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D5GKI6

- D5GKI6_TUBMM

UniProt

D5GKI6 - D5GKI6_TUBMM

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Protein

Histone-lysine N-methyltransferase, H3 lysine-4 specific

Gene
GSTUM_00009579001
Organism
Tuber melanosporum (strain Mel28) (Perigord black truffle)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotationSAAS annotations

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
  2. nucleic acid binding Source: InterPro
  3. nucleotide binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotationSAAS annotations, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotationSAAS annotations

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-4 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Gene namesi
ORF Names:GSTUM_00009579001Imported
OrganismiTuber melanosporum (strain Mel28) (Perigord black truffle)
Taxonomic identifieri656061 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaPezizomycetesPezizalesTuberaceaeTuber
ProteomesiUP000006911: Unassembled WGS sequence

Subcellular locationi

Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. chromosome Source: UniProtKB-KW
  2. Set1C/COMPASS complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

ChromosomeUniRule annotation, NucleusUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Component of the COMPASS (Set1C) complex By similarity.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Contains 1 post-SET domain.UniRule annotation
Contains SET domain.SAAS annotations
Contains post-SET domain.SAAS annotations

Phylogenomic databases

KOiK11422.
OrthoDBiEOG7P8PH3.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR012677. Nucleotide-bd_a/b_plait.
IPR003616. Post-SET_dom.
IPR000504. RRM_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view]
PfamiPF11764. N-SET. 1 hit.
PF00076. RRM_1. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view]
PIRSFiPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTiSM00508. PostSET. 1 hit.
SM00360. RRM. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS50102. RRM. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D5GKI6-1 [UniParc]FASTAAdd to Basket

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MSRAGYADFF PAAPSVLAEK EKKRAQAERQ DRRARNVPDD YDRESNAISV     50
SDPGHIHSSS CAPISVGVSL PSGHLVTTST LTPTTTSSSP PPPLLSPSAG 100
TTAKGDYPPN KLAAQSTSAR EPYPLPPPPI PPPLAPLTPK GTPPAIKSDP 150
SRRNWKVKYD PFLEKKSTTR KSREPILRWD GEGITTPVTD PRLEVGRYTD 200
GPKTGKKRLR SQGLYRTRWK WDENYIGPGP PSQILITGLS PLTTETEISM 250
HFRPHGDIQT LEIRIDPATG GSLGICSIIY RDGPRSRSPA HEAAKRAAQE 300
VNGSRVGIQR VRVELDRDGL KCKKLTGRIL EEKRRKEAEA EKNRLKQPLN 350
ISYGELGSRP RSPSARGSSP SRRDSRIDGR SDDRSRDQRP TPAPRPDNYR 400
ALDHVGRLPY IFITSRCIPG DERYVRHLNG RLKNFGLKDI LWDRTGFYVV 450
FWERRDMERC FKVCDGDRLF SYTMIMEKHP GSNRSPSPPP VARPELRKMG 500
PNELVVEATN ALMKDMKLVL MKDLRKRLAA PTIYDSLEVG RFNKRRKVEE 550
EEVQGITAGS HQVLAVSLEA SIRSPTTLLP TLALKSTEKL TSAVAKSALQ 600
KPTALPRFKK RILTKAEDSS TPEASPLLHG SRTRLSKADA RPLAHRLNQY 650
NSDAGSDDES TITENRPVSR GSRALSLDTG DDDSVSVALS ANEGYRKRKR 700
SVGPTSKLRD TAVSTDDEDH SLEKDDGSQG LHDLKKPRID HPRPYEDGEV 750
FMGDEVDEEP AVATPHRTST TTPQLKPITK NKSRTIESDS EYYEDEMVFT 800
KADPKDESEL VNVLDDEDDR GPEIEIPNRT TLSREPRKRI KTTESRTNRD 850
LLAVPSFDAD EEKHDSEMAG MDIEVSWGVS TTEGPMVTVQ DDPDAILDID 900
SLQNLVKDAE DFKFLAQALA AVEPADLGNV QAWAYKEKQL KVAQKQSIAR 950
SQEKIEGFYR PNPTGCARTE GYRRVPEAEK SMYLPHRLQL AAKVKSAANK 1000
IPEVTAAAVT NPTKNPSSTS RMNRVNNRRL VVGLNNQKQM LSSDADVMRF 1050
NQLKKRKKPV KFARSAIHNW GLYAMENISA GDMIIEYVGE IIRQQVADMR 1100
EKKYLKSGIG SSYLFRIDDT TVIDATKAGG IARFINHSCT PNCTAKIIKV 1150
EGSKRIVIYA LRDIRENEEL TYDYKFEREL ESEERIPCLC GSSGCKGFLN 1200
Length:1,200
Mass (Da):133,979
Last modified:June 15, 2010 - v1
Checksum:i31B3F9519764CA6B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN430339 Genomic DNA. Translation: CAZ85029.1.
RefSeqiXP_002840838.1. XM_002840792.1.
UniGeneiTme.1693.

Genome annotation databases

EnsemblFungiiCAZ85029; CAZ85029; GSTUM_00009579001.
GeneIDi9184690.
KEGGitml:GSTUM_00009579001.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN430339 Genomic DNA. Translation: CAZ85029.1 .
RefSeqi XP_002840838.1. XM_002840792.1.
UniGenei Tme.1693.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CAZ85029 ; CAZ85029 ; GSTUM_00009579001 .
GeneIDi 9184690.
KEGGi tml:GSTUM_00009579001.

Phylogenomic databases

KOi K11422.
OrthoDBi EOG7P8PH3.

Family and domain databases

Gene3Di 3.30.70.330. 1 hit.
InterProi IPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR012677. Nucleotide-bd_a/b_plait.
IPR003616. Post-SET_dom.
IPR000504. RRM_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF11764. N-SET. 1 hit.
PF00076. RRM_1. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view ]
PIRSFi PIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTi SM00508. PostSET. 1 hit.
SM00360. RRM. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS50868. POST_SET. 1 hit.
PS50102. RRM. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Mel28.

Entry informationi

Entry nameiD5GKI6_TUBMM
AccessioniPrimary (citable) accession number: D5GKI6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: May 14, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3