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Protein

Alanine racemase

Gene

Amico_0212

Organism
Aminobacterium colombiense (strain DSM 12261 / ALA-1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei135 – 1351SubstrateUniRule annotation
Active sitei264 – 2641Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei313 – 3131Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciACOL572547:GHQ0-212-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Amico_0212Imported
OrganismiAminobacterium colombiense (strain DSM 12261 / ALA-1)Imported
Taxonomic identifieri572547 [NCBI]
Taxonomic lineageiBacteriaSynergistetesSynergistiaSynergistalesSynergistaceaeAminobacterium
ProteomesiUP000002366 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei37 – 371N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD5ECS6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiNANCARL.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

D5ECS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWRPTRLEV DLEKVRNNYR AIRKHVGESV RIFGVVKGDA YNLGADKIGR
60 70 80 90 100
VLADMGVDFF AVATGDEAIS LRESGIESPI LVLGPSPYGI AEEYVRLGIR
110 120 130 140 150
AAINDKGIAK ALSDASVRLQ KPAYGHVKID SGMGRIGFFP HEAADAVEEI
160 170 180 190 200
SHLPGLNLEG IFTHFAISDA RDLTYTYEQH STFVKVIGEL EKRGITFSIK
210 220 230 240 250
HCCNSGATLA LPQFVMDGVR PGQLVVGMYP SKEVVRSIAI EPVFEFKTAI
260 270 280 290 300
SAIRTVPAGK KLSYGLTYET TADERIAVIP VGYHDGYSRE LSGKGTEVLI
310 320 330 340 350
HGKRCPIVGR ICMDQALVDV SVLQNPQIGD EVVLLGKQGE ETITGDEIAD
360 370
KIGTIFTTLP NMIGKRVPRV YLNE
Length:374
Mass (Da):40,802
Last modified:June 15, 2010 - v1
Checksum:iEBADE8BFCFA1E59F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001997 Genomic DNA. Translation: ADE56358.1.
RefSeqiYP_003553082.1. NC_014011.1.

Genome annotation databases

EnsemblBacteriaiADE56358; ADE56358; Amico_0212.
KEGGiaco:Amico_0212.
PATRICi35452560. VBIAmiCol31354_0222.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001997 Genomic DNA. Translation: ADE56358.1.
RefSeqiYP_003553082.1. NC_014011.1.

3D structure databases

ProteinModelPortaliD5ECS6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADE56358; ADE56358; Amico_0212.
KEGGiaco:Amico_0212.
PATRICi35452560. VBIAmiCol31354_0222.

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiNANCARL.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciACOL572547:GHQ0-212-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 12261 / ALA-1Imported.

Entry informationi

Entry nameiD5ECS6_AMICL
AccessioniPrimary (citable) accession number: D5ECS6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: April 1, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.