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D5GM60

- DAPB_TUBMM

UniProt

D5GM60 - DAPB_TUBMM

Protein

Probable dipeptidyl-aminopeptidase B

Gene

DAPB

Organism
Tuber melanosporum (strain Mel28) (Perigord black truffle)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 20 (01 Oct 2014)
      Sequence version 1 (15 Jun 2010)
      Previous versions | rss
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    Functioni

    Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

    Catalytic activityi

    Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei746 – 7461Charge relay systemBy similarity
    Active sitei823 – 8231Charge relay systemBy similarity
    Active sitei856 – 8561Charge relay systemBy similarity

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-KW
    2. serine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS09.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
    Short name:
    DPAP B
    Gene namesi
    Name:DAPB
    ORF Names:GSTUM_00010539001
    OrganismiTuber melanosporum (strain Mel28) (Perigord black truffle)
    Taxonomic identifieri656061 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaPezizomycetesPezizalesTuberaceaeTuber
    ProteomesiUP000006911: Unassembled WGS sequence

    Subcellular locationi

    Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
    Note: Lysosome-like vacuoles.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. vacuolar membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 907907Probable dipeptidyl-aminopeptidase BPRO_0000412166Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi341 – 3411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi800 – 8001N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliD5GM60.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 8888CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini110 – 907798VacuolarSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei89 – 10921Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S9B family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    KOiK01282.
    OMAiEGFNHIA.
    OrthoDBiEOG72VHFG.

    Family and domain databases

    Gene3Di2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view]
    PfamiPF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    D5GM60-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYDQVPYRDT DEATPQIKND ASDSNRSSID TTSTTSLILE RLHREDPDDS    50
    PGEYESSGPS QRGKPDEDDD LEIGRAARLK PMERKVRRAM YLLAFLMIGG 100
    WFLALAVYVS REHFGTPDTA HDPSATATRK AGKKITLNQV MRGAWRSKTH 150
    GIQWINGPHG DQDGLLLTQN SFGDGNFLEV QDVKNDSNTI VLIKDGALQG 200
    SGQPVSAIKG WPSSDLKKVL VASDHEKRWR HSYNARYWIY DVEKATTEPL 250
    VPSEPEARLS LATWSPKGDA IAFVKDNNVF IRQLGLDLTS EYYSVTQVTK 300
    DGGPDLFYGI PDWVYEEEVF SGNSALWWSQ DGEFLAFLRT NETEVPEYPI 350
    QYFVSRPSGN NPPNGLENYP ELEFIKYPKA GAPNPVVHLR FYDLKKKEDF 400
    AVTVENDFPD DDRLITEVVW SDGKYLLVRE TNRESDVLRM VLIDVSARSG 450
    KVVREVDISA IDGGWFEVSK NTRYIPADPA SGRPYEGYID TVIHEGYDHL 500
    GYFTPLDNKD PILLTKGQWE VVDAPSAVDL KNGIVYFVAT EKSPIERHVY 550
    SVKLDGSNFR PVTSTSEDGR YDVSFSKLSG YALLTYEGPG IPWQKVVGTP 600
    SGDQSFVKDI EKNQGLATLA AKHELPTFHY STVNIDGFDL HVVERRPPHF 650
    NKKRKYPVLF QVYGGPGSQQ VSKSFSIDFQ AYIAAGLEYI VVTVDGRGTG 700
    FIGRKARVAV RGNLGYWEAH DQIETAKIWG KKGYVDKKRI AIWGWSYGGF 750
    MTLKTLEQDA GRTFSYGMAV APVTDWRFYD SIYTERYMHT PQHNQEGYRN 800
    ATISDTQALS KSVRFLLMHG VADDNVHMQN SLALLDKLDL ASVENYDVHV 850
    FPDSDHSIYF HNANRMVYDR LEQWLIRAFN GEFLKLDGLK PIREISEPLR 900
    KRNRELV 907
    Length:907
    Mass (Da):102,621
    Last modified:June 15, 2010 - v1
    Checksum:i137143AE5B685B7F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FN430352 Genomic DNA. Translation: CAZ85603.1.
    RefSeqiXP_002841412.1. XM_002841366.1.
    UniGeneiTme.1126.

    Genome annotation databases

    EnsemblFungiiCAZ85603; CAZ85603; GSTUM_00010539001.
    GeneIDi9187387.
    KEGGitml:GSTUM_00010539001.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FN430352 Genomic DNA. Translation: CAZ85603.1 .
    RefSeqi XP_002841412.1. XM_002841366.1.
    UniGenei Tme.1126.

    3D structure databases

    ProteinModelPortali D5GM60.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S09.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CAZ85603 ; CAZ85603 ; GSTUM_00010539001 .
    GeneIDi 9187387.
    KEGGi tml:GSTUM_00010539001.

    Phylogenomic databases

    KOi K01282.
    OMAi EGFNHIA.
    OrthoDBi EOG72VHFG.

    Family and domain databases

    Gene3Di 2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view ]
    Pfami PF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Mel28.

    Entry informationi

    Entry nameiDAPB_TUBMM
    AccessioniPrimary (citable) accession number: D5GM60
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: June 15, 2010
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3