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D5GHA6

- D5GHA6_TUBMM

UniProt

D5GHA6 - D5GHA6_TUBMM

Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

GSTUM_00007723001

Organism
Tuber melanosporum (strain Mel28) (Perigord black truffle)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (15 Jun 2010)
      Previous versions | rss
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    Functioni

    Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei226 – 2261S-adenosyl-L-methionineUniRule annotation

    GO - Molecular functioni

    1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotation

    Keywords - Ligandi

    S-adenosyl-L-methionineUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
    Alternative name(s):
    Histone H3-K79 methyltransferaseUniRule annotation
    Gene namesi
    ORF Names:GSTUM_00007723001Imported
    OrganismiTuber melanosporum (strain Mel28) (Perigord black truffle)Imported
    Taxonomic identifieri656061 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaPezizomycetesPezizalesTuberaceaeTuber
    ProteomesiUP000006911: Unassembled WGS sequence

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    NucleusUniRule annotation

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni177 – 1804S-adenosyl-L-methionine bindingUniRule annotation
    Regioni200 – 20910S-adenosyl-L-methionine bindingUniRule annotation
    Regioni262 – 2632S-adenosyl-L-methionine bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.UniRule annotation

    Phylogenomic databases

    KOiK11427.
    OMAiATSIHIT.
    OrthoDBiEOG7KH9VN.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR013110. DOT1.
    IPR025789. Histone_H3-K79_MeTrfase.
    IPR021162. Histone_H3-K79_MeTrfase_fungi.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF08123. DOT1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51569. DOT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D5GHA6-1 [UniParc]FASTAAdd to Basket

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    MIANMGIREG GKGPSRIFRK TDQKLLSRGI STSDLDSINP RLTAFRYELV    50
    RLAEPDEFSP DLDILSTAEH VATYLLTPPE SDKLLTGTLS GSSGGIVYNM 100
    RKAIRNEKAQ DFLENLNKYN NLIAKYRRDG TIKANIARMK SLPFPLVEHI 150
    LSQAYARTVA PEVESLKDYE AFTSNVYGEL LPNFTTKLFR ESGLGLGKVF 200
    VDLGSGTGNV VLHAALETGC EAYGCEIMKN ATRLADRQKV EFAARCRMWG 250
    INPGKFRLEK GDFLESARIA EALKRADVVL VNNYVFDSEL NQRLLNLFLD 300
    LKEGARILSL KPFVPINHVI TTRNAENPVS RLRVEEKEYF SGSVSWTDTG 350
    GKYYVQTVDG SMLREFLASD RSDRRRR 377
    Length:377
    Mass (Da):42,350
    Last modified:June 15, 2010 - v1
    Checksum:i93AD00FDD4C668CE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FN430308 Genomic DNA. Translation: CAZ83858.1.
    RefSeqiXP_002839667.1. XM_002839621.1.

    Genome annotation databases

    EnsemblFungiiCAZ83858; CAZ83858; GSTUM_00007723001.
    GeneIDi9182563.
    KEGGitml:GSTUM_00007723001.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FN430308 Genomic DNA. Translation: CAZ83858.1 .
    RefSeqi XP_002839667.1. XM_002839621.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CAZ83858 ; CAZ83858 ; GSTUM_00007723001 .
    GeneIDi 9182563.
    KEGGi tml:GSTUM_00007723001.

    Phylogenomic databases

    KOi K11427.
    OMAi ATSIHIT.
    OrthoDBi EOG7KH9VN.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR013110. DOT1.
    IPR025789. Histone_H3-K79_MeTrfase.
    IPR021162. Histone_H3-K79_MeTrfase_fungi.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF08123. DOT1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51569. DOT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Mel28Imported.

    Entry informationi

    Entry nameiD5GHA6_TUBMM
    AccessioniPrimary (citable) accession number: D5GHA6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 15, 2010
    Last sequence update: June 15, 2010
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3