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D5EP32

- D5EP32_CORAD

UniProt

D5EP32 - D5EP32_CORAD

Protein
Submitted name:

Isocitrate dehydrogenase, NADP-dependent

Gene

Caka_2526

Organism
Coraliomargarita akajimensis (strain DSM 45221 / IAM 15411 / JCM 23193 / KCTC 12865)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (15 Jun 2010)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei146 – 1461Substrate
    Sitei255 – 2551Critical for catalysisUniRule annotation
    Metal bindingi350 – 3501Magnesium or manganeseUniRule annotation
    Sitei420 – 4201Critical for catalysisUniRule annotation
    Binding sitei547 – 5471SubstrateUniRule annotation
    Metal bindingi548 – 5481Magnesium or manganeseUniRule annotation
    Metal bindingi552 – 5521Magnesium or manganeseUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseImported

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciCAKA583355:GI4D-2571-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Isocitrate dehydrogenase, NADP-dependentImported (EC:1.1.1.42Imported)
    Gene namesi
    Ordered Locus Names:Caka_2526Imported
    OrganismiCoraliomargarita akajimensis (strain DSM 45221 / IAM 15411 / JCM 23193 / KCTC 12865)Imported
    Taxonomic identifieri583355 [NCBI]
    Taxonomic lineageiBacteriaVerrucomicrobiaOpitutaePuniceicoccalesPuniceicoccaceaeCoraliomargarita
    ProteomesiUP000000925: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliD5EP32.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni133 – 1408Substrate binding

    Phylogenomic databases

    HOGENOMiHOG000240860.
    KOiK00031.
    OMAiEEQRIGD.

    Family and domain databases

    Gene3Di3.40.718.10. 3 hits.
    InterProiIPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PfamiPF03971. IDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    D5EP32-1 [UniParc]FASTAAdd to Basket

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    MSDKEKILYT ITDEAPALAT HSLLPIISAY TAAAGVSVET RDISLSGRIL    50
    ANFPDYLTED QQISDALAEL GELAKTPEAN IIKLPNISAS IPQMKAAIAE 100
    LQAQGYKLPD YPEEASSDEE QSIKARYDKI KGSAVNPVLR EGNSDRRAAA 150
    AVKQYAKNNP HRMGAWASDS KSVVSSMSGN DFFGNEKSVT IPEATTAKIE 200
    LVTAEGVTVL KDGLALQAGE VLDGTFMSAK ALRAFLAEQV CATKEAGTLF 250
    SLHMKATMMK VSDPIIFGHC VEVFYKAVFE KHADVIAELG VDVKNGLGDL 300
    YAKIESLPAD KKAEIEADIA AVYATAPDIA MVDSDKGITN LHVPSDVIID 350
    ASMPAAIRDS GKMWNTAGER QDANFVIPDR CYSGVYAATV EFCKQNGAFD 400
    PATMGTVPNV GLMAQKAEEY GSHDKTFEIS AAGTVRVSDA AGNVLFEHAV 450
    EEGDIWRACQ VKDAPIRDWV KLAVTRARAT GAPAIFWLNK ERAHDANLIA 500
    KVEEYLKDHD TDGLDIRILA PVEATQVTLE RAKAGEDTIS VTGNVLRDYL 550
    TDLFPILELG TSAKMLSIVP LMNGGGLFET GAGGSAPKHV QQFEKENHLR 600
    WDSLGEFLAL GVSLEHLATV FNNDKAQVLA ETLDVANTKF LEENKSPSRK 650
    VNELDNRGSH FYLALYWAQA LAAQGQDAEL KARFAPLADA LTSNESKIVD 700
    ELNSAQGVAM DIAGYYRPSD ELASKAMRPS ETFNAALAAL 740
    Length:740
    Mass (Da):79,740
    Last modified:June 15, 2010 - v1
    Checksum:i96CCF455EAF999AB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001998 Genomic DNA. Translation: ADE55542.1.
    RefSeqiWP_013044264.1. NC_014008.1.
    YP_003549712.1. NC_014008.1.

    Genome annotation databases

    EnsemblBacteriaiADE55542; ADE55542; Caka_2526.
    GeneIDi8959683.
    KEGGicaa:Caka_2526.
    PATRICi35445706. VBICorAka2911_2505.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001998 Genomic DNA. Translation: ADE55542.1 .
    RefSeqi WP_013044264.1. NC_014008.1.
    YP_003549712.1. NC_014008.1.

    3D structure databases

    ProteinModelPortali D5EP32.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADE55542 ; ADE55542 ; Caka_2526 .
    GeneIDi 8959683.
    KEGGi caa:Caka_2526.
    PATRICi 35445706. VBICorAka2911_2505.

    Phylogenomic databases

    HOGENOMi HOG000240860.
    KOi K00031.
    OMAi EEQRIGD.

    Enzyme and pathway databases

    BioCyci CAKA583355:GI4D-2571-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 3 hits.
    InterProi IPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    Pfami PF03971. IDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 45221 / IAM 15411 / JCM 23193 / KCTC 12865Imported.

    Entry informationi

    Entry nameiD5EP32_CORAD
    AccessioniPrimary (citable) accession number: D5EP32
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 15, 2010
    Last sequence update: June 15, 2010
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3