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Protein

4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase

Gene

kduI

Organism
Coraliomargarita akajimensis (strain DSM 45221 / IAM 15411 / JCM 23193 / KCTC 12865)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.UniRule annotationSAAS annotation

Catalytic activityi

5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate.UniRule annotationSAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation
  • Zn2+SAAS annotationNote: Binds 1 zinc ion per subunit.SAAS annotation

Pathway: pectin degradation

This protein is involved in step 4 of the subpathway that synthesizes 2-dehydro-3-deoxy-D-gluconate from pectin.UniRule annotationSAAS annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase (kduI), 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase (kduI)
  5. no protein annotated in this organism
This subpathway is part of the pathway pectin degradation, which is itself part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2-dehydro-3-deoxy-D-gluconate from pectin, the pathway pectin degradation and in Glycan metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi194 – 1941ZincUniRule annotation
Metal bindingi196 – 1961ZincUniRule annotation
Metal bindingi201 – 2011ZincUniRule annotation
Metal bindingi243 – 2431ZincUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Metal-bindingUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciCAKA583355:GI4D-823-MONOMER.
UniPathwayiUPA00545; UER00826.

Names & Taxonomyi

Protein namesi
Recommended name:
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomeraseUniRule annotation (EC:5.3.1.17UniRule annotation)
Alternative name(s):
5-keto-4-deoxyuronate isomeraseUniRule annotation
DKI isomeraseUniRule annotation
Gene namesi
Name:kduIUniRule annotation
Ordered Locus Names:Caka_0816Imported
OrganismiCoraliomargarita akajimensis (strain DSM 45221 / IAM 15411 / JCM 23193 / KCTC 12865)Imported
Taxonomic identifieri583355 [NCBI]
Taxonomic lineageiBacteriaVerrucomicrobiaOpitutaePuniceicoccalesPuniceicoccaceaeCoraliomargarita
ProteomesiUP000000925 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi583355.Caka_0816.

Structurei

3D structure databases

ProteinModelPortaliD5EQ72.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KduI family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000124379.
KOiK01815.
OMAiKNYTFIW.

Family and domain databases

Gene3Di2.60.120.500. 1 hit.
2.60.120.520. 1 hit.
HAMAPiMF_00687. KduI.
InterProiIPR007045. KduI.
IPR021120. KduI/IolB_isomerase.
IPR027447. KduI_C.
IPR027449. KduI_N.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF04962. KduI. 1 hit.
[Graphical view]
PIRSFiPIRSF006625. KduI. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.

Sequencei

Sequence statusi: Complete.

D5EQ72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESRYATGIN EYKSMNTAQL RDAFLIDQLF KEDEVHLQYC ETDRTIVGSA
60 70 80 90 100
VPTSTELALE AGSALAAEYF CERRELGILN LGASGTVQVD GETYTLDTLD
110 120 130 140 150
CLYVGRGSRD IRFISASADQ PAQFYLASYP AHTSYPTTLT KRSAANPIQL
160 170 180 190 200
GDTHNANKRT IYQYIHEGGV QSCQLVMGIT ALEDGSVWNT MPAHTHERRT
210 220 230 240 250
EVYLYFNVDE DATVFHFMGT GDETRHITVH DKQAVISPAW SIHSGSGTRN
260 270
YSFAWCMGGE NQDFSDMQGI PIQALK
Length:276
Mass (Da):30,679
Last modified:June 15, 2010 - v1
Checksum:i5276FF77617822D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001998 Genomic DNA. Translation: ADE53840.1.
RefSeqiWP_013042564.1. NC_014008.1.
YP_003548010.1. NC_014008.1.

Genome annotation databases

EnsemblBacteriaiADE53840; ADE53840; Caka_0816.
KEGGicaa:Caka_0816.
PATRICi35442220. VBICorAka2911_0794.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001998 Genomic DNA. Translation: ADE53840.1.
RefSeqiWP_013042564.1. NC_014008.1.
YP_003548010.1. NC_014008.1.

3D structure databases

ProteinModelPortaliD5EQ72.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi583355.Caka_0816.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADE53840; ADE53840; Caka_0816.
KEGGicaa:Caka_0816.
PATRICi35442220. VBICorAka2911_0794.

Phylogenomic databases

HOGENOMiHOG000124379.
KOiK01815.
OMAiKNYTFIW.

Enzyme and pathway databases

UniPathwayiUPA00545; UER00826.
BioCyciCAKA583355:GI4D-823-MONOMER.

Family and domain databases

Gene3Di2.60.120.500. 1 hit.
2.60.120.520. 1 hit.
HAMAPiMF_00687. KduI.
InterProiIPR007045. KduI.
IPR021120. KduI/IolB_isomerase.
IPR027447. KduI_C.
IPR027449. KduI_N.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF04962. KduI. 1 hit.
[Graphical view]
PIRSFiPIRSF006625. KduI. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 45221 / IAM 15411 / JCM 23193 / KCTC 12865Imported.

Entry informationi

Entry nameiD5EQ72_CORAD
AccessioniPrimary (citable) accession number: D5EQ72
Entry historyi
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: June 24, 2015
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.