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D5GKI6

- D5GKI6_TUBMM

UniProt

D5GKI6 - D5GKI6_TUBMM

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Protein

Histone-lysine N-methyltransferase, H3 lysine-4 specific

Gene

GSTUM_00009579001

Organism
Tuber melanosporum (strain Mel28) (Perigord black truffle)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotationSAAS annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
  2. nucleic acid binding Source: InterPro
  3. nucleotide binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-4 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Gene namesi
ORF Names:GSTUM_00009579001Imported
OrganismiTuber melanosporum (strain Mel28) (Perigord black truffle)Imported
Taxonomic identifieri656061 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaPezizomycetesPezizalesTuberaceaeTuber
ProteomesiUP000006911: Unassembled WGS sequence

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. chromosome Source: UniProtKB-KW
  2. Set1C/COMPASS complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

ChromosomeUniRule annotation, NucleusUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Component of the COMPASS (Set1C) complex.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Contains 1 post-SET domain.UniRule annotation
Contains SET domain.SAAS annotation
Contains post-SET domain.SAAS annotation

Phylogenomic databases

InParanoidiD5GKI6.
KOiK11422.
OrthoDBiEOG7P8PH3.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR012677. Nucleotide-bd_a/b_plait.
IPR003616. Post-SET_dom.
IPR000504. RRM_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view]
PfamiPF11764. N-SET. 1 hit.
PF00076. RRM_1. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view]
PIRSFiPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTiSM00508. PostSET. 1 hit.
SM00360. RRM. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS50102. RRM. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D5GKI6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRAGYADFF PAAPSVLAEK EKKRAQAERQ DRRARNVPDD YDRESNAISV
60 70 80 90 100
SDPGHIHSSS CAPISVGVSL PSGHLVTTST LTPTTTSSSP PPPLLSPSAG
110 120 130 140 150
TTAKGDYPPN KLAAQSTSAR EPYPLPPPPI PPPLAPLTPK GTPPAIKSDP
160 170 180 190 200
SRRNWKVKYD PFLEKKSTTR KSREPILRWD GEGITTPVTD PRLEVGRYTD
210 220 230 240 250
GPKTGKKRLR SQGLYRTRWK WDENYIGPGP PSQILITGLS PLTTETEISM
260 270 280 290 300
HFRPHGDIQT LEIRIDPATG GSLGICSIIY RDGPRSRSPA HEAAKRAAQE
310 320 330 340 350
VNGSRVGIQR VRVELDRDGL KCKKLTGRIL EEKRRKEAEA EKNRLKQPLN
360 370 380 390 400
ISYGELGSRP RSPSARGSSP SRRDSRIDGR SDDRSRDQRP TPAPRPDNYR
410 420 430 440 450
ALDHVGRLPY IFITSRCIPG DERYVRHLNG RLKNFGLKDI LWDRTGFYVV
460 470 480 490 500
FWERRDMERC FKVCDGDRLF SYTMIMEKHP GSNRSPSPPP VARPELRKMG
510 520 530 540 550
PNELVVEATN ALMKDMKLVL MKDLRKRLAA PTIYDSLEVG RFNKRRKVEE
560 570 580 590 600
EEVQGITAGS HQVLAVSLEA SIRSPTTLLP TLALKSTEKL TSAVAKSALQ
610 620 630 640 650
KPTALPRFKK RILTKAEDSS TPEASPLLHG SRTRLSKADA RPLAHRLNQY
660 670 680 690 700
NSDAGSDDES TITENRPVSR GSRALSLDTG DDDSVSVALS ANEGYRKRKR
710 720 730 740 750
SVGPTSKLRD TAVSTDDEDH SLEKDDGSQG LHDLKKPRID HPRPYEDGEV
760 770 780 790 800
FMGDEVDEEP AVATPHRTST TTPQLKPITK NKSRTIESDS EYYEDEMVFT
810 820 830 840 850
KADPKDESEL VNVLDDEDDR GPEIEIPNRT TLSREPRKRI KTTESRTNRD
860 870 880 890 900
LLAVPSFDAD EEKHDSEMAG MDIEVSWGVS TTEGPMVTVQ DDPDAILDID
910 920 930 940 950
SLQNLVKDAE DFKFLAQALA AVEPADLGNV QAWAYKEKQL KVAQKQSIAR
960 970 980 990 1000
SQEKIEGFYR PNPTGCARTE GYRRVPEAEK SMYLPHRLQL AAKVKSAANK
1010 1020 1030 1040 1050
IPEVTAAAVT NPTKNPSSTS RMNRVNNRRL VVGLNNQKQM LSSDADVMRF
1060 1070 1080 1090 1100
NQLKKRKKPV KFARSAIHNW GLYAMENISA GDMIIEYVGE IIRQQVADMR
1110 1120 1130 1140 1150
EKKYLKSGIG SSYLFRIDDT TVIDATKAGG IARFINHSCT PNCTAKIIKV
1160 1170 1180 1190 1200
EGSKRIVIYA LRDIRENEEL TYDYKFEREL ESEERIPCLC GSSGCKGFLN
Length:1,200
Mass (Da):133,979
Last modified:June 15, 2010 - v1
Checksum:i31B3F9519764CA6B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN430339 Genomic DNA. Translation: CAZ85029.1.
RefSeqiXP_002840838.1. XM_002840792.1.
UniGeneiTme.1693.

Genome annotation databases

EnsemblFungiiCAZ85029; CAZ85029; GSTUM_00009579001.
GeneIDi9184690.
KEGGitml:GSTUM_00009579001.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN430339 Genomic DNA. Translation: CAZ85029.1 .
RefSeqi XP_002840838.1. XM_002840792.1.
UniGenei Tme.1693.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CAZ85029 ; CAZ85029 ; GSTUM_00009579001 .
GeneIDi 9184690.
KEGGi tml:GSTUM_00009579001.

Phylogenomic databases

InParanoidi D5GKI6.
KOi K11422.
OrthoDBi EOG7P8PH3.

Family and domain databases

Gene3Di 3.30.70.330. 1 hit.
InterProi IPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR012677. Nucleotide-bd_a/b_plait.
IPR003616. Post-SET_dom.
IPR000504. RRM_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF11764. N-SET. 1 hit.
PF00076. RRM_1. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view ]
PIRSFi PIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTi SM00508. PostSET. 1 hit.
SM00360. RRM. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS50868. POST_SET. 1 hit.
PS50102. RRM. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Mel28Imported.

Entry informationi

Entry nameiD5GKI6_TUBMM
AccessioniPrimary (citable) accession number: D5GKI6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: October 29, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3