi341 – 3411N-linked (GlcNAc...) Reviewed prediction
Glycosylationi800 – 8001N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliD5GM60.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK01282.
OMAiEGFNHIA.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

D5GM60-1 [UniParc]FASTAAdd to Basket

« Hide

MYDQVPYRDT DEATPQIKND ASDSNRSSID TTSTTSLILE RLHREDPDDS    50
PGEYESSGPS QRGKPDEDDD LEIGRAARLK PMERKVRRAM YLLAFLMIGG 100
WFLALAVYVS REHFGTPDTA HDPSATATRK AGKKITLNQV MRGAWRSKTH 150
GIQWINGPHG DQDGLLLTQN SFGDGNFLEV QDVKNDSNTI VLIKDGALQG 200
SGQPVSAIKG WPSSDLKKVL VASDHEKRWR HSYNARYWIY DVEKATTEPL 250
VPSEPEARLS LATWSPKGDA IAFVKDNNVF IRQLGLDLTS EYYSVTQVTK 300
DGGPDLFYGI PDWVYEEEVF SGNSALWWSQ DGEFLAFLRT NETEVPEYPI 350
QYFVSRPSGN NPPNGLENYP ELEFIKYPKA GAPNPVVHLR FYDLKKKEDF 400
AVTVENDFPD DDRLITEVVW SDGKYLLVRE TNRESDVLRM VLIDVSARSG 450
KVVREVDISA IDGGWFEVSK NTRYIPADPA SGRPYEGYID TVIHEGYDHL 500
GYFTPLDNKD PILLTKGQWE VVDAPSAVDL KNGIVYFVAT EKSPIERHVY 550
SVKLDGSNFR PVTSTSEDGR YDVSFSKLSG YALLTYEGPG IPWQKVVGTP 600
SGDQSFVKDI EKNQGLATLA AKHELPTFHY STVNIDGFDL HVVERRPPHF 650
NKKRKYPVLF QVYGGPGSQQ VSKSFSIDFQ AYIAAGLEYI VVTVDGRGTG 700
FIGRKARVAV RGNLGYWEAH DQIETAKIWG KKGYVDKKRI AIWGWSYGGF 750
MTLKTLEQDA GRTFSYGMAV APVTDWRFYD SIYTERYMHT PQHNQEGYRN 800
ATISDTQALS KSVRFLLMHG VADDNVHMQN SLALLDKLDL ASVENYDVHV 850
FPDSDHSIYF HNANRMVYDR LEQWLIRAFN GEFLKLDGLK PIREISEPLR 900
KRNRELV 907
Length:907
Mass (Da):102,621
Last modified:June 15, 2010 - v1
Checksum:i137143AE5B685B7F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN430352 Genomic DNA. Translation: CAZ85603.1.
RefSeqiXP_002841412.1. XM_002841366.1.
UniGeneiTme.1126.

Genome annotation databases

EnsemblFungiiCAZ85603; CAZ85603; GSTUM_00010539001.
GeneIDi9187387.
KEGGitml:GSTUM_00010539001.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN430352 Genomic DNA. Translation: CAZ85603.1 .
RefSeqi XP_002841412.1. XM_002841366.1.
UniGenei Tme.1126.

3D structure databases

ProteinModelPortali D5GM60.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S09.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CAZ85603 ; CAZ85603 ; GSTUM_00010539001 .
GeneIDi 9187387.
KEGGi tml:GSTUM_00010539001.

Phylogenomic databases

KOi K01282.
OMAi EGFNHIA.
OrthoDBi EOG72VHFG.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Mel28.

Entry informationi

Entry nameiDAPB_TUBMM
AccessioniPrimary (citable) accession number: D5GM60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: June 15, 2010
Last modified: June 11, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi