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D5GHA6 (D5GHA6_TUBMM) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specific PIRNR PIRNR017570

EC=2.1.1.43 PIRNR PIRNR017570
Alternative name(s):
Histone H3-K79 methyltransferase PIRNR PIRNR017570
Gene names
ORF Names:GSTUM_00007723001 EMBL CAZ83858.1
OrganismTuber melanosporum (strain Mel28) (Perigord black truffle) [Reference proteome]
Taxonomic identifier656061 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaPezizomycetesPezizalesTuberaceaeTuber

Protein attributes

Sequence length377 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones By similarity. PIRNR PIRNR017570

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. PIRNR PIRNR017570

Subcellular location

Nucleus By similarity PIRNR PIRNR017570.

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family. PIRNR PIRNR017570

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region177 – 1804S-adenosyl-L-methionine binding By similarity PIRSR PIRSR017570-1
Region200 – 20910S-adenosyl-L-methionine binding By similarity PIRSR PIRSR017570-1
Region262 – 2632S-adenosyl-L-methionine binding By similarity PIRSR PIRSR017570-1

Sites

Binding site2261S-adenosyl-L-methionine By similarity PIRSR PIRSR017570-1

Sequences

Sequence LengthMass (Da)Tools
D5GHA6 [UniParc].

Last modified June 15, 2010. Version 1.
Checksum: 93AD00FDD4C668CE

FASTA37742,350
        10         20         30         40         50         60 
MIANMGIREG GKGPSRIFRK TDQKLLSRGI STSDLDSINP RLTAFRYELV RLAEPDEFSP 

        70         80         90        100        110        120 
DLDILSTAEH VATYLLTPPE SDKLLTGTLS GSSGGIVYNM RKAIRNEKAQ DFLENLNKYN 

       130        140        150        160        170        180 
NLIAKYRRDG TIKANIARMK SLPFPLVEHI LSQAYARTVA PEVESLKDYE AFTSNVYGEL 

       190        200        210        220        230        240 
LPNFTTKLFR ESGLGLGKVF VDLGSGTGNV VLHAALETGC EAYGCEIMKN ATRLADRQKV 

       250        260        270        280        290        300 
EFAARCRMWG INPGKFRLEK GDFLESARIA EALKRADVVL VNNYVFDSEL NQRLLNLFLD 

       310        320        330        340        350        360 
LKEGARILSL KPFVPINHVI TTRNAENPVS RLRVEEKEYF SGSVSWTDTG GKYYVQTVDG 

       370 
SMLREFLASD RSDRRRR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FN430308 Genomic DNA. Translation: CAZ83858.1.
RefSeqXP_002839667.1. XM_002839621.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCAZ83858; CAZ83858; GSTUM_00007723001.
GeneID9182563.
KEGGtml:GSTUM_00007723001.

Phylogenomic databases

KOK11427.
OMAATSIHIT.
OrthoDBEOG7KH9VN.

Family and domain databases

InterProIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021162. Histone_H3-K79_MeTrfase_fungi.
[Graphical view]
PfamPF08123. DOT1. 1 hit.
[Graphical view]
PIRSFPIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
PROSITEPS51569. DOT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD5GHA6_TUBMM
AccessionPrimary (citable) accession number: D5GHA6
Entry history
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: April 16, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)