SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

D5EA92

- D5EA92_METMS

UniProt

D5EA92 - D5EA92_METMS

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
DNA ligase
Gene
lig, Mmah_0567
Organism
Methanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei254 – 2541ATP By similarityUniRule annotation
Active sitei256 – 2561N6-AMP-lysine intermediate By similarityUniRule annotation
Binding sitei261 – 2611ATP By similarityUniRule annotation
Binding sitei276 – 2761ATP By similarityUniRule annotation
Binding sitei306 – 3061ATP By similarityUniRule annotation
Binding sitei346 – 3461ATP By similarityUniRule annotation
Binding sitei421 – 4211ATP By similarityUniRule annotation
Binding sitei427 – 4271ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-HAMAP
  3. DNA replication Source: UniProtKB-HAMAP
  4. cell cycle Source: UniProtKB-KW
  5. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAH547558:GHP5-584-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Mmah_0567Imported
OrganismiMethanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP)Imported
Taxonomic identifieri547558 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanohalophilus
ProteomesiUP000001059: Chromosome

Structurei

3D structure databases

ProteinModelPortaliD5EA92.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000036008.
KOiK10747.
OMAiARVQVHK.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D5EA92-1 [UniParc]FASTAAdd to Basket

« Hide

MTSFEYFANT CASIEHIPGS LEMTDVIAKL LKEVTIEELP IVTHFVMGSV    50
FPAWSDRQMG VGNRLLYTAL SKSSGVSEEE IENIIRKTGD IGETAVQALS 100
SNPAGQSTFS AFIEEKPGME IKEVYERFTH IADTAGKRSH GTKIKNLQYL 150
FNSATPIEAR YLARLAIEQL RIGVGEGIVR DAISKAFETD VDVVERALML 200
TNDLGLVAVA ACNGGNEEVQ KLDIQLNRPV KMMLAQVTSS IQSALNDLGE 250
VAVEWKFDGA RVQIHKEGEN IHIFSRRLEN VTSSLPDVVK EVQENVNADT 300
AILEGEAVAI GKDGKPRAFQ DILKRFRRKY DVEAIAKAIP LKLNLFDVLY 350
LNGESLIDNP LRKRRELLFQ NVQSSDRILV DRQVITDNEE EIQEIYADAL 400
RAGHEGIMIK KPDAPYSPGK RGKNWLKKKP LMETLDLVVI GAEWGYGRRA 450
NLIGSYALGC YDPDTGKFPA IGKVATGITD EKLAELTTLF SDLVVYEAGR 500
KIELKPEIVF EIAFEEIQKS PNYESGYALR FPRLVNVRDD KSPEEAESLE 550
RIGEIYHSQR S 561
Length:561
Mass (Da):62,553
Last modified:June 15, 2010 - v1
Checksum:i3F8B391E8D73AF83
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001994 Genomic DNA. Translation: ADE36093.1.
RefSeqiWP_013037036.1. NC_014002.1.
YP_003541738.1. NC_014002.1.

Genome annotation databases

EnsemblBacteriaiADE36093; ADE36093; Mmah_0567.
GeneIDi8982715.
KEGGimmh:Mmah_0567.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001994 Genomic DNA. Translation: ADE36093.1 .
RefSeqi WP_013037036.1. NC_014002.1.
YP_003541738.1. NC_014002.1.

3D structure databases

ProteinModelPortali D5EA92.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADE36093 ; ADE36093 ; Mmah_0567 .
GeneIDi 8982715.
KEGGi mmh:Mmah_0567.

Phylogenomic databases

HOGENOMi HOG000036008.
KOi K10747.
OMAi ARVQVHK.

Enzyme and pathway databases

BioCyci MMAH547558:GHP5-584-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35705 / DSM 5219 / SLP.

Entry informationi

Entry nameiD5EA92_METMS
AccessioniPrimary (citable) accession number: D5EA92
Entry historyi
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: September 3, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi