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D5G4B1

- KEX1_TUBMM

UniProt

D5G4B1 - KEX1_TUBMM

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Protein

Pheromone-processing carboxypeptidase KEX1

Gene
KEX1, GSTUM_00004029001
Organism
Tuber melanosporum (strain Mel28) (Perigord black truffle)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei182 – 1821 By similarity
Active sitei381 – 3811 By similarity
Active sitei445 – 4451 By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:GSTUM_00004029001
OrganismiTuber melanosporum (strain Mel28) (Perigord black truffle)
Taxonomic identifieri656061 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaPezizomycetesPezizalesTuberaceaeTuber
ProteomesiUP000006911: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 516492Lumenal Reviewed predictionAdd
BLAST
Transmembranei517 – 53721Helical; Reviewed predictionAdd
BLAST
Topological domaini538 – 62588Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed predictionAdd
BLAST
Chaini25 – 625601Pheromone-processing carboxypeptidase KEX1PRO_0000411948Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi434 – 4341N-linked (GlcNAc...) Reviewed prediction
Glycosylationi442 – 4421N-linked (GlcNAc...) Reviewed prediction
Glycosylationi494 – 4941N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK01288.
OMAiDMCLNIY.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D5G4B1-1 [UniParc]FASTAAdd to Basket

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MRLAASSLLL GAAASLLSSA TALAVRSDNP GSSAGYFVRS LPGQPPGPLI    50
KMHAGHIEVD HATNGNLFFW HFQNKHIANR QRTVIWLNGG PGCSSMDGAL 100
MEVGPYRLKD DHTLAENEGS WHEFANLLFV DQPVGTGFSY VNTDSYLTEL 150
TQMSDHFIKF LTKFFELFPE YESDDIYLSG ESYAGQHIPY IADAILKRNA 200
DASIKWNVKG LLIGNGWIDP SNQYLSYLPF AYESGIVEKG SPIADQIEKQ 250
VAVCVKTIAE KGRHHVDLNQ CEQILQDILA KTKHHKDGKE VCWNMYDVRL 300
EDTYPSCGMN WPPDLSSLTP YLRRKDVLQA LHVNPDKTAG WTECAGAVSS 350
SFRALKSKPS VELLPDLLKE MPILLFSGNK DLICNHIGTE ELIHNMEWNG 400
GKGFELDGAP GTWAPREDWV FEDEPAGIYQ SARNLTYVLI YNSSHMVPFD 450
FSRRTRDMLD RFMEVDIGKI GGTPADSVIG GEKAPITSVG GTPNSTAAVE 500
KEKERVDQAR WAAYYRSGEV ALVLVASAAA IWGIFIWRQR HRRRGRRGSY 550
AGLGGLKMTG GSRDRLADGR ESFDEDELRD LTVASPMFER DRDLEAAEAR 600
RYSLGGVSDD ESDDEGRIEK RPSVG 625
Length:625
Mass (Da):69,432
Last modified:June 15, 2010 - v1
Checksum:iB5055DB7C13107F9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN429986 Genomic DNA. Translation: CAZ79354.1.
RefSeqiXP_002835233.1. XM_002835187.1.
UniGeneiTme.7187.

Genome annotation databases

EnsemblFungiiCAZ79354; CAZ79354; GSTUM_00004029001.
GeneIDi9184979.
KEGGitml:GSTUM_00004029001.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN429986 Genomic DNA. Translation: CAZ79354.1 .
RefSeqi XP_002835233.1. XM_002835187.1.
UniGenei Tme.7187.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CAZ79354 ; CAZ79354 ; GSTUM_00004029001 .
GeneIDi 9184979.
KEGGi tml:GSTUM_00004029001.

Phylogenomic databases

KOi K01288.
OMAi DMCLNIY.
OrthoDBi EOG7TJ3SJ.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Mel28.

Entry informationi

Entry nameiKEX1_TUBMM
AccessioniPrimary (citable) accession number: D5G4B1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: June 15, 2010
Last modified: June 11, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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