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D5EBP8

- D5EBP8_METMS

UniProt

D5EBP8 - D5EBP8_METMS

Protein

DNA ligase

Gene

lig

Organism
Methanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (15 Jun 2010)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei245 – 2451ATPUniRule annotation
    Active sitei247 – 2471N6-AMP-lysine intermediateUniRule annotation
    Binding sitei252 – 2521ATPUniRule annotation
    Binding sitei267 – 2671ATPUniRule annotation
    Binding sitei297 – 2971ATPUniRule annotation
    Binding sitei335 – 3351ATPUniRule annotation
    Binding sitei412 – 4121ATPUniRule annotation
    Binding sitei418 – 4181ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMMAH547558:GHP5-1128-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:Mmah_1091Imported
    OrganismiMethanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP)Imported
    Taxonomic identifieri547558 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanohalophilus
    ProteomesiUP000001059: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliD5EBP8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000036008.
    KOiK10747.
    OMAiCTDIGEL.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D5EBP8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASFRKLVEL YEELDNSTSH MKIIELLAEH FQSLEPAEVK ITAYLALGTI    50
    GPRFEKIDLG IGDKYGIQAI SRAYNVDKEK VEIAFGNQGD LGDVASALNE 100
    RQRSSLTLNY VFQHFVQIRD ISGKGSQKRK INLLAEVLSK ARPLESRYIM 150
    RIAQGNLRLG FGEKFLLEAL ALAFTGSRDN TSKVEDTYNI CTDIGQLGES 200
    LANHGMDSLG KFSIKIGRPV QMMLASRVDT MEELNEKFSG TMAAEEKYDG 250
    ERVQVHVDGD NIKAFSRRLT YISAQFPDVI EAARESVKAE KIVLDGEIVA 300
    YRQGEFRPFQ ELMQRRRKYH VEEYVKKIPV TVFFFDVLYL NGKSLMKWSY 350
    PERRQVLEEN LVETEKVKLA GRVVSADFSR IQHFFDDCVE KGMEGIIIKS 400
    VKAKSTYRPG KRGWLWVKWK KEYIEDVRET FDLVIVGSYY GKGRRKGSFG 450
    ALLCAVLNES EKRYETLAKV GTGFKDEDFE EINDLLKKYS IEKKPVNILI 500
    DSNMQPDNYI EPAVVIEVIG SEITSSPSHT SGQENSGNGY ALRFPRFLRI 550
    RYDKGPGDAT TVEEVKHLK 569
    Length:569
    Mass (Da):64,705
    Last modified:June 15, 2010 - v1
    Checksum:iB657E9C1668A102C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001994 Genomic DNA. Translation: ADE36599.1.
    RefSeqiYP_003542244.1. NC_014002.1.

    Genome annotation databases

    EnsemblBacteriaiADE36599; ADE36599; Mmah_1091.
    GeneIDi8983258.
    KEGGimmh:Mmah_1091.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001994 Genomic DNA. Translation: ADE36599.1 .
    RefSeqi YP_003542244.1. NC_014002.1.

    3D structure databases

    ProteinModelPortali D5EBP8.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADE36599 ; ADE36599 ; Mmah_1091 .
    GeneIDi 8983258.
    KEGGi mmh:Mmah_1091.

    Phylogenomic databases

    HOGENOMi HOG000036008.
    KOi K10747.
    OMAi CTDIGEL.

    Enzyme and pathway databases

    BioCyci MMAH547558:GHP5-1128-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35705 / DSM 5219 / SLPImported.

    Entry informationi

    Entry nameiD5EBP8_METMS
    AccessioniPrimary (citable) accession number: D5EBP8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 15, 2010
    Last sequence update: June 15, 2010
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3