Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Thymidine kinase

Gene

tdk

Organism
Prevotella ruminicola (strain ATCC 19189 / JCM 8958 / 23)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei93 – 931Proton acceptorUniRule annotation
Metal bindingi149 – 1491ZincUniRule annotation
Metal bindingi152 – 1521ZincUniRule annotation
Metal bindingi181 – 1811ZincUniRule annotation
Metal bindingi184 – 1841ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi20 – 278ATPUniRule annotation
Nucleotide bindingi92 – 954ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

BioCyciPRUM264731:GHX6-1805-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:PRU_1868Imported
OrganismiPrevotella ruminicola (strain ATCC 19189 / JCM 8958 / 23)Imported
Taxonomic identifieri264731 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPrevotellaceaePrevotella
ProteomesiUP000000927 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi264731.PRU_1868.

Structurei

3D structure databases

ProteinModelPortaliD5EU48.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076390.
KOiK00857.
OMAiVITGPMY.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

D5EU48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIENLTGEAH RPGRIEVVCG SMFSGKTEEL IRRMRRAQFA RQKVEIFKPA
60 70 80 90 100
IDVRYSEEDV VSHDQKHIQS TPIDSPGSIL LLSSDIDVVG IDEAQFFDMG
110 120 130 140 150
IVDVCNELAN RGVRVIVAGL DMDYKGVPFG PMPALCAIAD DVTKVHAICV
160 170 180 190 200
KCGNLAYVSH RKVQSEQRVL LGETTEYEPL CRECYQKAIR EENERKDNHA
Length:200
Mass (Da):22,435
Last modified:June 15, 2010 - v1
Checksum:i76B3936E72D50FFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002006 Genomic DNA. Translation: ADE81888.1.
RefSeqiWP_013063875.1. NC_014033.1.
YP_003575152.1. NC_014033.1.

Genome annotation databases

EnsemblBacteriaiADE81888; ADE81888; PRU_1868.
KEGGipru:PRU_1868.
PATRICi35497877. VBIPreRum14515_1815.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002006 Genomic DNA. Translation: ADE81888.1.
RefSeqiWP_013063875.1. NC_014033.1.
YP_003575152.1. NC_014033.1.

3D structure databases

ProteinModelPortaliD5EU48.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi264731.PRU_1868.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADE81888; ADE81888; PRU_1868.
KEGGipru:PRU_1868.
PATRICi35497877. VBIPreRum14515_1815.

Phylogenomic databases

HOGENOMiHOG000076390.
KOiK00857.
OMAiVITGPMY.

Enzyme and pathway databases

BioCyciPRUM264731:GHX6-1805-MONOMER.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Comparative genome analysis of Prevotella ruminicola and Prevotella bryantii: insights into their environmental niche."
    North American Consortium for Rumen Bacteria
    Purushe J., Fouts D.E., Morrison M., White B.A., Mackie R.I., Coutinho P.M., Henrissat B., Nelson K.E.
    Microb. Ecol. 60:721-729(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19189 / JCM 8958 / 23Imported.

Entry informationi

Entry nameiD5EU48_PRER2
AccessioniPrimary (citable) accession number: D5EU48
Entry historyi
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: June 24, 2015
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.