Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

D5EA92

- D5EA92_METMS

UniProt

D5EA92 - D5EA92_METMS

Protein

DNA ligase

Gene

lig

Organism
Methanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (15 Jun 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei254 – 2541ATPUniRule annotation
    Active sitei256 – 2561N6-AMP-lysine intermediateUniRule annotation
    Binding sitei261 – 2611ATPUniRule annotation
    Binding sitei276 – 2761ATPUniRule annotation
    Binding sitei306 – 3061ATPUniRule annotation
    Binding sitei346 – 3461ATPUniRule annotation
    Binding sitei421 – 4211ATPUniRule annotation
    Binding sitei427 – 4271ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMMAH547558:GHP5-584-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:Mmah_0567Imported
    OrganismiMethanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP)Imported
    Taxonomic identifieri547558 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanohalophilus
    ProteomesiUP000001059: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliD5EA92.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000036008.
    KOiK10747.
    OMAiARVQVHK.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D5EA92-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSFEYFANT CASIEHIPGS LEMTDVIAKL LKEVTIEELP IVTHFVMGSV    50
    FPAWSDRQMG VGNRLLYTAL SKSSGVSEEE IENIIRKTGD IGETAVQALS 100
    SNPAGQSTFS AFIEEKPGME IKEVYERFTH IADTAGKRSH GTKIKNLQYL 150
    FNSATPIEAR YLARLAIEQL RIGVGEGIVR DAISKAFETD VDVVERALML 200
    TNDLGLVAVA ACNGGNEEVQ KLDIQLNRPV KMMLAQVTSS IQSALNDLGE 250
    VAVEWKFDGA RVQIHKEGEN IHIFSRRLEN VTSSLPDVVK EVQENVNADT 300
    AILEGEAVAI GKDGKPRAFQ DILKRFRRKY DVEAIAKAIP LKLNLFDVLY 350
    LNGESLIDNP LRKRRELLFQ NVQSSDRILV DRQVITDNEE EIQEIYADAL 400
    RAGHEGIMIK KPDAPYSPGK RGKNWLKKKP LMETLDLVVI GAEWGYGRRA 450
    NLIGSYALGC YDPDTGKFPA IGKVATGITD EKLAELTTLF SDLVVYEAGR 500
    KIELKPEIVF EIAFEEIQKS PNYESGYALR FPRLVNVRDD KSPEEAESLE 550
    RIGEIYHSQR S 561
    Length:561
    Mass (Da):62,553
    Last modified:June 15, 2010 - v1
    Checksum:i3F8B391E8D73AF83
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001994 Genomic DNA. Translation: ADE36093.1.
    RefSeqiWP_013037036.1. NC_014002.1.
    YP_003541738.1. NC_014002.1.

    Genome annotation databases

    EnsemblBacteriaiADE36093; ADE36093; Mmah_0567.
    GeneIDi8982715.
    KEGGimmh:Mmah_0567.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001994 Genomic DNA. Translation: ADE36093.1 .
    RefSeqi WP_013037036.1. NC_014002.1.
    YP_003541738.1. NC_014002.1.

    3D structure databases

    ProteinModelPortali D5EA92.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADE36093 ; ADE36093 ; Mmah_0567 .
    GeneIDi 8982715.
    KEGGi mmh:Mmah_0567.

    Phylogenomic databases

    HOGENOMi HOG000036008.
    KOi K10747.
    OMAi ARVQVHK.

    Enzyme and pathway databases

    BioCyci MMAH547558:GHP5-584-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35705 / DSM 5219 / SLPImported.

    Entry informationi

    Entry nameiD5EA92_METMS
    AccessioniPrimary (citable) accession number: D5EA92
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 15, 2010
    Last sequence update: June 15, 2010
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3