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D5E898

- D5E898_METMS

UniProt

D5E898 - D5E898_METMS

Protein

Lysine--tRNA ligase

Gene

lysS

Organism
Methanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (15 Jun 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. lysine-tRNA ligase activity Source: UniProtKB-HAMAP
    3. tRNA binding Source: InterPro

    GO - Biological processi

    1. lysyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetaseUniRule annotationImported, Ligase

    Keywords - Biological processi

    Protein biosynthesisUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMMAH547558:GHP5-1948-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysine--tRNA ligaseUniRule annotation (EC:6.1.1.6UniRule annotation)
    Alternative name(s):
    Lysyl-tRNA synthetaseUniRule annotation
    Gene namesi
    Name:lysSUniRule annotation
    Ordered Locus Names:Mmah_1891Imported
    OrganismiMethanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP)Imported
    Taxonomic identifieri547558 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanohalophilus
    ProteomesiUP000001059: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD5E898.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi30 – 389"HIGH" regionUniRule annotation
    Motifi276 – 2805"KMSKS" regionUniRule annotation

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000226938.
    KOiK04566.
    OMAiHENKKIM.

    Family and domain databases

    Gene3Di1.10.10.350. 1 hit.
    2.30.30.300. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPiMF_00177. Lys_tRNA_synth_class1.
    InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR001412. aa-tRNA-synth_I_CS.
    IPR002904. Lys-tRNA-ligase.
    IPR023386. Lys-tRNA-ligase_insertion.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF01921. tRNA-synt_1f. 1 hit.
    [Graphical view]
    SUPFAMiSSF48163. SSF48163. 1 hit.
    TIGRFAMsiTIGR00467. lysS_arch. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D5E898-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTEITHWADV VAEETLERGN THLVATGITP SGHIHVGNMR EVVTADAAYR    50
    ALLDRDANAE LIYIADTYDP LRKVYPFLDE SYEEHVGKPL SEIPCPCGEC 100
    KNYADHFLQP FLKSLHRLGI KPEVYLADEL YKSGRYNEGI KTALKKRDKI 150
    AAILKEVSGR QPGDDWSPFN PICMQCGKIN TTRVTSFDER EETVDYTCSC 200
    GHSGTVPMQG GGKLTWRVDW PARWQILGVT VEPFGKDHAS RGGSYDTGKR 250
    IAREIFGCEP PHPIVYEWIM LGKEGAMSSS TGVVVSIADM LKVVPPEVLR 300
    YLIIRTKPEK HIRFDPAQPL LTLVDQYEKL HQTGGTSEYD RRVKELSHAS 350
    GLCHTDIPFK HMTTIHQVAH GDFDRILKIV ERAGYDTKNT ECIKQLADNV 400
    GNWLDMYAPP FAKFSVQEKL PELAATLSDK QRAFLTTLAD VLEESAELDG 450
    SDYHNLVYSA KEEGGRLHRE MEKVLGEEFT IGPKDLFKAL YISLLGQASG 500
    PKAGWFLSSL EKDFLIKRFR EAAAYRP 527
    Length:527
    Mass (Da):59,248
    Last modified:June 15, 2010 - v1
    Checksum:i882460191408D300
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001994 Genomic DNA. Translation: ADE37386.1.
    RefSeqiWP_013038328.1. NC_014002.1.
    YP_003543031.1. NC_014002.1.

    Genome annotation databases

    EnsemblBacteriaiADE37386; ADE37386; Mmah_1891.
    GeneIDi8984078.
    KEGGimmh:Mmah_1891.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001994 Genomic DNA. Translation: ADE37386.1 .
    RefSeqi WP_013038328.1. NC_014002.1.
    YP_003543031.1. NC_014002.1.

    3D structure databases

    ProteinModelPortali D5E898.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADE37386 ; ADE37386 ; Mmah_1891 .
    GeneIDi 8984078.
    KEGGi mmh:Mmah_1891.

    Phylogenomic databases

    HOGENOMi HOG000226938.
    KOi K04566.
    OMAi HENKKIM.

    Enzyme and pathway databases

    BioCyci MMAH547558:GHP5-1948-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.350. 1 hit.
    2.30.30.300. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPi MF_00177. Lys_tRNA_synth_class1.
    InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR001412. aa-tRNA-synth_I_CS.
    IPR002904. Lys-tRNA-ligase.
    IPR023386. Lys-tRNA-ligase_insertion.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF01921. tRNA-synt_1f. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48163. SSF48163. 1 hit.
    TIGRFAMsi TIGR00467. lysS_arch. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35705 / DSM 5219 / SLPImported.

    Entry informationi

    Entry nameiD5E898_METMS
    AccessioniPrimary (citable) accession number: D5E898
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 15, 2010
    Last sequence update: June 15, 2010
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3