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Protein

Thymidine kinase

Gene

tdk

Organism
Prevotella ruminicola (strain ATCC 19189 / JCM 8958 / 23)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei93Proton acceptorUniRule annotation1
Metal bindingi149ZincUniRule annotation1
Metal bindingi152ZincUniRule annotation1
Metal bindingi181ZincUniRule annotation1
Metal bindingi184ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi20 – 27ATPUniRule annotation8
Nucleotide bindingi92 – 95ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

BioCyciPRUM264731:G1GHW-1950-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:PRU_1868Imported
OrganismiPrevotella ruminicola (strain ATCC 19189 / JCM 8958 / 23)Imported
Taxonomic identifieri264731 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPrevotellaceaePrevotella
Proteomesi
  • UP000000927 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi264731.PRU_1868

Structurei

3D structure databases

ProteinModelPortaliD5EU48
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107T8J Bacteria
COG1435 LUCA
HOGENOMiHOG000076390
KOiK00857
OMAiKEQFGWI
OrthoDBiPOG091H0659

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

D5EU48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIENLTGEAH RPGRIEVVCG SMFSGKTEEL IRRMRRAQFA RQKVEIFKPA
60 70 80 90 100
IDVRYSEEDV VSHDQKHIQS TPIDSPGSIL LLSSDIDVVG IDEAQFFDMG
110 120 130 140 150
IVDVCNELAN RGVRVIVAGL DMDYKGVPFG PMPALCAIAD DVTKVHAICV
160 170 180 190 200
KCGNLAYVSH RKVQSEQRVL LGETTEYEPL CRECYQKAIR EENERKDNHA
Length:200
Mass (Da):22,435
Last modified:June 15, 2010 - v1
Checksum:i76B3936E72D50FFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002006 Genomic DNA Translation: ADE81888.1
RefSeqiWP_013063875.1, NC_014033.1

Genome annotation databases

EnsemblBacteriaiADE81888; ADE81888; PRU_1868
GeneIDi31501420
KEGGipru:PRU_1868

Similar proteinsi

Entry informationi

Entry nameiD5EU48_PRER2
AccessioniPrimary (citable) accession number: D5EU48
Entry historyiIntegrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: March 28, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health