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D5G4B1

- KEX1_TUBMM

UniProt

D5G4B1 - KEX1_TUBMM

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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Tuber melanosporum (strain Mel28) (Perigord black truffle)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei182 – 1821By similarity
Active sitei381 – 3811By similarity
Active sitei445 – 4451By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:GSTUM_00004029001
OrganismiTuber melanosporum (strain Mel28) (Perigord black truffle)
Taxonomic identifieri656061 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaPezizomycetesPezizalesTuberaceaeTuber
ProteomesiUP000006911: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 625601Pheromone-processing carboxypeptidase KEX1PRO_0000411948Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi434 – 4341N-linked (GlcNAc...)Sequence Analysis
Glycosylationi442 – 4421N-linked (GlcNAc...)Sequence Analysis
Glycosylationi494 – 4941N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 516492LumenalSequence AnalysisAdd
BLAST
Topological domaini538 – 62588CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei517 – 53721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiD5G4B1.
KOiK01288.
OMAiDMCLNIY.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D5G4B1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLAASSLLL GAAASLLSSA TALAVRSDNP GSSAGYFVRS LPGQPPGPLI
60 70 80 90 100
KMHAGHIEVD HATNGNLFFW HFQNKHIANR QRTVIWLNGG PGCSSMDGAL
110 120 130 140 150
MEVGPYRLKD DHTLAENEGS WHEFANLLFV DQPVGTGFSY VNTDSYLTEL
160 170 180 190 200
TQMSDHFIKF LTKFFELFPE YESDDIYLSG ESYAGQHIPY IADAILKRNA
210 220 230 240 250
DASIKWNVKG LLIGNGWIDP SNQYLSYLPF AYESGIVEKG SPIADQIEKQ
260 270 280 290 300
VAVCVKTIAE KGRHHVDLNQ CEQILQDILA KTKHHKDGKE VCWNMYDVRL
310 320 330 340 350
EDTYPSCGMN WPPDLSSLTP YLRRKDVLQA LHVNPDKTAG WTECAGAVSS
360 370 380 390 400
SFRALKSKPS VELLPDLLKE MPILLFSGNK DLICNHIGTE ELIHNMEWNG
410 420 430 440 450
GKGFELDGAP GTWAPREDWV FEDEPAGIYQ SARNLTYVLI YNSSHMVPFD
460 470 480 490 500
FSRRTRDMLD RFMEVDIGKI GGTPADSVIG GEKAPITSVG GTPNSTAAVE
510 520 530 540 550
KEKERVDQAR WAAYYRSGEV ALVLVASAAA IWGIFIWRQR HRRRGRRGSY
560 570 580 590 600
AGLGGLKMTG GSRDRLADGR ESFDEDELRD LTVASPMFER DRDLEAAEAR
610 620
RYSLGGVSDD ESDDEGRIEK RPSVG
Length:625
Mass (Da):69,432
Last modified:June 15, 2010 - v1
Checksum:iB5055DB7C13107F9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN429986 Genomic DNA. Translation: CAZ79354.1.
RefSeqiXP_002835233.1. XM_002835187.1.
UniGeneiTme.7187.

Genome annotation databases

EnsemblFungiiCAZ79354; CAZ79354; GSTUM_00004029001.
GeneIDi9184979.
KEGGitml:GSTUM_00004029001.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN429986 Genomic DNA. Translation: CAZ79354.1 .
RefSeqi XP_002835233.1. XM_002835187.1.
UniGenei Tme.7187.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CAZ79354 ; CAZ79354 ; GSTUM_00004029001 .
GeneIDi 9184979.
KEGGi tml:GSTUM_00004029001.

Phylogenomic databases

InParanoidi D5G4B1.
KOi K01288.
OMAi DMCLNIY.
OrthoDBi EOG7TJ3SJ.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Mel28.

Entry informationi

Entry nameiKEX1_TUBMM
AccessioniPrimary (citable) accession number: D5G4B1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: June 15, 2010
Last modified: October 29, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3