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D5G4B1

- KEX1_TUBMM

UniProt

D5G4B1 - KEX1_TUBMM

Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Tuber melanosporum (strain Mel28) (Perigord black truffle)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 20 (01 Oct 2014)
      Sequence version 1 (15 Jun 2010)
      Previous versions | rss
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    Functioni

    Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.By similarity

    Catalytic activityi

    Preferential release of a C-terminal arginine or lysine residue.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei182 – 1821By similarity
    Active sitei381 – 3811By similarity
    Active sitei445 – 4451By similarity

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Keywords - Biological processi

    Apoptosis

    Protein family/group databases

    MEROPSiS10.007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
    Alternative name(s):
    Carboxypeptidase D
    Gene namesi
    Name:KEX1
    ORF Names:GSTUM_00004029001
    OrganismiTuber melanosporum (strain Mel28) (Perigord black truffle)
    Taxonomic identifieri656061 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaPezizomycetesPezizalesTuberaceaeTuber
    ProteomesiUP000006911: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 625601Pheromone-processing carboxypeptidase KEX1PRO_0000411948Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi434 – 4341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi442 – 4421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi494 – 4941N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 516492LumenalSequence AnalysisAdd
    BLAST
    Topological domaini538 – 62588CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei517 – 53721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    KOiK01288.
    OMAiDMCLNIY.
    OrthoDBiEOG7TJ3SJ.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
    PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    D5G4B1-1 [UniParc]FASTAAdd to Basket

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    MRLAASSLLL GAAASLLSSA TALAVRSDNP GSSAGYFVRS LPGQPPGPLI    50
    KMHAGHIEVD HATNGNLFFW HFQNKHIANR QRTVIWLNGG PGCSSMDGAL 100
    MEVGPYRLKD DHTLAENEGS WHEFANLLFV DQPVGTGFSY VNTDSYLTEL 150
    TQMSDHFIKF LTKFFELFPE YESDDIYLSG ESYAGQHIPY IADAILKRNA 200
    DASIKWNVKG LLIGNGWIDP SNQYLSYLPF AYESGIVEKG SPIADQIEKQ 250
    VAVCVKTIAE KGRHHVDLNQ CEQILQDILA KTKHHKDGKE VCWNMYDVRL 300
    EDTYPSCGMN WPPDLSSLTP YLRRKDVLQA LHVNPDKTAG WTECAGAVSS 350
    SFRALKSKPS VELLPDLLKE MPILLFSGNK DLICNHIGTE ELIHNMEWNG 400
    GKGFELDGAP GTWAPREDWV FEDEPAGIYQ SARNLTYVLI YNSSHMVPFD 450
    FSRRTRDMLD RFMEVDIGKI GGTPADSVIG GEKAPITSVG GTPNSTAAVE 500
    KEKERVDQAR WAAYYRSGEV ALVLVASAAA IWGIFIWRQR HRRRGRRGSY 550
    AGLGGLKMTG GSRDRLADGR ESFDEDELRD LTVASPMFER DRDLEAAEAR 600
    RYSLGGVSDD ESDDEGRIEK RPSVG 625
    Length:625
    Mass (Da):69,432
    Last modified:June 15, 2010 - v1
    Checksum:iB5055DB7C13107F9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FN429986 Genomic DNA. Translation: CAZ79354.1.
    RefSeqiXP_002835233.1. XM_002835187.1.
    UniGeneiTme.7187.

    Genome annotation databases

    EnsemblFungiiCAZ79354; CAZ79354; GSTUM_00004029001.
    GeneIDi9184979.
    KEGGitml:GSTUM_00004029001.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FN429986 Genomic DNA. Translation: CAZ79354.1 .
    RefSeqi XP_002835233.1. XM_002835187.1.
    UniGenei Tme.7187.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S10.007.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CAZ79354 ; CAZ79354 ; GSTUM_00004029001 .
    GeneIDi 9184979.
    KEGGi tml:GSTUM_00004029001.

    Phylogenomic databases

    KOi K01288.
    OMAi DMCLNIY.
    OrthoDBi EOG7TJ3SJ.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
    PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Mel28.

    Entry informationi

    Entry nameiKEX1_TUBMM
    AccessioniPrimary (citable) accession number: D5G4B1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: June 15, 2010
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3