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D5EB23

- D5EB23_METMS

UniProt

D5EB23 - D5EB23_METMS

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Protein

DNA gyrase subunit A

Gene
gyrA, Mmah_0851
Organism
Methanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity.UniRule annotation

Catalytic activityi

ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei138 – 1381O-(5'-phospho-DNA)-tyrosine intermediate By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: UniProtKB-HAMAP
  3. DNA topoisomerase type II (ATP-hydrolyzing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA-dependent DNA replication Source: UniProtKB-HAMAP
  2. DNA topological change Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, TopoisomeraseUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, DNA-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAH547558:GHP5-885-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA gyrase subunit AUniRule annotation (EC:5.99.1.3UniRule annotation)
Gene namesi
Name:gyrAUniRule annotation
Ordered Locus Names:Mmah_0851Imported
OrganismiMethanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP)Imported
Taxonomic identifieri547558 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanohalophilus
ProteomesiUP000001059: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. chromosome Source: InterPro
  2. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Heterotetramer, composed of two GyrA and two GyrB chains. Within the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB contributes the cofactor binding sites and catalyzes ATP hydrolysis By similarity.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000076278.
KOiK02469.
OMAiRIATINR.

Family and domain databases

Gene3Di3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPiMF_01897. GyrA.
InterProiIPR024946. Arg_repress_C-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
[Graphical view]
PfamiPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTiSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMiSSF56719. SSF56719. 1 hit.
TIGRFAMsiTIGR01063. gyrA. 1 hit.

Sequencei

Sequence statusi: Complete.

D5EB23-1 [UniParc]FASTAAdd to Basket

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MADYDDINPL DEKIEQHDGE GGRVVPVLIQ DEMKRSYIDY SMSVIVGRAL    50
PDARDGLKPV HRRILHSMNE AGITHDKAYK KSARVVGDVL GKFHPHGDTA 100
VYDSLVRMVQ DFSLRYPLID GQGNFGSVDG DSAAAMRYTE VRMDKITTEM 150
LEDIKKGTVD FKPNYDGSLE EPEVLPSKLP NLLLNGSTGI AVGMATNMAP 200
HNLGEVVDAT VKLIDDPETE LAELRKIVKG PDFPTGGIIM GTSGIKSAYE 250
TGRSPIYLRA VTEIEEMKND KYRIVVYELP YQVNKARLVE SIANLVRDKK 300
IEGISDLRDE SGREGMRVVI ELKKAANPKV LLNQLYKQTQ LETTFGIINL 350
ALVDGVPRVL NLRELIQIYL KHRIDVISRR TVFDLRKAEE RAHILQGLKV 400
ALDNIDEVIK LIRGSSTTEE AREGLISNFD LDEIQAKAIL DMKLQRLTGL 450
ERQKIDEEYN GLIDTIADLK DILANDERKY AIIRDEVLEL KDKYGDERRT 500
LIQSSREELA DEDLIPEEEV VVTSTQSGYI KNIPLQTYNM QHRGGRGVRG 550
METKEDDTVG SIFVASTHDY ILFFTNRGKV YWQKVYDIPR GSRQSRGKAI 600
VNLLELAEGE SVNAMIPVHD FENDRYLFMG TRDGTVKRCS LSDFSNPRKA 650
GIIAISLKEG DELVNVLQTD GNQDIMLASR HGKALRISEE DVRVMGRTAR 700
GVRGMKLAGP DVIVSLDVVD SDGTLLTVTE NGFGKRTPFD EYRTLRRGGQ 750
GVITIFTDMR NGPVVTVKTV EDDDEIILTS SAGIVMRIPV TDIRVQGRNT 800
KGVKIMNIRE KDKLVSLARI KKEE 824
Length:824
Mass (Da):92,330
Last modified:June 15, 2010 - v1
Checksum:i02C9B22C9914B8D8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001994 Genomic DNA. Translation: ADE36374.1.
RefSeqiYP_003542019.1. NC_014002.1.

Genome annotation databases

EnsemblBacteriaiADE36374; ADE36374; Mmah_0851.
GeneIDi8983015.
KEGGimmh:Mmah_0851.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001994 Genomic DNA. Translation: ADE36374.1 .
RefSeqi YP_003542019.1. NC_014002.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADE36374 ; ADE36374 ; Mmah_0851 .
GeneIDi 8983015.
KEGGi mmh:Mmah_0851.

Phylogenomic databases

HOGENOMi HOG000076278.
KOi K02469.
OMAi RIATINR.

Enzyme and pathway databases

BioCyci MMAH547558:GHP5-885-MONOMER.

Family and domain databases

Gene3Di 3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPi MF_01897. GyrA.
InterProi IPR024946. Arg_repress_C-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
[Graphical view ]
Pfami PF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view ]
SMARTi SM00434. TOP4c. 1 hit.
[Graphical view ]
SUPFAMi SSF56719. SSF56719. 1 hit.
TIGRFAMsi TIGR01063. gyrA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35705 / DSM 5219 / SLP.

Entry informationi

Entry nameiD5EB23_METMS
AccessioniPrimary (citable) accession number: D5EB23
Entry historyi
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: June 11, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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