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D5GHA6

- D5GHA6_TUBMM

UniProt

D5GHA6 - D5GHA6_TUBMM

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Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

GSTUM_00007723001

Organism
Tuber melanosporum (strain Mel28) (Perigord black truffle)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei226 – 2261S-adenosyl-L-methionineUniRule annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Alternative name(s):
Histone H3-K79 methyltransferaseUniRule annotation
Gene namesi
ORF Names:GSTUM_00007723001Imported
OrganismiTuber melanosporum (strain Mel28) (Perigord black truffle)Imported
Taxonomic identifieri656061 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaPezizomycetesPezizalesTuberaceaeTuber
ProteomesiUP000006911: Unassembled WGS sequence

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni177 – 1804S-adenosyl-L-methionine bindingUniRule annotation
Regioni200 – 20910S-adenosyl-L-methionine bindingUniRule annotation
Regioni262 – 2632S-adenosyl-L-methionine bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.UniRule annotation

Phylogenomic databases

InParanoidiD5GHA6.
KOiK11427.
OMAiATSIHIT.
OrthoDBiEOG7KH9VN.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021162. Histone_H3-K79_MeTrfase_fungi.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
PIRSFiPIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D5GHA6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIANMGIREG GKGPSRIFRK TDQKLLSRGI STSDLDSINP RLTAFRYELV
60 70 80 90 100
RLAEPDEFSP DLDILSTAEH VATYLLTPPE SDKLLTGTLS GSSGGIVYNM
110 120 130 140 150
RKAIRNEKAQ DFLENLNKYN NLIAKYRRDG TIKANIARMK SLPFPLVEHI
160 170 180 190 200
LSQAYARTVA PEVESLKDYE AFTSNVYGEL LPNFTTKLFR ESGLGLGKVF
210 220 230 240 250
VDLGSGTGNV VLHAALETGC EAYGCEIMKN ATRLADRQKV EFAARCRMWG
260 270 280 290 300
INPGKFRLEK GDFLESARIA EALKRADVVL VNNYVFDSEL NQRLLNLFLD
310 320 330 340 350
LKEGARILSL KPFVPINHVI TTRNAENPVS RLRVEEKEYF SGSVSWTDTG
360 370
GKYYVQTVDG SMLREFLASD RSDRRRR
Length:377
Mass (Da):42,350
Last modified:June 15, 2010 - v1
Checksum:i93AD00FDD4C668CE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN430308 Genomic DNA. Translation: CAZ83858.1.
RefSeqiXP_002839667.1. XM_002839621.1.

Genome annotation databases

EnsemblFungiiCAZ83858; CAZ83858; GSTUM_00007723001.
GeneIDi9182563.
KEGGitml:GSTUM_00007723001.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN430308 Genomic DNA. Translation: CAZ83858.1 .
RefSeqi XP_002839667.1. XM_002839621.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CAZ83858 ; CAZ83858 ; GSTUM_00007723001 .
GeneIDi 9182563.
KEGGi tml:GSTUM_00007723001.

Phylogenomic databases

InParanoidi D5GHA6.
KOi K11427.
OMAi ATSIHIT.
OrthoDBi EOG7KH9VN.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021162. Histone_H3-K79_MeTrfase_fungi.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF08123. DOT1. 1 hit.
[Graphical view ]
PIRSFi PIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51569. DOT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Mel28Imported.

Entry informationi

Entry nameiD5GHA6_TUBMM
AccessioniPrimary (citable) accession number: D5GHA6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: October 29, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3