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D5EU48

- D5EU48_PRER2

UniProt

D5EU48 - D5EU48_PRER2

Protein

Thymidine kinase

Gene

tdk

Organism
Prevotella ruminicola (strain ATCC 19189 / JCM 8958 / 23)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (15 Jun 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei93 – 931Proton acceptorUniRule annotation
    Metal bindingi149 – 1491ZincUniRule annotation
    Metal bindingi152 – 1521ZincUniRule annotation
    Metal bindingi181 – 1811ZincUniRule annotation
    Metal bindingi184 – 1841ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi20 – 278ATPUniRule annotation
    Nucleotide bindingi92 – 954ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

    Enzyme and pathway databases

    BioCyciPRUM264731:GHX6-1805-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotationImported
    Ordered Locus Names:PRU_1868Imported
    OrganismiPrevotella ruminicola (strain ATCC 19189 / JCM 8958 / 23)Imported
    Taxonomic identifieri264731 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPrevotellaceaePrevotella
    ProteomesiUP000000927: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD5EU48.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000076390.
    KOiK00857.

    Family and domain databases

    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    D5EU48-1 [UniParc]FASTAAdd to Basket

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    MIENLTGEAH RPGRIEVVCG SMFSGKTEEL IRRMRRAQFA RQKVEIFKPA    50
    IDVRYSEEDV VSHDQKHIQS TPIDSPGSIL LLSSDIDVVG IDEAQFFDMG 100
    IVDVCNELAN RGVRVIVAGL DMDYKGVPFG PMPALCAIAD DVTKVHAICV 150
    KCGNLAYVSH RKVQSEQRVL LGETTEYEPL CRECYQKAIR EENERKDNHA 200
    Length:200
    Mass (Da):22,435
    Last modified:June 15, 2010 - v1
    Checksum:i76B3936E72D50FFA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002006 Genomic DNA. Translation: ADE81888.1.
    RefSeqiWP_013063875.1. NC_014033.1.
    YP_003575152.1. NC_014033.1.

    Genome annotation databases

    EnsemblBacteriaiADE81888; ADE81888; PRU_1868.
    GeneIDi9001142.
    KEGGipru:PRU_1868.
    PATRICi35497877. VBIPreRum14515_1815.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002006 Genomic DNA. Translation: ADE81888.1 .
    RefSeqi WP_013063875.1. NC_014033.1.
    YP_003575152.1. NC_014033.1.

    3D structure databases

    ProteinModelPortali D5EU48.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADE81888 ; ADE81888 ; PRU_1868 .
    GeneIDi 9001142.
    KEGGi pru:PRU_1868.
    PATRICi 35497877. VBIPreRum14515_1815.

    Phylogenomic databases

    HOGENOMi HOG000076390.
    KOi K00857.

    Enzyme and pathway databases

    BioCyci PRUM264731:GHX6-1805-MONOMER.

    Family and domain databases

    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genome analysis of Prevotella ruminicola and Prevotella bryantii: insights into their environmental niche."
      North American Consortium for Rumen Bacteria
      Purushe J., Fouts D.E., Morrison M., White B.A., Mackie R.I., Coutinho P.M., Henrissat B., Nelson K.E.
      Microb. Ecol. 60:721-729(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 19189 / JCM 8958 / 23Imported.

    Entry informationi

    Entry nameiD5EU48_PRER2
    AccessioniPrimary (citable) accession number: D5EU48
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 15, 2010
    Last sequence update: June 15, 2010
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3