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D5E7U7

- HPRT_METMS

UniProt

D5E7U7 - HPRT_METMS

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Protein
Hypoxanthine/guanine phosphoribosyltransferase
Gene
hpt, Mmah_1740
Organism
Methanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis By similarity.UniRule annotation

Catalytic activityi

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. guanine phosphoribosyltransferase activity Source: UniProtKB-EC
  2. hypoxanthine phosphoribosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. IMP salvage Source: UniProtKB-UniPathway
  2. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

BioCyciMMAH547558:GHP5-1792-MONOMER.
UniPathwayiUPA00591; UER00648.

Names & Taxonomyi

Protein namesi
Recommended name:
Hypoxanthine/guanine phosphoribosyltransferase (EC:2.4.2.8)
Short name:
HGPRTase
Gene namesi
Name:hpt
Ordered Locus Names:Mmah_1740
OrganismiMethanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP)
Taxonomic identifieri547558 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanohalophilus
ProteomesiUP000001059: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 190190Hypoxanthine/guanine phosphoribosyltransferaseUniRule annotation
PRO_0000415476Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD5E7U7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000228520.
KOiK00759.
OMAiMAAICEA.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01467. Hypx_phosphoribosyltr.
InterProiIPR026597. HGPRTase-like.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D5E7U7-1 [UniParc]FASTAAdd to Basket

« Hide

MLEILKKSLK KAPIVKRGKY PYFIHPITDG VPAIDPKLLD EISDYIIEYS    50
DMDVDRILSI EAMGIPLATA ISLKTGIPFS IVRKRQYQLP GEIKISQSTG 100
YSKGELYING IEKGNRILLV DDVISTGGTL RFLVKALEEK GVTISDIIVI 150
VGRGDGVQQL AGEGIRVKTL VDINVSEDGV SILEDTGETN 190
Length:190
Mass (Da):20,772
Last modified:June 15, 2010 - v1
Checksum:i7F8020FBFD2AEE2A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001994 Genomic DNA. Translation: ADE37235.1.
RefSeqiYP_003542880.1. NC_014002.1.

Genome annotation databases

EnsemblBacteriaiADE37235; ADE37235; Mmah_1740.
GeneIDi8983922.
KEGGimmh:Mmah_1740.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001994 Genomic DNA. Translation: ADE37235.1 .
RefSeqi YP_003542880.1. NC_014002.1.

3D structure databases

ProteinModelPortali D5E7U7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADE37235 ; ADE37235 ; Mmah_1740 .
GeneIDi 8983922.
KEGGi mmh:Mmah_1740.

Phylogenomic databases

HOGENOMi HOG000228520.
KOi K00759.
OMAi MAAICEA.

Enzyme and pathway databases

UniPathwayi UPA00591 ; UER00648 .
BioCyci MMAH547558:GHP5-1792-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
HAMAPi MF_01467. Hypx_phosphoribosyltr.
InterProi IPR026597. HGPRTase-like.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view ]
Pfami PF00156. Pribosyltran. 1 hit.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 1 hit.
PROSITEi PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35705 / DSM 5219 / SLP.

Entry informationi

Entry nameiHPRT_METMS
AccessioniPrimary (citable) accession number: D5E7U7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: June 15, 2010
Last modified: June 11, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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