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D5EU48

- D5EU48_PRER2

UniProt

D5EU48 - D5EU48_PRER2

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Protein

Thymidine kinase

Gene

tdk

Organism
Prevotella ruminicola (strain ATCC 19189 / JCM 8958 / 23)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei93 – 931Proton acceptorUniRule annotation
Metal bindingi149 – 1491ZincUniRule annotation
Metal bindingi152 – 1521ZincUniRule annotation
Metal bindingi181 – 1811ZincUniRule annotation
Metal bindingi184 – 1841ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi20 – 278ATPUniRule annotation
Nucleotide bindingi92 – 954ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

BioCyciPRUM264731:GHX6-1805-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:PRU_1868Imported
OrganismiPrevotella ruminicola (strain ATCC 19189 / JCM 8958 / 23)Imported
Taxonomic identifieri264731 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPrevotellaceaePrevotella
ProteomesiUP000000927: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD5EU48.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076390.
KOiK00857.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

D5EU48-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIENLTGEAH RPGRIEVVCG SMFSGKTEEL IRRMRRAQFA RQKVEIFKPA
60 70 80 90 100
IDVRYSEEDV VSHDQKHIQS TPIDSPGSIL LLSSDIDVVG IDEAQFFDMG
110 120 130 140 150
IVDVCNELAN RGVRVIVAGL DMDYKGVPFG PMPALCAIAD DVTKVHAICV
160 170 180 190 200
KCGNLAYVSH RKVQSEQRVL LGETTEYEPL CRECYQKAIR EENERKDNHA
Length:200
Mass (Da):22,435
Last modified:June 15, 2010 - v1
Checksum:i76B3936E72D50FFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002006 Genomic DNA. Translation: ADE81888.1.
RefSeqiWP_013063875.1. NC_014033.1.
YP_003575152.1. NC_014033.1.

Genome annotation databases

EnsemblBacteriaiADE81888; ADE81888; PRU_1868.
GeneIDi9001142.
KEGGipru:PRU_1868.
PATRICi35497877. VBIPreRum14515_1815.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002006 Genomic DNA. Translation: ADE81888.1 .
RefSeqi WP_013063875.1. NC_014033.1.
YP_003575152.1. NC_014033.1.

3D structure databases

ProteinModelPortali D5EU48.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADE81888 ; ADE81888 ; PRU_1868 .
GeneIDi 9001142.
KEGGi pru:PRU_1868.
PATRICi 35497877. VBIPreRum14515_1815.

Phylogenomic databases

HOGENOMi HOG000076390.
KOi K00857.

Enzyme and pathway databases

BioCyci PRUM264731:GHX6-1805-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative genome analysis of Prevotella ruminicola and Prevotella bryantii: insights into their environmental niche."
    North American Consortium for Rumen Bacteria
    Purushe J., Fouts D.E., Morrison M., White B.A., Mackie R.I., Coutinho P.M., Henrissat B., Nelson K.E.
    Microb. Ecol. 60:721-729(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19189 / JCM 8958 / 23Imported.

Entry informationi

Entry nameiD5EU48_PRER2
AccessioniPrimary (citable) accession number: D5EU48
Entry historyi
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: November 26, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3