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D5EA92

- D5EA92_METMS

UniProt

D5EA92 - D5EA92_METMS

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Protein

DNA ligase

Gene

lig

Organism
Methanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Note: Divalent metal cations.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei254 – 2541ATPUniRule annotation
Active sitei256 – 2561N6-AMP-lysine intermediateUniRule annotation
Binding sitei261 – 2611ATPUniRule annotation
Binding sitei276 – 2761ATPUniRule annotation
Binding sitei306 – 3061ATPUniRule annotation
Binding sitei346 – 3461ATPUniRule annotation
Binding sitei421 – 4211ATPUniRule annotation
Binding sitei427 – 4271ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA biosynthetic process Source: InterPro
  4. DNA ligation involved in DNA repair Source: InterPro
  5. DNA recombination Source: UniProtKB-HAMAP
  6. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAH547558:GHP5-584-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Mmah_0567Imported
OrganismiMethanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP)Imported
Taxonomic identifieri547558 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanohalophilus
ProteomesiUP000001059: Chromosome

Structurei

3D structure databases

ProteinModelPortaliD5EA92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000036008.
KOiK10747.
OMAiARVQVHK.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D5EA92-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSFEYFANT CASIEHIPGS LEMTDVIAKL LKEVTIEELP IVTHFVMGSV
60 70 80 90 100
FPAWSDRQMG VGNRLLYTAL SKSSGVSEEE IENIIRKTGD IGETAVQALS
110 120 130 140 150
SNPAGQSTFS AFIEEKPGME IKEVYERFTH IADTAGKRSH GTKIKNLQYL
160 170 180 190 200
FNSATPIEAR YLARLAIEQL RIGVGEGIVR DAISKAFETD VDVVERALML
210 220 230 240 250
TNDLGLVAVA ACNGGNEEVQ KLDIQLNRPV KMMLAQVTSS IQSALNDLGE
260 270 280 290 300
VAVEWKFDGA RVQIHKEGEN IHIFSRRLEN VTSSLPDVVK EVQENVNADT
310 320 330 340 350
AILEGEAVAI GKDGKPRAFQ DILKRFRRKY DVEAIAKAIP LKLNLFDVLY
360 370 380 390 400
LNGESLIDNP LRKRRELLFQ NVQSSDRILV DRQVITDNEE EIQEIYADAL
410 420 430 440 450
RAGHEGIMIK KPDAPYSPGK RGKNWLKKKP LMETLDLVVI GAEWGYGRRA
460 470 480 490 500
NLIGSYALGC YDPDTGKFPA IGKVATGITD EKLAELTTLF SDLVVYEAGR
510 520 530 540 550
KIELKPEIVF EIAFEEIQKS PNYESGYALR FPRLVNVRDD KSPEEAESLE
560
RIGEIYHSQR S
Length:561
Mass (Da):62,553
Last modified:June 15, 2010 - v1
Checksum:i3F8B391E8D73AF83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001994 Genomic DNA. Translation: ADE36093.1.
RefSeqiWP_013037036.1. NC_014002.1.
YP_003541738.1. NC_014002.1.

Genome annotation databases

EnsemblBacteriaiADE36093; ADE36093; Mmah_0567.
GeneIDi8982715.
KEGGimmh:Mmah_0567.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001994 Genomic DNA. Translation: ADE36093.1 .
RefSeqi WP_013037036.1. NC_014002.1.
YP_003541738.1. NC_014002.1.

3D structure databases

ProteinModelPortali D5EA92.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADE36093 ; ADE36093 ; Mmah_0567 .
GeneIDi 8982715.
KEGGi mmh:Mmah_0567.

Phylogenomic databases

HOGENOMi HOG000036008.
KOi K10747.
OMAi ARVQVHK.

Enzyme and pathway databases

BioCyci MMAH547558:GHP5-584-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35705 / DSM 5219 / SLPImported.

Entry informationi

Entry nameiD5EA92_METMS
AccessioniPrimary (citable) accession number: D5EA92
Entry historyi
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: November 26, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3