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D5EGA4

- D5EGA4_AMICL

UniProt

D5EGA4 - D5EGA4_AMICL

Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Aminobacterium colombiense (strain DSM 12261 / ALA-1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 30 (01 Oct 2014)
      Sequence version 1 (15 Jun 2010)
      Previous versions | rss
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    Functioni

    Cell wall formation.UniRule annotationSAAS annotation

    Catalytic activityi

    ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi272 – 2721Magnesium or manganese 1UniRule annotation
    Metal bindingi285 – 2851Magnesium or manganese 1UniRule annotation
    Metal bindingi285 – 2851Magnesium or manganese 2UniRule annotation
    Metal bindingi287 – 2871Magnesium or manganese 2UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi145 – 20056ATPUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. D-alanine-D-alanine ligase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP
    4. manganese ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
    2. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    LigaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciACOL572547:GHQ0-1524-MONOMER.
    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
    Alternative name(s):
    D-Ala-D-Ala ligaseUniRule annotation
    D-alanylalanine synthetaseUniRule annotation
    Gene namesi
    Name:ddlUniRule annotation
    Ordered Locus Names:Amico_1469Imported
    OrganismiAminobacterium colombiense (strain DSM 12261 / ALA-1)Imported
    Taxonomic identifieri572547 [NCBI]
    Taxonomic lineageiBacteriaSynergistetesSynergistiaSynergistalesSynergistaceaeAminobacterium
    ProteomesiUP000002366: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD5EGA4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini115 – 318204ATP-graspUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the D-alanine--D-alanine ligase family.UniRule annotation
    Contains 1 ATP-grasp domain.UniRule annotation
    Contains ATP-grasp domain.SAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000011592.
    KOiK01921.
    OMAiANDTQYR.

    Family and domain databases

    Gene3Di3.30.1490.20. 1 hit.
    3.30.470.20. 2 hits.
    3.40.50.20. 1 hit.
    HAMAPiMF_00047. Dala_Dala_lig.
    InterProiIPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR000291. D-Ala_lig_Van_CS.
    IPR005905. D_ala_D_ala.
    IPR011095. Dala_Dala_lig_C.
    IPR011127. Dala_Dala_lig_N.
    IPR016185. PreATP-grasp_dom.
    [Graphical view]
    PANTHERiPTHR23132. PTHR23132. 1 hit.
    PfamiPF07478. Dala_Dala_lig_C. 1 hit.
    PF01820. Dala_Dala_lig_N. 2 hits.
    [Graphical view]
    SUPFAMiSSF52440. SSF52440. 1 hit.
    TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
    PROSITEiPS50975. ATP_GRASP. 1 hit.
    PS00843. DALA_DALA_LIGASE_1. 1 hit.
    PS00844. DALA_DALA_LIGASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D5EGA4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLGQRNEDDI VDKKLNVAVL YGGDGPEREV SLKSGAAVVS ALEEAGFKVV    50
    PFDITDLGQL SDLRKTGHID SVFIALHGSW GEDGRVQSAL DALRLPYSGS 100
    GSLACCLSMD KAATKGLLNL FGVPTPEGVL VLKGSSFSLE KARHFAERHH 150
    SVVVKPCNGG STLGVTVVHN SQGLSDAFNE AWKYDSRCVI EKYIDGVDLA 200
    VTVWKQKGYL EALPEVMICP EKGFYDYDSK YTPGKTRYIV PAPFDPSIRS 250
    DIHQMACRAF EALSCEGYAR VDFRVEEKGT PWVLEVNTAP GMTGTSLTPK 300
    AAAAAGYDFP AFLSHVVCLS LEKKSACR 328
    Length:328
    Mass (Da):35,474
    Last modified:June 15, 2010 - v1
    Checksum:i816B35BD8C6ABC9F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001997 Genomic DNA. Translation: ADE57586.1.
    RefSeqiYP_003554310.1. NC_014011.1.

    Genome annotation databases

    EnsemblBacteriaiADE57586; ADE57586; Amico_1469.
    GeneIDi8964421.
    KEGGiaco:Amico_1469.
    PATRICi35455260. VBIAmiCol31354_1521.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001997 Genomic DNA. Translation: ADE57586.1 .
    RefSeqi YP_003554310.1. NC_014011.1.

    3D structure databases

    ProteinModelPortali D5EGA4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADE57586 ; ADE57586 ; Amico_1469 .
    GeneIDi 8964421.
    KEGGi aco:Amico_1469.
    PATRICi 35455260. VBIAmiCol31354_1521.

    Phylogenomic databases

    HOGENOMi HOG000011592.
    KOi K01921.
    OMAi ANDTQYR.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .
    BioCyci ACOL572547:GHQ0-1524-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1490.20. 1 hit.
    3.30.470.20. 2 hits.
    3.40.50.20. 1 hit.
    HAMAPi MF_00047. Dala_Dala_lig.
    InterProi IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR000291. D-Ala_lig_Van_CS.
    IPR005905. D_ala_D_ala.
    IPR011095. Dala_Dala_lig_C.
    IPR011127. Dala_Dala_lig_N.
    IPR016185. PreATP-grasp_dom.
    [Graphical view ]
    PANTHERi PTHR23132. PTHR23132. 1 hit.
    Pfami PF07478. Dala_Dala_lig_C. 1 hit.
    PF01820. Dala_Dala_lig_N. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52440. SSF52440. 1 hit.
    TIGRFAMsi TIGR01205. D_ala_D_alaTIGR. 1 hit.
    PROSITEi PS50975. ATP_GRASP. 1 hit.
    PS00843. DALA_DALA_LIGASE_1. 1 hit.
    PS00844. DALA_DALA_LIGASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 12261 / ALA-1Imported.

    Entry informationi

    Entry nameiD5EGA4_AMICL
    AccessioniPrimary (citable) accession number: D5EGA4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 15, 2010
    Last sequence update: June 15, 2010
    Last modified: October 1, 2014
    This is version 30 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3