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Protein

Alanine racemase

Gene

Amico_1389

Organism
Aminobacterium colombiense (strain DSM 12261 / ALA-1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathway:iD-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (Amico_1389), Alanine racemase (Amico_0212)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei135 – 1351SubstrateUniRule annotation
Active sitei264 – 2641Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei312 – 3121Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciACOL572547:GHQ0-1443-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotationSAAS annotation (EC:5.1.1.1UniRule annotationSAAS annotation)
Gene namesi
Ordered Locus Names:Amico_1389Imported
OrganismiAminobacterium colombiense (strain DSM 12261 / ALA-1)Imported
Taxonomic identifieri572547 [NCBI]
Taxonomic lineageiBacteriaSynergistetesSynergistiaSynergistalesSynergistaceaeAminobacterium
ProteomesiUP000002366 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei37 – 371N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi572547.Amico_1389.

Structurei

3D structure databases

ProteinModelPortaliD5EG24.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiDKYRLTT.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D5EG24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLRPTRMEV NLANIQSNFK TIRRHVGAGP QIMAVVKADA YGHGAVEVAK
60 70 80 90 100
SLIEAGCQRF AVATPDEAVV LREAGINDPI LVLGPSPYDA ASAYVKHDIS
110 120 130 140 150
AALTDLVFAQ MMSREAVNQG KTALLHLKID TGMGRIGFLP EQIPGIIDDI
160 170 180 190 200
LKLPGIKIEG LFTHFATADE KRLDYTNQQF ARYMKVYHFL ESKGVRVPLR
210 220 230 240 250
HVCNSAAVLN SPEKHLDAVR PGIILYGMYP SSECIRPIEL KPTFEVKTAI
260 270 280 290 300
AAVKEISSNS GVGYGLRYMS RGTEKIAVLP IGYGDGFSRC LSMKVPVLVH
310 320 330 340 350
GKRVSLVGNI CMDQTMIDVT DIEDVKVGDE VVIVGRQGEE AITPEEIAPA
360 370
RGTINYEIPI MFSKRVPRVY IR
Length:372
Mass (Da):40,821
Last modified:June 15, 2010 - v1
Checksum:i3555EB62AB553E8D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001997 Genomic DNA. Translation: ADE57506.1.
RefSeqiWP_013048769.1. NC_014011.1.

Genome annotation databases

EnsemblBacteriaiADE57506; ADE57506; Amico_1389.
KEGGiaco:Amico_1389.
PATRICi35455102. VBIAmiCol31354_1443.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001997 Genomic DNA. Translation: ADE57506.1.
RefSeqiWP_013048769.1. NC_014011.1.

3D structure databases

ProteinModelPortaliD5EG24.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi572547.Amico_1389.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADE57506; ADE57506; Amico_1389.
KEGGiaco:Amico_1389.
PATRICi35455102. VBIAmiCol31354_1443.

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiDKYRLTT.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciACOL572547:GHQ0-1443-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 12261 / ALA-1Imported.

Entry informationi

Entry nameiD5EG24_AMICL
AccessioniPrimary (citable) accession number: D5EG24
Entry historyi
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: July 22, 2015
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.