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D5EG24

- D5EG24_AMICL

UniProt

D5EG24 - D5EG24_AMICL

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Protein

Alanine racemase

Gene

Amico_1389

Organism
Aminobacterium colombiense (strain DSM 12261 / ALA-1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei135 – 1351SubstrateUniRule annotation
Active sitei264 – 2641Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei312 – 3121Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciACOL572547:GHQ0-1443-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Amico_1389Imported
OrganismiAminobacterium colombiense (strain DSM 12261 / ALA-1)Imported
Taxonomic identifieri572547 [NCBI]
Taxonomic lineageiBacteriaSynergistetesSynergistiaSynergistalesSynergistaceaeAminobacterium
ProteomesiUP000002366: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei37 – 371N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD5EG24.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiPSECAGV.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D5EG24-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFLRPTRMEV NLANIQSNFK TIRRHVGAGP QIMAVVKADA YGHGAVEVAK
60 70 80 90 100
SLIEAGCQRF AVATPDEAVV LREAGINDPI LVLGPSPYDA ASAYVKHDIS
110 120 130 140 150
AALTDLVFAQ MMSREAVNQG KTALLHLKID TGMGRIGFLP EQIPGIIDDI
160 170 180 190 200
LKLPGIKIEG LFTHFATADE KRLDYTNQQF ARYMKVYHFL ESKGVRVPLR
210 220 230 240 250
HVCNSAAVLN SPEKHLDAVR PGIILYGMYP SSECIRPIEL KPTFEVKTAI
260 270 280 290 300
AAVKEISSNS GVGYGLRYMS RGTEKIAVLP IGYGDGFSRC LSMKVPVLVH
310 320 330 340 350
GKRVSLVGNI CMDQTMIDVT DIEDVKVGDE VVIVGRQGEE AITPEEIAPA
360 370
RGTINYEIPI MFSKRVPRVY IR
Length:372
Mass (Da):40,821
Last modified:June 15, 2010 - v1
Checksum:i3555EB62AB553E8D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001997 Genomic DNA. Translation: ADE57506.1.
RefSeqiWP_013048769.1. NC_014011.1.
YP_003554230.1. NC_014011.1.

Genome annotation databases

EnsemblBacteriaiADE57506; ADE57506; Amico_1389.
GeneIDi8964340.
KEGGiaco:Amico_1389.
PATRICi35455102. VBIAmiCol31354_1443.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001997 Genomic DNA. Translation: ADE57506.1 .
RefSeqi WP_013048769.1. NC_014011.1.
YP_003554230.1. NC_014011.1.

3D structure databases

ProteinModelPortali D5EG24.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADE57506 ; ADE57506 ; Amico_1389 .
GeneIDi 8964340.
KEGGi aco:Amico_1389.
PATRICi 35455102. VBIAmiCol31354_1443.

Phylogenomic databases

HOGENOMi HOG000031444.
KOi K01775.
OMAi PSECAGV.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci ACOL572547:GHQ0-1443-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 12261 / ALA-1Imported.

Entry informationi

Entry nameiD5EG24_AMICL
AccessioniPrimary (citable) accession number: D5EG24
Entry historyi
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: October 29, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3