D5EBF9 (D5EBF9_METMS) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrA HAMAP-Rule MF_01401
Short name=Protein-methionine-S-oxide reductase HAMAP-Rule MF_01401
EC=1.8.4.11 HAMAP-Rule MF_01401

Alternative name(s):
Peptide-methionine (S)-S-oxide reductase HAMAP-Rule MF_01401

Gene names

Name:	msrA HAMAP-Rule MF_01401
Ordered Locus Names:	Mmah_0990

Organism

Methanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP) [Complete proteome] [HAMAP] EMBL ADE36510.1

Taxonomic identifier

547558 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanohalophilus › Methanohalophilus mahii

Protein attributes

Sequence length	164 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP-Rule MF_01401
Catalytic activity	L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP-Rule MF_01401 Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP-Rule MF_01401
Sequence similarities	Belongs to the MsrA Met sulfoxide reductase family. HAMAP-Rule MF_01401

Ontologies

Keywords
Domain	Signal EMBL ADE36510.1
Molecular function	Oxidoreductase HAMAP-Rule MF_01401 EMBL ADE36510.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular protein modification process Inferred from electronic annotation. Source: HAMAP
Molecular_function	peptide-methionine (S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential EMBL ADE36510.1
	Chain	22 – 164	143	Potential EMBL ADE36510.1		PRO_5000583201
Sites
	Active site	15	1	By similarity HAMAP-Rule MF_01401

Sequences

	Sequence		Length	Mass (Da)
	D5EBF9 [UniParc]. Last modified June 15, 2010. Version 1. Checksum: 68584523839C7645	FASTA	164	18,531
	10 20 30 40 50 60 MSLKSIEKAT FAAGCFWGVE AAFREVEGVI STQVGYTGGS MSNPSYKEVC TGRTGHAEAV 70 80 90 100 110 120 EVTYDPQIVS YEQMLDIFWN IHDPTTPNRQ GPDIGTQYRS AIFYHDIKQK EIALRSLHKL 130 140 150 160 QESGKFNTIV TEIKPASEFY PAEDYHQQYF EKKGICRSGK CGWK

References

[1]

"The complete genome of Methanohalophilus mahii DSM 5219." US DOE Joint Genome Institute (JGI-PGF) Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N., Lykidis A., Saunders E., Brettin T., Detter J.C., Han C., Land M. , Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Spring S., Schneider S., Schroeder M., Klenk H.-P., Eisen J.A. Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35705 / DSM 5219 / SLP.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001994 Genomic DNA. Translation: ADE36510.1.
RefSeq	YP_003542155.1. NC_014002.1.
3D structure databases
ProteinModelPortal	D5EBF9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ADE36510; ADE36510; Mmah_0990.
GeneID	8983155.
KEGG	mmh:Mmah_0990.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000263862.
KO	K07304.
OMA	QPFYPAE.
Enzyme and pathway databases
BioCyc	MMAH547558:GHP5-1024-MONOMER.
Family and domain databases
Gene3D	3.30.1060.10. 1 hit.
HAMAP	MF_01401. MsrA.
InterPro	IPR002569. Met_Sox_Rdtase_MsrA. [Graphical view]
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
SUPFAM	SSF55068. MsrA. 1 hit.
TIGRFAMs	TIGR00401. msrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

D5EBF9_METMS

Accession

Primary (citable) accession number: D5EBF9

Entry history

Integrated into UniProtKB/TrEMBL:	June 15, 2010
Last sequence update:	June 15, 2010
Last modified:	May 1, 2013
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)