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D5EG24

- D5EG24_AMICL

UniProt

D5EG24 - D5EG24_AMICL

Protein

Alanine racemase

Gene

Amico_1389

Organism
Aminobacterium colombiense (strain DSM 12261 / ALA-1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (15 Jun 2010)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei37 – 371Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei135 – 1351SubstrateUniRule annotation
    Active sitei264 – 2641Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei312 – 3121Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciACOL572547:GHQ0-1443-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:Amico_1389Imported
    OrganismiAminobacterium colombiense (strain DSM 12261 / ALA-1)Imported
    Taxonomic identifieri572547 [NCBI]
    Taxonomic lineageiBacteriaSynergistetesSynergistiaSynergistalesSynergistaceaeAminobacterium
    ProteomesiUP000002366: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei37 – 371N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD5EG24.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000031444.
    KOiK01775.
    OMAiPSECAGV.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D5EG24-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFLRPTRMEV NLANIQSNFK TIRRHVGAGP QIMAVVKADA YGHGAVEVAK    50
    SLIEAGCQRF AVATPDEAVV LREAGINDPI LVLGPSPYDA ASAYVKHDIS 100
    AALTDLVFAQ MMSREAVNQG KTALLHLKID TGMGRIGFLP EQIPGIIDDI 150
    LKLPGIKIEG LFTHFATADE KRLDYTNQQF ARYMKVYHFL ESKGVRVPLR 200
    HVCNSAAVLN SPEKHLDAVR PGIILYGMYP SSECIRPIEL KPTFEVKTAI 250
    AAVKEISSNS GVGYGLRYMS RGTEKIAVLP IGYGDGFSRC LSMKVPVLVH 300
    GKRVSLVGNI CMDQTMIDVT DIEDVKVGDE VVIVGRQGEE AITPEEIAPA 350
    RGTINYEIPI MFSKRVPRVY IR 372
    Length:372
    Mass (Da):40,821
    Last modified:June 15, 2010 - v1
    Checksum:i3555EB62AB553E8D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001997 Genomic DNA. Translation: ADE57506.1.
    RefSeqiYP_003554230.1. NC_014011.1.

    Genome annotation databases

    EnsemblBacteriaiADE57506; ADE57506; Amico_1389.
    GeneIDi8964340.
    KEGGiaco:Amico_1389.
    PATRICi35455102. VBIAmiCol31354_1443.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001997 Genomic DNA. Translation: ADE57506.1 .
    RefSeqi YP_003554230.1. NC_014011.1.

    3D structure databases

    ProteinModelPortali D5EG24.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADE57506 ; ADE57506 ; Amico_1389 .
    GeneIDi 8964340.
    KEGGi aco:Amico_1389.
    PATRICi 35455102. VBIAmiCol31354_1443.

    Phylogenomic databases

    HOGENOMi HOG000031444.
    KOi K01775.
    OMAi PSECAGV.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci ACOL572547:GHQ0-1443-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 12261 / ALA-1Imported.

    Entry informationi

    Entry nameiD5EG24_AMICL
    AccessioniPrimary (citable) accession number: D5EG24
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 15, 2010
    Last sequence update: June 15, 2010
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3