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Protein
Submitted name:

Isocitrate dehydrogenase, NADP-dependent

Gene

Caka_2526

Organism
Coraliomargarita akajimensis (strain DSM 45221 / IAM 15411 / JCM 23193 / KCTC 12865)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei146 – 1461SubstrateUniRule annotation
Sitei255 – 2551Critical for catalysisUniRule annotation
Metal bindingi350 – 3501Magnesium or manganeseUniRule annotation
Sitei420 – 4201Critical for catalysisUniRule annotation
Binding sitei547 – 5471SubstrateUniRule annotation
Metal bindingi548 – 5481Magnesium or manganeseUniRule annotation
Metal bindingi552 – 5521Magnesium or manganeseUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciCAKA583355:GI4D-2571-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase, NADP-dependentImported (EC:1.1.1.42Imported)
Gene namesi
Ordered Locus Names:Caka_2526Imported
OrganismiCoraliomargarita akajimensis (strain DSM 45221 / IAM 15411 / JCM 23193 / KCTC 12865)Imported
Taxonomic identifieri583355 [NCBI]
Taxonomic lineageiBacteriaVerrucomicrobiaOpitutaePuniceicoccalesPuniceicoccaceaeCoraliomargarita
ProteomesiUP000000925 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi583355.Caka_2526.

Structurei

3D structure databases

ProteinModelPortaliD5EP32.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni133 – 1408Substrate bindingUniRule annotation

Phylogenomic databases

HOGENOMiHOG000240860.
KOiK00031.
OMAiRDSGKMW.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

D5EP32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDKEKILYT ITDEAPALAT HSLLPIISAY TAAAGVSVET RDISLSGRIL
60 70 80 90 100
ANFPDYLTED QQISDALAEL GELAKTPEAN IIKLPNISAS IPQMKAAIAE
110 120 130 140 150
LQAQGYKLPD YPEEASSDEE QSIKARYDKI KGSAVNPVLR EGNSDRRAAA
160 170 180 190 200
AVKQYAKNNP HRMGAWASDS KSVVSSMSGN DFFGNEKSVT IPEATTAKIE
210 220 230 240 250
LVTAEGVTVL KDGLALQAGE VLDGTFMSAK ALRAFLAEQV CATKEAGTLF
260 270 280 290 300
SLHMKATMMK VSDPIIFGHC VEVFYKAVFE KHADVIAELG VDVKNGLGDL
310 320 330 340 350
YAKIESLPAD KKAEIEADIA AVYATAPDIA MVDSDKGITN LHVPSDVIID
360 370 380 390 400
ASMPAAIRDS GKMWNTAGER QDANFVIPDR CYSGVYAATV EFCKQNGAFD
410 420 430 440 450
PATMGTVPNV GLMAQKAEEY GSHDKTFEIS AAGTVRVSDA AGNVLFEHAV
460 470 480 490 500
EEGDIWRACQ VKDAPIRDWV KLAVTRARAT GAPAIFWLNK ERAHDANLIA
510 520 530 540 550
KVEEYLKDHD TDGLDIRILA PVEATQVTLE RAKAGEDTIS VTGNVLRDYL
560 570 580 590 600
TDLFPILELG TSAKMLSIVP LMNGGGLFET GAGGSAPKHV QQFEKENHLR
610 620 630 640 650
WDSLGEFLAL GVSLEHLATV FNNDKAQVLA ETLDVANTKF LEENKSPSRK
660 670 680 690 700
VNELDNRGSH FYLALYWAQA LAAQGQDAEL KARFAPLADA LTSNESKIVD
710 720 730 740
ELNSAQGVAM DIAGYYRPSD ELASKAMRPS ETFNAALAAL
Length:740
Mass (Da):79,740
Last modified:June 15, 2010 - v1
Checksum:i96CCF455EAF999AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001998 Genomic DNA. Translation: ADE55542.1.
RefSeqiWP_013044264.1. NC_014008.1.

Genome annotation databases

EnsemblBacteriaiADE55542; ADE55542; Caka_2526.
KEGGicaa:Caka_2526.
PATRICi35445706. VBICorAka2911_2505.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001998 Genomic DNA. Translation: ADE55542.1.
RefSeqiWP_013044264.1. NC_014008.1.

3D structure databases

ProteinModelPortaliD5EP32.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi583355.Caka_2526.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADE55542; ADE55542; Caka_2526.
KEGGicaa:Caka_2526.
PATRICi35445706. VBICorAka2911_2505.

Phylogenomic databases

HOGENOMiHOG000240860.
KOiK00031.
OMAiRDSGKMW.

Enzyme and pathway databases

BioCyciCAKA583355:GI4D-2571-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 45221 / IAM 15411 / JCM 23193 / KCTC 12865Imported.

Entry informationi

Entry nameiD5EP32_CORAD
AccessioniPrimary (citable) accession number: D5EP32
Entry historyi
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: July 22, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.