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D5EB23

- D5EB23_METMS

UniProt

D5EB23 - D5EB23_METMS

Protein

DNA gyrase subunit A

Gene

gyrA

Organism
Methanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 30 (01 Oct 2014)
      Sequence version 1 (15 Jun 2010)
      Previous versions | rss
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    Functioni

    DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.UniRule annotation

    Catalytic activityi

    ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei138 – 1381O-(5'-phospho-DNA)-tyrosine intermediateUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: UniProtKB-HAMAP
    3. DNA topoisomerase type II (ATP-hydrolyzing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA-dependent DNA replication Source: UniProtKB-HAMAP
    2. DNA topological change Source: InterPro

    Keywords - Molecular functioni

    Isomerase, TopoisomeraseUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, DNA-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMMAH547558:GHP5-885-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA gyrase subunit AUniRule annotation (EC:5.99.1.3UniRule annotation)
    Gene namesi
    Name:gyrAUniRule annotation
    Ordered Locus Names:Mmah_0851Imported
    OrganismiMethanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP)Imported
    Taxonomic identifieri547558 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanohalophilus
    ProteomesiUP000001059: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. chromosome Source: InterPro
    2. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Subunit structurei

    Heterotetramer, composed of two GyrA and two GyrB chains. Within the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB contributes the cofactor binding sites and catalyzes ATP hydrolysis.UniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the topoisomerase GyrA/ParC subunit family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000076278.
    KOiK02469.
    OMAiRIATINR.

    Family and domain databases

    Gene3Di3.30.1360.40. 1 hit.
    3.90.199.10. 2 hits.
    HAMAPiMF_01897. GyrA.
    InterProiIPR024946. Arg_repress_C-like.
    IPR005743. GyrA.
    IPR006691. GyrA/parC_pinwhl.
    IPR002205. Topo_IIA_A/C.
    IPR013758. Topo_IIA_A/C_ab.
    IPR013760. Topo_IIA_like_dom.
    [Graphical view]
    PfamiPF03989. DNA_gyraseA_C. 6 hits.
    PF00521. DNA_topoisoIV. 1 hit.
    [Graphical view]
    SMARTiSM00434. TOP4c. 1 hit.
    [Graphical view]
    SUPFAMiSSF56719. SSF56719. 1 hit.
    TIGRFAMsiTIGR01063. gyrA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    D5EB23-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADYDDINPL DEKIEQHDGE GGRVVPVLIQ DEMKRSYIDY SMSVIVGRAL    50
    PDARDGLKPV HRRILHSMNE AGITHDKAYK KSARVVGDVL GKFHPHGDTA 100
    VYDSLVRMVQ DFSLRYPLID GQGNFGSVDG DSAAAMRYTE VRMDKITTEM 150
    LEDIKKGTVD FKPNYDGSLE EPEVLPSKLP NLLLNGSTGI AVGMATNMAP 200
    HNLGEVVDAT VKLIDDPETE LAELRKIVKG PDFPTGGIIM GTSGIKSAYE 250
    TGRSPIYLRA VTEIEEMKND KYRIVVYELP YQVNKARLVE SIANLVRDKK 300
    IEGISDLRDE SGREGMRVVI ELKKAANPKV LLNQLYKQTQ LETTFGIINL 350
    ALVDGVPRVL NLRELIQIYL KHRIDVISRR TVFDLRKAEE RAHILQGLKV 400
    ALDNIDEVIK LIRGSSTTEE AREGLISNFD LDEIQAKAIL DMKLQRLTGL 450
    ERQKIDEEYN GLIDTIADLK DILANDERKY AIIRDEVLEL KDKYGDERRT 500
    LIQSSREELA DEDLIPEEEV VVTSTQSGYI KNIPLQTYNM QHRGGRGVRG 550
    METKEDDTVG SIFVASTHDY ILFFTNRGKV YWQKVYDIPR GSRQSRGKAI 600
    VNLLELAEGE SVNAMIPVHD FENDRYLFMG TRDGTVKRCS LSDFSNPRKA 650
    GIIAISLKEG DELVNVLQTD GNQDIMLASR HGKALRISEE DVRVMGRTAR 700
    GVRGMKLAGP DVIVSLDVVD SDGTLLTVTE NGFGKRTPFD EYRTLRRGGQ 750
    GVITIFTDMR NGPVVTVKTV EDDDEIILTS SAGIVMRIPV TDIRVQGRNT 800
    KGVKIMNIRE KDKLVSLARI KKEE 824
    Length:824
    Mass (Da):92,330
    Last modified:June 15, 2010 - v1
    Checksum:i02C9B22C9914B8D8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001994 Genomic DNA. Translation: ADE36374.1.
    RefSeqiYP_003542019.1. NC_014002.1.

    Genome annotation databases

    EnsemblBacteriaiADE36374; ADE36374; Mmah_0851.
    GeneIDi8983015.
    KEGGimmh:Mmah_0851.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001994 Genomic DNA. Translation: ADE36374.1 .
    RefSeqi YP_003542019.1. NC_014002.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADE36374 ; ADE36374 ; Mmah_0851 .
    GeneIDi 8983015.
    KEGGi mmh:Mmah_0851.

    Phylogenomic databases

    HOGENOMi HOG000076278.
    KOi K02469.
    OMAi RIATINR.

    Enzyme and pathway databases

    BioCyci MMAH547558:GHP5-885-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1360.40. 1 hit.
    3.90.199.10. 2 hits.
    HAMAPi MF_01897. GyrA.
    InterProi IPR024946. Arg_repress_C-like.
    IPR005743. GyrA.
    IPR006691. GyrA/parC_pinwhl.
    IPR002205. Topo_IIA_A/C.
    IPR013758. Topo_IIA_A/C_ab.
    IPR013760. Topo_IIA_like_dom.
    [Graphical view ]
    Pfami PF03989. DNA_gyraseA_C. 6 hits.
    PF00521. DNA_topoisoIV. 1 hit.
    [Graphical view ]
    SMARTi SM00434. TOP4c. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56719. SSF56719. 1 hit.
    TIGRFAMsi TIGR01063. gyrA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35705 / DSM 5219 / SLPImported.

    Entry informationi

    Entry nameiD5EB23_METMS
    AccessioniPrimary (citable) accession number: D5EB23
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 15, 2010
    Last sequence update: June 15, 2010
    Last modified: October 1, 2014
    This is version 30 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3