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Protein

Lysine--tRNA ligase

Gene

lysS

Organism
Methanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAH547558:G1GHT-1900-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine--tRNA ligaseUniRule annotation (EC:6.1.1.6UniRule annotation)
Alternative name(s):
Lysyl-tRNA synthetaseUniRule annotation
Short name:
LysRSUniRule annotation
Gene namesi
Name:lysSUniRule annotation
Ordered Locus Names:Mmah_1891Imported
OrganismiMethanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP)Imported
Taxonomic identifieri547558 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanohalophilus
Proteomesi
  • UP000001059 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi547558.Mmah_1891

Structurei

3D structure databases

ProteinModelPortaliD5E898
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi30 – 38"HIGH" regionUniRule annotation9
Motifi276 – 280"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00485 Archaea
COG1384 LUCA
HOGENOMiHOG000226938
KOiK04566
OMAiDWPMRWA
OrthoDBiPOG093Z01CB

Family and domain databases

Gene3Di1.10.10.350, 1 hit
2.30.30.300, 1 hit
3.40.50.620, 2 hits
HAMAPiMF_00177 Lys_tRNA_synth_class1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR002904 Lys-tRNA-ligase
IPR023386 Lys-tRNA-ligase_insertion_sf
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR37940 PTHR37940, 1 hit
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00467 lysS_arch, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

D5E898-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEITHWADV VAEETLERGN THLVATGITP SGHIHVGNMR EVVTADAAYR
60 70 80 90 100
ALLDRDANAE LIYIADTYDP LRKVYPFLDE SYEEHVGKPL SEIPCPCGEC
110 120 130 140 150
KNYADHFLQP FLKSLHRLGI KPEVYLADEL YKSGRYNEGI KTALKKRDKI
160 170 180 190 200
AAILKEVSGR QPGDDWSPFN PICMQCGKIN TTRVTSFDER EETVDYTCSC
210 220 230 240 250
GHSGTVPMQG GGKLTWRVDW PARWQILGVT VEPFGKDHAS RGGSYDTGKR
260 270 280 290 300
IAREIFGCEP PHPIVYEWIM LGKEGAMSSS TGVVVSIADM LKVVPPEVLR
310 320 330 340 350
YLIIRTKPEK HIRFDPAQPL LTLVDQYEKL HQTGGTSEYD RRVKELSHAS
360 370 380 390 400
GLCHTDIPFK HMTTIHQVAH GDFDRILKIV ERAGYDTKNT ECIKQLADNV
410 420 430 440 450
GNWLDMYAPP FAKFSVQEKL PELAATLSDK QRAFLTTLAD VLEESAELDG
460 470 480 490 500
SDYHNLVYSA KEEGGRLHRE MEKVLGEEFT IGPKDLFKAL YISLLGQASG
510 520
PKAGWFLSSL EKDFLIKRFR EAAAYRP
Length:527
Mass (Da):59,248
Last modified:June 15, 2010 - v1
Checksum:i882460191408D300
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001994 Genomic DNA Translation: ADE37386.1
RefSeqiWP_013038328.1, NC_014002.1

Genome annotation databases

EnsemblBacteriaiADE37386; ADE37386; Mmah_1891
GeneIDi8984078
KEGGimmh:Mmah_1891

Similar proteinsi

Entry informationi

Entry nameiD5E898_METMS
AccessioniPrimary (citable) accession number: D5E898
Entry historyiIntegrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: March 28, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health