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D5G4B1 (KEX1_TUBMM) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pheromone-processing carboxypeptidase KEX1

EC=3.4.16.6
Alternative name(s):
Carboxypeptidase D
Gene names
Name:KEX1
ORF Names:GSTUM_00004029001
OrganismTuber melanosporum (strain Mel28) (Perigord black truffle) [Reference proteome]
Taxonomic identifier656061 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaPezizomycetesPezizalesTuberaceaeTuber

Protein attributes

Sequence length625 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activity

Preferential release of a C-terminal arginine or lysine residue.

Subcellular location

Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentGolgi apparatus
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 625601Pheromone-processing carboxypeptidase KEX1
PRO_0000411948

Regions

Topological domain25 – 516492Lumenal Potential
Transmembrane517 – 53721Helical; Potential
Topological domain538 – 62588Cytoplasmic Potential

Sites

Active site1821 By similarity
Active site3811 By similarity
Active site4451 By similarity

Amino acid modifications

Glycosylation4341N-linked (GlcNAc...) Potential
Glycosylation4421N-linked (GlcNAc...) Potential
Glycosylation4941N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
D5G4B1 [UniParc].

Last modified June 15, 2010. Version 1.
Checksum: B5055DB7C13107F9

FASTA62569,432
        10         20         30         40         50         60 
MRLAASSLLL GAAASLLSSA TALAVRSDNP GSSAGYFVRS LPGQPPGPLI KMHAGHIEVD 

        70         80         90        100        110        120 
HATNGNLFFW HFQNKHIANR QRTVIWLNGG PGCSSMDGAL MEVGPYRLKD DHTLAENEGS 

       130        140        150        160        170        180 
WHEFANLLFV DQPVGTGFSY VNTDSYLTEL TQMSDHFIKF LTKFFELFPE YESDDIYLSG 

       190        200        210        220        230        240 
ESYAGQHIPY IADAILKRNA DASIKWNVKG LLIGNGWIDP SNQYLSYLPF AYESGIVEKG 

       250        260        270        280        290        300 
SPIADQIEKQ VAVCVKTIAE KGRHHVDLNQ CEQILQDILA KTKHHKDGKE VCWNMYDVRL 

       310        320        330        340        350        360 
EDTYPSCGMN WPPDLSSLTP YLRRKDVLQA LHVNPDKTAG WTECAGAVSS SFRALKSKPS 

       370        380        390        400        410        420 
VELLPDLLKE MPILLFSGNK DLICNHIGTE ELIHNMEWNG GKGFELDGAP GTWAPREDWV 

       430        440        450        460        470        480 
FEDEPAGIYQ SARNLTYVLI YNSSHMVPFD FSRRTRDMLD RFMEVDIGKI GGTPADSVIG 

       490        500        510        520        530        540 
GEKAPITSVG GTPNSTAAVE KEKERVDQAR WAAYYRSGEV ALVLVASAAA IWGIFIWRQR 

       550        560        570        580        590        600 
HRRRGRRGSY AGLGGLKMTG GSRDRLADGR ESFDEDELRD LTVASPMFER DRDLEAAEAR 

       610        620 
RYSLGGVSDD ESDDEGRIEK RPSVG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FN429986 Genomic DNA. Translation: CAZ79354.1.
RefSeqXP_002835233.1. XM_002835187.1.
UniGeneTme.7187.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS10.007.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCAZ79354; CAZ79354; GSTUM_00004029001.
GeneID9184979.
KEGGtml:GSTUM_00004029001.

Phylogenomic databases

KOK01288.
OMADMCLNIY.
OrthoDBEOG7TJ3SJ.

Family and domain databases

Gene3D3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
SUPFAMSSF53474. SSF53474. 1 hit.
PROSITEPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKEX1_TUBMM
AccessionPrimary (citable) accession number: D5G4B1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: June 15, 2010
Last modified: June 11, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries