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D5GKI6 (D5GKI6_TUBMM) Unreviewed, UniProtKB/TrEMBL

Last modified March 19, 2014. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase, H3 lysine-4 specific PIRNR PIRNR037104

EC=2.1.1.43 PIRNR PIRNR037104
Gene names
ORF Names:GSTUM_00009579001 EMBL CAZ85029.1
OrganismTuber melanosporum (strain Mel28) (Perigord black truffle) [Reference proteome]
Taxonomic identifier656061 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaPezizomycetesPezizalesTuberaceaeTuber

Protein attributes

Sequence length1200 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation By similarity. PIRNR PIRNR037104

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. PIRNR PIRNR037104 SAAS SAAS001214

Subunit structure

Component of the COMPASS (Set1C) complex By similarity. PIRNR PIRNR037104

Subcellular location

Nucleus By similarity PIRNR PIRNR037104.

Sequence similarities

Contains 1 post-SET domain. RuleBase RU004541

Contains SET domain. SAAS SAAS001214

Contains post-SET domain. SAAS SAAS001214

Sequences

Sequence LengthMass (Da)Tools
D5GKI6 [UniParc].

Last modified June 15, 2010. Version 1.
Checksum: 31B3F9519764CA6B

FASTA1,200133,979
        10         20         30         40         50         60 
MSRAGYADFF PAAPSVLAEK EKKRAQAERQ DRRARNVPDD YDRESNAISV SDPGHIHSSS 

        70         80         90        100        110        120 
CAPISVGVSL PSGHLVTTST LTPTTTSSSP PPPLLSPSAG TTAKGDYPPN KLAAQSTSAR 

       130        140        150        160        170        180 
EPYPLPPPPI PPPLAPLTPK GTPPAIKSDP SRRNWKVKYD PFLEKKSTTR KSREPILRWD 

       190        200        210        220        230        240 
GEGITTPVTD PRLEVGRYTD GPKTGKKRLR SQGLYRTRWK WDENYIGPGP PSQILITGLS 

       250        260        270        280        290        300 
PLTTETEISM HFRPHGDIQT LEIRIDPATG GSLGICSIIY RDGPRSRSPA HEAAKRAAQE 

       310        320        330        340        350        360 
VNGSRVGIQR VRVELDRDGL KCKKLTGRIL EEKRRKEAEA EKNRLKQPLN ISYGELGSRP 

       370        380        390        400        410        420 
RSPSARGSSP SRRDSRIDGR SDDRSRDQRP TPAPRPDNYR ALDHVGRLPY IFITSRCIPG 

       430        440        450        460        470        480 
DERYVRHLNG RLKNFGLKDI LWDRTGFYVV FWERRDMERC FKVCDGDRLF SYTMIMEKHP 

       490        500        510        520        530        540 
GSNRSPSPPP VARPELRKMG PNELVVEATN ALMKDMKLVL MKDLRKRLAA PTIYDSLEVG 

       550        560        570        580        590        600 
RFNKRRKVEE EEVQGITAGS HQVLAVSLEA SIRSPTTLLP TLALKSTEKL TSAVAKSALQ 

       610        620        630        640        650        660 
KPTALPRFKK RILTKAEDSS TPEASPLLHG SRTRLSKADA RPLAHRLNQY NSDAGSDDES 

       670        680        690        700        710        720 
TITENRPVSR GSRALSLDTG DDDSVSVALS ANEGYRKRKR SVGPTSKLRD TAVSTDDEDH 

       730        740        750        760        770        780 
SLEKDDGSQG LHDLKKPRID HPRPYEDGEV FMGDEVDEEP AVATPHRTST TTPQLKPITK 

       790        800        810        820        830        840 
NKSRTIESDS EYYEDEMVFT KADPKDESEL VNVLDDEDDR GPEIEIPNRT TLSREPRKRI 

       850        860        870        880        890        900 
KTTESRTNRD LLAVPSFDAD EEKHDSEMAG MDIEVSWGVS TTEGPMVTVQ DDPDAILDID 

       910        920        930        940        950        960 
SLQNLVKDAE DFKFLAQALA AVEPADLGNV QAWAYKEKQL KVAQKQSIAR SQEKIEGFYR 

       970        980        990       1000       1010       1020 
PNPTGCARTE GYRRVPEAEK SMYLPHRLQL AAKVKSAANK IPEVTAAAVT NPTKNPSSTS 

      1030       1040       1050       1060       1070       1080 
RMNRVNNRRL VVGLNNQKQM LSSDADVMRF NQLKKRKKPV KFARSAIHNW GLYAMENISA 

      1090       1100       1110       1120       1130       1140 
GDMIIEYVGE IIRQQVADMR EKKYLKSGIG SSYLFRIDDT TVIDATKAGG IARFINHSCT 

      1150       1160       1170       1180       1190       1200 
PNCTAKIIKV EGSKRIVIYA LRDIRENEEL TYDYKFEREL ESEERIPCLC GSSGCKGFLN 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FN430339 Genomic DNA. Translation: CAZ85029.1.
RefSeqXP_002840838.1. XM_002840792.1.
UniGeneTme.1693.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCAZ85029; CAZ85029; GSTUM_00009579001.
GeneID9184690.
KEGGtml:GSTUM_00009579001.

Phylogenomic databases

KOK11422.
OrthoDBEOG7P8PH3.

Family and domain databases

Gene3D3.30.70.330. 1 hit.
InterProIPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR015722. Histone-lysine_MeTfrase.
IPR012677. Nucleotide-bd_a/b_plait.
IPR003616. Post-SET_dom.
IPR000504. RRM_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view]
PANTHERPTHR22884:SF10. PTHR22884:SF10. 1 hit.
PfamPF11764. N-SET. 1 hit.
PF00076. RRM_1. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view]
PIRSFPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTSM00508. PostSET. 1 hit.
SM00360. RRM. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEPS50868. POST_SET. 1 hit.
PS50102. RRM. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD5GKI6_TUBMM
AccessionPrimary (citable) accession number: D5GKI6
Entry history
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: March 19, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)