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Protein

Lysine--tRNA ligase

Gene

lysS

Organism
Methanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. lysine-tRNA ligase activity Source: UniProtKB-HAMAP
  3. tRNA binding Source: InterPro

GO - Biological processi

  1. lysyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetaseUniRule annotation, Ligase

Keywords - Biological processi

Protein biosynthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAH547558:GHP5-1948-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine--tRNA ligaseUniRule annotation (EC:6.1.1.6UniRule annotation)
Alternative name(s):
Lysyl-tRNA synthetaseUniRule annotation
Gene namesi
Name:lysSUniRule annotation
Ordered Locus Names:Mmah_1891Imported
OrganismiMethanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP)Imported
Taxonomic identifieri547558 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanohalophilus
ProteomesiUP000001059: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD5E898.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi30 – 389"HIGH" regionUniRule annotation
Motifi276 – 2805"KMSKS" regionUniRule annotation

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000226938.
KOiK04566.
OMAiDTYDPLR.

Family and domain databases

Gene3Di1.10.10.350. 1 hit.
2.30.30.300. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00177. Lys_tRNA_synth_class1.
InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR002904. Lys-tRNA-ligase.
IPR023386. Lys-tRNA-ligase_insertion.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01921. tRNA-synt_1f. 1 hit.
[Graphical view]
SUPFAMiSSF48163. SSF48163. 1 hit.
TIGRFAMsiTIGR00467. lysS_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D5E898-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEITHWADV VAEETLERGN THLVATGITP SGHIHVGNMR EVVTADAAYR
60 70 80 90 100
ALLDRDANAE LIYIADTYDP LRKVYPFLDE SYEEHVGKPL SEIPCPCGEC
110 120 130 140 150
KNYADHFLQP FLKSLHRLGI KPEVYLADEL YKSGRYNEGI KTALKKRDKI
160 170 180 190 200
AAILKEVSGR QPGDDWSPFN PICMQCGKIN TTRVTSFDER EETVDYTCSC
210 220 230 240 250
GHSGTVPMQG GGKLTWRVDW PARWQILGVT VEPFGKDHAS RGGSYDTGKR
260 270 280 290 300
IAREIFGCEP PHPIVYEWIM LGKEGAMSSS TGVVVSIADM LKVVPPEVLR
310 320 330 340 350
YLIIRTKPEK HIRFDPAQPL LTLVDQYEKL HQTGGTSEYD RRVKELSHAS
360 370 380 390 400
GLCHTDIPFK HMTTIHQVAH GDFDRILKIV ERAGYDTKNT ECIKQLADNV
410 420 430 440 450
GNWLDMYAPP FAKFSVQEKL PELAATLSDK QRAFLTTLAD VLEESAELDG
460 470 480 490 500
SDYHNLVYSA KEEGGRLHRE MEKVLGEEFT IGPKDLFKAL YISLLGQASG
510 520
PKAGWFLSSL EKDFLIKRFR EAAAYRP
Length:527
Mass (Da):59,248
Last modified:June 15, 2010 - v1
Checksum:i882460191408D300
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001994 Genomic DNA. Translation: ADE37386.1.
RefSeqiYP_003543031.1. NC_014002.1.

Genome annotation databases

EnsemblBacteriaiADE37386; ADE37386; Mmah_1891.
GeneIDi8984078.
KEGGimmh:Mmah_1891.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001994 Genomic DNA. Translation: ADE37386.1.
RefSeqiYP_003543031.1. NC_014002.1.

3D structure databases

ProteinModelPortaliD5E898.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADE37386; ADE37386; Mmah_1891.
GeneIDi8984078.
KEGGimmh:Mmah_1891.

Phylogenomic databases

HOGENOMiHOG000226938.
KOiK04566.
OMAiDTYDPLR.

Enzyme and pathway databases

BioCyciMMAH547558:GHP5-1948-MONOMER.

Family and domain databases

Gene3Di1.10.10.350. 1 hit.
2.30.30.300. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00177. Lys_tRNA_synth_class1.
InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR002904. Lys-tRNA-ligase.
IPR023386. Lys-tRNA-ligase_insertion.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01921. tRNA-synt_1f. 1 hit.
[Graphical view]
SUPFAMiSSF48163. SSF48163. 1 hit.
TIGRFAMsiTIGR00467. lysS_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35705 / DSM 5219 / SLPImported.

Entry informationi

Entry nameiD5E898_METMS
AccessioniPrimary (citable) accession number: D5E898
Entry historyi
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: January 7, 2015
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.