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D5EBP8

- D5EBP8_METMS

UniProt

D5EBP8 - D5EBP8_METMS

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Protein

DNA ligase

Gene

lig

Organism
Methanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei245 – 2451ATPUniRule annotation
Active sitei247 – 2471N6-AMP-lysine intermediateUniRule annotation
Binding sitei252 – 2521ATPUniRule annotation
Binding sitei267 – 2671ATPUniRule annotation
Binding sitei297 – 2971ATPUniRule annotation
Binding sitei335 – 3351ATPUniRule annotation
Binding sitei412 – 4121ATPUniRule annotation
Binding sitei418 – 4181ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA biosynthetic process Source: InterPro
  4. DNA ligation involved in DNA repair Source: InterPro
  5. DNA recombination Source: UniProtKB-HAMAP
  6. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAH547558:GHP5-1128-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Mmah_1091Imported
OrganismiMethanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP)Imported
Taxonomic identifieri547558 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanohalophilus
ProteomesiUP000001059: Chromosome

Structurei

3D structure databases

ProteinModelPortaliD5EBP8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000036008.
KOiK10747.
OMAiCTDIGEL.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D5EBP8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASFRKLVEL YEELDNSTSH MKIIELLAEH FQSLEPAEVK ITAYLALGTI
60 70 80 90 100
GPRFEKIDLG IGDKYGIQAI SRAYNVDKEK VEIAFGNQGD LGDVASALNE
110 120 130 140 150
RQRSSLTLNY VFQHFVQIRD ISGKGSQKRK INLLAEVLSK ARPLESRYIM
160 170 180 190 200
RIAQGNLRLG FGEKFLLEAL ALAFTGSRDN TSKVEDTYNI CTDIGQLGES
210 220 230 240 250
LANHGMDSLG KFSIKIGRPV QMMLASRVDT MEELNEKFSG TMAAEEKYDG
260 270 280 290 300
ERVQVHVDGD NIKAFSRRLT YISAQFPDVI EAARESVKAE KIVLDGEIVA
310 320 330 340 350
YRQGEFRPFQ ELMQRRRKYH VEEYVKKIPV TVFFFDVLYL NGKSLMKWSY
360 370 380 390 400
PERRQVLEEN LVETEKVKLA GRVVSADFSR IQHFFDDCVE KGMEGIIIKS
410 420 430 440 450
VKAKSTYRPG KRGWLWVKWK KEYIEDVRET FDLVIVGSYY GKGRRKGSFG
460 470 480 490 500
ALLCAVLNES EKRYETLAKV GTGFKDEDFE EINDLLKKYS IEKKPVNILI
510 520 530 540 550
DSNMQPDNYI EPAVVIEVIG SEITSSPSHT SGQENSGNGY ALRFPRFLRI
560
RYDKGPGDAT TVEEVKHLK
Length:569
Mass (Da):64,705
Last modified:June 15, 2010 - v1
Checksum:iB657E9C1668A102C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001994 Genomic DNA. Translation: ADE36599.1.
RefSeqiYP_003542244.1. NC_014002.1.

Genome annotation databases

EnsemblBacteriaiADE36599; ADE36599; Mmah_1091.
GeneIDi8983258.
KEGGimmh:Mmah_1091.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001994 Genomic DNA. Translation: ADE36599.1 .
RefSeqi YP_003542244.1. NC_014002.1.

3D structure databases

ProteinModelPortali D5EBP8.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADE36599 ; ADE36599 ; Mmah_1091 .
GeneIDi 8983258.
KEGGi mmh:Mmah_1091.

Phylogenomic databases

HOGENOMi HOG000036008.
KOi K10747.
OMAi CTDIGEL.

Enzyme and pathway databases

BioCyci MMAH547558:GHP5-1128-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35705 / DSM 5219 / SLPImported.

Entry informationi

Entry nameiD5EBP8_METMS
AccessioniPrimary (citable) accession number: D5EBP8
Entry historyi
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: October 29, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3