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D5GM60 (DAPB_TUBMM) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable dipeptidyl-aminopeptidase B

Short name=DPAP B
EC=3.4.14.5
Gene names
Name:DAPB
ORF Names:GSTUM_00010539001
OrganismTuber melanosporum (strain Mel28) (Perigord black truffle) [Reference proteome]
Taxonomic identifier656061 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaPezizomycetesPezizalesTuberaceaeTuber

Protein attributes

Sequence length907 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activity

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Subcellular location

Vacuole membrane; Single-pass type II membrane protein By similarity. Note: Lysosome-like vacuoles By similarity.

Sequence similarities

Belongs to the peptidase S9B family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 907907Probable dipeptidyl-aminopeptidase B
PRO_0000412166

Regions

Topological domain1 – 8888Cytoplasmic Potential
Transmembrane89 – 10921Helical; Signal-anchor for type II membrane protein; Potential
Topological domain110 – 907798Vacuolar Potential

Sites

Active site7461Charge relay system By similarity
Active site8231Charge relay system By similarity
Active site8561Charge relay system By similarity

Amino acid modifications

Glycosylation1851N-linked (GlcNAc...) Potential
Glycosylation3411N-linked (GlcNAc...) Potential
Glycosylation8001N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
D5GM60 [UniParc].

Last modified June 15, 2010. Version 1.
Checksum: 137143AE5B685B7F

FASTA907102,621
        10         20         30         40         50         60 
MYDQVPYRDT DEATPQIKND ASDSNRSSID TTSTTSLILE RLHREDPDDS PGEYESSGPS 

        70         80         90        100        110        120 
QRGKPDEDDD LEIGRAARLK PMERKVRRAM YLLAFLMIGG WFLALAVYVS REHFGTPDTA 

       130        140        150        160        170        180 
HDPSATATRK AGKKITLNQV MRGAWRSKTH GIQWINGPHG DQDGLLLTQN SFGDGNFLEV 

       190        200        210        220        230        240 
QDVKNDSNTI VLIKDGALQG SGQPVSAIKG WPSSDLKKVL VASDHEKRWR HSYNARYWIY 

       250        260        270        280        290        300 
DVEKATTEPL VPSEPEARLS LATWSPKGDA IAFVKDNNVF IRQLGLDLTS EYYSVTQVTK 

       310        320        330        340        350        360 
DGGPDLFYGI PDWVYEEEVF SGNSALWWSQ DGEFLAFLRT NETEVPEYPI QYFVSRPSGN 

       370        380        390        400        410        420 
NPPNGLENYP ELEFIKYPKA GAPNPVVHLR FYDLKKKEDF AVTVENDFPD DDRLITEVVW 

       430        440        450        460        470        480 
SDGKYLLVRE TNRESDVLRM VLIDVSARSG KVVREVDISA IDGGWFEVSK NTRYIPADPA 

       490        500        510        520        530        540 
SGRPYEGYID TVIHEGYDHL GYFTPLDNKD PILLTKGQWE VVDAPSAVDL KNGIVYFVAT 

       550        560        570        580        590        600 
EKSPIERHVY SVKLDGSNFR PVTSTSEDGR YDVSFSKLSG YALLTYEGPG IPWQKVVGTP 

       610        620        630        640        650        660 
SGDQSFVKDI EKNQGLATLA AKHELPTFHY STVNIDGFDL HVVERRPPHF NKKRKYPVLF 

       670        680        690        700        710        720 
QVYGGPGSQQ VSKSFSIDFQ AYIAAGLEYI VVTVDGRGTG FIGRKARVAV RGNLGYWEAH 

       730        740        750        760        770        780 
DQIETAKIWG KKGYVDKKRI AIWGWSYGGF MTLKTLEQDA GRTFSYGMAV APVTDWRFYD 

       790        800        810        820        830        840 
SIYTERYMHT PQHNQEGYRN ATISDTQALS KSVRFLLMHG VADDNVHMQN SLALLDKLDL 

       850        860        870        880        890        900 
ASVENYDVHV FPDSDHSIYF HNANRMVYDR LEQWLIRAFN GEFLKLDGLK PIREISEPLR 


KRNRELV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FN430352 Genomic DNA. Translation: CAZ85603.1.
RefSeqXP_002841412.1. XM_002841366.1.
UniGeneTme.1126.

3D structure databases

ProteinModelPortalD5GM60.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS09.006.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCAZ85603; CAZ85603; GSTUM_00010539001.
GeneID9187387.
KEGGtml:GSTUM_00010539001.

Phylogenomic databases

KOK01282.
OMARASHEEM.
OrthoDBEOG72VHFG.

Family and domain databases

Gene3D2.140.10.30. 1 hit.
InterProIPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPB_TUBMM
AccessionPrimary (citable) accession number: D5GM60
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: June 15, 2010
Last modified: April 16, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries