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Protein

Histone-lysine N-methyltransferase, H3 lysine-4 specific

Gene

GSTUM_00009579001

Organism
Tuber melanosporum (strain Mel28) (Perigord black truffle)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].UniRule annotationSAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionChromatin regulatorUniRule annotation, MethyltransferaseUniRule annotationSAAS annotation, RNA-bindingPROSITE-ProRule annotation, Transferase
LigandS-adenosyl-L-methionineUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-4 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Gene namesi
ORF Names:GSTUM_00009579001Imported
OrganismiTuber melanosporum (strain Mel28) (Perigord black truffle)Imported
Taxonomic identifieri656061 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaPezizomycetesPezizalesTuberaceaeTuber
Proteomesi
  • UP000006911 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

ChromosomeUniRule annotation, NucleusUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Component of the COMPASS (Set1C) complex.UniRule annotation

Protein-protein interaction databases

STRINGi39416.CAZ85029

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini232 – 318RRMInterPro annotationAdd BLAST87
Domaini1058 – 1175SETInterPro annotationAdd BLAST118
Domaini1184 – 1200Post-SETInterPro annotationAdd BLAST17

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili17 – 37Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

InParanoidiD5GKI6
KOiK11422
OrthoDBiEOG092C3T9B

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR024657 COMPASS_Set1_N-SET
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR003616 Post-SET_dom
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR017111 Set1
IPR024636 SET_assoc
IPR001214 SET_dom
PANTHERiPTHR22884:SF462 PTHR22884:SF462, 3 hits
PfamiView protein in Pfam
PF11764 N-SET, 1 hit
PF00076 RRM_1, 1 hit
PF00856 SET, 1 hit
PF11767 SET_assoc, 1 hit
PIRSFiPIRSF037104 Histone_H3-K4_mtfrase_Set1_fun, 2 hits
SMARTiView protein in SMART
SM01291 N-SET, 1 hit
SM00508 PostSET, 1 hit
SM00360 RRM, 1 hit
SM00317 SET, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50868 POST_SET, 1 hit
PS50102 RRM, 1 hit
PS51572 SAM_MT43_1, 1 hit
PS50280 SET, 1 hit

Sequencei

Sequence statusi: Complete.

D5GKI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRAGYADFF PAAPSVLAEK EKKRAQAERQ DRRARNVPDD YDRESNAISV
60 70 80 90 100
SDPGHIHSSS CAPISVGVSL PSGHLVTTST LTPTTTSSSP PPPLLSPSAG
110 120 130 140 150
TTAKGDYPPN KLAAQSTSAR EPYPLPPPPI PPPLAPLTPK GTPPAIKSDP
160 170 180 190 200
SRRNWKVKYD PFLEKKSTTR KSREPILRWD GEGITTPVTD PRLEVGRYTD
210 220 230 240 250
GPKTGKKRLR SQGLYRTRWK WDENYIGPGP PSQILITGLS PLTTETEISM
260 270 280 290 300
HFRPHGDIQT LEIRIDPATG GSLGICSIIY RDGPRSRSPA HEAAKRAAQE
310 320 330 340 350
VNGSRVGIQR VRVELDRDGL KCKKLTGRIL EEKRRKEAEA EKNRLKQPLN
360 370 380 390 400
ISYGELGSRP RSPSARGSSP SRRDSRIDGR SDDRSRDQRP TPAPRPDNYR
410 420 430 440 450
ALDHVGRLPY IFITSRCIPG DERYVRHLNG RLKNFGLKDI LWDRTGFYVV
460 470 480 490 500
FWERRDMERC FKVCDGDRLF SYTMIMEKHP GSNRSPSPPP VARPELRKMG
510 520 530 540 550
PNELVVEATN ALMKDMKLVL MKDLRKRLAA PTIYDSLEVG RFNKRRKVEE
560 570 580 590 600
EEVQGITAGS HQVLAVSLEA SIRSPTTLLP TLALKSTEKL TSAVAKSALQ
610 620 630 640 650
KPTALPRFKK RILTKAEDSS TPEASPLLHG SRTRLSKADA RPLAHRLNQY
660 670 680 690 700
NSDAGSDDES TITENRPVSR GSRALSLDTG DDDSVSVALS ANEGYRKRKR
710 720 730 740 750
SVGPTSKLRD TAVSTDDEDH SLEKDDGSQG LHDLKKPRID HPRPYEDGEV
760 770 780 790 800
FMGDEVDEEP AVATPHRTST TTPQLKPITK NKSRTIESDS EYYEDEMVFT
810 820 830 840 850
KADPKDESEL VNVLDDEDDR GPEIEIPNRT TLSREPRKRI KTTESRTNRD
860 870 880 890 900
LLAVPSFDAD EEKHDSEMAG MDIEVSWGVS TTEGPMVTVQ DDPDAILDID
910 920 930 940 950
SLQNLVKDAE DFKFLAQALA AVEPADLGNV QAWAYKEKQL KVAQKQSIAR
960 970 980 990 1000
SQEKIEGFYR PNPTGCARTE GYRRVPEAEK SMYLPHRLQL AAKVKSAANK
1010 1020 1030 1040 1050
IPEVTAAAVT NPTKNPSSTS RMNRVNNRRL VVGLNNQKQM LSSDADVMRF
1060 1070 1080 1090 1100
NQLKKRKKPV KFARSAIHNW GLYAMENISA GDMIIEYVGE IIRQQVADMR
1110 1120 1130 1140 1150
EKKYLKSGIG SSYLFRIDDT TVIDATKAGG IARFINHSCT PNCTAKIIKV
1160 1170 1180 1190 1200
EGSKRIVIYA LRDIRENEEL TYDYKFEREL ESEERIPCLC GSSGCKGFLN
Length:1,200
Mass (Da):133,979
Last modified:June 15, 2010 - v1
Checksum:i31B3F9519764CA6B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN430339 Genomic DNA Translation: CAZ85029.1
RefSeqiXP_002840838.1, XM_002840792.1
UniGeneiTme.1693

Genome annotation databases

EnsemblFungiiCAZ85029; CAZ85029; GSTUM_00009579001
GeneIDi9184690
KEGGitml:GSTUM_00009579001

Entry informationi

Entry nameiD5GKI6_TUBMM
AccessioniPrimary (citable) accession number: D5GKI6
Entry historyiIntegrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: March 28, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health